检索结果-南通市图书馆

构树花粗多糖对紫外线诱导小鼠皮肤光损伤的保护作用及机制研究

在线全文

学校读者我要写书评

暂无评论

日用化学工业（中英文） 2024年第9期54卷 1069-1077页

作者：赖梓漩宋雨轩段雪伟刘诗芸刘冰张敏君杨慧文广东药科大学药学院广东广州510006 广东药科大学护理学院广东广州510006

研究构树花粗多糖对紫外线诱导小鼠皮肤光损伤的保护作用,并探讨其作用机制。采用雌性昆明鼠建立长波紫外线(UVA)诱导小鼠皮肤光损伤模型,并对小鼠背部皮肤进行评分。采用苏木素-伊红(HE)、Masson染色考察小鼠皮肤组织病理学变化、皮肤... 详细信息

研究构树花粗多糖对紫外线诱导小鼠皮肤光损伤的保护作用,并探讨其作用机制。采用雌性昆明鼠建立长波紫外线(UVA)诱导小鼠皮肤光损伤模型,并对小鼠背部皮肤进行评分。采用苏木素-伊红(HE)、Masson染色考察小鼠皮肤组织病理学变化、皮肤厚度和胶原纤维的变化;考察皮肤组织Hyp、抗氧化酶SOD、GSH-Px、CAT和MDA,TNF-α、IL-1β、IL-6的含量,MMPs、Nrf2、HO-1和NF-κB通路相关蛋白的表达。结果显示,构树花粗多糖凝胶可不同程度改善皮肤粗糙溃烂现象,抑制皮肤增厚,提高真皮层胶原含量,使胶原纤维排列趋于紧密;提高皮肤组织中SOD、GSH-Px和CAT活力,降低MDA含量(P<0.05);降低皮肤促炎因子TNF-α、IL-1β和IL-6含量(P<0.05);MMP-1和MMP-3含量明显降低(P<0.05),Nrf2蛋白和HO-1蛋白表达显著升高(P<0.01),p-p65/p65蛋白表达比例显著降低(P<0.05)。可见,构树花粗多糖对紫外线致小鼠皮肤光损伤具有显著的保护作用,其机制可能与构树花粗多糖激活Nrf2通路、增强SOD等抗氧化酶活性,抑制NF-κB通路有关。

关键词：构树花粗多糖皮肤光损伤氧化应激炎症因子 Nrf2通路

基于双模通信技术的GNSS地表位移解算精度分析

在线全文

学校读者我要写书评

暂无评论

现代信息科技 2024年第3期8卷 54-58,63页

作者：刘诗云郭倩倩潘伟锋广州南方卫星导航仪器有限公司广东广州510663

地质灾害监测中往往通过移动通信的方式将观测数据回传至服务器,数据传输方式比较单一,对于信号不稳定或灾害造成的信号中断问题难以解决。结合使用电台自组网通信技术与4G通信技术,研制具备双模通信方式的GNSS接收机,弥补单模通信的短... 详细信息

地质灾害监测中往往通过移动通信的方式将观测数据回传至服务器,数据传输方式比较单一,对于信号不稳定或灾害造成的信号中断问题难以解决。结合使用电台自组网通信技术与4G通信技术,研制具备双模通信方式的GNSS接收机,弥补单模通信的短板。在稳定区域搭建测试环境,以4G通信为基准,验证电台自组网通信方式的稳定性与可靠性。将基准站安装在稳定位置,分别在距离基准站1.5、3、5、6 km位置各安装一台GNSS接收机,各主机均开启电台与4G两路数据传输,验证电台数据传输质量随距离增大的衰减程度。根据测试结果,验证电台传输方式的适用场景及最佳组网距离。

关键词：地质灾害监测双模通信技术电台自组网最佳组网距离

西安市燃煤锅炉颗粒物中有机碳和元素碳的排放特征研究

在线全文

学校读者我要写书评

暂无评论

地球与环境 2024年第3期52卷 343-353页

作者：沈利娟刁一伟王红磊孙杰娟刘诗云刘焕武赵天良无锡学院大气与遥感学院江苏无锡214105 南京信息工程大学中国气象局气溶胶-云-降水重点开放实验室南京210044 西安市环境监测站西安710119 中科三清科技有限公司北京100029

燃煤锅炉是城市地区含碳气溶胶的重要来源之一,本研究采集分析了西安市9个燃煤锅炉的PM_(10)和PM_(2.5)样品中的有机碳(OC)和元素碳(EC)。结果表明:燃煤锅炉颗粒物中OC在PM_(2.5)中的质量占比高于在PM_(10)中质量占比,而EC在PM_(10)中... 详细信息

