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SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia feng shixian Dong Luyi Sun Huizhu Li Fuchun Chen Nguyen Thi Kim Thanh Yunxia Li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and aging.resulting in a decline in skeletal muscle function.Therefore,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related disorders.Owing to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle regeneration.Here,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФtransplantation.SWIR fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse models.It is found that the implanted M2MФaccumulated at the injury site for two weeks.Then,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 post-injury.Finally,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle regeneration.These results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

CC@BCN@PANI core-shell nanoarrays as ultra-high cycle stability cathode for Zn-ion hybrid supercapacitors

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能源前沿:英文版 2023年第4期17卷 555-566页

作者： shixian XIONG Hongcheng KE Lei CAO Yu WANG Qian ZHU Liqin ZHONG Lanlan FAN feng GU Nanchang Key Laboratory for Advanced Manufacturing of Electronic Information Materials and Devices/Jiangxi Provincial Key Laboratory for Simulation and Modelling of Particulate Systems International Institute for InnovationJiangxi University of Science and TechnologyNanchang330013China

Exploring cathode materials that combine excellent cycling stability and high energy density poses a challenge to aqueous Zn-ion hybrid supercapacitors(ZHSCs).Herein,polyaniline(PANI)coated boron-carbon-nitrogen(BCN)nanoarray on carbon cloth surface is prepared as advanced cathode materials via simple high-temperature calcination and electrochemical deposition methods.Because of the excellent specific capacity and conductivity of PANI,the CC@BCN@PANI core-shell nanoarrays cathode shows an excellent ion storage capability.Moreover,the 3D nanoarray structure can provide enough space for the volume expansion and contraction of PANI in the charging/discharging cycles,which effectively avoids the collapse of the microstructure and greatly improves the electrochemical stability of PANI.Therefore,the CC@BCN@PANI-based ZHSCs exhibit superior electrochemical performances showing a specific capacity of 145.8 mAh/g,a high energy density of 116.78 Wh/kg,an excellent power density of 12 kW/kg,and a capacity retention rate of 86.2%after 8000 charge/discharge cycles at a current density of 2 A/g.In addition,the flexible ZHSCs(FZHSCs)also show a capacity retention rate of 87.7%at the current density of 2 A/g after 450 cycles.

关键词： CC@BCN@PANI cathode Zn-ion hybrid supercapacitor core-shell nanoarrays high energy density ultra-high cycle stability

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河南省40岁及以上常住居民握力水平调查

现代疾病预防控制 2024年第5期35卷 321-324,333页

作者：冯石献范雷高莉李卉田惠子安伟锋康锴河南省疾病预防控制中心慢性非传染性疾病防治研究所河南郑州450016

目的分析河南省≥40岁常住居民握力水平及影响因素。方法采用多阶段整群随机抽样方法,于2019—2020年选择11个县区≥40岁常住居民,采用机械握力计测量调查对象双手握力,取最大握力值进行分析。使用多因素logistic回归分析人群特征与低... 详细信息

目的分析河南省≥40岁常住居民握力水平及影响因素。方法采用多阶段整群随机抽样方法,于2019—2020年选择11个县区≥40岁常住居民,采用机械握力计测量调查对象双手握力,取最大握力值进行分析。使用多因素logistic回归分析人群特征与低握力水平之间的关系。结果共纳入≥40岁常住居民6435人,平均年龄(57.7±9.0)岁。握力水平中位数为30.5 kg,其中男性39.8 kg,女性25.6 kg。低握力率为7.7%,标化率为7.2%。多因素分析结果显示,年龄(OR=1.103,95%CI:1.090~1.116)、城市居民(OR=1.455,95%CI:1.161~1.823)、心血管疾病史(OR=1.276,95%CI:1.033~1.577)、文化程度[以小学及以下为参照,初中(OR=0.796,95%CI:0.639~0.992)、高中及以上(OR=0.535,95%CI:0.286~0.999)]、BMI(OR=0.949,95%CI:0.916~0.983)、肌肉率(OR=0.925,95%CI:0.877~0.975)是低握力的独立影响因素。结论河南省≥40岁常住居民握力水平略低于全国平均水平,不同特征人群握力存在差异。低握力受年龄、文化程度、居住地、心血管病史、BMI和肌肉率的影响。

