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增强现实光学全肺诊疗导航引导下肺外周结节诊断、定位及治疗专家共识

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中华医学杂志 2024年第16期104卷 1371-1380页

作者：中华医学会呼吸病学分会介入学组浙江省医学会呼吸病学分会介入学组陈恩国李时悦张冀松李晓燕荆蕾徐珊徐航娣董良良徐笠不详浙江大学医学院附属邵逸夫医院呼吸与危重症医学科杭州310016 广州医科大学附属第一医院呼吸与危重症医学科广州510120 中国人民解放军总医院第五医学中心肿瘤内科应急总医院呼吸与危重症医学科浙江大学医学院附属邵逸夫医院呼吸与危重症医学科

肺癌是全世界第二大常见、死亡率最高的恶性肿瘤。近年来,各种支气管镜导航技术的快速发展,为早期肺癌筛查提供了有力手段,也为肺外周结节经气道的微创诊断及治疗提供了条件。增强现实光学全肺诊疗导航是在虚拟导航支气管镜(VBN)的基础... 详细信息

肺癌是全世界第二大常见、死亡率最高的恶性肿瘤。近年来,各种支气管镜导航技术的快速发展,为早期肺癌筛查提供了有力手段,也为肺外周结节经气道的微创诊断及治疗提供了条件。增强现实光学全肺诊疗导航是在虚拟导航支气管镜(VBN)的基础上,融入增强现实和光学导航技术,以辅助支气管镜检查的新技术,是临床应用最为广泛的导航技术之一。现有众多临床证据显示该技术在引导支气管镜下肺外周结节诊断、定位和治疗方面均具有良好的安全性和有效性。为规范增强现实光学全肺诊疗导航技术的临床操作,指导其在临床实践中的应用,中华医学会呼吸病学分会介入学组与浙江省医学会呼吸病学分会介入学组组织多学科专家经过多轮的研讨,牵头制订了《增强现实光学全肺诊疗导航引导下肺外周结节诊断、定位及治疗专家共识》,针对增强现实光学全肺诊疗导航技术适用的肺外周结节诊断、定位和治疗的适应证和禁忌证、设备和器械、围手术期处置、操作流程及并发症管理等方面提供了推荐意见和临床指导。

关键词：肺肺外周结节增强现实光学全肺诊疗导航支气管镜导航诊断定位治疗

Carboniferous–Permian marine transgressions in the Jiyang Depression

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International Journal of Mining Science and Technology 2014年第1期24卷 87-92页

作者： Zhang Kuihua chen shiyue Zhang Guanlong Department of Earth Resource and Information China University of Petroleum Qingdao Western New Prospect Research Center Shengli Oilfield

In recent years,great attention has been paid to oil and gas exploration in the Carboniferous–Permian strata of the Bohaiwan basin,especially the Carboniferous–Permian marine transgression,using data from drilling,outcrops and carbonate acid-insoluble residue experiments together with the tectonic evolutionary history of the peripheral orogenic zones of the North China plate and the Tan-Lu fault zones.The study concludes that marine transgressions took place on six occasions during Carboniferous–Permian time in the Jiyang Depression.The marine transgressions were concentrated in the Late Carboniferous:two marine transgressions occurred in the early Late Carboniferous,and the scale of the first was smaller and the time was shorter than those of the second.The other four marine transgressions happened in the late Late Carboniferous,the first and the fourth of which were larger in scale and longer in time than the second and the third.The seawater came from the Jiaobei area,the eastward part of the Qinling–Dabie residual sea basin,and invaded progressively as a planar flow from south to north and from east to west.These findings have great significance for thorough analysis of the sedimentary characteristics and evolution of the Carboniferous–Permian strata in the Jiyang Depression.

