检索结果-南通市图书馆

Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases:Mechanistic insights and therapeutic implications

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2025年第2期17卷 9-21页

作者： Hong-ni Wang Ye Wang Si-Yao Zhang Lan Bai State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

Metabolic diseases have emerged as a leading cause of mortality from non-communicable diseases,posing a significant global public health ***-though the association between ceramides(Cers)and metabolic diseases is well-established,the role of the acid sphingomyelinase(ASMase)/Cer pathway in these diseases remains *** review synthesizes recent research on the biological functions,regulatory mechanisms,and targeted therapies related to the ASMase/Cer pathway in metabolic conditions,including obesity,diabetes,non-alcoholic fatty liver disease,and cardiovascular *** effects of the ASMase/Cer pathway on metabolic disease-related indicators,such as glycolipid metabolism,insulin resistance,inflammation,and mitochondrial homeostasis are ***,this article discusses the therapeutic strategies using ASMase/Cer inhibitors for inverse prevention and treatment of these metabolic diseases in light of the possible efficacy of blockade of the ASMase/Cer pathway in arresting the progression of metabolic *** insights offered herein should provide insight into the contribution of the ASMase/Cer pathway to metabolic diseases and offer tools to develop therapeutic interventions for such pathologies and their severe complications.

关键词： Acid sphingomyelinase Ceramide Metabolic and cardiovascular diseases Glycolipid metabolism Inflammation Mitochondrial homeostasis

Pyrite Geochemistry and S-Hg Isotopes Reveal the Ore Genesis of the Hydrothermal Vein-type Cuiluan Ag-Pb-Zn Deposit in NE China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2025年

作者： Lidong Zhang Changzhou Deng Yao Tang Xinran ni Bizheng Yang Shanshan Liang Weipeng Liu Jishuang Ding Xiaohui Zeng Heilongjiang Institute of Natural Resources Survey State Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of Sciences College of Earth and Planetary Sciences， Chengdu University of Technology

The Xing'an-Mongolian orogenic belt is an important Ag-Pb-Zn metallogenic province in China. The study on the genesis of the newly discovered Cuiluan hydrothermal vein-type Ag-Pb-Zn deposit located in the Lesser Xing'an Range， within the eastern of Xing'an-Mongolian orogenic belt， is pivotal in understanding the metallogenic mechanism and regularity of Ag-Pb-Zn deposits in this region. This study utilizes pyrite trace elements and sulfur isotopic geochemistry， and mercury isotope of rocks and ores to constrain the genesis of the Cuiluan deposit. Pyrite geochemical data show that Ag exists in the form of galena inclusions (Ag++(Bi3+， Sb3+) ? Pb2+) in the polymetallic sulfide stage， and independent Ag-bearing minerals （matildite and gustavite） precipitate during the main mineralization stage. The small varied δ34S values （3.24‰ - 4.94‰） of pyrites from four hydrothermal stages are within the range of magmatic S isotopes， indicating that the ore-forming fluid of the Cuiluan deposit mainly originated from the magma. The Δ199Hg values of the ores are close to 0‰， which are consistent with the Δ199Hg values of mantle， further indicating that the ore-forming materials came from the lithospheric mantle. Combined with the regional tectonic evolution， we conclude that the plate subduction of Paleo-oceans in NE China triggered the partial melting of metasomatized mantle. The mantle-derived magma rose along the deep fractures and evolved ore-forming fluids， and finally caused the formation of Cuiluan quartz vein-type Ag-Pb-Zn deposit in the shallow crust. Accompany with previous documents， we infer that the fractures in the large-scale “Granite Sea” in the Lesser Xing'an Range may have significant potential for vein-type Ag-Pb-Zn exploration.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

文化遗产档案化保护的理论溯源与学术谱系

山西档案 2025年第2期 126-129页

作者：倪皓上海城建职业学院上海201415

通过揭示文化遗产档案化保护理论的历史渊源、展现文化遗产档案化保护的学术发展脉络、探讨中国文化遗产档案化保护理论体系的构建路径,对中国文化遗产档案化保护的理论与实践进行了系统梳理,以期为新时代文化遗产档案化保护的理论体系... 详细信息

通过揭示文化遗产档案化保护理论的历史渊源、展现文化遗产档案化保护的学术发展脉络、探讨中国文化遗产档案化保护理论体系的构建路径,对中国文化遗产档案化保护的理论与实践进行了系统梳理,以期为新时代文化遗产档案化保护的理论体系建设提出了思路和建议。

关键词：文化遗产档案化保护理论溯源学术谱系理论体系

在线全文

学校读者我要写书评

暂无评论

智能时代的教育选择及应对

中国电化教育 2025年第2期 92-99页

作者：吴霓郭嘉中国教育科学研究院教育战略与宏观政策研究所北京100088 北京邮电大学人文学院北京100876

人工智能的迅猛发展正在重塑教育的面貌,并带来了一系列的机遇与挑战。数字化转型是技术发展演进历程中的必然趋势,亦是智能时代教育事业发展进程中的重要标志,教育必须积极应对时代变革。该文深入探讨了信息技术革命对教育的影响,全面... 详细信息

