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Horticulture Research 2023年第4期10卷 249-258页

作者： Misaki Ishibashi Kei Zaitsu Ikue Yoshikawa Shungo Otagaki shogo matsumoto Akira Oikawa Katsuhiro Shiratake Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoyaAichi 464-8601Japan Graduate School of Agriculture Kyoto UniversitySakyoKyoto 606-8502Japan Faculty of Biology-Oriented Science and Technology Kindai UniversityNishimitaniKinokawaWakayama 649-6493Japan Faculty of Agriculture Meijo UniversityTenpakuNagoyaAichi 468-8502Japan

Plant secondary metabolites exhibit various horticultural traits.Simple and rapid analysis methods for evaluating these metabolites are in demand in breeding and consumer markets dealing with horticultural crops.We applied probe electrospray ionization(PESI)to evaluate secondary metabolite levels in horticultural crops.PESI does not require pre-treatment and separation of samples,which makes it suitable for high-throughput analysis.In this study,we targeted anthocyanins,one of the primary pigments in horticultural crops.Eighty-one anthocyanins were detected in approximately 3 minutes in the selected reaction-monitoring mode.Tandem mass spectrometry(MS/MS)could adequately distinguish between the fragments of anthocyanins and flavonols.Probe sampling,an intuitive method of sticking a probe directly to the sample,could detect anthocyanins qualitatively on a micro-area scale,such as achenes and receptacles in strawberry fruit.Our results suggest that PESI/MS/MS can be a powerful tool to characterize the profile of anthocyanins and compare their content among cultivars.

关键词： MS/MS ionization dealing

Efficient Breeding and Cultivation of Type 2 Red-fleshed Apple Cultivars Using a Search System for Suitable Apple Cultivar Combination

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Horticultural Plant Journal 2018年第6期4卷 219-225页

作者： shogo matsumoto LI Tianzhong SHUNGO Otagaki LI Yang BAI Songling Graduate School of Bioagricultural Sciences Nagoya University Laboratory of Fruit Cell and Molecular Breeding China Agricultural University Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University

As apple possesses self-incompatibility, knowledge of the S-genotypes is very important for apple breeding and cultivation. We investigated the S-RNase genotypes of 13 type 2 red-fleshed apple cultivars and 8 lineages. All of the investigated type 2 red-fleshed apples contained the S3-RNase allele closely linked to the red-fleshed trait. We made a search system for ovule parents to efficiently produce new type 2 red-fleshed cultivars based on the S-RNase allele information(http://www.***.nagoya-u.***.jp/～hort/apple/red/). More than 90% of progenies from crossing a selected white-fleshed ovule parent with a type 2 red-fleshed pollen parent are expected to show the red-fleshed phenotype. We also compiled a database of the S-RNase genotypes of more than 1 000 apple cultivars, including a survey system of cultivar combinations showing those that were fully incompatible, semicompatible and fully compatible, written in Chinese(http://www.***.nagoya-u.***.jp/～hort/apple/ch/) and Japanese(http://www.***.nagoya-u.***.jp/～hort/apple/ja/).

关键词： Malus×domestica type 2 red-fleshed S-RNase genotype cultivar combination self-incompatibility

Regenerative medicine strategies for chronic complete spinal cord injury

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Neural Regeneration Research 2024年第4期19卷 818-824页

作者： shogo Hashimoto Narihito Nagoshi Masaya Nakamura Hideyuki Okano Department of Orthopedic Surgery Keio University School of Medicine Department of Physiology Keio University School of Medicine

Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases.While rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable,most research in this field has focused on the early phase of incomplete injury.However,the majority of patients have chronic severe injuries;therefore,treatments for these situations are of fundamental importance.The reason why the treatment of complete spinal cord injury has not been studied is that,unlike in the early stage of incomplete spinal cord injury,there are various inhibitors of neural regeneration.Thus,we assumed that it is difficult to address all conditions with a single treatment in chronic complete spinal cord injury and that a combination of several treatments is essential to target severe pathologies.First,we established a combination therapy of cell transplantation and drug-releasing scaffolds,which contributes to functional recovery after chronic complete transection spinal cord injury,but we found that functional recovery was limited and still needs further investigation.Here,for the further development of the treatment of chronic complete spinal cord injury,we review the necessary approaches to the different pathologies based on our findings and the many studies that have been accumulated to date and discuss,with reference to the literature,which combination of treatments is most effective in achieving functional recovery.

