检索结果-南通市图书馆

Repetitive administration of cultured human CD34+cells improve adenine-induced kidney injury in mice

World Journal of Stem Cells 2023年第4期15卷 268-280页

作者： Takayasu Ohtake shoichi itaba Amankeldi A Salybekov Yin Sheng Tsutomu Sato Mitsuru Yanai Makoto Imagawa Shigeo Fujii Hiroki Kumagai Masamitsu Harata Takayuki Asahara Shuzo Kobayashi Regenerative Medicine The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Regenerative Medicine Shonan Research Institute of Innovative MedicineKamakura 247-8533KanagawaJapan Kamakura Techno-science Inc. Kamakura 248-0036Japan Advanced Medicine Science Tokai University School of MedicineIsehara 259-1193Japan Department of Pathology Sapporo Tokushukai HospitalSapporo 004-0041Japan Department of Pathology Sapporo Medical CenterSapporo 004-0041Japan Human Life CORD Japan Inc Chuo-ku 103-0012TokyoJapan Cell Processing and Cell/Genome Analysis Center The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant Center Shonan Kamakura General HospitalKamakura 247-8533KanazawaJapan

BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in mice.METHODS Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning medium.Vasculogenic culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming units.Adenineinduced tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine diet.RESULTS Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control group.Both interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney injury.Repetitive administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.

关键词： Chronic kidney disease CD34+cell Adenine Tubulointerstitial injury Quality and quantity control culture Umbilical cord blood

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A unified multi-view multi-person tracking framework

引用

Computational Visual Media 2024年第1期10卷 137-160页

作者： Fan Yang Shigeyuki Odashima Sosuke Yamao Hiroaki Fujimoto shoichi Masui Shan Jiang Nanjing University China 不详 Fujitsu Research

Despite significant developments in 3D multi-view multi-person (3D MM) tracking, current frameworks separately target footprint tracking, or pose tracking. Frameworks designed for the former cannot be used for the latter, because they directly obtain 3D positions on the ground plane via a homography projection, which is inapplicable to 3D poses above the ground. In contrast, frameworks designed for pose tracking generally isolate multi-view and multi-frame associations and may not be sufficiently robust for footprint tracking, which utilizes fewer key points than pose tracking, weakening multi-view association cues in a single frame. This study presents a unified multi-view multi-person tracking framework to bridge the gap between footprint tracking and pose tracking. Without additional modifications, the framework can adopt monocular 2D bounding boxes and 2D poses as its input to produce robust 3D trajectories for multiple persons. Importantly, multi-frame and multi-view information are jointly employed to improve association and triangulation. Our framework is shown to provide state-of-the-art performance on the Campus and Shelf datasets for 3D pose tracking, with comparable results on the WILDTRACK and MMPTRACK datasets for 3D footprint tracking.

关键词： multi-camera multi-person tracking pose tracking footprint tracking triangulation spatiotemporal clustering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Local oxynitriding of AZ31 magnesium alloy by atmospheric-pressure plasma treatment at room temperature

引用

Journal of Magnesium and Alloys 2022年第7期10卷 1878-1886页

作者： Kenta Nakazawa Tatsuki Ohashi Shotaro Saiki shoichi Kikuchi Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1JohokuNaka-kuHamamatsu432-8561Japan Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsu432-8561Japan

A surface-hardening treatment for AZ31 magnesium alloy using an atmospheric-pressure plasma jet(APPJ)at room temperature was developed.Magnesium is a potential engineering material because it is lightweight;however,magnesium alloys are difficult to heat-treat because of their low flaming temperature.Magnesium alloy specimens were irradiated with a localized atmospheric-pressure plasma jet generated by dielectric-barrier discharge for 180 s in air.The APPJ excited oxygen and nitrogen molecules in the ambient air,resulting in the formation of an oxynitrided layer;oxygen and nitrogen diffusion layer,on the surface of the magnesium alloy.The hardness and elemental distribution for the treated surface were examined.The top surface of the APPJ-treated magnesium alloy achieved a maximum hardness of 108 HV,which was~1.7 times greater than that of the untreated surface.Elemental analysis using an electron-probe microanalyzer revealed strong oxygen and nitrogen signals corresponding to the hardened region of the magnesium alloy,meaning that the hardness increased as a result of the formation of the oxynitrided layer.The proposed APPJ treatment is a promising approach for locally hardening magnesium alloys without using a heat treatment.