关键词：济阳坳陷石炭纪二叠系海侵地层演化晚石炭世渤海湾盆地天然气勘探

Characteristics and Controlling Factors of Shale Oil Reservoir Spaces in the Bohai Bay Basin

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Acta Geologica Sinica(English Edition) 2020年第2期94卷 253-268页

作者： DENG Yuan chen shiyue PU Xiugang YAN Jihua School of Geosciences China University of Petroleum(East China)Qingdao 266580China Research Institute of Exploration and Development PetroChina Dagang Oilfield CompanyTianjin 300280China

The Cenozoic continental strata of the Bohai Bay Basin are rich in shale oil resources, and they contain various types of reservoir spaces that are controlled by complex factors. Using field emission scanning electron microscopy(FESEM), automatic mineral identification and characterization system(AMICS), CO2 and N2 gas adsorption, and focused ion beam scanning electron microscopy(FIB-SEM), the types of shale reservoir spaces in the Bohai Bay Basin are summarized, the spatial distribution and connectivity of the various types of pores are described in detail, the microscopic pore structures are characterized, and the key geological mechanisms affecting the formation and evolution of the reservoir spaces are determined. Three conclusions can be drawn in the present study. First, the shale reservoir spaces in the Bohai Bay Basin can be divided into three broad categories, including mineral matrix pores, organic matter pores, and micro fractures. Those spaces can be subdivided into seven categories and fourteen sub-categories based on the distribution and formation mechanisms of the pores. Second, the complex pore-throat structures of the shale reservoir can be divided into two types based on the shape of the adsorption hysteresis loop. The pore structures mainly include wedge-shaped, flat slit-shaped, and ink bottle-shaped pores. The mesopores and micropores are the main contributors to pore volume and specific surface area, respectively. The macropores provide a portion of the pore volume, but they do not significantly contribute to the specific surface area. Third, the factors controlling the development of microscopic pores in the shale are complex. The sedimentary environment determines the composition and structure of the shale and provides the material basis for pore development. Diagenesis controls the types and characteristics of the pores. In addition, the thermal evolution of the organic matter is closely related to inorganic diagenesis and drives the formation and evolution of the pores.

关键词： reservoir characteristic pore structure controlling factor shale oil Bohai Bay Basin

Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy

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中国科学:生命科学英文版 2023年第9期66卷 2152-2166页

作者： shiyue Du Sheng Zeng Li Song Hongying Ma Rui chen Junyu Luo Xu Wang Tingbin Ma Xuan Xu Hao Sun Ping Yi Jifeng Guo Yaling Huang Mugen Liu Tao Wang Wei-Ping Liao Luoying Zhang Jing Yu Liu Beisha Tang Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and Technology(HUST)Wuhan 430074China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Geriatrics The Second Xiangya HospitalCentral South UniversityChangsha 410011China National Reference Laboratory of Veterinary Drug Residues and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Neurology Union Hospital of HUSTWuhan 430022China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaGuangzhou Medical UniversityGuangzhou 510260China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Focal epilepsy accounts for 60% of all forms of epilepsy, but the pathogenic mechanism is not well understood. In this study,three novel mutations in NPRL3(nitrogen permease regulator-like 3), c.937_945del, c.1514dup C and 6,706-bp genomic DNA(g DNA) deletion, were identified in three families with focal epilepsy by linkage analysis, whole exome sequencing(WES) and Sanger sequencing. NPRL3 protein is a component of the GATOR1 complex, a major inhibitor of m TOR signaling. These mutations led to truncation of the NPRL3 protein and hampered the binding between NPRL3 and DEPDC5, which is another component of the GATOR1 complex. Consequently, the mutant proteins enhanced m TOR signaling in cultured cells, possibly due to impaired inhibition of m TORC1 by GATOR1. Knockdown of nprl3 in Drosophila resulted in epilepsy-like behavior and abnormal synaptic development. Taken together, these findings expand the genotypic spectrum of NPRL3-associated focal epilepsy and provide further insight into how NPRL3 mutations lead to epilepsy.