关键词：握力水平影响因素横断面调查

In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window

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Nano Research 2019年第12期12卷 3059-3068页

作者： Zhujun feng Yimeng Yang Jian Zhang Kan Wang Yunxia Li Heng Xu Zhen Wang Ewelina Biskup shixian Dong Xing Yang Yuefeng Hao Jun Chen Yan Wo Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Sports Medicine Institute ofFudan University Department of Orthopedic Sports MedicineHuashan HospitalFudan UniversityShanghaiChina Department of Instrument Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao long UniversityShanghai Engineering Research Center for Intelligent diagnosis and treatment instrumentKey Laboratory of Thin Film and Microfabrication(Ministry of Education)Shanghai 200240China Department of Plastic Surgery Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department cf physical education Fudan UniversityShanghai 200040China Department of Internal Medicine University Hospital of BaselPetersgraben 44051 BaselSwitzerland Department of orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China

The peripheral nervous system(PNS)is essential for performing and maintaining various motor and sensory functions.Abnormalities can lead to a series of peripheral neurological conditions,such as paraesthesia,pain,or spasms,which are debilitating and lowering the quality of life.Thecurrent guidelines for diagnosis rely predominantly on clinical symptoms resulting from PNS dysfunction,which occur already at an advancedstage.There are currently no effective methods that visually reflect the extent of peripheral neuropathy.In our study,we present a novel in vivoand in situ real-time imaging of peripheral nerves based on the second near-infrared window(NIR-II)fluoresce nee.In NIR-II system,lead sulfidequa ntum dots(PbS Qds)with NIR-II fluoresce nee specifically bound to motor neuro rvspecific protein agrin,acting as image con trast.In micemodel,peripheral nerves were visible as soon as after 2 h post injection.We provide evidenee for the efficacy of this approach,which allows todirectly dem on strate peripheral nerves,their structure,and pote ntial damagesites and degree.Furthermore,our products were of goodbiocompatibility,while the n eural fluoresce nee signal was solid,bright and stable for 4 h in vivo.Thus,overall,our results suggest that NIR-II isan effective new method for direct imaging of peripheral nerves in vivo,opening new horizons on early,improved and more precise,targeteddiag no sis.A resulti ng more rapid installatio n of perso nalized therapy facilitates a better prognosis of clinical peripheral neuropathy.

关键词： peripheral nerve the second near-infrared window(NIR-II) fluorescent imaging Agrin@PbS Qds biocompatibility

Erratum to: In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window

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Nano Research 2021年第12期14卷 4901-4902页

作者： feng, Zhujun Yang, Yimeng Zhang, Jian Wang, Kan Li, Yunxia Xu, Heng Wang, Zhen Biskup, Ewelina Dong, shixian Yang, Xing Hao, Yuefeng Chen, Jun Wo, Yan Department of Anatomy and Physiology School of Medicine Shanghai Jiao Tong University Shanghai China Sports Medicine Institute of Fudan University Department of Orthopedic Sports Medicine Huashan Hospital Fudan University Shanghai China Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai Engineering Research Center for Intelligent diagnosis and treatment instrument Key Laboratory of Thin Film and Microfabrication (Ministry of Education) Shanghai China Department of Plastic Surgery Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of physical education Fudan University Shanghai China Department of Internal Medicine University Hospital of Basel Basel Switzerland Department of orthopedics Affiliated Suzhou Hospital of Nanjing Medical University Suzhou China

高熵(Y_(0.2)Gd_(0.2)Dy_(0.2)Ce_(0.2)La_(0.2))TaO_(4)陶瓷材料的热学、力学及抗熔融硅酸盐环境沉积物侵蚀性能

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硅酸盐学报 2023年第12期51卷 3133-3143页

作者：王瑞达赵世贤李磊陈留刚司瑶晨李凌锋李红霞冯晶郑州大学材料科学与工程学院河南省高温功能材料重点实验室郑州450000 中钢集团洛阳耐火材料研究院有限公司先进耐火材料国家重点实验室河南洛阳471039 中国中钢集团有限公司北京100080 昆明理工大学材料科学与工程学院昆明650000