关键词： Magnesium alloy Oxynitriding Atmospheric-pressure plasma jet Hardness Surface modification Diffusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of multifunction cavitation using phosphoric acid on fatigue and surface properties of AZ31 magnesium alloy

引用

镁合金学报(英文) 2023年第6期11卷 1996-2005页

作者： Shunta Matsuoka Fumihiro Kato Toshihiko Yoshimura Masataka Ijiri shoichi Kikuchi Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Department of Mechanical Engineering Sanyo-Onoda City University1-1-1 Daigaku-DoriSanyo-OnodaYamaguchi 756-0884Japan Tokyo Metropolitan University 1-1 Minami-OsawaHachiojiTokyo 192-0397Japan Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1 JohokuNaka-kuHamamatsu-shiShizuoka 432-8561Japan

Magnesium alloy is attractive for lightweight construction but often suffers from poor corrosion resistance and low strength.Cavitation processing with chemicals,i.e.,multifunction cavitation(MFC),was introduced to form a high-corrosion film and improve the fatigue properties of an AZ31 magnesium alloy.Surface analysis and plane bending fatigue tests were conducted for the MFC-treated magnesium alloy at a stress ratio,R,of-1.The mechanical action of cavitation bubbles improved the fatigue life of magnesium alloys due to increasing the surface hardness and generating compressive residual stress.However,the combined mechanical and electrochemical action during MFC formed pits on the surface.These pits were large enough to easily nucleate an initial fatigue crack.In addition,the magnesium alloys without pit formation,for which a coating process using phosphoric acid was conducted after MFC using water,showed superior fatigue properties.

关键词： Magnesium alloy Multifunction cavitation Surface modification Fatigue Residual stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Importance of Three-Dimensional Piezoelectric Coupling Modeling in Quantitative Analysis of Piezoelectric Actuators

引用

Computer Modeling in Engineering & Sciences 2023年第8期136卷 1187-1206页

作者： Daisuke Ishihara Prakasha Chigahalli Ramegowda shoichi Aikawa Naoki Iwamaru Department of Intelligent and Control Systems Kyushu Institute of TechnologyIizukaFukuoka820-8502Japan Institute of Microelectronics Agency for ScienceTechnology and ResearchInnovis Tower138634Singapore

This paper demonstrates the importance of three-dimensional(3-D)piezoelectric coupling in the electromechanical behavior of piezoelectric devices using three-dimensional finite element analyses based on weak and strong coupling models for a thin cantilevered piezoelectric bimorph actuator.It is found that there is a significant difference between the strong and weak coupling solutions given by coupling direct and inverse piezoelectric effects(i.e.,piezoelectric coupling effect).In addition,there is significant longitudinal bending caused by the constraint of the inverse piezoelectric effect in the width direction at the fixed end(i.e.,3-D effect).Hence,modeling of these effects or 3-D piezoelectric coupling modeling is an electromechanical basis for the piezoelectric devices,which contributes to the accurate prediction of their behavior.

关键词： Piezoelectric coupling effect piezoelectric bimorph actuator weak coupling strong coupling three-dimensional finite element analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression

引用

World Journal of Gastroenterology 2012年第15期18卷 1781-1788页

作者： Junichi Takino shoichi Yamagishi Masayoshi Takeuchi Department of Biochemistry Faculty of Pharmaceutical SciencesHiroshima International UniversityHiroshima 737-0112Japan Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications Kurume University School of MedicineKurume 830-0011Japan Department of Advanced Medicine Medical Research InstituteKanazawa Medical UniversityIshikawa 920-0293Japan

