检索结果-南通市图书馆

Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 2613-2630页

作者： Xuemin He Siying wen Xixiang Tang Zheyao wen Rui Zhang Shasha Li Rong Gao Jin Wang Yanhua Zhu Dong Fang Ting Li Ruiping Peng Zhaotian Zhang shiyi wen Li Zhou Heying Ai Yan Lu Shaochong Zhang Guojun Shi Yanming Chen Department of Endocrinology and Metabolic Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Diabetology&Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Fundus Shenzhen Eye Hospital of Jinan UniversityShenzhen 518048China

Glucagon-like peptide-1 receptor agonists(GLP-1 RAs)protect against diabetic cardiovascular diseases and ***,their activity in diabetic retinopathy(DR)remains *** retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other glucose-lowering medications,suggesting their advantage in DR *** single-cell RNA-sequencing analysis and immunostaining,we observed a high expression of GLP-1R in retinal endothelial cells,which was down-regulated under diabetic *** of GLP-1 RAs significantly restored the receptor expression,resulting in an improvement in retinal degeneration,vascular tortuosity,avascular vessels,and vascular integrity in diabetic *** and GSEA analyses further implicated enhanced mitochondrial gene translation and mitochondrial functions by GLP-1 ***,the treatment attenuated STING signaling activation in retinal endothelial cells,which is typically activated by leaked mitochondrial *** of STING mRNA was positively correlated to the levels of angiogenic and inflammatory factors in the endothelial cells of human fibrovascular *** investigation revealed that the cAMP-responsive element binding protein played a role in the GLP-1R signaling pathway on suppression of STING *** study demonstrates a novel role of GLP-1 RAs in the protection of diabetic retinal vasculature by inhibiting STING-elicited inflammatory signals.

关键词： GLP-1 RAs STING signaling Retinal endothelial cells Mitochondrial leakage Retinal vascular dysfunction Diabetic retinopathy CREB Inflammation

A new model to describe composition and temperature dependence of thermal conductivity for solution phases in binary alloys

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第24期59卷 72-82页

作者： shiyi wen Yuling Liu George Kaptay Yong Du State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China University of Miskolc MiskolcEgyetemvaros3515Hungary

Modelling temperature-and composition-dependent thermal conductivity in alloys is challengeable and is seldom studied *** the present work,a new model is developed to describe the temperature and concentration dependence of thermal conductivity for binary *** this new model,firstly thermal conductivity of pure metals was modelled as the function of temperature for each phase and each magnetic state by the corresponding physically sound ***,in order to describe the composition and temperature dependence of thermal conductivity for solid phases,the combination of the theories of Nordheim and Mott for electric conductivity of alloys with the Wiedemann-Franz law was ***,the reliability of the new model was verified by presently measured thermal conductivities for pure Co,Ni and Co-Ni alloys at 300,600,900 and 1100 K as well as for binary Al-Zn,Mg-Zn and U-Zr systems using the data taken from the *** calculated thermal conductivities can well reproduce the measured ones in one-phase regions of a series of Co-Ni *** thermal conductivity in a two-phase region of the Co-Ni system is reasonably predicted as *** is demonstrated that the new model can be utilized to evaluate the thermal conductivity over the whole investigated composition and temperature ranges for the first time and is expected to be extended to ternary and multicomponent systems by CALPHAD method,which contributes significantly to the development of computational design of materials.

关键词： Thermal conductivity Co-Ni alloys CALPHAD method Measurement Modelling

在线全文

学校读者我要写书评

暂无评论

“五维度”安全类课程思政教学模式研究

安全 2024年第7期45卷 74-79页

作者：高玉坤文诗怡黄志安北京科技大学大安全科学研究院北京100083 北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083

为加强安全专业学生的价值观建设、提升安全类课程思政水平,以社会主义核心价值观为思想政治引领,基于ADDIE教学模式,构建“五维度”安全类课程思政教学模式。在分析阶段,分析社会主义核心价值观融入安全类课程思政教学的现实依据;在设... 详细信息

