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Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
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Acta Pharmaceutica Sinica B 2024年 第7期14卷 3286-3290页
作者： Miao Zheng Bo Feng Yumin Zhang Xin Liu NaZhao Hui Liu Zichao Xu Xinheng He Zhiyan Qu shizhaochen Zhidong Jiang Xi Cheng Hong Liu Yi Zang Linxiang Zhao Jie Zheng Leike Zhang Jia Li Yu Zhou Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Sciences and Biopharmaceuticals Shenyang Pharmaceutical UniversityShenyang 110016China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Lingang Laboratory Shanghai 200031China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Jiangxia Laboratory Wuhan 430200China
To the Editor:The papain-like protease(PL^(pro)),as one of the most important proteases of SARS-CoV-2,has emerged as a highly promising target protein,its inhibitor probably holds dual potentials,namely blocking the c... 详细信息
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