AIM:To investigate the effect of glyceraldehyde-derived advanced glycation end-products(Glycer-AGEs) on hepatocellular carcinoma(HCC)cells.METHODS:Two HCC cell lines(Hep3B and HepG2 cells)and human umbilical vein endothelial cells(HUVEC)were used.Cell viability was determined using the WST-8 assay.Western blotting,enzyme linked immunosorbent assay,and real-time reverse transcriptionpolymerase chain reactions were used to detect protein and mRNA.Angiogenesis was evaluated by assessing the proliferation,migration,and tube formation of HUVEC.RESULTS:The receptor for AGEs(RAGE)protein was detected in Hep3B and HepG2 cells.HepG2 cells werenot affected by the addition of Glycer-AGEs.GlycerAGEs markedly increased vascular endothelial growth factor(VEGF)mRNA and protein expression,which is one of the most potent angiogenic factors.Compared with the control unglycated bovine serum albumin(BSA) treatment,VEGF mRNA expression levels induced by the Glycer-AGEs treatment were 1.00±0.10 vs 1.92 ±0.09(P<0.01).Similarly,protein expression levels induced by the Glycer-AGEs treatment were 1.63±0.04 ng/mL vs 2.28±0.17 ng/mL for the 24 h treatment and 3.36±0.10 ng/mL vs 4.79±0.31 ng/mL for the 48 h treatment,respectively(P<0.01).Furthermore,compared with the effect of the control unglycated BSA-treated conditioned medium,the Glycer-AGEstreated conditioned medium significantly increased the proliferation,migration,and tube formation of HUVEC,with values of 122.4%±9.0%vs 144.5%±11.3%for cell viability,4.29±1.53 vs 6.78±1.84 for migration indices,and 71.0±7.5 vs 112.4±8.0 for the number of branching points,respectively(P<0.01).CONCLUSION:These results suggest that Glycer-AGEs-RAGE signaling enhances the angiogenic potential of HCC cells by upregulating VEGF expression.

关键词：血管生成因子 VEGF RAGE 肝癌细胞信号增强 mRNA表达水平血管内皮生长因子 HepG2细胞

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of slab geometry and obliquity on the interplate thermal regime associated with the subduction of three-dimensionally curved oceanic plates

引用

Geoscience Frontiers 2015年第1期6卷 61-78页

作者： Yingfeng Ji shoichi Yoshioka Research Center for Urban Safety and Security Kobe University Department of Earth and Planetary Science Graduate School of ScienceKobe University

We investigated the relationships among slab geometry, obliquity, and the thermal regime associated with the subduction of oceanic plates using a three-dimensional （3D） parallelepiped thermal convection model. Various models with convex and concave slab shapes were constructed in the numerical simu- lation, and the temperature and mantle flow distributions were calculated. The results revealed that when the slab dip angle increases, or the obliquity of subduction becomes steeper, the interplate tem- perature decreases remarkably. Cooler （warmer） zones on the plate interface were identified from the modeling where there was a larger （smaller） subduction angle. Consequently, the interplate temperature distribution is partly controlled by the true subduction angle （TSA）, which is a function of the slab dip angle and the obliquity of subduction. The rate of change of the interface temperature for the TSA was 10-50 ℃ （10°〈 TSA 〈 20°） at depths ranging from （TSA 10） × 5 km to 60 ＋（TSA 10） × 5 km for a fiat slab after a subduction history of 7 Myrs. The along-arc slab curvature affects the variation in TSA. The slab radius also appeared to influence the radius of induced mantle flow.

