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Reduced port surgery for appendectomy:Early experience and surgical technique

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World Journal of Surgical Procedures 2013年第2期3卷 8-12页

作者： Shinichiro Mori Kenji Baba Shigehiro Yanagita Yoshiaki Kita Kosei Maemura Yuko Mataki Yasuto Uchikado Hiroshi Okumura Tetsuhiro Nakajyo shoji Natsugoe Sonshin Takao Kuniaki Aridome Department of Digestive Surgery Breast and Thyroid Surgery Graduate School of Medicine Kagoshima University Kagoshima 890-8520 Japan Frontier Science Research Center Kagoshima University Kagoshima 890-8520 Japan Department of Surgery Nanpuh Hospital NKagoshima 892-8512 Japan

AIM: To evaluate our experience and surgical technique of laparoscopic appendectomy via reduced port surgery(LARPS). METHODS: Sixteen patients(8 men and 8 women; median age: 31.0 years) who underwent LARPS between November 2009 and May 2012 were included in the present study. We performed LARPS, in which access devices were inserted through an umbilical skin incision with 1 additional skin incision in the left lower abdomen. After setting access devices, pneumoperitoneum was maintained at 10 mmH g using CO2 and a 3 mm trocar was positioned(or direct puncture was performed by the Endo Relief system) under laparoscopic guidance. The mesoappendix was dissected using an ultrasonically activated device. After mesoappendix dissection, ligation was performed near the appendix base and the appendix was dissected using an ultrasonically activated device. The appendix was then removed. At the end of surgery, we administered local anesthesia with ropivacaine 1%(10 mL) for the skin incisions. The outcomes were evaluated in terms of operation time, intraoperative blood loss, length of postoperative hospital stay and surgical complications. RESULTS: Our surgical procedure allowed operators to use instruments as in conventional laparoscopic appendectomy. The basic principle of triangulation of instrumentation was maintained to some degree. LARPS was performed in 9 patients with catarrhal appendicitis, 5 with phlegmonous appendicitis, and 2 with gangrenous appendicitis. The median surgery time was 60 min and the median intraoperative blood loss was 1.2 mL. The median length of postoperative hospitalization was 4 d. There were no conversions to open surgery, no operation-related complications or mortality. CONCLUSION: Our experience and surgical technique suggest that LARPS is a safe and feasible procedure for patients with appendicitis.

关键词： Reduced port surgery Appendectomy Laparoscopy Cosmesis Single incision

晶界工程处理对Inconel 690TT合金微动磨损行为的影响

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材料工程 2020年第10期48卷 123-132页

作者：韩永明韩俊玲辛龙刘廷光陆永浩庄子哲雄北京科技大学国家材料服役安全科学中心北京100083 东北大学(日本)未来科学技术共同研究中心日本仙台980-8579

采用热处理加冷轧的晶界工程处理,利用OM,SEM,EBSD和白光干涉仪等研究Inconel 690TT合金在室温与320℃空气中的微动磨损行为。结果表明:经5%冷轧变形及高温短时间退火处理后Inconel 690TT合金的显微组织中低∑重位点阵(CSL)晶界比例达到... 详细信息

采用热处理加冷轧的晶界工程处理,利用OM,SEM,EBSD和白光干涉仪等研究Inconel 690TT合金在室温与320℃空气中的微动磨损行为。结果表明:经5%冷轧变形及高温短时间退火处理后Inconel 690TT合金的显微组织中低∑重位点阵(CSL)晶界比例达到70%以上;Inconel 690TT合金试样在室温和320℃下的微动磨损体积与摩擦因数均随硬度增加而降低,随晶粒尺寸和低∑CSL晶界比例增加而增大;在相同微动实验参数下,晶粒尺寸越大、低∑CSL晶界比例越高试样的微动运动区域特性倾向于完全滑移,反之倾向于部分滑移;与晶粒尺寸相比,低∑CSL晶界比例对晶界工程处理试样的微动磨损抗力的影响更强,低∑CSL晶界比例越高材料的抗微动磨损能力越差,晶界工程处理不利于提高材料的微动磨损抗力。

关键词： Inconel 690TT合金晶界工程微动磨损低∑CSL晶界晶粒尺寸

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有机砷中毒出现上视诱发的眼震

世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 5-5页

作者： Nakamagoe K. Ishii K. Tamaoka A. shoji S. 张磊 Department of Neurology Ryugasaki Saiseikai Hospital1-1 NakazatoRyugasakiIbaraki 305-0854Japan Dr.

