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Social Data:CESSDA Best Practices

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Data Intelligence 2020年第1期2卷 220-229,316页

作者： ron Dekker Main Office of the Consortium of Social Science Data Archives Parkveien 20BergenNorway

The European Commission report“Turning FAIR into reality”provides an index of 27 FAIR Action Plan *** index is used for a self-assessment on CESSDA,the Consortium of European Social Science Data *** is performing well on“Concepts for FAIR implementation”,“Skills for FAIR”,and“Investment in FAIR”;there is work in progress on“FAIR culture”,and work to start up on“FAIR ecosystem”and especially on“Incentives and metrics for FAIR data and services”.Next,an analysis on the FAIR components,reveals that CESSDA has accomplished the“F”,is working on the“A”-considering the sensitivity and security requirements of social data,just started on“I”,and that there is lack of clarity on what should be in“R”.On Findability,the CESSDA Data Catalogue is explained,showing the building blocks that need to be in place before one can produce a *** article ends with a forward look on CESSDA’s deployment on the FAIR principles.

关键词： Social data Distributed infrastructure FAIR Action Plan Data catalogue

The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery

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Neural Regeneration Research 2021年第9期16卷 1751-1759页

作者： Maya Ross ron Ofri Koret School of Veterinary Medicine The Hebrew University of JerusalemRehovotIsrael

Inherited retinal degenerations are a leading and untreatbale cause of blindness, and as such they are targets for gene therapy. Numerous gene therapy treatments have progressed from laboratory research to clinical trails, and a pioneering gene therapy received the first ever FDA approval for treating patients. However, currently retinal gene therapy mostly involves subretinal injection of the therapeutic agent, which treats a limited area, entails retinal detachment and other potential complications, and requires general anesthesia with consequent risks, costs and prolonged recovery. Therefore there is great impetus to develop safer, less invasive and cheapter methods of gene delivery. A promising method is intravitreal injection, that does not cause retinal detachment, can lead to pan-retinal transduction and can be performed under local anesthesia in outpatient clinics. Intravitreally-injected vectors face several obstacles. First, the vector is diluted by the vitreous and has to overcome a long diffusion distance to the target cells. Second, the vector is exposed to the host's immune response, risking neutralization by pre-existing antibodies and triggering a stronger immune response to the injection. Third, the vector has to cross the inner limiting membrane which is both a physical and a biological barrier as it contains binding sites that could cause the vector's sequestration. Finally, in the target cell the vector is prone to proteasome degradation before delivering the transgene to the nucleus. Strategies to overcome these obstacles include modifications of the viral capsid, through rational design or directed evolution, which allow resistance to the immune system, enhancement of penetration through the inner limiting membrane or reduced degradation by intracellular proteasomes. Furthermore, physical and chemical manipulations of the inner limiting membrane and vitreous aim to improve vector penetration. Finally, compact non-viral vectors that can overcome

关键词： adeno-associated virus animal model blindness gene therapy inner limiting membrane photoreceptors retina retinitis pigmentosa vitreous

Launching jets from accretion belts

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Research in Astronomy and Astrophysics 2016年第5期16卷 1-6页

作者： ron Schreier Noam Soker Department of Physics Technion–Israel Institute of Technology

We propose that sub-Keplerian accretion belts around stars might launch jets. The sub-Keplerian inflow does not form a rotationally supported accretion disk, but it rather reaches the accreting object from a wide solid angle. The basic ingredients of the flow are a turbulent region where the accretion belt interacts with the accreting object via a shear layer, and two avoidance regions on the poles where the accretion rate is very low. A dynamo that is developed in the shear layer amplifies magnetic fields to high values. It is likely that the amplified magnetic fields form polar outflows from the avoidance regions. Our speculative belt-launched jets model has implications on a rich variety of astrophysical objects, from the removal of common envelopes to the explosion of core collapse supernovae by jittering jets.

关键词： stars: jets -- (stars:) binaries: accretion discs -- (stars:) supernovae: general -- accretion accretion disks

Improved Ligand-Field Theory with Effect of Electron-Phonon Interaction

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Communications in Theoretical Physics 2005年第3期43卷 529-538页

作者： MADong-Ping CHENJu-ron DepartmentofAppliedPhysics SichuanUniversityChengdu610065China／／InternationalCentreforMaterialsPhysicsAcademiaSinicaShenyang110015China DepartmentofAppliedPhysics SichuanUniversityChengdu610065China

Traditional ligand-field theory has to be improved by taking into account both 'pure electronic' contribution and electron-phonon interaction one (including lattice-vibrational relaxation energy). By means of improved ligand-field theory, R1, R2, R'3, R'2, and R'1 lines, U band, ground-state zero-field-splitting (GSZFS), and ground-state g factors of ruby and/or GSGG: Cr3+ as well as thermal shifts of GSZFS, R1 line and R2 line of ruby have been *** results are in very good agreement with the experimental data. Moreover, it is found that the value of cubic-field parameter given by traditional ligand-field theory is inappropriately large. For thermal shifts of GSZFS, R1 line and R2 line of ruby, several conclusions have also been obtained.

关键词： improved ligand-field theory electron-phonon interaction Stokes shift energy spectrum thermal shift g factor

Regularized Principal Component Analysis

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 1-12页

作者： Yonathan AFLALO ron KIMMEL Samsung Research Labs Ramat GanIsrael Computer Science Department TechnionIsrael Institute of TechnologyHaifaIsrael.

