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Mimetic Preparation of Analogues of Territrem B, A Potent Acetylcholinesterase Inhibitor

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Chinese Chemical Letters 2000年第12期11卷 1045-1048页

作者： Yu ZHAO Yuan Ling KU shoei sheng lee Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 School of Pharmacy College of MedicineNational Taiwan UniversityTaipei 10018

A mimetic synthesis of a potent acetylcholinesterase inhibitor, Territrem B, was carried out from the naturally occurring jujubosides. The anti-AChE activity of the product, which possesses the 2-en-1-one pharmacophore and the aromatic ring, was measured. The aromatic ring moiety seemed to be less influencing when comparing with the 2-en-1-one moiety.

关键词： acetylcholinesterase inhibitor territrem B analogues jujubosides

Removal and fluorescence detection of antibiotics from wastewater by layered double oxides/metal-organic frameworks with different topological configurations

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Chinese Chemical Letters 2024年第8期35卷 401-405页

作者： Zhiqiang Liu Qiang Gao Wei Shen Meifeng Xu Yunxin Li Weilin Hou Hai-Wei Shi Yaozuo Yuan Erwin Adams Hian Kee lee sheng Tang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China National Medical Products Administration Key Laboratory for Impurity Profile of Chemical Drugs Nanjing 210019China Chemical Drug Inspection Laboratory 2 Jiangsu Institute for Food and Drug ControlNanjing 210019China Department of Pharmaceutical and Pharmacological Sciences Pharmaceutical AnalysisKU LeuvenHerestraat 49O&N2PB 923Leuven B-3000Belgium Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore

Owing to the serious potential side-effects on the environment and human health,the rapid detection and removal of antibiotics have become an important research *** this work,four zinc-based metal-organic frameworks(MOFs)with different functional groups,i.e.,Zn-MOF,Zn-MOF-CH_(3),Zn-MOF-NO_(2),Zn-MOF-COOH,were utilized for the construction of LDO/MOF composite materials with a nickel-iron-cobalt-based layered double oxide,*** results showed that the LDO/MOF composites not only had high sensitivity in detecting sulfonamide and quinolone antibiotics,but also had an appreciable ability to adsorb them from *** maximum adsorption capacities of all the four types of LDO@Zn-MOFs to all antibiotics can at least reach 150 mg/g,and the limits of detection in relation to all four antibiotics were at least as low as 100μg/*** work suggested the dual-function extraction performance can be attributed to the synergistic effects between the LDO and the ***,the strong ferromagnetism derived from the LDO provided great convenience for the separation and regeneration of the LDO/MOF composites.

关键词： Light-emitting metal-organic frameworks Layered double oxides Antibiotics Topological configurations Fluorescence detection

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

Féeton(B-L gauge boson)dark matter for the 511-keV gamma-ray excess and the prediction of low-energy neutrino flux

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Chinese Physics C 2024年第8期48卷 76-82页

作者： Jie sheng Yu Cheng Weikang Lin Tsutomu T.Yanagida Tsung-Dao lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityChina Key Laboratory for Particle Astrophysics and Cosmology(MOE)&Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai Jiao Tong UniversityShanghai 200240China South-Western Institute For Astronomy Research Yunnan UniversityKunming 650500China Kavli IPMU(WPI) UTIASUniversity of TokyoKashiwa277-8583Japan

The féeton is the gauge boson of the U(1)_(B−L) gauge *** the gauge coupling constant is extremely small,the féeton becomes a candidate for dark *** show that its decay to a pair of an electron and a positron explains the observed Galactic 511-keV gamma-ray excess in a consistent *** féeton dark matter decays mainly into pairs neutrino and *** low-energy experiments with improved directional capability will enable capturing these neutrino *** seesaw-motivated parameter space predicts a relatively short féeton lifetime that is comparable to the current cosmological constraint.

关键词： feeton 511-keV gamma-ray excess low-energy neutrino

Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer

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Food Science and Human Wellness 2024年

作者： Han-sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Pei-Han Liao Yu-Ching lee Chi-Tang Ho Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho Department of Biological Science & Technology， College of Life Sciences， China Medical University Institute of Biochemistry and Molecular Biology， College of Life Sciences， China Medical University Department of Surgery， School of Medicine， College of Medicine， Taipei Medical University Research Center of Cancer Translational Medicine， Taipei Medical University Department of Food Science， Rutgers University New Jersey， USA Institute of Food Sciences and Technology， Taiwan University