The authors report assessment of abnormal ocular movements in three patients after organoarsenic poisoning from diphenylarsinic *** characteristic and principal sign is upward gaze-evoked ***,vertical gaze holding imp... 详细信息

关键词：眼震电流描记砷中毒患者视诱发眼球运动特征性

人类胆囊收缩素基因的新遗传多态性及其与酒精依赖的关系

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吉林医药学院学报 2011年第4期32卷 192-194页

作者：张绍轩林光柱金刚大久保武人原田勝二贺昕吉林大学再生医学科学研究所吉林长春130021 吉林大学第一临床医院吉林长春130021 吉林省肿瘤医院吉林长春130012 筑波大学社会医学系中国人民解放军北京军区总医院北京100700

目的分析人胆囊收缩素基因遗传多态性及其与酒精依赖的关系。方法基于荧光的单构象变化分析及PCR直接测序的方法分析了66名日本人、66名美国白人、52名中国人和41名哥伦比亚原住民前胆囊收缩素原基因启动子和编码区的新遗传变异,并通过... 详细信息

目的分析人胆囊收缩素基因遗传多态性及其与酒精依赖的关系。方法基于荧光的单构象变化分析及PCR直接测序的方法分析了66名日本人、66名美国白人、52名中国人和41名哥伦比亚原住民前胆囊收缩素原基因启动子和编码区的新遗传变异,并通过对10对孪生子家庭的分离,分析确定了两等位基因的遗传方式。还对66名健康对照日本人和108名酗酒者的基因型分布及等位基因频率进行了分析。结果发现了两个核苷酸变异体:其中一个频繁突变处于启动子Sp1结合顺式结构的核心区-45位置,是一个C和T的置换;另一个位于内含子2的1 662处,也是一个C和T的置换。结论这两个遗传变异属于新基因多态性,呈共显性遗传。酗酒者中等位基因的T变异体的频率明显的高于对照组,而且两组中这些基因型的分布亦存在明显的差异。

关键词：胆囊收缩素基因启动子区基因多态性酒精依赖

An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

ICRF Heated Long-Pulse Plasma Discharges in LHD

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Plasma Science and Technology 2006年第1期8卷 28-32页

作者： R. KUMAZAWA T. SEKI T. MUTOH K. SAITO T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIHARA M. shoji S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. ASHIKAWA K. NISHIMURA H. FUNABA H. CHIKARAISHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.NOMURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK H. YAMADA K. KAWAHATA N. OHYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA National Institute for Fusion Science Toki Japan Kyusyu University Kasuga Japan Nagoya University Faculty of Engineering Nagoya Japan Kyoto University Institute of Advanced Energy Uji Japan Tsukuba University Plasma Research Center Tsukuba Japan Tokyo University Graduate School of Frontier Sciences Tokyo Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China KAERI 150 Deogjin-dong Yuseong-gu Daejeon Korea Rep.

A long-pulse plasma discharge for more than 30 min. was achieved on the Large Helical Device （LHD）. A plasma of ne = 0.8 × 10^19 m^-3 and T10 = 2.0 keV was sustained with PICH = 0.52 MW, PECH = 0.1 MW and averaged PNBI = 0.067 MW. Total injected heating energy was 1.3 G J, which was a quarter of the prepared RF heating energy. One of the keys to the success of the experiment was a dispersion of the local plasma heat load to divertors, accomplished by shifting the magnetic axis inward and outward.

关键词： helical/stellarator configuration ICRF heating steady state operation

年龄相关的血浆Aβ水平变化及其对阿尔茨海默病的诊断意义

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中华神经医学杂志 2005年第8期4卷 766-768页

作者：徐武华東海林幹夫松原悦朗梁瑞华何丽婵张素平广州市红十字会医院暨南大学医学院第四附属医院神经内科510220 日本冈山大学大学院医学综合研究科神经内科

目的探讨血浆Aβ变量(Aβ40、Aβ42水平及其比值)在正常衰老和阿尔茨海默病(AD)疾病过程中的变化规律及对AD其诊断价值。方法双抗体夹心ELISA检测113例AD患者和205例不同年龄段健康者的血浆Aβ水平并分析其与AD临床的相关关系。结果在... 详细信息