新型高温热障涂层材料已成为新一代航空发动机发展的关键材料。本工作通过固相反应法合成了一种单斜结构的高熵稀土钽酸盐材料(Y_(0.2)Gd_(0.2)Dy_(0.2)Ce_(0.2)La_(0.2))TaO_(4)[(5RE_(0.2))TaO_(4)],研究了其热、力学性能及抗熔融硅... 详细信息

新型高温热障涂层材料已成为新一代航空发动机发展的关键材料。本工作通过固相反应法合成了一种单斜结构的高熵稀土钽酸盐材料(Y_(0.2)Gd_(0.2)Dy_(0.2)Ce_(0.2)La_(0.2))TaO_(4)[(5RE_(0.2))TaO_(4)],研究了其热、力学性能及抗熔融硅酸盐环境沉积物(CMAS)侵蚀性能。结果表明:(5RE_(0.2))TaO_(4)具有极低的热导率(1.22 W·m^(–1)·K^(–1),600℃)和较高的热膨胀系数(10.3×10^(–6)K^(–1),1 200℃),与YSZ材料相比(2.1~2.7 W·m^(–1)·K^(–1),100~900℃)热导率下降了近42%。由于独特的铁弹增韧效应,其断裂韧性达2.8 MPa·m^(1/2),优于多数新型热障涂层材料。1 350℃不同时间及CMAS侵蚀后,(5RE_(0.2))TaO_(4)反应层厚度和渗透深度均显著小于YSZ材料,是一种极具应用潜力的新型热障涂层材料。

关键词：稀土钽酸盐高熵陶瓷熔融硅酸盐环境沉积物侵蚀热障涂层

肠道菌群移植对重症肺炎恢复期患者及其肠道微生态影响的初步研究

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中华危重病急救医学 2023年第4期35卷 352-357页

作者：钟佩燕许怡梦叶世贤杨峰吴璐璐苏冠升刘雨欣冯嘉杰王玉吴镇宇郑则广广州医科大学附属第一医院呼吸与危重症医学科广州呼吸健康研究院呼吸疾病国家重点实验室国家呼吸系统疾病临床医学研究中心广东广州510120 深圳市第三人民医院全科医学科广东深圳518112 南方医科大学附属顺德医院内科广东佛山528399 河南大学河南开封475004

目的探讨肠道菌群移植(FMT)对重症肺炎恢复期患者肠道微生态和机体的影响。方法采用前瞻性非随机对照研究方法,选择2021年12月至2022年5月广州医科大学附属第一医院收治的接受FMT的重症肺炎恢复期患者(FMT组),以及同期住院未接受FMT的... 详细信息

目的探讨肠道菌群移植(FMT)对重症肺炎恢复期患者肠道微生态和机体的影响。方法采用前瞻性非随机对照研究方法,选择2021年12月至2022年5月广州医科大学附属第一医院收治的接受FMT的重症肺炎恢复期患者(FMT组),以及同期住院未接受FMT的重症肺炎恢复期患者(非FMT组)。比较两组患者入组前1 d和入组后10 d临床观察指标、胃肠道功能及粪便性状等差异。采用16S rDNA基因测序技术分析FMT组患者入组前后肠道菌群多样性及差异物种的变化,并进行京都基因与基因组百科全书数据库(KEGG)代谢通路分析预测;采用Pearson相关法分析FMT组患者肠道菌群与临床观察指标的相关性。结果FMT组患者入组后10 d三酰甘油(TG)水平较入组前显著降低〔mmol/L:0.94(0.71,1.40)比1.47(0.78,1.86),P<0.05〕;非FMT组患者入组后10 d高密度脂蛋白胆固醇(HDL-C)水平较入组前显著降低(mmol/L:0.68±0.27比0.80±0.31,P<0.05)。两组患者其他临床观察指标、胃肠道功能及粪便性状评分等在入组前后差异均无统计学意义。多样性分析显示,FMT组患者入组后10 d肠道菌群α多样性指数均显著高于非FMT组,且β多样性亦与非FMT组存在显著差异。差异物种分析显示,与入组前比较,FMT组患者入组后10 d肠道菌群门水平中变形杆菌门相对丰度明显降低〔8.554%(5.977%,12.159%)比19.285%(8.054%,33.207%),P<0.05〕,梭杆菌门相对丰度明显升高〔6.801%(1.373%,20.586%)比0.003%(0%,9.324%),P<0.05〕;肠道菌群属水平中丁酸单胞菌属、梭杆菌属及双歧杆菌属等相对丰度均明显升高〔丁酸单胞菌属:1.634%(0.813%,2.387%)比0%(0%,0.061%),梭杆菌属:6.801%(1.373%,20.586%)比0.002%(0%,9.324%),双歧杆菌属:0.037%(0%,0.153%)比0%(0%,0%),均P<0.05〕。KEGG代谢途径通路分析显示,FMT组患者肠道菌群在双酚降解、矿物质吸收、磷酸盐和次磷酸盐代谢、心肌收缩及帕金森病等代谢通路与疾病中发生改变。相关性分析显示,FMT组患者肠道菌群中放线菌门与前白蛋白(PA)呈显著正相关(r=0.53,P=0.043),拟杆菌门与血尿素氮(BUN;r=0.56,P=0.029)和补体C3(r=0.57,P=0.027)呈显著正相关,厚壁菌门与BUN(r=0.56,P=0.029)和补体C3(r=0.57,P=0.027)呈显著正相关,梭杆菌门与免疫球蛋白M(IgM)呈显著正相关(r=0.71,P=0.003),变形杆菌门与降钙素原(PCT;r=0.63,P=0.012)和补体C4(r=0.56,P=0.030)呈显著正相关。结论FMT能降低重症肺炎恢复期患者TG水平,重建肠道微生态结构,改变机体代谢和功能,通过降低有害菌相对丰度缓解机体的炎症反应。

