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Protein neddylation and its role in health and diseases

Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： shizhen zhang Qing Yu Zhijian Li Yongchao Zhao Yi Sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Head&Neck Cancer Translational Research of Zhejiang Province Hangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Hangzhou 310024China Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

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Al-driven analysis establishes the single base substitution signatures as personalized prognostic predictors for five-year survival of gastric cancer

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Genes & Diseases 2024年第4期11卷 73-76页

作者： Zhenzhang Li Lingqing Xu Wen Luo Shaoan zhangg Chunyu Hou Xiaohong Xu ,Xubei Peng E.Shiju Janak L.Pathak shizhen zhang Jiawei Liu Linhai Li Yang Li School of Biomedical Engineering The Sixth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China College of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhouGuangdong 510665China The Second Affiliated Hospital Guangzhou Medical UniversityGuangzhouGuangdong 510260China Center for Learning Sciences and Technologies The Chinese University of Hong KongShatinNew Territories 999077China Affiliated Stomatology Hospital of Guangzhou Medical University Guangzhou Medical UniversityGuangzhouGuangdong 510182China International School of Photonics Cochin University of Science and TechnologyKochiKerala 682022India

Al-driven genetic engineering,as a burgeoning diagnostic tool,can offer predictive information on the five-year survival rate(FYSR)in the setup of a prognostic therapeutic *** approach provides the individuality and accuracy of prognosis for FYSR of gastric cancer(GC).Unlike traditional neoplasm staging criteria,our technique ensures accuracy and individuality without relying on statistical data and empirical study.

关键词： cancer gastric prognosis

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西藏措勤地区敌布错组时代重新厘定

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地球科学 2024年第9期49卷 3071-3088页

作者：刘函李俊高睿苟正彬张士贞中国地质调查局成都地质调查中心四川成都610081 成都理工大学地球科学学院四川成都610059 中国地质大学地球科学与资源学院北京100083

措勤地区上二叠统敌布错组与区域上古生物及地层研究进展存在矛盾,需要加强对其时代的厘定以准确理解其地质意义.基于锆石U-Pb定年,并结合野外调查与区域地层对比,将敌布错组重新归并为3类时代不同的岩石地层单元.敌布错组A以含砾砂板... 详细信息

措勤地区上二叠统敌布错组与区域上古生物及地层研究进展存在矛盾,需要加强对其时代的厘定以准确理解其地质意义.基于锆石U-Pb定年,并结合野外调查与区域地层对比,将敌布错组重新归并为3类时代不同的岩石地层单元.敌布错组A以含砾砂板岩及晚古生代植物化石为特征,碎屑锆石年龄谱与拉嘎组类似,为拉嘎组或者昂杰组.敌布错组B为海陆交互相碎屑岩,获得系列早白垩世早期年龄值,结合被早白垩世岩体侵位的特征将其厘定为则弄群下部.敌布错组C完全由早白垩世晚期火山岩与火山碎屑岩组成,与则弄群上部一致.结合区域资料,认为措勤地区中二叠世‒晚三叠世为连续的碳酸盐岩沉积,没有受到晚古生代岛弧造山作用的影响,早白垩世班公湖‒怒江残余海盆的南界在措勤地区较之前的认识向南推进了约50 km.

关键词：冈底斯敌布错组晚二叠世早白垩世措勤地层学岩石学.

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富水层地铁施工竖井垂直冻结法应用研究

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铁道建筑技术 2024年第5期 165-167,209页

作者：张士振中铁二十二局集团轨道工程有限公司北京100042

为响应北京市非降水工程的地下水保护政策,通过非降水措施完成地下工程施工作业。以北京地铁昌平线南延工程新建西土城暗挖车站施工竖井冻结法开挖为依托,介绍了垂直冻结法止水在富水砂卵石地层的竖井施工中的应用。竖井施工前通过周密... 详细信息

为响应北京市非降水工程的地下水保护政策,通过非降水措施完成地下工程施工作业。以北京地铁昌平线南延工程新建西土城暗挖车站施工竖井冻结法开挖为依托,介绍了垂直冻结法止水在富水砂卵石地层的竖井施工中的应用。竖井施工前通过周密的理论计算、合理的冻结孔布置、严格的冻结施工控制和精密的冻结过程监测,竖井井壁四周成功形成止水帷幕,为竖井的无水开挖安全作业提供了便利条件,可为北京市在非降水施工项目提供工程经验。

