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国外医药（抗生素分册） 1989年第4期10卷 262-263页

作者： Takashi kawaguchi 唐建国

自身提供的调节因子改善次级代谢的诱导,首先由灰色链霉菌产生链霉素的A—因子所证实。相关的γ—内酯化合物,L—因子和诱导因子分别是灰色链霉菌产生leucaemo-mycin和维及尼链霉菌产生维及尼霉素的自我调节因子。

关键词：诺卡氏菌利福霉素生物合成

柔性张拉构件补强下细长结构稳定性的基础性研究

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建筑结构学报 2015年第5期36卷 140-149页

作者：陈坤川口健一东京大学建筑学专攻东京1138656 东京大学生产技术研究所东京1538505

为了分析膜、索等结构中柔性张拉构件在张力作用下对柱和拱的补强作用,基于静力平衡方程,在折线索上作用有集中荷载的情况下,提出虚拟弹簧刚度系数的概念并推导其计算式。在此基础上,分别得出一组和二组折线索-柱模型的屈曲控制方程,并... 详细信息

为了分析膜、索等结构中柔性张拉构件在张力作用下对柱和拱的补强作用,基于静力平衡方程,在折线索上作用有集中荷载的情况下,提出虚拟弹簧刚度系数的概念并推导其计算式。在此基础上,分别得出一组和二组折线索-柱模型的屈曲控制方程,并采用非线性有限元分析进行对比。分析结果表明:有限元分析结果与理论分析结果吻合。补强效果中,折线索弹性刚度的贡献可以忽略,索张力起主要作用;随着折线索上荷载的增大,柱的屈曲荷载存在着先增后减的规律;折线索会起到类似铰接约束的作用,使得柱的屈曲模态发生迁移;与一组索补强效果相比,两组索补强下柱的屈曲荷载的最大值变化较小。最后,对曲线索-柱模型和曲线索-拱模型分别进行研究,分析结果表明,曲线索上集中荷载存在一个最优值,使得柱和拱的屈曲荷载取得最大值。

关键词：张拉构件索柱拱虚拟弹簧有限元分析屈曲稳定性

miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 344-350页

作者： Suguru Maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa First Department of Surgery Faculty of Medicine University of Yamanashi

AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of *** We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary *** next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their *** also investigated the expression levels of the selected miRNA not only in tissue but also in plasma ***,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant *** Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric ***,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC *** contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC *** miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC.

关键词： Gastric cancer Alpha-fetoprotein Alphafetoprotein producing gastric cancer MicroRNA miR-122-5p

Long-Term Effect of Ferric Citrate Hydrate on Mineral Metabolism and Anemia in Maintenance Hemodialysis Patients

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International Journal of Clinical Medicine 2020年第11期11卷 719-730页

作者： Yuta Bando Mizuki Komatsu Masayuki Okazaki Hiroshi kawaguchi Kosaku Nitta Department of Nephrology Jyoban Hospital Fukushima Japan Department of Nephrology Tokyo Women’s Medical University Tokyo Japan

Background: Ferric citrate hydrate is a phosphate (P)-binder drug that is indicated for patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis (MHD). Objectives: The objectives of this study were to evaluate the changes in the serum mineral metabolism biomarker levels and treatment status of anemia in MHD patients receiving ferric citrate hydrate. Methods: A total of 132 adult dialysis patients were enrolled in this study. Bone turnover marker levels, anemia status and iron biomarker levels over a period of 18 months after the start of the ferric citrate hydrate treatment were extracted from the medical records of the patients. Results: At enrollment, 14 (10.6%) patients were P-binder-naïve, and 118 (89.4%) patients were receiving other P-binders. The serum P level before the start of ferric citrate hydrate treatment was ≤5.5 mg/dL in 18.8% of the patients. After 18 months of ferric citrate hydrate treatment, the proportion of patients with serum P levels ≤ 5.5 mg/dL increased to 47.7%. The mean ± standard error of the mean (SEM) of the serum P level was 7.05 ± 0.14 mg/dL at the baseline, and decreased to 5.83 ± 0.17 mg/dL after 18 months of treatment with ferric citrate hydrate. The mean ± SEM of the serum hemoglobin (Hb), ferritin, and transferrin saturation (TSAT) levels were 11.96 ± 0.76 g/dL, 71.13 ± 6.09 ng/mL, and 25.19% ± 1.21%, respectively, at the baseline, and 11.45 ± 0.13 g/dL, 124.94 ± 8.62 ng/mL, and 26.18% ± 0.99%, respectively, after 18 months of ferric citrate hydrate treatment. Conclusions: These results suggest that the serum P and anemia biomarker levels observed in this study were similar to those reported in clinical trials.

