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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

Neural Regeneration Research 2024年第8期19卷 1828-1834页

作者： Yongjiang Zhang shiyi yin Run Song Xiaoyi Lai Mengmeng Shen Jiannan Wu Junqiang Yan Key Laboratory of Neuromolecular Biology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains ***-2(PHB2)is a newly discove red autophagy receptor in the mitochondrial inner membrane,and its role in Parkinson’s disease remains *** kinase R(PKR)-like endoplasmic reticulum kinase(PERK)is a factor that regulates cell fate during endoplasmic reticulum *** is regulated by PERK and is a target of the unfolded protein *** is unclear whether PERK regulates PHB2-mediated mitophagy thro ugh *** this study,we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’s *** used adeno-associated virus to knockdown PHB2 *** res ults showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson’s *** rexpression of PHB2 inhibited these *** also established a 1-methyl-4-phenylpyridine(MPP+)-induced SH-SY5Y cell model of Parkinson’s *** found that ove rexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3,and promoted *** addition,MPP+regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of *** findings suggest that PHB2 participates in the development of Parkinson’s disease by intera cting with endoplasmic reticulum stress and Parkin.

关键词： endoplasmic reticulum dopaminergic neuron microtubule-associated protein 1 light chain 3 mitophagy oxidative stress Parkin Parkinson’s disease PKR-like endoplasmic reticulum kinase reactive oxygen species prohibitin-2

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Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song shiyi yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu Zhang Shicheng Yu Hongyan Li Shaohong Chen Jingting Luo Haibo Wang Yuxia Guan Haihan Zhang shiyi yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang ying Sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

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通信技术在智能电网中的应用研究

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通信电源技术 2024年第1期41卷 135-137页

作者：尹诗倚中邮通建设咨询有限公司江苏南京210003

在国家电网信息化快速发展的背景下,智能电网有效改善了电力网络建设与运行的可靠性,并积极发挥信息通信的作用。以智能电网为切入点,研究智能电网关于通信技术的要求,并对智能电网和通信技术层次展开研究,进一步探讨通信技术在智能电... 详细信息

在国家电网信息化快速发展的背景下,智能电网有效改善了电力网络建设与运行的可靠性,并积极发挥信息通信的作用。以智能电网为切入点,研究智能电网关于通信技术的要求,并对智能电网和通信技术层次展开研究,进一步探讨通信技术在智能电网送电、配电、变电及安全领域等方面的应用,以期为通信技术在智能电网中的应用提供参考。

关键词：通信技术智能电网变电

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基于ReliefF-NOSCA-AdakNN的肌肉疲劳识别技术研究

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上海师范大学学报（自然科学版中英文） 2024年第2期53卷 205-210页

作者：李传江吉星照尹仕熠上海师范大学信息与机电工程学院上海201418

针对竞技体育训练中的肌肉疲劳监测问题,提出了一种基于ReliefF-NOSCA-AdakNN(RNA)的表面肌电信号(sEMG)特征提取和分类算法.该算法结合了特征和类别之间的相关性分析和启发式搜索算法,对高维特征进行了有效的筛选和分类.将RNA算法应用... 详细信息

针对竞技体育训练中的肌肉疲劳监测问题,提出了一种基于ReliefF-NOSCA-AdakNN(RNA)的表面肌电信号(sEMG)特征提取和分类算法.该算法结合了特征和类别之间的相关性分析和启发式搜索算法,对高维特征进行了有效的筛选和分类.将RNA算法应用于经过滤波处理的肱二头肌肌电信号数据,对不同疲劳状态进行了识别和分类.实验结果表明,提出的RNA算法在平均分类准确率和标准差方面分别达到了83.88%和0.0127,均显著优于传统单一算法,体现了较好的分类性能.

关键词：表面肌电信号(sEMG) 特征选择肌肉疲劳模式识别

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Multi-level coarse-grained discrete element method modeling of cylinder particle flow in a rotating drum

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Particuology 2024年第5期88卷 218-238页

作者： Lei Xu Xiukai Wu Shuai Wang shiyi Bao Institute of Process Equipment and Control Engineering Zhejiang University of TechnologyHangzhou 310023China Engineering Research Center of Process Equipment and Remanufacturing Ministry of EducationZhejiang University of TechnologyHangzhou 310023China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

The coarse-grained discrete element method(DEM)is probably a feasible option for simulating an actual drum-type biomass boiler,which contains over 10 million cylinder particles.A multi-level study was conducted based on particle and coarse-grained level data to evaluate the adequacy of the coarse-grained approach in terms of geometrical characteristics,kinematic features,and dynamic *** scaling laws for contact parameters were used and compared during the *** results show that the coarse-grained approach can accurately predict the positions of the free surface and active-passive interface,the mixing index,and the orientation *** in the velocity fields may occur due to the worse flowability of coarse-grained particles near the free *** efficiency is significantly improved by the coarse-grained model compared with the corresponding original case(the same DEM code without a coarse-grained model was used for the original simulations).