为加强安全专业学生的价值观建设、提升安全类课程思政水平,以社会主义核心价值观为思想政治引领,基于ADDIE教学模式,构建“五维度”安全类课程思政教学模式。在分析阶段,分析社会主义核心价值观融入安全类课程思政教学的现实依据;在设计开发阶段,将社会主义核心价值观与专业课程内容融合,构建“五维度”思政教育素材库;在实施阶段,运用案例教学法等多元化手段;在评价阶段,构建四位一体评价体系。形成分析—设计开发—实施—评价的教学闭环,既有助于提高教师的思政能力与专业课的思政水平,也有助于提高学生的爱国热情和对专业的认知,为学生将来服务社会提供价值引领。

关键词：课程思政安全类课程五维度社会主义核心价值观教学模式

A new model for thermal conductivity of“continuous matrix/dispersed and separated 3D-particles”type composite materials and its application to WC-M(M=Co,Ag)systems

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第2期97卷 123-133页

作者： shiyi wen Yong Du Jing Tan Yuling Liu Peng Zhou Jianzhan Long George Kaptay State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Provincial Key Defense Laboratory of High Temperature Wear-Resisting Materials and Preparation Technology Hunan University of Science and TechnologyXiangtan 411201China State Key Laboratory of Cemented Carbide Zhuzhou 412000China University of Miskolc MiskolcEgyetemváros3515Hungary

In the present work a new thermal conductivity model is developed for two-phase composite materials,which are consisted of a continuous matrix and dispersed 3 D-particles separated from each other by the matrix as a function of grain size and volume ratio of the dispersed particles at different *** model is applied to reproduce experimental thermal conductivity values of cemented carbide systems WC-Co and *** agreement was found between measured thermal conductivity data originating from both this work and recent literature and the calculated ones only using semi-empirical parameters for the interfacial thermal resistance(ITR)values at WC/Co,WC/Ag and WC/WC interfaces as a function of ***,the temperature and grain size dependence of the thermal conductivity for WC is established for the first *** model works well for the case when the matrix(Ag)has a higher thermal conductivity compared to that of the WC particles and also for the case when the matrix(Co)has a lower thermal conductivity compared to that of the WC *** new model forms a physically sound basis for further development/materials design of cemented carbides and particlereinforced composite materials.

关键词： Thermal conductivity WC-Co WC-Ag Modeling Cemented carbides Composite materials

Assessment of atomic mobilities and simulation of precipitation evolution in Mg-X(X=Al,Zn,Sn)alloys

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第3期62卷 70-82页

作者： Yuhui Zhang Yuling Liu Shuhong Liu Hai-Lin Chen Qing Chen shiyi wen Yong Du National Key Laboratory of Science and Technology for National Defense on High-strength Structural Materials Central South UniversityChangsha 410083China Thermo-Calc Software AB Råsundavägen 1816967 SolnaSweden

As potential cast and wrought Mg alloys,Mg-X(X=Al,Zn,Sn)based alloys have attracted great *** work is to develop a dataset of atomic mobilities that is valid over a wide composition *** the obtained mobilities,and a compatible thermodynamic description,as well as thermophysical parameters,simulations are performed to predict the characteristics of precipitation *** are presented for the isothermal aging processes in Mg-x wt.%Al(x=5.9,6,8.8,9),Mg-x wt.%Zn(x=6,6.2,8,8.65),Mg-x wt.%Sn(x=6.04,6.92,8.64)*** simulated size distribution,number density and volume fraction of precipitates reasonably account for the experimental results and provide additional information for further alloy composition design and heat treatment optimization.

关键词： Atomic mobility Magnesium alloys Precipitation Alloy design

CALTPP:A general program to calculate thermophysical properties

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第7期42卷 229-240页

作者： Yuling Liu Cong Zhang Changfa Du Yong Du Zhoushun Zheng Shuhong Liu Lei Huang shiyi wen Youliang Jin Huaqing Zhang Fan Zhang George Kaptay State Key Lab of Powder Metallurgy Central South UniversityChangshaHunan 410083China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Mathematics and Statistics Central South UniversityChangshaHunan 410083China School of Materials Science and Engineering Xiangtan UniversityXiangtanHunan 411105China Department of Nanotechnology University of MiskolcH-3515 MiskolcEgyetemvarosHungary