关键词： Ferric Citrate Hydrate Hemodialysis Mineral Metabolism Anemia

Automated liver tumor detection in abdominal ultrasonography with a modified faster region-based convolutional neural networks(Faster R-CNN)architecture

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 675-683,I0001页

作者： Kenji Karako Yuichiro Mihara Junichi Arita Akihiko Ichida Sung Kwan Bae Yoshikuni kawaguchi Takeaki Ishizawa Nobuhisa Akamatsu Junichi Kaneko Kiyoshi Hasegawa Yu Chen Department of Human and Engineered Environmental Studies Graduate School of Frontier SciencesThe University of TokyoChibaJapan Artificial Organ and Transplantation Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan

Background:Although diagnostic ultrasound can non-invasively capture the image of abdominal viscera,diagnosis of the continuous ultrasound liver images to detect a liver tumor effectively and to determine whether the detected is benign or malignant is *** order to minimize the gaps in diagnostic accuracy depending on doctor’s proficiency,we built an automated system to support the ultrasonography of liver tumors by employing deep learning ***:We constructed a neural network model for the automated detection of tumor tissues and blood vessels from the sequential liver ultrasound *** region-based convolutional neural networks(Faster R-CNN)is employed as a base model for the object detection,which can output the detection results in 4 frames per second and enable the system to be particularly suitable for the real time ***,we proposed a new neural network architecture feeding both the current and previous images into Faster *** training the models,intraoperative ultrasound images obtained from one hepatocellular carcinoma(HCC)patient were *** obtained image was a multifaceted observation of the liver and includes one HCC and some blood *** labeled 91 images with the help of a liver *** compared the tumor detection performance of the plain Faster R-CNN model with that of the proposed ***:We find that both the models performed well in detecting HCC and blood vessels,after training with 400 epochs using ***,the mean precision of our model reaches 0.549,which is 0.019 better than that of the plain Faster R-CNN,and the mean sensitivity of our model about HCC reaches 0.623±0.385 for 30 scenes of sequential liver ultrasound images,which is also 0.146 better than that of the plain Faster R-CNN ***:The comparison between the proposed model and the plain Faster R-CNN model shows that we achieved better accuracy in tumor detection,in terms of the mean precision a

关键词： Liver deep learning ultrasonography object detection hepatocellular carcinoma(HCC)

Dipeptidyl peptidase-4: A key player in chronic liver disease

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World Journal of Gastroenterology 2013年第15期19卷 2298-2306页

作者： Minoru Itou Takumi kawaguchi Eitaro Taniguchi Michio Sata Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume 830-0011Japan Division of Gastroenterology Department of Medicine and Department of Digestive Disease Information and ResearchKurume University School of MedicineKurume 830-0011Japan

Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A representative target peptide is glucagon-like peptide-1, and inactivation of glucagon-like peptide-1 results in the development of glucose intolerance/diabetes mellitus and hepatic steatosis. In addition to its peptidase activity, DPP-4 is known to be associated with immune stimulation, binding to and degradation of extracellular matrix, resistance to anti-cancer agents, and lipid accumulation. The liver expresses DPP-4 to a high degree, and recent accumulating data suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, DPP-4 occurs in hepatic stem cells and plays a crucial role in hepatic regeneration. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor.

关键词： Incretin Viral hepatitis Insulin resistance Steatohepatitis Cancer Sitagliptin Vildagliptin Alogliptin Teneligliptin Linagliptin

Single-Incision Robotic Surgery

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Surgical Science 2012年第2期3卷 84-86页

作者： Norihiko Ishikawa Masahiko kawaguchi Hideki Moriyama Go Watanabe Department of General and Cardiothoracic Surgery Kanazawa University Kanazawa Japan

Introduction: Single Incision Laparoscopic Surgery (SILSTM) has been developed as a less invasive laparoscopic surgery. On the other hand, robotically assisted surgical technology has offered new options for minimally invasive surgery. In this study, we report a new surgical technology to perform SILS using the da Vinci S surgical system (Intuitive Surgical Inc., Sunnyvale, CA). Materials and Surgical Technique: A porcine liver with gallbladder was placed on an endoscopic surgery trainer, and a 25 mm incision was made for one robotic camera and two instruments at the umbilicus position. Both instruments were crossed while preventing them from colliding with each other, and Robot-assisted single-incision cholecyctectomy was perfumed. Discussion: This technique is expected to contribute to the development of a number of procedures in the future.