目的探讨血浆Aβ变量(Aβ40、Aβ42水平及其比值)在正常衰老和阿尔茨海默病(AD)疾病过程中的变化规律及对AD其诊断价值。方法双抗体夹心ELISA检测113例AD患者和205例不同年龄段健康者的血浆Aβ水平并分析其与AD临床的相关关系。结果在正常衰老过程中Aβ40和Aβ42水平呈现相反的变化曲线。AD患者Aβ40水平显著高于与其年龄匹配的正常老年组(P=0.002),而Aβ42水平却显著低于后者(P<0.001),但在AD自然病程中Aβ变量没有明显改变。ROC分析表明:以aNC组Aβ比值的x+2s(15.9)为截断点时,其对AD诊断的敏感度和特异度分别为24%和96%。结论血浆Aβ变量呈现年龄和疾病相关性变化,其中Aβ比值有助于AD的临床诊断。

关键词：阿尔茨海默病 Aβ 酶联免疫吸附法

专门皮肤标记多层螺旋CT的病变影像定位在乳腺癌保乳手术中有用性

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国际医学放射学杂志 2009年第3期 306-306页

作者： N.Harada-shoji T.Yamada T.Ishida M.Amari A.Suzuki T.Moriya 谭艳 Department of Surgical Oncology Seiryo-machi 1-1Aoba-kuSendai 980-8574Japan

研究皮肤标记CT在乳腺癌保乳手术(BCS)中确定切除范围并减少了阳性或密切边缘率。对诊断为原发性乳腺癌并行CT皮肤标记MDCT检查的病人(117例)行多层螺旋CT(MDCT)定位影像重建。手术标本行连续5mm厚的切片用于病理分析。"阳性边缘"(posit... 详细信息

研究皮肤标记CT在乳腺癌保乳手术(BCS)中确定切除范围并减少了阳性或密切边缘率。对诊断为原发性乳腺癌并行CT皮肤标记MDCT检查的病人(117例)行多层螺旋CT(MDCT)定位影像重建。手术标本行连续5mm厚的切片用于病理分析。"阳性边缘"(positive margin)的定义是在手术切缘存在恶性细胞,而"密切边缘"(close margin)是在手术切缘5mm范围内存在肿瘤。计算"阳性边缘"和"密切边缘"率。

关键词：乳腺癌影像多层螺旋CT 肿瘤扩展乳腺癌保乳手术

大麻抑制β淀粉样多肽导致的星形胶质细胞半通道激活:一种神经元保护机制

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神经损伤与功能重建 2017年第1期12卷 F0003-F0003页

作者： Gajardo-Gómez R Labra VC Maturana CJ shoji KF Santiba?ez CA Sáez JC Giaume C Orellana JA 唐颖馨 Departamento de Neurología Escuela de Medicina Pontificia Universidad Católica de Chile Departamento de Fisiología Pontificia Universidad Católica de ChileSantiago de ChileChile and Instituto MilenioCentro Interdisciplinario de Neurociencias de Valparaíso Center for Interdisciplinary Research in Biology Collège de France/Centre National de la Recherche ScientifiqueUnité Mixte de Recherche 7241Institut National de la Santé et de la Recherche Médicale U1050

阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放... 详细信息

阿尔茨海默病(AD)的机制尚不完全清楚,星形胶质细胞及其信号传导在AD中的作用也有待进一步研究。既往研究表明,β淀粉样多肽(Aβ)会导致神经元死亡,其可能的机制为Aβ导致星形胶质细胞半通道开放,并由此增加兴奋性毒性ATP和谷氨酸释放。本课题组的既往研究显示,激活的小胶质细胞或炎症介质可导致星形胶质细胞上缝隙连接43半通道开放;而外源性或内源性大麻均可以减少这种开放。但尚不清楚大麻是否可以减少由Aβ激活星形胶质细胞半通道导致的神经元死亡。本研究培养星形胶质细胞及海马脑片,分别单用Aβ处理或用Aβ及大麻(WIN,2-AG,或甲酰胺基)联合处理。采用单通道膜片钳及延时乙啡啶摄取法记录胶质细胞半通道的活动,采用Fluoro-Jade C染色检测神经元死亡。结果显示,大麻完全抑制了由Aβ导致的星形胶质细胞半通道的活性及炎症反应。而且,大麻完全抑制了由Aβ导致的星形胶质细胞缝隙连接43半通道开放而引起的兴奋毒性谷氨酸及ATP的释放,大麻也可以很大程度上减少由Aβ导致的海马脑片神经元的损伤。通过调节星形胶质细胞的功能来保护神经元是目前治疗AD的新策略,本研究结果为此提供了新思路。

关键词：阿尔茨海默病缝隙连接蛋白43 胶质细胞神经炎症反应神经元