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Rupture of small cystic pancreatic neuroendocrine tumor with many microtumors

World Journal of Gastroenterology 2017年第37期23卷 6911-6919页

作者： Ryota Sagami Hidefumi Nishikiori shoichiro ikuyama Kazunari Murakami Department of Gas--troenterology Oita San-ai Medical Center Department of Internal Medicine and Clinical Investigation Oita San-ai Medical Center Department of Gastroenterology Faculty of Medicine Oita University

Pancreatic neuroendocrine tumors(p NETs) are particularly rare. The various forms of PNETs, such as cystic degeneration, make differentiation from other similar pancreatic lesions difficult. We can detect small lesions by endoscopic ultrasound(EUS) and obtain preoperative pathological diagnosis by EUS-guided fine needle aspiration(FNA). We describe, here, an interesting case of p NET in a 42-year-old woman with no family history. Computed tomography and magnetic resonance imaging revealed an 18 mm × 17 mm cystic lesion with a nodule in the pancreatic tail. Two microtumors about 7 mm in diameter in the pancreatic body detected only by EUS, cystic rim and nodules all showed similar enhancement on contrast-harmonic EUS. Preoperative EUS-FNA of the microtumor was performed, diagnosing multiple p NETs. Macroscopic examination of the resected pancreatic body and tail showed that the cystic lesion had morphologically changed to a 13-mm main nodule, and 11 new microtumors(diameter 1-3 mm). Microscopically, all microtumors represented p NETs. From the findings of a broken peripheral rim on the main lesion with fibrosis, rupture of the cystic p NET was suspected. Postoperatively, pituitary adenoma and parathyroid adenoma were detected. The final diagnosis was multiple grade 1 p NETs with multiple endocrine neoplasia type 1. To the best of our knowledge, no case of spontaneous rupture of a cystic p NET has previously been reported in the English literature. Therefore, this case of very rare p NET with various morphological changes is reported.

关键词： Rupture Cystic pancreatic neuroendocrinetumor MEN1 NET Microtumor

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Toll样受体9对巨噬细胞脂周素2表达的影响

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中国动脉硬化杂志 2011年第2期19卷 100-104页

作者：范斌谷剑秋张锦生山祥一郎中国医科大学附属盛京医院神经内科辽宁省沈阳市110004 中国医科大学附属第一医院内分泌科辽宁省沈阳市110004 日本九州大学生体防御医学研究所免疫病态学分野

目的研究ODN1826对巨噬细胞脂周素2表达的影响,并揭示其调控的相关分子机制。方法应用半定量PCR和免疫印迹法分别测定ODN1826对脂周素2 mRNA和蛋白水平表达影响。应用荧光素酶活性分析方法检测ODN1826对脂周素2启动子活性的影响。结果 O... 详细信息

目的研究ODN1826对巨噬细胞脂周素2表达的影响,并揭示其调控的相关分子机制。方法应用半定量PCR和免疫印迹法分别测定ODN1826对脂周素2 mRNA和蛋白水平表达影响。应用荧光素酶活性分析方法检测ODN1826对脂周素2启动子活性的影响。结果 ODN1826以剂量和浓度依赖方式上调脂周素2 mRNA和蛋白水平表达,并且通过Ets/AP-1位点促进脂周素2启动子活性。结论在巨噬细胞中,TLR9信号显著诱导了脂周素2 mRNA和蛋白的表达,并且脂周素2启动子区域的Ets/AP-1位点参与了这一诱导过程。

关键词： Toll样受体泡沫细胞动脉粥样硬化脂周素2

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长链脂肪酸对脂周素2表达的影响

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中华临床医师杂志（电子版） 2012年第2期6卷 102-104页

作者：谷剑秋范斌张锦生山祥一郎中国医科大学附属第一医院内分泌科中国医科大学附属盛京医院神经内科日本九州大学生体防御医学研究所

目的研究长链脂肪酸对肝细胞脂周素2表达的影响,并揭示其调控的相关分子机制。方法应用实时定量PCR测定不同长度脂肪酸对脂周素2mRNA表达的影响。应用实时定量PCR和West-ernblot分别测定长链脂肪酸油酸对脂周素2mRNA和蛋白表达的影响。... 详细信息