关键词： focal epilepsy NPRL3 GATOR1 mTOR abnormal synaptic development

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介入呼吸病学年度进展2022

中华结核和呼吸杂志 2023年第1期46卷 67-72页

作者：陈迪非苏柱泉李时悦广州医科大学附属第一医院呼吸与危重症医学科、国家呼吸医学中心、国家呼吸系统疾病临床医学研究中心、呼吸疾病国家重点实验室、广州呼吸健康研究院广州510120

介入呼吸病学是呼吸系统疾病诊疗不可或缺的基本手段,是现代呼吸病学的重要组成部分。近几年,介入呼吸病学紧跟时代潮流,不断开发、融合各种技术,一方面拓展了介入呼吸病学的应用范围,一方面也向着个体化、精准化的方向发展。本文就2021... 详细信息

介入呼吸病学是呼吸系统疾病诊疗不可或缺的基本手段,是现代呼吸病学的重要组成部分。近几年,介入呼吸病学紧跟时代潮流,不断开发、融合各种技术,一方面拓展了介入呼吸病学的应用范围,一方面也向着个体化、精准化的方向发展。本文就2021年10月至2022年9月介入呼吸病学的最新研究进展综述如下。

关键词：介入呼吸病学呼吸系统疾病最新研究进展精准化个体化紧跟时代现代呼吸病学

NAD^(+) exhaustion by CD38 upregulation contributes to blood pressuree elevation and vascular damage in hypertension

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4964-4977页

作者： Yumin Qiu shiyue Xu Xi chen Xing Wu Zhe Zhou Jianning Zhang Qiang Tu Bing Dong Zhefu Liu Jiang He Xiaoyu Zhang Shuangshuang Liu chen Su Hui Huang Wenhao Xia Jun Tao Department of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University510080 GuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases 510080 GuangzhouChina Key Laboratory on Assisted Circulation Ministry of Health510080 GuangzhouChina Department of Cardiology The Eighth Affiliated Hospital of Sun Yat-sen University518033 ShenzhenChina Guangxi Hospital Division of The First Affiliated Hospital Sun Yat-sen University530022 NanningChina

Hypertension is characterized by endothelial dysfunction and arterial stiffness,which contribute to the pathogenesis of atherosclerotic cardiovascular diseases.Nicotinamide adenine dinucleotide(NAD^(+))is an indispensable cofactor in all living cells that is involved in fundamental biological processes.However,in hypertensive patients,alterations in NAD^(+)levels and their relation with blood pressure(BP)elevation and vascular damage have not yet been studied.

关键词： damage arterial hypertension

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气道内光学相干断层扫描成像技术的研究进展

中华结核和呼吸杂志 2023年第9期46卷 930-935页

作者：许航周子青李时悦陈愉广州医科大学附属第一医院呼吸与危重症医学科、国家呼吸医学中心、国家呼吸系统疾病临床医学研究中心、呼吸疾病全国重点实验室、广州呼吸健康研究院广州510120

光学相干断层扫描成像技术(OCT)是一种特殊光成像技术,距今已有30余年的历史,因其具有高分辨率、高灵敏度等特点,被誉为"光学活检"。气道内OCT也有20余年的研究历史,研究者在气道内成像方法上进行了相关探索和改进,主要集中在拓展成像... 详细信息

光学相干断层扫描成像技术(OCT)是一种特殊光成像技术,距今已有30余年的历史,因其具有高分辨率、高灵敏度等特点,被誉为"光学活检"。气道内OCT也有20余年的研究历史,研究者在气道内成像方法上进行了相关探索和改进,主要集中在拓展成像部位和丰富成像内容两个方面。在拓展成像部位方面,已覆盖第0级至第9级支气管;在丰富成像内容上,可额外对气道壁血管、气道内平滑肌、纤维组织和气道顺应性评估。在各类呼吸系统疾病的研究中具有重要作用。因此,本文主要就气道内OCT在成像部位和成像内容上的探索进行综述。

关键词：纤维组织气道壁呼吸系统疾病成像方法高分辨率 OCT 高灵敏度

曲流河砂体构型及非均质性特征——以山西保德扒楼沟剖面二叠系曲流河砂体为例

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石油勘探与开发 2016年第2期43卷 209-218页

作者：王越陈世悦中国石油大学(华东)地球科学与技术学院

对山西保德扒楼沟剖面二叠系曲流河砂体进行实测、精细解剖和岩相分析,建立不同类型河道砂体的构型模式,定量表征其内部沉积非均质性,预测不同类型河道砂体的剩余油聚集区。基于露头的岩性、粒度、沉积构造和颜色等特征,在扒楼沟二叠系... 详细信息