关键词： Coarse-grained method Discrete element method(DEM) Cylinder particle Rotating drum Granular flow

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Shape optimisation of basin insulator for DC gas insulated switchgear/gas insulated transmission lines based on artificial bee colony algorithm

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High Voltage 2024年第2期9卷 275-286页

作者： Yi Luo shiyi Mao Ju Tang Zijun Pan Cheng Pan State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

The surface charge accumulation on the basin insulator is a particular problem in high-voltage direct current(HVDC)gas insulated switchgears(GIS)and gas insulated trans-mission lines(GIL),which restricts the development and application of extra/ultra high-voltage(EHV/UHV)*** surface charge distribution and anti-flashover performance are closely related to the insulator *** obtain the optimal basin insulator,a shape optimisation model based on artificial bee colony algorithm was established,and the minimisation objective functions based on capacitive(initial)electric field distribution and resistive(steady-state)electric field distribution were respectively *** optimisation results of the two objective functions were calculated,and the electric field and charge distribution on the surface of the insulator before and after optimisation were evaluated and compared using the simulation *** results indicated that the optimisation based on the capacitive electric field can significantly inhibit the surface charge accumulation,and the optimised insulator can significantly reduce the surface normal electric field and make the distribution of the tangential electric field more uniform,and the maximum tangential electric field can be reduced by 10%;the optimisation based on resistive electric field can achieve similar results,but requires more computational *** on the results,the‘anti-charge’basin insulator structure suitable for the DC field was given.

关键词： insulator artificial charge

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Striking a growth–defense balance:Stress regulators that function in maize development

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Journal of Integrative Plant Biology 2024年第3期66卷 424-442页

作者： shiyi Xie Hongbing Luo Wei Huang Weiwei Jin Zhaobin Dong Maize Engineering and Technology Research Center of Hunan Province College of AgronomyHunan Agricultural UniversityChangsha 410128China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingChina Agricultural UniversityBeijing 100193China Tianjin Key Laboratory of Intelligent Breeding of Major Crops Fresh Corn Research Center of BTHCollege of Agronomy&Resources and EnvironmentTianjin Agricultural UniversityTianjin 300384China

Maize(Zea mays)cultivation is strongly affected by both abiotic and biotic stress,leading to reduced growth and *** has recently become clear that regulators of plant stress responses,including the phytohormones abscisic acid(ABA),ethylene(ET),and jasmonic acid(JA),together with reactive oxygen species(ROS),shape plant growth and *** their well established functions in stress responses,these molecules play crucial roles in balancing growth and defense,which must be finely tuned to achieve high yields in crops while maintaining some level of *** this review,we provide an in-depth analysis of recent research on the developmental functions of stress regulators,focusing specifically on *** unraveling the contributions of these regulators to maize development,we present new avenues for enhancing maize cultivation and growth while highlighting the potential risks associated with manipulating stress regulators to enhance grain yields in the face of environmental challenges.

关键词： stress regulators maize development ABA ET JA ROS

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Overhead-free Noise-tolerant Federated Learning: A New Baseline

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Machine Intelligence Research 2024年第3期21卷 526-537页

作者： shiyi Lin Deming Zhai Feilong Zhang Junjun Jiang Xianming Liu Xiangyang Ji Department of Computer Science and Technology Harbin Institute of TechnologyHarbin150000China Department of Automation Tsinghua UniversityBeijing100084China

Federated learning (FL) is a promising decentralized machine learning approach that enables multiple distributed clients to train a model jointly while keeping their data private. However, in real-world scenarios, the supervised training data stored in local clients inevitably suffer from imperfect annotations, resulting in subjective, inconsistent and biased labels. These noisy labels can harm the collaborative aggregation process of FL by inducing inconsistent decision boundaries. Unfortunately, few attempts have been made towards noise-tolerant federated learning, with most of them relying on the strategy of transmitting overhead messages to assist noisy labels detection and correction, which increases the communication burden as well as privacy risks. In this paper, we propose a simple yet effective method for noise-tolerant FL based on the well-established co-training framework. Our method leverages the inherent discrepancy in the learning ability of the local and global models in FL, which can be regarded as two complementary views. By iteratively exchanging samples with their high confident predictions, the two models “teach each other” to suppress the influence of noisy labels. The proposed scheme enjoys the benefit of overhead cost-free and can serve as a robust and efficient baseline for noise-tolerant federated learning. Experimental results demonstrate that our method outperforms existing approaches, highlighting the superiority of our method.

关键词： Federated learning noise-label learning privacy-preserving machine learning edge intelligence distributed machine learning

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Unraveling the complex landscape of endocrine resistance in breast cancer: Emerging role of long noncoding RNA AGPG and beyond

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中华医学杂志(英文版) 2024年第16期137卷 1985-1987页

作者： Khawar Muhammad Babar Yu shiyi Afzal Ali Sun Haibo Institute of Translational Medicine Medical College Yangzhou University Yangzhou Jiangsu China Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research Yangzhou University Yangzhou Jiangsu China Applied Molecular Biology and Biomedicine Lab Department of Zoology University of Narowal Narowal Pakistan Molecular Medicine and Cancer Therapeutics Lab Department of Zoology Faculty of Sciences Technology University of Central Punjab Lahore Pakistan

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