关键词： cell transplantation chronic phase complete transection regenerative medicine spinal cord injury

Operationally Simple Enantioselective Silane Reduction of Ketones by the [Ir(OMe)(cod)]₂/Azolium Catalytic System

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International Journal of Organic Chemistry 2024年第1期14卷 1-19页

作者： Satoshi Sakaguchi Chika Nagao Ryo Ichihara shogo Matsuo Department of Chemistry and Materials Engineering Faculty of Chemistry Materials and Bioengineering Kansai University Suita Japan

An operationally simple protocol was designed for the enantioselective silane reduction (ESR) of ketones using air- and moisture-stable [Ir(OMe)(cod)]2 (cod = 1,5-cyclooctadiene) (3) as a metal catalyst precursor. This reaction was driven by chiral hydroxyamide-functionalized azolium salt 2. The catalytic ESR reaction could be performed under benchtop conditions at room temperature. Treatment of 2 with 3 in THF yielded the monodentate IrCl(NHC)(cod) (NHC = N-heterocyclic carbene) complex 4 in 93% yield, herein the anionic methoxy ligand of 3 serves as an internal base that deprotonates the azolium ring of 2. The well-defined Ir complex 4 catalyzed the ESR reaction of propiophenone (6) with (EtO)2MeSiH using the pre-mixing reaction procedure. Based on this success, the catalytic ESR reaction was designed and implemented using an in situ-generated NHC/Ir catalyst derived from 2 and 3. Thus, a wide variety of aryl ketones could be reduced to the corresponding optically active alcohols in moderate to excellent stereoselectivities at room temperature without temperature control. Since the high catalytic activity of 3 was observed, we next evaluated several other transition metal catalyst precursors for the catalytic ESR reaction under the influence of 2. This evaluation revealed that Ir(acac)(cod) (acac = acetylacetonate) (28) and [IrCl(cod)]2 (5) can be successfully used as metal catalyst precursors in the ESR reaction.

关键词： Asymmetric Catalysis Enantioselective Reduction Hydrosilylation Reaction N-Heterocyclic Carbene Iridium

PMSSC:Parallelizable multi-subset based self-expressive model for subspace clustering

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Computational Visual Media 2023年第3期9卷 479-494页

作者： Katsuya Hotta Takuya Akashi shogo Tokai Chao Zhang Department of Engineering University of FukuiFukui-shi 910-8507Japan Faculty of Science and Engineering Iwate UniversityMorioka-shi 020-8551Japan

Subspace clustering methods which embrace a self-expressive model that represents each data point as a linear combination of other data points in the dataset provide powerful unsupervised learning techniques.However,when dealing with large datasets,representation of each data point by referring to all data points via a dictionary suffers from high computational complexity.To alleviate this issue,we introduce a parallelizable multi-subset based self-expressive model(PMS)which represents each data point by combining multiple subsets,with each consisting of only a small proportion of the samples.The adoption of PMS in subspace clustering(PMSSC)leads to computational advantages because the optimization problems decomposed over each subset are small,and can be solved efficiently in parallel.Furthermore,PMSSC is able to combine multiple self-expressive coefficient vectors obtained from subsets,which contributes to an improvement in self-expressiveness.Extensive experiments on synthetic and real-world datasets show the efficiency and effectiveness of our approach in comparison to other methods.

关键词： subspace clustering self-expressive model big data subsetting

Evaluation of dry-in-place lubricants for cold forging by using an optimal steady combined forward and backward extrusion testing method

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Friction 2023年第10期11卷 1862-1876页

作者： Chengliang HU shogo OSAKI Baixuan CAI Mitsuru AOYAMA Kuniaki DOHDA Institute of Forming Technology&Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China Central Research Laboratories Nihon Parkerizing Co.Ltd.Hiratsuka-shi 254-0012Japan Department of Mechanical Engineering Northwestern UniversityEvanston 60208-3111USA