关键词： Temperature Mantle flow Heat flow Numerical simulation Slab geometry Obliquity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Control method for the stable operation of distributed inverters following the introduction of large-scale renewable energy to a remote island grid

引用

Clean Energy 2021年第2期5卷 196-207页

作者： shoichi Sato Yasuhiro Noro Department of Electrical and Electronic Engineering Kogakuin University1-24-2 Nishi-ShinjukuShinjuku-kuTokyo 163-8677Japan

The introduction of large-scale renewable energy requires a control system that can operate multiple distributed inverters in a stable way.This study proposes an inverter control method that uses information corresponding to the inertia of the synchronous generator to coordinate the operation of battery energy storage systems.Simulation results for a system with multiple inverters applying the control method are presented.Various faults such as line-to-line short circuits and three-phase line-to-ground faults were simulated.Two fault points with different characteristics were compared.The voltage,frequency and active power quickly returned to their steady-state values after the fault was eliminated.From the obtained simulation results,it was verified that our control method can be operated stably against various faults.

关键词： renewable energy photovoltaic battery energy storage system inverter remote island

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unsteady Correlation between Pressure and Temperature Field on Impinging Plate for Dual Underexpanded Jets

引用

Journal of Thermal Science 2009年第3期18卷 215-219页

作者： Minoru YAGA Hiroyuki HIGA shoichi MATSUDA Izuru SENAHA Depts. Mech. Systems Eng. Univ. of the Ryukyus Graduate student Faculty of Eng. Univ. of the Ryukyus Okinawa National College of Technology

In this paper, dual underexpanded impinging jets are experimentally studied by measuring unsteady wall staticpressure and temperature fields using high response semiconductor pressure sensors and infrared imaging cam-era(100 captures per sec) with dual converging sonic nozzles. The flow field is also visualized by means of highspeed schlieren system( up to 70000 frame per second) to clarify the unsteady behavior of the jet structures suchas barrel shock wave, and Mach disk. Experiments were performed with a blow down tunnel changing the parameterssuch as the nozzle to plate distance, the distance between the two nozzles, and wind tunnel pressure ratio.The nozzle to plate distance L and the distance between the two nozzles H are non-dimensionalized by the nozzlediameter D covering H/D=1.5, 2.0, and 3, L/D= 2, 3,and 4, and po/pb=1.0 - 5.0, where po and pb are stagnationpressure and back pressure respectively. Although the response of the infrared camera is quite different fromthat of the high speed camera, the unsteady correlation between the pressure and temperature fields is confirmedunder some conditions. Also the high speed schlieren pictures and the wall static pressure fluctuations suggestthat the generation of the Mach disk promote the unsteady behavior of the jets. After the confirmation of the correlation,a simple way to find the severe fluctuating region can be provided according to the two dimensional unsteadytemperature images without a lot of unsteady pressure measurements.

关键词：射流压力温度场非定常对撞板

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synchronal Measurement of Flow Structure and Heat Transfer of Impingement Jet

引用

Journal of Thermal Science 2010年第3期19卷 228-233页

作者： shoichi MATSUDA Naomichi SAJI Minoru YAGA Masaaki ISHIKAWA Kenyu OYAKAWA Dept.Mech.Systems Eng. Univ.of the RyukyusSenbaru 1NishiharaOkinawaJapan903-0213 Graduate student Faculty of Eng.Univ.of the RyukyusSenbaru 1NishiharaOkinawaJapan903-0213

This paper will present the characteristics of flow behavior and thermal field of both free and impingement jet issued from a circular orifice nozzle at Re=8900.The flow behavior of a single round jet and impingement jet was observed by smoke flow visualization recorded by a high speed camera using 5000 frame per second.Heat transfer coefficient on the impingement surface was measured by means of infrared camera (TVS-8500,Avio) with a two-dimensional array of Indeum-Antimony (In Sb) sensors varying in the separation distance between the nozzle and the target plate.The heat transfer coefficient changes in time and spatial.Therefore,the root mean square distribution of the heat transfer was obtained from the data.As a result,it was confirmed that the longitudinal vortex was observed outside of the ring vortex,and then the longitudinal vortex was penetrated in the jet flow.Moreover,the high value of root mean square of the heat transfer coefficient has spread radially in stripy manner,which is caused as the results of the longitudinal vortexes flowing in the radial direction on the impingement plate.

关键词：冲击射流流动结构同步测量撞击平均传热系数热传递流动行为摄影机使用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：