关键词： Single-Incision Laparoscopic Surgery Robotic Surgery Surgical System of da Vinci S

Development of novel rare earth doped fluoride and oxide scintillators for two-dimensional imaging

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Journal of Rare Earths 2011年第12期29卷 1178-1182页

作者： A.Yoshikawa T.Yanagida Y.Yokota K.Kamada N.kawaguchi K.Fukuda A.Yamazaki K.Watanabe A.Uritani T.Iguchi G.Boulon M.Nikl Institute for Materials Research Tohoku University New Industry Creation Hatchery Center Tohoku University R&D Center Tokuyama CorporationShibuya 3-ChomeShibuya-ku Nagoya University Furo-choChikusa-ku Physical Chemistry of Luminescent Materials(LPCML) University of Lyon Institute of Physics AS CR

Two topics were focused. The first one was about the gamma-ray scintillator, Pr^3＋：Lu3Al5O12 （LuAG）. The second one was about neutron scintillator, Ce^3＋：^6LiCaAlF6 and Eu^2＋：^6LiCaAlF6 （^6LiCAF）. Those scintillators have been developed very recently for modem imaging applications in the medical and homeland security fields. In both cases, the rare earth ions are playing the crucial role as emission centers. Pr^3＋ in LuAG provided fast 5d→4f transition providing noticeably shorter decay time than that of Ce^3＋. Among several candidate hosts, LuAG showed the best performance. Bulk crystal growth, basic scintillation properties, two-dimensional gamma-ray imaging and positron emission mammography （PEM） application were demonstrated. Due to the international situation, the homeland security was compromized by illicit traffic of explosives, drugs, nuclear materials, etc. and the ways to its improvement became an important R＆D topic. For this purpose the Ce and Eu doped LiCAF appeared competitive candidates. Especially, when substitution of 3He neutron detectors was considered, the discrimination ability of gamma-ray from alpha-ray was important. Bulk crystal growth, basic scintillation properties and two-dimensional neutron imaging were demonstrated.

关键词： Scintillator gamma-ray detection neutron detection oxide fluoride Ce, Eu rare earth

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一期前路病灶清除加植骨术治疗化脓性脊椎炎

中华骨科杂志 2005年第11期25卷 700-701页

作者：刘洪 Hirokazu Ishihara 马忠泰 Yoshiharu kawaguchi 北京大学第一医院骨科 100034 日本富山医科药科大学骨科

抗生素效力的高度发展已使化脓性脊椎炎患者相对少见.然而,随着糖尿病、恶性肿瘤及滥用毒品等患者的增多,化脓性脊椎炎在这些患者中的发病日益增加[1,2].传统的治疗包括卧床、支具外固定以及静脉应用抗生素;但上述治疗周、期较长,且仍... 详细信息

抗生素效力的高度发展已使化脓性脊椎炎患者相对少见.然而,随着糖尿病、恶性肿瘤及滥用毒品等患者的增多,化脓性脊椎炎在这些患者中的发病日益增加[1,2].传统的治疗包括卧床、支具外固定以及静脉应用抗生素;但上述治疗周、期较长,且仍有相当一部分患者治疗无效,病变进行性发展,出现明显的脊柱不稳定及神经压迫症状.1980年8月至1998年8月,日本富山医科药科大学骨科采用一期前路病灶清除加植骨术治疗化脓性脊椎炎48例,取得良好效果。

关键词：化脓性脊椎炎前路病灶清除治疗包植骨术进行性发展脊柱不稳定滥用毒品恶性肿瘤静脉应用压迫症状

The Influence of Phlorotannins and Bromophenols on the Feeding Behavior of Marine Herbivorous Gastropod <i>Turbo cornutus</i>

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American Journal of Plant Sciences 2014年第3期5卷 387-392页

作者： Toshiyuki Shibata Taiko Miyasaki Hideo Miyake Reiji Tanaka Shigeo kawaguchi Department of Food Science and Technolo- gy National Fisheries University Yamaguchi Japan Faculty of Agriculture Kyushu University Fukuoka Japan Major of Life Sciences Graduate School of Bioresources Mie University Mie Japan

The influence of phlorotannins and bromophenols on the feeding behavior of marine herbivores was determined using bioassay of Turbo cornutus. It was found that phloroglucinol and its oligomers isolated from the brown alga Eisenia bicyclis (eckol, fucofuroeckol A, phlorofucofuroeckol A, dieckol, and 8,8’-bieckol) had a deterrent effect against feeding behavior of T. cornutus in the concentration of algal body, respectively. In the case of the examination of 0.1 mM concentration, although fucofuroeckol A and phlorofucofuroeckol A significantly reduced feeding by T. cornutus, phloroglucinol and 8,8’-bieckol did not show any significant influence on feeding behavior, and eckol and dieckol had stimulating activity. 2,4-Dibromophenol and 2,4,6-tribromophenol, which are major components of extracellular secretions from Eisenia and Ecklonia species, caused the death, the torpidity, and the decreased appetite of T. cornutus at the concentration of 0.1 mM. In addition, 2,4-dibromophenol had strong feeding deterrent activity at the concentration of 1 μM. These results indicate that phlorotannins and bromophenols act as chemical defense agents of brown algae against environmental stresses such as the herbivore attack.

关键词： Bromophenols Brown Algae Chemical Defenses Feeding Deterrent Eisenia bicyclis Phlorotannins Plant-Herbivore Interactions Turban Shell Turbo cornutus