Given a set of signals, a classical construction of an optimal truncatable basis for optimally representing the signals, is the principal component analysis(PCA for short)approach. When the information about the signals one would like to represent is a more general property, like smoothness, a different basis should be considered. One example is the Fourier basis which is optimal for representation smooth functions sampled on regular grid. It is derived as the eigenfunctions of the circulant Laplacian operator. In this paper,based on the optimality of the eigenfunctions of the Laplace-Beltrami operator(LBO for short), the construction of PCA for geometric structures is regularized. By assuming smoothness of a given data, one could exploit the intrinsic geometric structure to regularize the construction of a basis by which the observed data is represented. The LBO can be decomposed to provide a representation space optimized for both internal structure and external observations. The proposed model takes the best from both the intrinsic and the extrinsic structures of the data and provides an optimal smooth representation of shapes and forms.

关键词： Laplace-Beltrami operator Principal component analysis Isometry

Novel active fault-tolerant control scheme and its application to a double inverted pendulum system

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Journal of Systems Engineering and Electronics 2008年第1期19卷 134-140页

作者： Cui Ping Weng Zhengxin Patton ron Dept. of Automation Shanghai Jiaotong Univ. Shanghai 200240 P. R. China Dept. of Engineering Univ. of Hull Hull HU6 7RX UK

On the basis of the gain-scheduled H∞ design strategy, a novel active fault-tolerant control scheme is proposed. Under the assumption that the effects of faults on the state-space matrices of systems can be of affine parameter dependence, a reconfigurable robust H∞ linear parameter varying controller is developed. The designed controller is a function of the fault effect factors that can be derived online by using a well-trained neural network. To demonstrate the effectiveness of the proposed method, a double inverted pendulum system, with a fault in the motor tachometer loop, is considered.

关键词： active fault-tolerant control neural network estimator gain-scheduled controller double inverted pendulum.

GEX3, Expressed in the Male Gametophyte and in the Egg Cell of Arabidopsisthaliana, Is Essential for Micropylar Pollen Tube Guidance and Plays a Role during Early Embryogenesis

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Molecular Plant 2008年第4期1卷 586-598页

作者： Monica Alandete-Saez Mily ron Sheila McCormick Plant Gene Expression Center and Department of Plant and Microbial Biology USDA/ARS-UC-Berkeley 800 Buchanan St Albany CA 94710 USA

Double fertilization in flowering plants occurs when the two sperm cells, carried by the pollen tube, are released in a synergid cell of the embryo sac and then fertilize the egg and the central cell. Proteins on the surfaces of the sperm, egg, central, and synergid cells might be important for guidance and recognition/fusion of the gametes. Here, we present functional analyses ofArabidopsis GEX3, which encodes a plasma membrane-localized protein that has homologs in other plants. GEX3 is expressed in both the vegetative and sperm cells of the male gametophyte and in the egg cell of the female gametophyte. Transgenic lines in which GEX3 was down-regulated or overexpressed, using the Arabidopsis GEX2 promoter, had reduced seed set. Reciprocal crosses and imaging after pollination with a reporter line showed that, in both cases, the defect causing reduced seed set occurred in the female. In the antisense lines, micropylar pollen tube guidance failed, In the overexpression lines, fertilization of mutant ovules was mostly blocked because pollen tube guidance failed, although, occasionally, non-viable embryos were formed. We conclude that properly regulated expression of GEX3 in the egg cell of Arabidopsis is essential for pollen tube guidance.

关键词： antisense double fertilization female gametophyte real-time PCR plasma membrane protein PQQ domain

THE WALWORTH ALTERNATIVE:RETAINING AND ENHANCING B RITAIN'S SOCIAL HOUSING ESTATES UTILISING CONTEMPORARY TIMBER CONSTRUCTION

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Journal of Green Building 2017年第1期12卷 11-35页

作者： Mike Kane ron Yee Masters in Architecture London South Bank University Reg.Arch&Director KMK ArchitectsLondon Masters in Architecture London South Bank University RegArchRIBA&DirectorYee AssociatesLondon

INTRODUCTION This paper describes the research designs of London South Bank University(LSBU)Masters of Architecture students who investigated the future housing needs of expanding cities,focusing in detail on the Walworth area of South London as a potential model for application *** students then proposed innovative ideas on how to expand and remodel the Aylesbury Housing Estate through the use of contemporary timber construction without resorting to wholescale demolition.

关键词： contemporary timber construction resource efficient architecture sustainable cities London housing

Binary interactions with high accretion rates onto main sequence stars

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Research in Astronomy and Astrophysics 2016年第7期16卷 153-160页

作者： Sagiv Shiber ron Schreier Noam Soker Department of Physics Technion-Israel Institute of TechnologyHaifa 32000Israel

Energetic outflows from main sequence stars accreting mass at very high rates might account for the powering of some eruptive objects, such as merging main sequence stars, major eruptions of luminous blue variables, e.g., the Great Eruption of Eta Carinae, and other intermediate luminosity optical transients（ILOTs; red novae; red transients）. These powerful outflows could potentially also supply the extra energy required in the common envelope process and in the grazing envelope evolution of binary systems. We propose that a massive outflow/jets mediated by magnetic fields might remove energy and angular momentum from the accretion disk to allow such high accretion rate flows. By examining the possible activity of the magnetic fields of accretion disks, we conclude that indeed main sequence stars might accrete mass at very high rates, up to≈10^-2M⊙yr^-1for solar type stars, and up toion≈1 M⊙yr^-1for very massive stars. We speculate that magnetic fields amplified in such extreme condits might lead to the formation of massive bipolar outflows that can remove most of the disk＇s energy and angular momentum. It is this energy and angular momentum removal that allows the very high mass accretion rate onto main sequence stars.

关键词： stars AGB and post-AGB stars jets (stars ) binaries(including multiple) close