燃煤锅炉是城市地区含碳气溶胶的重要来源之一,本研究采集分析了西安市9个燃煤锅炉的PM_(10)和PM_(2.5)样品中的有机碳(OC)和元素碳(EC)。结果表明:燃煤锅炉颗粒物中OC在PM_(2.5)中的质量占比高于在PM_(10)中质量占比,而EC在PM_(10)中的质量占比高于在PM_(2.5)中质量占比。OC、EC和总碳气溶胶(TC)在PM_(10)中的质量占比分别为4.35%±1.09%、4.25%±1.02%和8.60%±1.87%,在PM_(2.5)中的质量占比分别为6.91%±1.09%、2.62%±0.41%和9.53%±1.40%。不同锅炉类型的OC/EC(二者浓度比)差异较大。链条炉、循环流化床和煤粉炉的OC/EC在PM_(10)中分别为1.50±0.96、0.89±1.06和12.03±8.48,在PM_(2.5)中分别为6.72±5.70、1.19±0.65和11.62±5.83。不同锅炉排放的PM_(10)和PM_(2.5)中含碳气溶胶的主导成分不同,通过含碳气溶胶的成分组成可以准确区分锅炉排放来源。PM_(10)中TC和EC的质量占比均呈链条炉(10.64%±5.13%和5.79%±4.78%)>循环流化床(7.25%±2.23%和4.15%±1.14%)>煤粉炉(4.85%±1.84%和0.50%±0.25%),OC的质量占比呈链条炉(4.85%±2.33%)>煤粉炉(4.35%±2.09%)>循环流化床(3.10%±3.37%)。PM_(2.5)中TC和OC的质量占比均呈链条炉(12.97%±5.57%和9.25%±5.63%)>煤粉炉(5.57%±1.86%和5.02%±1.79%)>循环流化床(4.92%±5.41%和2.94%±3.53%),EC的质量占比呈链条炉(3.71%±3.84%)>循环流化床(1.97%±1.88%)>煤粉炉(0.55%±0.07%)。不同锅炉类型对PM_(10)中的EC影响较大,对PM_(2.5)中的OC影响较大,主要是由于不同类型锅炉燃煤燃烧方式和燃烧效率差异所致。

关键词：燃煤锅炉有机碳元素碳排放特征西安

Plasma reforming of toluene as a model tar compound from biomass gasification:effect of CO_(2) and steam

在线全文

学校读者我要写书评

暂无评论

Waste Disposal and Sustainable Energy 2019年第2期1卷 133-141页

作者： shiyun liu Danhua Mei Yaolin Wang Yichen Ma Xin Tu Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK College of Electrical Engineering and Control Science Nanjing Tech UniversityNanjing 211816China

In this study, plasma reforming of toluene as a tar model compound from biomass gasification has been carried out using an AC gliding arc discharge reactor. The influence of steam and CO_(2) addition on the reforming of toluene has been evaluated. The results show that the highest toluene conversion (59.9%) was achieved when adding 3 vol% CO_(2) at a toluene concentra-tion of 16.1 g/Nm3 and a specific energy input of 0.25 kWh/m3. Further increasing CO_(2) concentration to 12 vol% decreased the conversion of toluene. The presence of steam in the plasma CO_(2) reforming of toluene creates oxidative OH radicals which contribute to the enhanced conversion of toluene and energy efficiency of the plasma reforming process through stepwise oxidation of toluene and reaction intermediates. Hydrogen and C_(2)H_(2) were identified as the major gas products in the plasma reforming of toluene without CO_(2) or steam, with a yield of 9.7% and 14.5%, respectively, while syngas was the primary products with a maximum yield of 58.3% (27.5% for H_(2) and 30.8% for CO) in the plasma reforming with the addition of 12 vol% CO_(2). The plausible reaction pathways and mechanism in the plasma reforming of toluene have been proposed through the combination of the analysis of gas and condensed products and spectroscopic diagnostics.

