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A Simple Compression Method Using Motion Vector of the Distributed Video Encoder System

通讯和计算机（中英文版） 2013年第1期10卷 49-58页

作者： Yasuyuki Miura sho Nakane Shigeyoshi watanabe Department of lnformation Science Shonan Institute of Technology 1-1-25 Tsujido Nishi-kaigan Fujisawa Kanagawa Japan

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Induction chemotherapy with docetaxel,cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report

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World Journal of Clinical Cases 2019年第6期7卷 765-772页

作者： sho watanabe Yoshitaka Honma Naoya Murakami Hiroshi Igaki Taisuke Mori Hidekazu Hirano Natsuko Okita Hirokazu shoji Satoru Iwasa Atsuo Takashima Ken Kato Kenya Kobayashi Fumihiko Matsumoto Seiichi Yoshimoto Jun Itami Narikazu Boku Department of Head and Neck Medical Oncology National Cancer Center Hospital Department of Radiation Oncology National Cancer Center Hospital Department of Pathology and Clinical Laboratories National Cancer Center Hospital Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Department of Head and Neck Surgery National Cancer Center Hospital

BACKGROUND Sinonasal undifferentiated carcinoma(SNUC) is a rare aggressive tumor that is often unresectable. Optimal treatment for patients with unresectable,locally advanced SNUC(LA-SNUC) has not been established,and the patient outcome remains poor. We report two cases of unresectable LA-SNUC in which induction chemotherapy with docetaxel,cisplatin and fluorouracil(TPF) followed by radiotherapy with concurrent cisplatin(CCRT),a standard treatment option for locally advanced head and neck cancer,demonstrated promising *** SUMMARY A 39-year-old man presented with tearing and pain in the right eye. A biopsy of the tumor invading the sinonasal cavities,right orbit and cranial base confirmed the diagnosis of LA-SNUC. Induction TPF chemotherapy induced remarkable tumor shrinkage and rapidly improved the symptoms. He subsequently received CCRT and achieved complete remission of the disease. The other case is a 21-year-old man who presented with worsening vision. The unresectable tumor involving the nasal septum and cranial base was pathologically diagnosed as SNUC. TPF chemotherapy followed by CCRT yielded complete remission of the disease with preserved visual function. Both patients have been disease-free for44 *** Induction TPF chemotherapy followed by CCRT may remarkably improve the outcomes in LA-SNUC patients.

关键词： Sinonasal undifferentiated carcinoma Chemotherapy with docetaxel, cisplatin and fluorouracil chemotherapy Docetaxel Cisplatin Fluorouracil Intensity-modulated radiotherapy Chemoradiotherapy Case report

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Response evaluation of a compact and highly efficient neutron diffractometer for compact accelerator neutron sources

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辐射防护 2020年第6期40卷 540-544页

作者： sho Imai Kenichi watanabe Astushi Yamazaki Sachiko Yoshihashi Akira Uritani Seiji Tasaki Setsuo Satoh Nagoya University Furo-choChikusa-kuNagoya464-8603Japan Kyoto University YoshidahonmachiSakyo-kuKyoto606-8501Japan High Energy Accelerator Research Organization Oh-hoTsukuba305-0801Japan

We fabricated the spheroid neutron diffractometer with 79 neutron detector rings using the transparent rubber sheet type Eu:LiCaAlF6 scintillators and wavelength-shifting *** confirmed that the fabricated detector shows a clear neutron peak and can discriminate neutron and gamma-ray events in a signal pulse *** additionally checked that the fabricated diffractometer can detect a neutron diffraction peak of ferrite powder at Kyoto University Accelerator-driven Neutron ***,it can be expected that crystal structural analysis will be possible even by small accelerator neutron sources.

关键词： TRUST Eu:LiCAF scintillator neutron diffractometer neutron detector time-of-flight KUANS LiTA12

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Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication

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World Journal of Gastroenterology 2016年第33期22卷 7569-7578页

作者： Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio watanabe Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital Department of Hepatology Shonan-East General Hospital Department of Pathology Juntendo University Shizuoka Hospital Department of Gastroenterology Juntendo University School of Medicine

AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus *** In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank *** Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 *** Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR.