目的研究长链脂肪酸对肝细胞脂周素2表达的影响,并揭示其调控的相关分子机制。方法应用实时定量PCR测定不同长度脂肪酸对脂周素2mRNA表达的影响。应用实时定量PCR和West-ernblot分别测定长链脂肪酸油酸对脂周素2mRNA和蛋白表达的影响。应用荧光素酶活性分析方法检测油酸对脂周素2启动子活性的影响。结果长链脂肪酸油酸、软脂酸、亚油酸、亚麻酸和花生四烯酸明显增加了脂周素2的表达,而短链脂肪酸己酸没有作用。油酸以剂量和浓度依赖方式上调脂周素2mRNA和蛋白的表达,乙酰辅酶A合成酶抑制剂triacsinC没有抑制油酸诱导的脂周素2表达。小鼠脂周素2启动子含有Ets/AP-1结合位点和PPARs反应元件(PPRE)。油酸以剂量依赖的方式显著增强了脂周素2的-2090bp启动子活性。Ets位点突变没有影响脂周素2的启动子活性,但AP-1位点突变,及PPRE突变显著抑制了油酸诱导的启动子活性。结论在肝细胞中,长链脂肪酸油酸诱导脂周素2的表达,需要启动子区域的AP-1和PPARs反应元件,为防治脂肪肝新药研发提供了新的靶点。

关键词：脂肪酸类过氧化物酶体增殖物激活受体转录因子AP-1 脂周素2

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Motion Analysis of Trunk Using Simplified Human Model in Sagittal Plane

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 20-27页

作者： Masato Kawaguchi shoichiro Takehara Division of Mechanical Engineering Graduate School of Science and TechnologySophia University Department of Engineering and Applied Sciences Sophia University

The mass of very small vehicles is often comparable to that of their drivers,and thus there is a greater degree of coupling between the vehicle and the driver,compared with a case for traditional *** developing small vehicles,it is necessary to give ample consideration to the dynamics of the person who ride ***,a model of a human body riding a small personal vehicle was constructed to investigate the dynamics of the person inside such a ***,an experiment on posture maintenance by acceleration of direction of travel was conducted and the parameters for posture control were identified using agenetic *** shows that body behavior could be successfully simulated using the proposed model,and the control parameters were effective in determining the posture maintenance characteristics of the vehicle occupant.

关键词： human dynamics trunk simulation human body vehicles

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Base flow separation for soil erosion simulation in a granitic forested headwater catchment using a process-based model, GeoWEPP

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International Journal of Sediment Research 2023年第4期38卷 494-502页

作者： Takuhei Yamasaki shoichiro Hamamoto Taku Nishimura The Graduate School of Agricultural and Life Sciences The University of Tokyo

Distributed erosion models, which simulate the physical processes of water flow and soil erosion, are effective for predicting soil erosion in forested catchments. Although subsurface flow through multiple pathways is dominant for runoff generation in forested headwater catchments, the process-based erosion model, Geo-spatial interface for Water Erosion Prediction Project(Geo WEPP), does not have an adequate subsurface component for the simulation of hillslope water flow. In the current study, the quick flow related to soil erosion during rainfall events is separated from the total hydrograph using base flow separation for Geo WEPP to use direct runoff to predict sediment discharge from a granitic-forested catchment in Japan. Water runoff and sediment discharge also are simulated using the conventional method that reproduces the total hydrograph, and the accuracy of the calculation and estimated erodibility parameters are evaluated. The proposed procedure reproduced the quick-flow runoff during rainfall and the cumulative sediment discharge from the catchment. Simultaneously, the proposed procedure overestimates water runoff during extreme weather events, such as typhoons. The estimated erodibility parameters for the hillslope soil were comparable to those of the surface soil in Japan using both the proposed procedure and the conventional one. Conversely, the channel erodibility obtained from the proposed procedure matched the observed sediment characteristics in the granitic forested catchment. The proposed procedure is a promising method to predict sediment discharge from forested catchments based on the geological features of the catchment.

关键词： Soil erosion Base flow separation GeoWEPP Headwater catchment Forest

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Synthesis of affinity column of phosphatidylinositol-3,4-diphosphate

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Chinese Journal of Chemistry 1997年第6期15卷 556-561页

作者： OZAKI shoichiro WATANABE Yutaka OGASAWARA Tomio Department of Chemistry Shandong University Jinan Shandong 250100 ChinaDepartment of Applied ChemistryFaculty of EngineeringEhime UniversityMatsuyama790JapanDepartment of Applied ChemistryFaculty of EngineeringEhime UniversityMatsuyama790Japan

Phosphatidylinositol polyphosphates (PIPx) are related with tyrosine kinase activation, cell proliferation and carcinogenesis. In order to investigate the action mechanism of PIPx, it is desirable to synthesize affinity column of PI-3,4-P-2, which is expected to be able to isolate the binding proteins of PI-3,4-P-2. Thyramine reacted with CH-Sepharose 4B giving column 13. The p-amino group of 3'-(1',2'-distearoyl-glyceryl)-1-(2-p-aminobenzyl)-3,4-di-O-phosphoryl-myo-inosityl phosphate (12) was diazotized, then diazo-coupled with column 13 to give PI-3,4-P-2 affinity column 14. This PI-3,4-P-2 affinity column is an effective tool to pick up binding proteins of PI-3,4-P-2.