关键词： Gliding arc discharge Non-thermal plasma Tar reforming Biomass gasification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中医外治法治疗肝癌腹水的研究进展

贵州中医药大学学报 2024年第4期46卷 68-72页

作者：吴慧娴刘诗云罗维劼叶涛贵州中医药大学贵州贵阳550025 贵州中医药大学第一附属医院贵州贵阳550001

腹水是临床上肝癌患者的常见并发症,治疗腹水在减轻患者痛苦、改善生活质量、提高患者生存率等方面具有重要意义。现代医学对于腹水的疗法包括腹腔穿刺引流以及内服西药,但存在一定的局限,随着对中医药防治肿瘤研究的逐渐深入,中医外治... 详细信息

腹水是临床上肝癌患者的常见并发症,治疗腹水在减轻患者痛苦、改善生活质量、提高患者生存率等方面具有重要意义。现代医学对于腹水的疗法包括腹腔穿刺引流以及内服西药,但存在一定的局限,随着对中医药防治肿瘤研究的逐渐深入,中医外治法在腹水防治方面的独特优势得以显现。本文通过对中医特色外治法治疗肝癌腹水的病因病机、病理机制及各类治疗方法进行论述,认为中医外治疗法通过调节免疫、改善微循环、调控炎症因子和杀伤肿瘤细胞等作用治疗肝癌腹水,进而改善患者症状,提高患者生存率,为患者带来福音。

关键词：中医外治法肝癌腹水机制

Liquid discharge plasma for fast biomass liquefaction at mild conditions: The effects of homogeneous catalysts

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2020年第5期14卷 763-771页

作者： Sen Wang shiyun liu Danhua Mei Rusen Zhou Congcong Jiang Xianhui Zhang Zhi Fang Kostya(Ken)Ostrikov College of Electrical Engineering and Control Science Nanjing Tech UniversityNanjing 211816China Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Institute of Electromagnetics and AcousticsDepartment of Electronic ScienceCollege of Electronic Science and TechnologyXiamen UniversityXiamen 361005China School of Chemistry Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQueensland 4000Australia

Non-thermal plasma exhibits unique advan-tages in biomass conversion for the sustainable production of higher-value energy *** homogeneous catalysts are usually required for plasma-enabled biomass liquefaction to achieve time-and energy-efficient ***,the effects of such catalysts on the plasma-assisted liquefaction process and of the plasma on those catalysts have not been thoroughly *** this study,an electrical discharge plasma is employed to promote the direct liquefaction of sawdust in a mixture of polyethylene glycol 200 and *** commonly used chemicals,sulfuric acid,nitric acid and sodium p-toluene sulfate,were selected as *** effects of the type of catalyst and concentration on the liquefaction yield were examined;further,the roles of the catalysts in the plasma liquefaction process have been *** results showed that the liquefaction yield attains a value of 90%within 5 min when 1%sulfuric acid was employed as the *** with the other catalysts,sulfuric acid presents the highest efficiency for the liquefaction of *** was observed that hydrogen ions from the catalyst were primarily responsible for the significant thermal effects on the liquefaction system and the generation of large quantities of active species;these effects directly con-tributed to a higher efficacy of the plasma-enabled liquefaction process.

关键词： discharge plasma biomass liquefaction cata-lyst homogeneous catalysts

Effect and mechanism of CyPA in radiosensitization of lung adenocarcinoma using CRISPR/Cas9 technology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medical Sciences 2020年第1期7卷 53-58页

作者： Jinkun Ma Lin Xu Jinchang Huang Qiaoli Zhang Yuqin Qiu Xuewei Qi Lina Wang Yuchan Cao Zeyu liu shiyun liu Beijing University of Chinese Medicine Third Affiliated Hospital Beijing University of Chinese MedicineBeijing100029China

Objective:To explore the role of cyclophilin A(CyPA)in sensitization of lung adenocarcinoma to radiotherapy using CRISPR/Cas9 ***:A CyPA knockout human lung adenocarcinoma cell line H1975 was established by CRISPR/Cas9 *** included a control group(wildtype),CyPA knockout group,traditional Chinese medicine(TCM)extract with Fuzhengzengxiao decoction group,and TCM extract with Fuzhengzengxiao decoction t CyPA knockout *** group was exposed to radiation at doses of 0,2,4,6,and 8 *** 24 h,MTT assays were used to determine the survival rate of lung cancer cells and calculate *** qPCR was used to measure mRNA expression of DDIT3,CDKN1A,and CDC25A associated with DNA damage ***:Without irradiation,Fuzhengzengxiao decoction reduced the survival rate of lung adenocarcinoma cells(P<.0001).After irradiation,TCM extract with Fuzhengzengxiao decoction,CyPA knockout,and TCM extract with Fuzhengzengxiao decoction t CyPA knockout groups had reduced survival rates(P<.0001)and radiosensitivity was increased *** of DDIT3,CDKN1A,and CDC25A was upregulated after knockout of CyPA(P<.0001).Expression of DDIT3 and CDC25A was increased after irradiation in wildtype cells treated with TCM extract with Fuzhengzengxiao decoction(DDIT3,P<.0001;CDC25A,P紏.0059).The TCM extract with Fuzhengzengxiao decoction t CyPA knockout group also had increased expression of DDIT3 and CDC25A after irradiation(P<.0001).Conclusion:Fuzhengzengxiao decoction significantly decreases the survival rate of lung cancer cells,and its mechanism may be related to radiosensitization by decreasing expression of CyPA and inducing G1/S cell cycle arrest.