关键词：肠道菌群移植重症肺炎恢复期肠道微生态

Development of Clinical Visual Physiology in China during Past Fifty Years

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Eye Science 2012年第1期27卷 1-4页

作者： Lezheng Wu Dezheng Wu Daiyan Xin Shizhou Huang Yu Wang feng Wen shixian Long Guangwei Luo Jiongji Liang Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Vision Science Lab Columbia University New York USA Alcon Laboratory Huston USA

The studies of clinical visual physiology (CVP)were initiated in 1950s in China.Clinical visual physiology,as an essential method to evaluate the vision function,provides important information for assessment and treatment of certain ocular diseases in retinal and optic pathway.It has become an important part in the development of ophthalmology in China.

关键词：视觉生理中国临床视觉功能眼部疾病组成部分 CVP 视神经

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跨海大桥混凝土服役挑战及检测方法综述

材料导报 2023年第S1期37卷 204-211页

作者：王鹏徐时贤李国红刘娟红刘嘉魏绍斌陆峰戴圣龙中国航发北京航空材料研究院北京100095 港珠澳大桥管理局广东珠海519060 北京科技大学土木与资源工程学院北京100083

跨海大桥除了承受车辆荷载、风荷载以及潜在的船舶撞击等,还面临潮汐、海浪、海上盐雾、氯盐、硫酸盐等复杂环境的侵蚀风险,服役环境恶劣。作为跨海大桥的主要建造材料——钢筋混凝土,其耐久性直接影响大桥的服役寿命。本文对跨海大桥... 详细信息

跨海大桥除了承受车辆荷载、风荷载以及潜在的船舶撞击等,还面临潮汐、海浪、海上盐雾、氯盐、硫酸盐等复杂环境的侵蚀风险,服役环境恶劣。作为跨海大桥的主要建造材料——钢筋混凝土,其耐久性直接影响大桥的服役寿命。本文对跨海大桥混凝土服役挑战及检测方法进行了综述,阐述了近40年来跨海大桥的发展、混凝土的服役现状、跨海大桥混凝土常见损伤类型及成因分析;分析了在海洋环境下影响混凝土耐久性的因素并归纳了跨海大桥桥墩基础受力损伤的类型。根据跨海大桥不同部位混凝土的劣化原因和检测难点,对现阶段跨海大桥混凝土的检测技术进行总结;分析以水下成像、多波束测探、三维成像声呐、声波、雷达、无人机、基于动力响应和动态实时检测技术等为代表的检测手段在跨海大桥混凝土检测方面的技术路线和优缺点,并总结了未来跨海大桥在检测和运维过程中的发展方向。

关键词：跨海大桥混凝土腐蚀智能检测