关键词： Human AKR1B10 protein Hepatocellular carcinoma Chronic hepatitis C Immunohistochemistry Risk factor Sustained virological response

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Feature-Tracking Strain Derived from Compressed Sensing Cine Cardiovascular Magnetic Resonance Imaging for Myocardial Infarct Detection: A Feasibility Study

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Open Journal of Radiology 2021年第3期11卷 101-114页

作者： Tomoro Morikawa Yuki Tanabe Tomoyuki Kido Ryo Ogawa Masashi Nakamura sho Akasaka Kouki watanabe Michaela Schmidt Osamu Yamaguchi Teruhito Kido Department of Radiology Ehime University Graduate School of Medicine Ehime Japan Department of Cardiology Saiseikai Matsuyama Hospital Ehime Japan Siemens Healthcare GmbH Allee am Roethelheimpark Erlangen Germany Department of Cardiology Pulmonology Hypertension and Nephrology Ehime University Graduate School of Medicine Ehime Japan

Purpose: This study aimed to use gadolinium-enhanced cardiovascular magnetic resonance (LGE-CMR) scanning to examine the clinical feasibility of feature-tracking strain (FT-strain) analysis on compressed sensing (CS) cine cardiovascular magnetic resonance (CMR) imaging for detecting myocardial infarction (MI). Methods: We enrolled 37 patients who underwent conventional cine CMR, CS cine CMR, and LGE-CMR scanning to assess cardiovascular disease. FT-strain analysis was used to assess peak circumferential strain (p-CS) based on an 18-segment model in both cine CMR imaging modalities. Based on LGE-CMR imaging findings, myocardial segments were classified as remote, adjacent, subendocardial infarcted, and transmural infarcted. The diagnostic performance of p-CS for detecting MI was compared between CS cine CMR imaging and conventional cine CMR imaging using the receiver operating characteristic (ROC) curve analysis. Results: A total of 440 remote, 85 adjacent, 76 subendocardial infarcted, and 65 transmural infarcted segments were diagnosed on LGE-CMR imaging. There were significant between-group differences in p-CS on both conventional and CS cine CMR (p Conclusion: FT-strain analysis of CS cine CMR imaging may help identify MI;it may be used alongside or instead of conventional CMR imaging.

关键词： Cardiovascular Magnetic Resonance Cardiac Function Compressed Sensing Myocardial Infarction Myocardial Strain

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Castor oil as booster for colon capsule endoscopy preparation reduction: A prospective pilot study and patient questionnaire

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第4期12卷 79-89页

作者： Kota Takashima Yoriaki Komeda Toshiharu Sakurai sho Masaki Tomoyuki Nagai Shigenaga Matsui Satoru Hagiwara Mamoru Takenaka Naoshi Nishida Hiroshi Kashida Konosuke Nakaji Tomohiro watanabe Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 589-8511Japan Division of Gastroenterology Department of Internal MedicineEndoscopy CenterAishinkai Nakae HospitalWakayama-Shi 640-8461Japan