This study evaluated dry-in-place lubricants used for cold forging.A group of isothermal compression tests with a strain rate(ε)e&range of 0.001–1 s^(−1) and temperature(T)range of 30–400℃ were completed.The flow stress(σ)curves of annealed steel S45C were obtained,and a corresponding Hensel–Spittel model was developed to support finite element(FE)simulation.The sensitivity of the steady combined forward and backward extrusion(SCFBE)test proposed in another study was improved by approximately 20%after it was optimized using the results of the FE simulations.Key parameters were identified,and the calibration curves after optimization were obtained.On the basis of the optimized test,a friction testing setup with a heating system was developed,in which the die temperature could be adjusted from room temperature(RT)to 230℃.Three dry-in-place lubricants and conventional phosphating lubricant were tested,and the friction factors(m),forming loads,and ejection loads were measured.The surface features of the specimens after testing were also investigated.According to the testing results,of the three tested dry-in-place lubricants,the mica type was the best.In addition,the optimized friction testing design was verified as effective.

关键词： lubrication optimization sensitivity friction factor(m) forming load cold forging

A comprehensive overview of recent developments on the mechanisms and pathways of ferroptosis in cancer: the potential implications for therapeutic strategies in ovarian cancer

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Cancer Drug Resistance 2023年第3期6卷 547-566页

作者： Hiroshi Kobayashi Chiharu Yoshimoto Sho Matsubara Hiroshi Shigetomi shogo Imanaka Department of Gynecology and Reproductive Medicine Ms.Clinic MayOneKashihara 634-0813Japan Department of Obstetrics and Gynecology Nara Medical UniversityKashihara 634-8522Japan Department of Obstetrics and Gynecology Nara Prefecture General Medical CenterNara 630-8581Japan Department of Medicine Kei Oushin ClinicNishinomiya 663-8184Japan Department of Gynecology and Reproductive Medicine Aska Ladies ClinicNara 634-0001Japan

Cancer cells adapt to environmental changes and alter their metabolic pathways to promote survival and proliferation. Metabolic reprogramming not only allows tumor cells to maintain a reduction-oxidation balance by rewiring resources for survival, but also causes nutrient addiction or metabolic vulnerability. Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxides. Excess iron in ovarian cancer amplifies free oxidative radicals and drives the Fenton reaction, thereby inducing ferroptosis. However, ovarian cancer is characterized by ferroptosis resistance. Therefore, the induction of ferroptosis is an exciting new targeted therapy for ovarian cancer. In this review, potential metabolic pathways targeting ferroptosis were summarized to promote anticancer effects, and current knowledge and future perspectives on ferroptosis for ovarian cancer therapy were discussed. Two therapeutic strategies were highlighted in this review: directly inducing the ferroptosis pathway and targeting metabolic vulnerabilities that affect ferroptosis. The overexpression of SLC7A11, a cystine/glutamate antiporter SLC7A11 (also known as xCT), is involved in the suppression of ferroptosis. xCT inhibition by ferroptosis inducers (e.g., erastin) can promote cell death when carbon as an energy source of glucose, glutamine, or fatty acids is abundant. On the contrary, xCT regulation has been reported to be highly dependent on the metabolic vulnerability. Drugs that target intrinsic metabolic vulnerabilities (e.g., GLUT1 inhibitors, PDK4 inhibitors, or glutaminase inhibitors) predispose cancer cells to death, which is triggered by decreased nicotinamide adenine dinucleotide phosphate generation or increased reactive oxygen species accumulation. Therefore, therapeutic approaches that either directly inhibit the xCT pathway or target metabolic vulnerabilities may be effective in overcoming ferroptosis resistance. Real-time monitoring of changes in metabolic pathways may aid in selecting per

关键词： Ferroptosis glutaminolysis glycolysis metabolic vulnerability ovarian cancer pentose phosphate pathway

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基于实践导向的高校财务管理教学改革

中国果树 2017年第5期 5-8页

作者：李洋刘春生于杰松本省吾王昆刘志李天忠中国农业大学果树细胞与分子育种实验室北京100193 日本名古屋大学农学部中国农业科学院果树研究所辽宁省果树科学研究所

苹果一般自花授粉不能结实,需配置一定比例的授粉品种,且依靠昆虫或人工授粉才能获得经济产量。苹果属于配子体型自交不亲和性类型,受17号染色体末端S基因座的复等位基因控制,最早人们将‘国光’品种2个同源染色体上控制自交不亲和性的... 详细信息