关键词： phosphatydylinositol-3,4-diphosphate binding protein inositol PI-3,4-P-2-affinity

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Revisiting ENSO impacts on the Indian Ocean SST based on a combined linear regression method

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Acta Oceanologica Sinica 2021年第5期40卷 47-57页

作者： Lianyi Zhang Yan Du Tomoki Tozuka shoichiro Kido State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Department of Earth and Planetary Science Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan Application Laboratory(APL) Research Institute for Value-Added-Information Generation(VAiG)Japan Agency for Marine-Earth Science and TechnologyYokohama 236-0001Japan

The El Nino-Southern Oscillation(ENSO)has great impacts on the Indian Ocean sea surface temperature(SST).In fact,two major modes of the Indian Ocean SST namely the Indian Ocean Basin(IOB)and the Indian Ocean Dipole(IOD)modes,exerting strong influences on the Indian Ocean rim countries,are both influenced by the *** on a combined linear regression method,this study quantifies the ENSO impacts on the IOB and the IOD during ENSO concurrent,developing,and decaying *** removing the ENSO impacts,the spring peak of the IOB disappears along with significant decrease in number of events,while the number of events is only slightly reduced and the autumn peak remains for the *** isolating the ENSO impacts during each stage,this study reveals that the leading impacts of ENSO contribute to the IOD development,while the delayed impacts facilitate the IOD phase switch and prompt the IOB ***,the decadal variations of ENSO impacts are various during each stage and over different *** imply that merely removing the concurrent ENSO impacts would not be sufficient to investigate intrinsic climate variability of the Indian Ocean,and the present method may be useful to study climate variabilities independent of ENSO.

关键词： Indian Ocean ENSO sea surface temperature climate modes combined linear regression

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Effects of reductive annealing on insulating polycrystalline thin films of Nb-doped anatase TiO2:recovery of high conductivity

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Journal of Semiconductors 2016年第2期37卷 10-13页

作者： shoichiro Nakao Yasushi Hirose Tetsuya Hasegawa Kanagawa Academy of Science and Technology(KAST) Kawasaki 213-0012Japan Japan Science and Technology Agency CRESTBunkyoTokyo 113-0033Japan Department of Chemistry The University of TokyoBunkyoTokyo 113-0033Japan

We studied the effects of reductive annealing on insulating polycrystalline thin films of anatase Nb- doped TiO2 （TNO）. The insulating TNO films were intentionally fabricated by annealing conductive TNO films in oxygen ambient at 400 ℃. Reduced free carrier absorption in the insulating TNO films indicated carrier com- pensation due to excess oxygen. With H2-annealing, both carrier density and Hall mobility recovered to the level of conducting TNO, demonstrating that the excess oxygen can be efficiently removed by the annealing process without introducing additional scattering centers.

关键词： transparent conductive oxide Nb-doped TiOa pulsed laser deposition

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A Spectral-Mode-Splitting Scheme for CSRZ and CSRZ-DPSK Signal Transmission

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光学学报 2003年第S1期23卷 595-596页

作者： Akira Hirano Yutaka Miyamoto shoichiro Kuwahara NTT Network Innovation Labs. NTT Corporation Hikarino-oka 1-1 Yokosuka Kanagawa JAPANNTT Network Innovation Labs. NTT Corporation Hikarino-oka 1-1 Yokosuka Kanagawa JAPANNTT Network Innovation Labs. NTT Corporation Hikarino-oka 1-1 Yokosuka Kanagawa JAPAN

We propose a spectral-mode-splitting scheme and how it can be applied to CSRZ and CSRZ-DPSK signal formats, and show that it provides both accurate chromatic dispersion detection in CSRZ application and robustness aga... 详细信息

关键词： CSRZ it DPSK NRZ for

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A case of conjunctival intraepithelial neoplasia with spheroidal degeneration:a clinicopathological study

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1401-1403页

作者： shoichiro Ota Satoru Kase Takayuki Tanaka Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

Dear Editor,I am shoichiro Ota from Hokkaido University hospital,*** intraepithelial neoplasia(CIN)is a disease concept that includes dysplasia and carcinoma in ***,CIN is characterized by tumor cell proliferation located within the epithelium with preservation of the basement membrane[1].In addition to histological diagnosis,anterior segment optical coherence tomography(ASOCT)plays an important role in clinical diagnosis,showing diffuse epithelial thickening with homogeneous high-intensity reflection in case of CIN[2-3].

关键词： diagnosis degeneration neoplasia

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