A program CALTPP(CALculation of ThermoPhysical Properties)is developed in order to provide various thermophysical properties such as diffusion coefficient,interfacial energy,thermal conductivity,viscosity and molar volume mainly as function of temperature and *** thermophysical properties are very important inputs for microstructure simulations and mechanical property *** general structure of CALTPP is briefly described,and the CALPHAD-type models for the description of these thermophysical properties are *** CALTPP program contains the input module,calculation and/or optimization modules and output module.A few case studies including(a)the calculation of diffusion coefficient and optimization of atomic mobility,(b)the calculation of solid/liquid,coherent solid/solid and liquid/liquid interfacial energies,(c)the calculation of thermal conductivity,(d)the calculation of viscosity,and(e)the establishment of molar volume database in binary and ternary alloys are demonstrated to show the features of *** is expected that CALTPP will be an effective contribution in both scientific research and education.

关键词： Thermophysical property Diffusion coefficient Interfacial energy Thermal conductivity Viscosity Molar volume CALPHAD-type modeling

A FAST APPROXIMATE IMAGING ALGORITHM FOR SPACEBORNE SYNTHETIC APERTURE RADAR

在线全文

学校读者我要写书评

暂无评论

Journal of Electronics(China) 1994年第2期11卷 97-103页

作者：黄永红毛士艺洪文 Beijing University of Aeronautics and Astronautics Beijing 100083

A fast algorithm of azimuth processing for spaceborne aperture radar (SAR), which is called SPECAN algorithm, is proposed. Compared with general frequency algorithms, SPECAN has advantages in computation, memory and structure. SPECAN algorithm is very important for surveying real time processing of spaceborne SAR. The structure and special problems for SPECAN algorithm used in spaceborne SAR are mainly engaged in this paper. Finally, raw data of SEASAT-A satellite is used to verify the feasibility of SPECAN algorithm.

关键词： Synthetic aperture radar Spectrum analysis Azimuth resolution Range migration

新生代农民工的社会公平感研究:职业流动与相对经济地位的影响

在线全文

学校读者我要写书评

暂无评论

同济大学学报（社会科学版） 2018年第1期29卷 75-82页

作者：时怡雯上海政法学院社会管理学院上海201701

新生代农民工的社会公平感是城市社会稳定和发展的基石,但近年来新生代农民工的公平感呈下降趋势。本研究采用"长三角地区工作与生活调查"数据,在对1766位新生代农民工样本分析后发现,由于新生代农民工频繁的职业流动并未给他们的客观... 详细信息

新生代农民工的社会公平感是城市社会稳定和发展的基石,但近年来新生代农民工的公平感呈下降趋势。本研究采用"长三角地区工作与生活调查"数据,在对1766位新生代农民工样本分析后发现,由于新生代农民工频繁的职业流动并未给他们的客观社会经济地位等带来明显的改善,导致他们在与本地人相互比较时主观经济地位明显降低,最终导致其社会公平感下降。因而,稳定的就业是提升新生代农民工社会公平感、促进城市融合的基础条件,有必要在公共政策层面予以保障。

关键词：新生代农民工职业流动短工化相对经济地位社会公平感

在线全文

学校读者我要写书评

暂无评论

浅论森林资源及其经济评价

林业科学 1989年第5期25卷 459-466页

作者：廖士义温亚力北京林业大学经济管理学院

本文从我国的国情和林情出发,分析了森林资源作为林业生产力基本要素,在生产经营中的地位与作用,森林资源的经济属性,及在经营利用上必需使经济与生态相结合,才能求得资源的合理配置和生产要素的优化组合,从而使林业再生产顺利进行。而... 详细信息

本文从我国的国情和林情出发,分析了森林资源作为林业生产力基本要素,在生产经营中的地位与作用,森林资源的经济属性,及在经营利用上必需使经济与生态相结合,才能求得资源的合理配置和生产要素的优化组合,从而使林业再生产顺利进行。而其实现措施的第一步,就是对森林资源作出科学的经济评价。森林资源经济评价,包括森林立木价值评价和森林生态社会效益评价两个方面。依据立木价值形成过程的特点,用正算法(成本法)计算成熟林活立木的价值,这种评价方法适合我国国情林情,具有科学性和实用性。明确区分森林的“功能”和“效益”这两个不同质的概念,用“等效益评价法”来补充和丰富现有的对森林生态社会效益评价的理论和方法,使之更加切合实际。

关键词：森林资源经济评价等效益评价法