苹果一般自花授粉不能结实,需配置一定比例的授粉品种,且依靠昆虫或人工授粉才能获得经济产量。苹果属于配子体型自交不亲和性类型,受17号染色体末端S基因座的复等位基因控制,最早人们将‘国光’品种2个同源染色体上控制自交不亲和性的等位基因分别命名为S_1和S_2之后(S基因型为S_1S_2),截至目前已从苹果属植物中鉴定出S_1、S_2、S_3、S_4、S_5、S_6、S_7、S_8、S_9等31种S等位基因,确定了‘鸡冠’‘富士’‘嘎拉’‘成保光’等1 000多个品种的S基因型,分别为S_3S_5、S_1S_9、S_2S_5和S_1S_2等。当‘国光’与‘鸡冠’相互授粉时,由于2个S基因型不同,相互授粉可结实,表现为亲和;当‘国光’与‘富士’相互授粉时,由于有一个S等位基因相同,有一半花粉可授粉受精结实,表现为半亲和;当‘国光’与‘成保光’相互授粉时,由于S基因型完全相同,相互授粉不结实,表现为不亲和。由于S基因型直接决定了相互授粉的亲和程度,可为栽培生产授粉树的配置和杂交育种亲本选配提供参考和帮助,因此,本研究室与日本名古屋大学合作,在对中国国家苹果资源圃和日本国家苹果资源圃S基因型大量鉴定的基础上,建立了苹果S基因型数据库,配有中、日、英等文字的操作页面,该网站可根据用户的需要,给出相应品种的对应授粉品种,用户再根据花期相遇、花粉育性等从中挑选出最适合的授粉组合。

关键词：苹果 S基因型数据库授粉树配置亲本选配

Dissipative structure for symmetric hyperbolic systems with memory

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Science China Mathematics 2018年第11期61卷 2053-2064页

作者： Shuichi Kawashima shogo Taniue Faculty of Mathematics Kyushu University Graduate School of Mathematics Kyushu University

We study symmetric hyperbolic systems with memory-type dissipation and investigate their dissipative structures.We treat two cases:memory-type diffusion and memory-type relaxation,and observe that the dissipative structures of these two cases are essentially different.Namely,we show that the dissipative structure of the system with memory-type diffusion is of the standard type,while that of the system with memory-type relaxation is of the regularity-loss type.

关键词：记忆消散系统结构对称标准类型松弛

LOV Domain-Containing Light-Dependent Protein in Arabidopsis F-Box Proteins： Degradation Modules

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Molecular Plant 2012年第3期5卷 573-582页

作者： shogo Ito Young Hun Song Takato Imaizumi Department of Biology Seattle WA 98195-1800 USA University of Washington Seattle WA 98195-1800 USA

Plants constantly survey the surrounding environment using several sets of photoreceptors. They can sense changes in the quantity （= intensity） and quality （=wavelength） of light and use this information to adjust their physiological responses, growth, and developmental patterns. In addition to the classical photoreceptors, such as phytochromes, crypto- chromes, and phototropins, ZEITLUPE （ZTL）, FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 （FKF1）, and LOV KELCH PROTEIN 2 （LKP2） proteins have been recently identified as blue-light photoreceptors that are important for regulation of the circadian clock and photoperiodic flowering. The ZTL/FKF1/LKP2 protein family possesses a unique combination of domains： a blue-light-absorb- ing LOV （Light, Oxygen, or Voltage） domain along with domains involved in protein degradation. Here, we summarize recent advances in our understanding of the function of the Arabidopsis ZTL/FKF1/LKP2 proteins. We summarize the distinct pho- tochemical properties of their LOV domains and discuss the molecular mechanisms by which the ZTL/FKF1/LKP2 proteins reg- ulate the circadian clock and photoperiodic flowering by controlling blue-light-dependent protein degradation.

关键词： blue light LOV domain ZTL FKF1 LKP2 photoperiodic flowering circadian clock Arabidopsis