关键词： CyPA Fuzhengzengxiao decoction Gene knockout Lung adenocarcinoma Radiosensitization

Evaluation of the Adaptability of Six Sets of Precipitation Data in Inner Mongolia

在线全文

学校读者我要写书评

暂无评论

Meteorological and Environmental Research 2021年第5期12卷 21-30,34页

作者： Yan HUANG Haiqing SONG Xiaolong SUN shiyun liu Ulanqab Meteorological Bureau Ulanqab 012000China Ecological and Agricultural Meteorology Center of Inner Mongolia Autonomous Region Hohhot 010051China

Based on daily precipitation data of 119 weather stations over Inner Mongolia in 2018,the adaptability of six sets of precipitation data( GLDAS2.1,ITPCAS,CLDAS2.0,CMPAS2.0 ERA5 and CMPAS2.1) in Inner Mongolia was evaluated and analyzed by using Pearson correlation coefficient( R),mean deviation( Bias) and root mean square error( RMSE).The results indicate that the six sets of precipitation data could well reflect the spatial and temporal variation of precipitation over Inner *** a ten-day scale,the mean deviation of CMPAS2.1 had a smaller variation,which slightly underestimated precipitation;the mean deviation of CLDAS2.0 had a smaller variation in the eastern region;the mean deviation of both ITPCAS and CMPAS2.0 was more stable in the central region than in the eastern and western regions;the mean deviation of GLDAS2.1 and ERA5 had a relatively larger variation,and ERA5 overestimated precipitation to a certain extent;the root mean square error of CMPAS2.1 had the smallest variation,whereas that of ERA5 was relatively *** monthly scale was similar to the ten-day *** correlation coefficient of the six sets of precipitation data in the central region was better than that in the east and west,and the mean deviation and root mean square error were relatively larger in areas with more complex mountain *** to statistical indicators,CMPAS2.1 performed better in Inner Mongolia than other five sets of data.

关键词： Precipitation data Inner Mongolia Evaluation

SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第8期8卷 3780-3793页

作者： Kai Yang shiyun liu Han Yan Wenju Lu Xiaoqian Shan Haixia Chen Changlei Bao Huazhuo Feng Jing Liao Shuxin Liang Lei Xu Haiyang Tang Jason X-J.Yuan Nanshan Zhong Jian Wang State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangdong Key Laboratory of Vascular DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhouGuangdongChina Department of Pulmonary and Critical Care Medicine The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotInner Mongolia Autonomous RegionChina Department of Pathology The Affiliated Cancer Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina Section of Physiology Division of PulmonaryCritical Care and Sleep MedicineDepartment of MedicineUniversity of California San DiegoLa JollaCAUSA

Exposure to the spike protein or receptor-binding domain(S-RBD)of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular *** this study,angiotensin-converting enzyme 2 humanized inbred(hACE2 Tg)mice and cultured pulmonary vascular endothelial cells were used to investigate how spike protein/S-RBD impacts pulmonary vascular *** show that S-RBD leads to acute-to-prolonged induction of the intracellular free calcium concentration([Ca^(2+)]i)via acute activation of TRPV4,and prolonged upregulation of mechanosensitive channel Piezo1 and store-operated calcium channel(SOCC)key component Orai1 in cultured human pulmonary arterial endothelial cells(PAECs).In mechanism,S-RBD interacts with ACE2 to induce formation of clusters involving Orai1,Piezo1 and TRPC1,facilitate the channel activation of Piezo1 and SOCC,and lead to elevated *** effects are blocked by Kobophenol A,which inhibits the binding between S-RBD and ACE2,or intracellular calcium chelator,*** of Piezo1 and SOCC by GsMTx4 effectively protects the S-RBDinduced pulmonary microvascular endothelial damage in hACE2 Tg mice via normalizing the elevated[Ca^(2+)]*** to prototypic strain,Omicron variants(BA.5.2 and XBB)of S-RBD induces significantly less severe cell *** analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda *** summary,this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering[Ca^(2+)]i through upregulation of Piezo1 and *** inhibition of ACE2-Piezo1/SOCC-[Ca^(2+)]i axis proves a powerful strategy to treat S-RBD-induced pulmonary vascular diseases.

关键词： ACE2 elevated homeostasis