关键词：地铁工程施工竖井垂直冻结法止水帷幕

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科普期刊基于短视频的知识服务研究——以中国知网精品科普期刊抖音短视频为例

中国数字出版

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中国数字出版 2024年第4期2卷 70-78页

作者：曾元祥张世祯四川大学出版学院四川大学文学与新闻学院

知识服务是科普期刊实现数字化转型的重要手段。短视频平台因其独有的下沉用户基数、内容呈现的富媒体化和传播工具的多样化，成为科普期刊向知识服务转型的重要选择。文章选取中国知网精品科普期刊文献库中的208种科普期刊为样本，以... 详细信息

知识服务是科普期刊实现数字化转型的重要手段。短视频平台因其独有的下沉用户基数、内容呈现的富媒体化和传播工具的多样化，成为科普期刊向知识服务转型的重要选择。文章选取中国知网精品科普期刊文献库中的208种科普期刊为样本，以抖音短视频平台为取样渠道，从知识服务主体、产品、场景3个层面，调查科普期刊基于短视频开展知识服务的现状，考察其开展知识服务的水平。研究发现，科普期刊基于短视频开展知识服务尚处于起步阶段，缺乏与纸刊的联动，知识服务主体身份模糊、虚拟主体运用不足，传播形式呈现泛娱乐化倾向。为此，科普期刊短视频运营应转变思维、强化联动、跨界合作，聚力打造融专业化、类型化及人格化于一体的知识类短视频媒体。

关键词：科普期刊知识服务抖音短视频中国知网精品科普期刊

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Functional characterization of SOX2 as an anticancer target

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1304-1320页

作者： shizhen zhang Xiufang Xiong Yi Sun The Cancer Institute of the Second Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,reprogramming,and *** cellular levels of SOX2 are precisely regulated by a complicated network at the levels of transcription,post-transcription,and *** many types of human cancer,SOX2 is dysregulated due to gene amplification and protein ***2 overexpression is associated with poor survival of cancer ***,SOX2 promotes proliferation,survival,invasion/metastasis,cancer stemness,and drug ***2 is,therefore,an attractive anticancer ***,little progress has been made in the efforts to discover SOX2 inhibitors,largely due to undruggable nature of SOX2 as a transcription *** this review,we first briefly introduced SOX2 as a transcription factor,its domain structure,normal physiological functions,and its involvement in human *** next discussed its role in embryonic development and stem *** then mainly focused on three aspects of SOX2:(a)the regulatory mechanisms of SOX2,including how SOX2 level is regulated,and how SOX2 cross-talks with multiple signaling pathways to control growth and survival;(b)the role of SOX2 in tumorigenesis and drug resistance;and(c)current drug discovery efforts on targeting SOX2,and the future perspectives to discover specific SOX2 inhibitors for effective cancer therapy.

关键词： SOX2 invasion involvement

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Targeting oncogenic SOX2 in human cancer cells: therapeutic application

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Protein & Cell 2020年第2期11卷 82-84页

作者： shizhen zhang Yi Sun Division of Radiation and Cancer Biology Department of Radiation OncologyUniversity of MichiganAnn ArborMl 48109USA The Cancer Institute of the Second Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China

Sry-related high-mobility box 2(SOX2)is a critical transcription factor that plays an important role in various phases of embryonic development and maintenance of undifferentiated embryonic stem cells(ESCs)(Feng and Wen,2015).SOX2,as one of the Yamanaka factors,is involved in the conversion of mouse embryonic fibroblast cells(MEFs)into induced pluripotent stem cells(iPSCs)(Takahashi and Yamanaka,2006).Recently,SOX2 amplification,usually couples with aberrantly increased expression,were found in various human cancers,including breast,lung,esophagus,colon,prostate,ovarian among the others(Novak et al.,2019).SOX2 overexpression promotes cancer progression by accelerating cell proliferation,colony formation,migration,invasion,and sphere ***,SOX2 is causally related to the development of the resistance of cancer cells to chemotherapy.

关键词： SOX2 cancer invasion

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Controller design of uncertain nonlinear systems based on T-S fuzzy model

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控制理论与应用（英文版） 2009年第2期7卷 139-143页

作者： Songtao zhang shizhen BAI School of Management Harbin University of Commerce Harbin Heilongjiang 150076 China

A robust control for uncertain nonlinear systems based on T-S fuzzy model is discussed in this paper. First, a T-S fuzzy system is adopted to model the uncertain nonlinear systems. Then, for the system with input variables adopting standard fuzzy partitions, the efficient maximal overlapped-rules group （EMORG） is presented, and a new sufficient condition to check the stability of T-S fuzzy system with uncertainty is derived, which is expressed in terms of Linear Matrix Inequalities. The derived stability condition, which only requires a local common positive definite matrix in each EMORG, can reduce the conservatism and difficulty in existing stability conditions. Finally, a simulation example shows the proposed approach is effective.