对山西保德扒楼沟剖面二叠系曲流河砂体进行实测、精细解剖和岩相分析,建立不同类型河道砂体的构型模式,定量表征其内部沉积非均质性,预测不同类型河道砂体的剩余油聚集区。基于露头的岩性、粒度、沉积构造和颜色等特征,在扒楼沟二叠系曲流河砂体中识别出8种岩相类型,通过对砂体进行精细解剖与岩相分析,将河道下部槽状交错层理砂体从传统定义的边滩砂体中划分出来称为"底滩",而将河道上部板状层理砂体称为"边滩"。在精细刻画河道内底滩与边滩砂体沉积特征及叠置关系的基础上,识别出侧向迁移型、串沟截直型、颈项截直型及废弃河道型4种河道砂体。结合不同类型河道砂体构型与非均质性特征,认为侧向迁移型河道砂体非均质性较弱,剩余油分布较少;串沟截直型与废弃河道型河道砂体非均质性较强,剩余油相对富集;颈项截直型河道砂体非均质性最强,剩余油最为富集。

关键词：扒楼沟剖面曲流河砂体边滩底滩砂体构型非均质性剩余油分布

陆相湖盆深水区页岩高频层序对储层发育的影响——以渤海湾盆地沧东凹陷孔店组二段页岩为例

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石油学报 2023年第10期44卷 1663-1682页

作者：方正蒲秀刚陈世悦鄢继华陈星燃崔绮梦中国石化集团胜利石油管理局有限公司博士后科研工作站山东东营257001 中国石油大港油田公司勘探开发研究院天津300280 中国石油大学(华东)地球科学与技术学院山东青岛266580 中国石油华北油田公司勘探开发研究院河北任丘062552

以渤海湾盆地沧东凹陷孔店组二段(孔二段)为代表的陆相湖盆深水区页岩具有良好的页岩油勘探开发潜力,但其岩相宏观分布与储层微观特征的联系尚不明确。利用岩心观察描述、岩石薄片鉴定、X射线衍射矿物定量分析、元素及有机地球化学测试... 详细信息

以渤海湾盆地沧东凹陷孔店组二段(孔二段)为代表的陆相湖盆深水区页岩具有良好的页岩油勘探开发潜力,但其岩相宏观分布与储层微观特征的联系尚不明确。利用岩心观察描述、岩石薄片鉴定、X射线衍射矿物定量分析、元素及有机地球化学测试、测井曲线、场发射扫描电镜分析、氮气吸附实验、高压压汞实验、聚焦离子束扫描电镜分析等方法,在页岩高频湖进-湖退(T-R)层序划分的基础上,分析了不同类型层序的岩相充填演化序列和不同岩相的储层特征,探讨了高频层序对储层发育的影响。研究结果表明:沧东凹陷孔二段富有机质页岩段可划分为11个高频T-R层序(五级层序SQ①-SQ⑪,其中,SQ⑨发育重力流成因砂岩);根据高频层序内T-R旋回的对称性,层序可分为以T旋回为主的不对称型、以R旋回为主的不对称型和近对称型;页岩储层主要发育粒间孔、粒内孔、有机质孔和微裂缝等微观孔隙,以粒间孔和粒内孔等无机孔为主;长英质矿物含量更高、纹层状构造更发育的纹层状长英页岩相和纹层状混合页岩相的宏孔更为发育,连通性更好,而碳酸盐矿物含量更高、块状构造更发育的块状混合页岩相和纹层状/块状碳酸盐页岩相的介孔更为发育,连通性一般;页岩的储层特征受矿物含量和沉积构造影响,呈现出明显的“相控”特征,而高频层序可以看作是连续时间序列下沉积环境变化的响应,影响着湖盆中心页岩的沉积作用;高频层序在不同演化阶段的储层特征差异明显,快速湖侵阶段的中—上部层序和振荡湖侵阶段的底部层序为优质储层发育段,而在稳定高位阶段仅局部层序发育优质储层。研究成果以期为陆相湖盆深水区页岩高频层序的划分及优质储层评价与预测提供理论支撑。

关键词：高频T-R层序层序类型层序演化孔隙结构沧东凹陷