This study presents novel findings on the potential of phloretin， an apple polyphenol， to enhance the effectiveness of anti-HER2 antibody therapy in HER2-positive breast cancer patients. Our research reveals that phloretin inhibits type II glucose transporter (GLUT2) activity， significantly reducing cancer cell glucose uptake. We confirmed the overexpression of GLUT1 and GLUT2 mRNA in paired human breast tumor tissues， with GLUT2 overexpression associated explicitly with poorer survival rates in breast cancer patients. Treatment with phloretin was observed to increase the interaction between GLUT2 and HER2 proteins， attenuate glycolysis， and enhance the binding affinity of anti-HER2 antibody drugs to target human breast cancer cells. Furthermore， the efficacy of the combination therapy involving phloretin and antibody drugs was reaffirmed in a cell-derived xenograft (CDX) tumor animal model， particularly in suppressing the growth of Trastuzumab-resistant HER2+ breast cancer. These significant findings suggest that targeting GLUT2 activity with phloretin in combination with anti-HER2 antibody drugs may help mitigate the development of drug-resistant breast cancer， offering valuable insights for enhancing tumor treatment strategies and contributing to developing more effective therapies.

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Compact ultrafast neutron sources via bulk acceleration of deuteron ions in an optical trap

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Matter and Radiation at Extremes 2024年第5期9卷 22-31页

作者： Zhiyu Lei Hanghang Ma Xiaobo Zhang Lin Yu Yihang Zhang Yutong Li Suming Weng Min Chen Jie Zhang Zhengming sheng Key Laboratory for Laser Plasmas and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Centre of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Tsung-Dao lee Institute Shanghai Jiao Tong UniversityShanghai 201210China College of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

A scheme for a quasi-monoenergetic high-flux neutron source with femtosecond duration and highly anisotropic angular distribution is *** scheme is based on bulk acceleration of deuteron ions in an optical trap or density grating formed by two counter-propagating laser pulses at an intensity of-10^(16)W~cm^(2)in a near-critical-density *** deuterons are first pre-accelerated to an energy of tens of keV in the ambipolar fields formed in the optical *** energy is boosted to the MeV level by another one or two laser pulses at an intensity of-10^(20)W~cm^(2),enabling fusion reactions to be triggered with high *** contrast to previously proposed pitcher–catcher configurations,our scheme can provide spatially periodic acceleration structures and effective collisions between deuterons inside the whole target ***,neutrons are generated directly inside the optical *** simulations show that neutron pulses with energy 2–8 MeV,yield 10^(18)–10^(19)n/s,and total number 106–107 in a duration-400 fs can be obtained with a 25μm ***,the neutron pulses exhibit unique angularly dependent energy spectra and flux distributions,predominantly along the axis of the energy-boosting *** microsize femtosecond neutron pulses may find many applications,such as high-resolution fast neutron imaging and nuclear physics research.

关键词： acceleration scheme angular

Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao sheng Victor CWTam Shara WYlee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

Fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.X.Wang X.L.Zhu S.M.Weng P.Li X.F.Li H.Ai H.R.Pan Z.M.sheng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser Fusion of China Academy of Engineering Physics MianyangSichuan 621900China State key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-IR)to terahertz(THz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-IR or THz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-IR or THz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enhances the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength IR and THz spectral ranges.

关键词： laser ultrashort photon

How Effective are Decentralized Anti-poverty Programs?

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China & World Economy 2024年第4期32卷 85-113页

作者： Shuai Chen Mingda Cheng Jie-sheng Tan-Soo China Academy for Rural Development and School of Public Affairs Zhejiang UniversityChina Jiangxi Caitong Supply Chain Financial Group Co. Ltd.Jiangxi Financial Holding Group Co.Ltd.China lee Kuan Yew School of Public Policy National University of SingaporeSingapore

This study examines the effectiveness of China's National Poor Counties(NPC)program,a decentralized anti-poverty initiative,by analyzing five rounds of individual-level panel data from 1988 to *** impact of two waves of the NPC program(1994 and 2001)is evaluated utilizing a panel fixed-effects regression *** results indicate substantial positive effects,with residents in NPC counties experiencing a 47 percent income increase,3.1 percent higher employment rates,and a 5.7 percent rise in household expenditure from 1988 to 2008,in comparison with non-NPC ***,the program benefited vulnerable populations,dispelling concerns about"elite capture."The study also reveals that evolving policy focus has played a pivotal role in sustaining the effects of the program over *** 1994 round prioritized low-skilled employment,and the 2001 wave emphasized productivity enhancement through skills *** findings highlight the continued efficacy of decentralized anti-povertyefforts.

关键词： decentralization elite capture National Poor Counties program poverty