关键词： Controller design Uncertain nonlinear systems T-S fuzzy model

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低成本无钒热轧钢筋HRB400E的生产工艺优化

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金属热处理 2024年第7期49卷 294-300页

作者：刘阳高茗马莉胡祯孙中梅张士震中冶检测认证有限公司北京100088 北京科技大学钢铁冶金新技术国家重点实验室北京100083

研究了HRB400E无钒盘螺钢筋的未再结晶区温度和动态CCT曲线,得出了钢筋的工业化生产工艺。结果表明:当应变速率为0.2 s^(-1)时,HRB400E钢在970℃热轧时发生明显的再结晶,当热轧温度降低到850℃及其以下时,HRB400E钢发生部分再结晶或未... 详细信息

研究了HRB400E无钒盘螺钢筋的未再结晶区温度和动态CCT曲线,得出了钢筋的工业化生产工艺。结果表明:当应变速率为0.2 s^(-1)时,HRB400E钢在970℃热轧时发生明显的再结晶,当热轧温度降低到850℃及其以下时,HRB400E钢发生部分再结晶或未发生再结晶;当冷却速度小于3℃/s时,HRB400E钢的组织为铁素体和珠光体,冷却速度在5~15℃/s时,得到铁素体、珠光体和贝氏体组织,冷却速度大于15℃/s时,得到珠光体和贝氏体组织。根据试验结果,设置开轧温度为(950±15)℃,进精轧温度为(870±10)℃、吐丝温度为(870±10)℃,1~4号风机开度分别为90%、90%、70%、70%的生产工艺。采用此优化工艺试生产时,钢筋的屈服强度R_(p0.2)≥409.5 MPa,同圈差≤32.6 MPa,最大力总延伸率A_(gt)≥10.26%,微观组织由铁素体和珠光体组成,全流程吨钢成本可降低16元左右。

关键词：未再结晶区 CCT曲线微观组织屈服强度最大力总伸长率

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Reservoir-forming age and its exploration significance to stratigraphic reservoirs in southern Songliao Basin

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Chinese Science Bulletin 2007年第23期52卷 3239-3252页

作者： ZOU CaiNeng TAO shizhen zhang YouYu PetroChina Research Institute of Petroleum Exploration & Development Beijing 100083 China

Despite many studies concerning the forming age, evolution characteristics and the age of petroleum charging in the Fuxin upheaval of southern Songliao Basin, no consensus has been reached so far. This paper presents the first K-Ar dating of autogenetic illite from stratigraphic petroleum reservoirs in the Fuyu oil layer of the Fuxin upheaval belt. Isotopic test and age calculation were carried out based on the separation and purification of illite mineral, X-diffraction analysis and the detection of scanning electron microscopy. The evolution characteristics of structure, sedimentation, reservoir-forming about the Fuxin upheaval belt were interpreted in terms of the synthetical analysis of "six-type geological history" evolution in southern Songliao Basin. The geologic background of petroleum evolution and reservoir formation are similar in the entire central depression region of southern Songliao Basin. The Changling sag and the Fuxin upheaval belt brought about obvious upheaval-sag separation after the hydrocarbon-generation peak of K2qn1 and the main reservoir-forming period of the Fuyu oil layer, namely reservoir-forming happened before the Fuxin upheaval belt extensively raised. The reservoirs have three characteristics: the hydrocarbon source rock above the reservoir, the oil source in the lo- cality, and the vertical migration. The geological cognition is corrected, that is, oil source came from the Changling sag and migrated from the side direction. The bulk process of petroleum charging in the stratigraphic hydrocarbon reservoirs in the Fuxin upheaval belt of southern Songliao Basin is deter- mined according to the isotopic age of autogenetic illite in combination with the method of fluid inclu- sions. The cognition is helpful to exactly evaluate the resource potential and exploration direction in the Fuxin upheaval belt, Changling sag and their peripheral areas. The present results indicate that the combination of the two methods (the K-Ar dating of autog

关键词：伊利石水库测定年代地层

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