BACKGROUND Preparation for colon capsule endoscopy(CCE)requires a large liquid laxative volume for capsule excretion,which compromises the procedure's *** To assess the safety and utility of castor oil-boosted bowel *** This prospective cohort study including 20 patients(age range,16-80 years;six men and 14 women)suspected of having colorectal disease was conducted at Kindai University Hospital from September 2017 to August *** patients underwent CCE because of the following inclusion criteria:previous incomplete colonoscopy in other facility(n=20),history of abdominal surgery(n=7),or organ abnormalities such as multiple diverticulum(n=4)and adhesion after surgery(n=6).The exclusion criteria were as follows:Dysphagia,history of allergic reactions to the drugs used in this study(magnesium citrate,polyethylene glycol,metoclopramide,and castor oil),possibility of pregnancy,possibility of bowel obstruction or stenosis based on symptoms,or scheduled magnetic resonance imaging within 2 wk after *** primary outcome was the capsule excretion rate within the battery life,as evaluated by the total large bowel observation rate,large bowel transit time,and bowel creasing level using a fivegrade scale in different colorectal *** secondary outcomes were complications,colorectal lesion detection rates,and patients’*** The castor oil-based regimen was implemented in 17 *** patients cancelled CCE because they could tolerate castor oil,but not liquid *** capsule excretion rate within the battery life was 88%(15/17).The mean large bowel transit time was 236 *** 70%of patients had satisfactory colon cleansing *** detected colon polyps(14/17,82%)and colonic diverticulum(4/12,33%).The sensitivity,specificity,and diagnostic accuracy rates for detecting colorectal polyps(size≥6 mm)were 76.9%,75.0%,and 76.4%,*** sensitivity,specificity,and diagnostic accuracy rates for dete

关键词： Bowel preparation regimen Castor oil Colon capsule endoscopy Colonoscopy Colorectal diseases Prospective study

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Serological surveillance for SARS-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R Conde Sofia L Costa Regina C S Sant’Anna Isa M F Antunes Mônica C Carneiro Fabio S Ronzei Julia C Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio C Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele C Alexandre Karla C de Paula Márcio watanabe Antonio Claudio L da Nóbrega Jackeline Christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BACKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-CoV-2 antibodies could indicate the immunoreactive profile during the COVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-CoV-2 antibodies in individuals within a university setting during the COVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of COVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%CI:1.02-1.31](Psho

关键词： Serological surveillance SARS-CoV-2 antibodies COVID-19 Serological rapid test Risk factors for COVID-19

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激素水平升高对68Ga-DOTATOC生理性摄取的影响

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中华核医学与分子影像杂志 2018年第8期38卷 584-584页

作者：唐军 Masao watanabe Yuji Nakamoto sho Koyasu Takayoshi Ishimori Akihiro Yasoda Kaori Togashi 上海交通大学医学院附属苏州九龙医院核医学科 Department of Diagnostic Imaging and Nuclear Medicine Graduate School of Medicine Kyoto University

目的68Ga-1,4,7,10-四氮杂环十二烷-N,N′,N″,N′″-乙底酸-奥曲肽(DOTATOC)PET/CT显像有益于神经内分泌肿瘤(NET)患者。功能性NETs可自行分泌相关激素,从而引起临床症状。某些器官会对68Ga-DOTATOC有生理性摄取,但激素水平升高是否会... 详细信息

目的68Ga-1,4,7,10-四氮杂环十二烷-N,N′,N″,N′″-乙底酸-奥曲肽(DOTATOC)PET/CT显像有益于神经内分泌肿瘤(NET)患者。功能性NETs可自行分泌相关激素,从而引起临床症状。某些器官会对68Ga-DOTATOC有生理性摄取,但激素水平升高是否会影响这种生理性摄取尚不得而知。该研究的目的是探讨激素水平升高对68Ga-DOTATOC生理性摄取的影响。方法纳入167例已知或疑有NET的患者,其中促肾上腺皮质激素(ACTH)升高组10例、胃泌素升高组25例、胰岛素升高组7例、无激素升高组125例。比较各组患者不同器官的最大标准摄取值(SUVmax)。结果 ACTH升高组患者中,垂体、胰腺钩突及肾上腺SUVmax较无激素升高组SUVmax低(5.7±1.9与8.4±3.1, P=0.015; 4.7±3.5与6.4±2.8, P=0.037; 10.8±4.8与13.9±4.7,P=0.020)。各组甲状腺、胰腺体部、肝脏、脾脏、肠道及肾脏的68Ga-DOTATOC生理性摄取未见差异。结论 ACTH升高组的NET患者垂体、胰腺钩突及肾上腺的68Ga-DOTATOC生理性摄取显著降低,其他器官的摄取未受激素水平影响。

关键词： 68Ga-DOTATOC SUVmax 生理性摄取 ACTH 垂体

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