人工智能的迅猛发展正在重塑教育的面貌,并带来了一系列的机遇与挑战。数字化转型是技术发展演进历程中的必然趋势,亦是智能时代教育事业发展进程中的重要标志,教育必须积极应对时代变革。该文深入探讨了信息技术革命对教育的影响,全面梳理了我国教育数字化转型的政策导向及发展历程。育人目标决定着教育形态的构成,智能时代促使教育系统在数字化转型背景下形成了新形态,其在五个方面发生了深刻变革,包括学校管理的效率与便捷性显著提升、教育教学变得更显丰富且多样化、学生发展能够更加精准实现个性化、教师发展专业化与需求能够更好匹配以及家校社育人更加紧密生动。然而,新技术的产生往往会引发诸多矛盾的产生,在智能时代教育理想与育人目标的达成存在四个矛盾关系,即工具伦理视角下的数字鸿沟愈发凸显、技术决定论削弱多元育人的要素功能、教师数字素养的提升滞后于技术更新以及应试教育理念抑制智能教育的实施。基于此,该文提出了相应的应对策略,利用智能技术优势助力数字鸿沟的弥合、促进技术刚性标准与人文关怀的融合、实现教师工具应用水平与技术的匹配以及健全基于综合素质的多元化评价体系。科学认识和审视智能时代教育的多维复杂性,确保技术的应用能够促进教育公平、提高教育质量,并培养学生适应未来社会的能力,这不仅是对教育工作者的挑战,也是政策制定者、技术开发者乃至整个社会的共同责任。

关键词：智能时代教育数字化教育选择矛盾关系

功能可恢复SFCB-ECC-混凝土桥墩抗震性能

在线全文

学校读者我要写书评

暂无评论

哈尔滨工业大学学报 2025年第1期57卷 13-23页

作者：白玉磊靳晓杰张玉峰韩世文城市与工程安全减灾教育部重点实验室(北京工业大学) 北京100124 哈尔滨工业大学(深圳)土木与环境工程学院广东深圳518055

为实现高耐久功能可恢复结构,设计了钢-FRP复合筋(steel-FRP composite bar,SFCB)替代钢筋,塑性铰区使用高延性水泥基复合材料(engineered cementitious composites,ECC)替代混凝土的新型组合柱。在0.13轴压比下,对SFCB-ECC-混凝土组合... 详细信息

为实现高耐久功能可恢复结构,设计了钢-FRP复合筋(steel-FRP composite bar,SFCB)替代钢筋,塑性铰区使用高延性水泥基复合材料(engineered cementitious composites,ECC)替代混凝土的新型组合柱。在0.13轴压比下,对SFCB-ECC-混凝土组合柱进行低周往复荷载试验研究。评估了SFCB中FRP体积分数(0%,43.6%,100%)和塑性铰区基体类型(ECC,混凝土)对组合柱抗震性能和可恢复性的影响。之后通过OpenSees进行了轴压比、SFCB配筋率和ECC强度的参数分析。结果表明:SFCB可使试件获得稳定的二次刚度,在2%位移角前,试件无需修复即可快速恢复原有功能;组合柱残余变形随SFCB中FRP体积分数增加而减少,但其初始刚度和峰值承载力也相应降低;在塑性铰区使用ECC可进一步减少残余位移,同时显著提高峰值承载力和延性;参数分析显示增大轴压比将提高SFCB-ECC-混凝土组合柱承载力,但会降低延性;随SFCB配筋率和ECC强度提高,组合柱承载力也相应增大;在实际工程中可合理设计SFCB和ECC材料特性以满足特定结构刚度、强度和可修复性的要求。

关键词：桥梁工程组合柱抗震性能 OpenSees 钢-FRP复合筋高延性水泥基复合材料可恢复

Red blood cell distribution width to albumin ratio is correlated with prognosis of patients in coronary care unit

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Cardiology 2025年第2期17卷 61-70页

作者： Jiao-ni Wang Ze-Song Hu Yong-Wei Yu Xiao-Hui Peng Department of Diagnostic Ultrasound and Echocardiography Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Cardiology The Second Affiliated and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 312500Zhejiang ProvinceChina Intensive Care Unit The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND As red blood cell distribution width(RDW)and albumin have been shown to be independent predictors of mortality from various diseases,this study aimed to investigate the effect of the RDW to albumin ratio(RA)as an independent predictor of the prognosis of patients admitted to the coronary care unit(CCU).AIM To use the RDW and albumin level to predict the prognosis of patients in the *** Data were obtained from the Medical Information Mart Intensive Care III *** primary outcome was 365-day all-cause mortality,whereas the secondary outcomes were 30-and 90-day all-cause mortality,hospital length of stay(LOS),and CCU *** proportional hazards regression model,propen-sity score matching,and receiver operating characteristic curve analyses were *** The hazard ratio(95%confidence interval)of the upper tertile(RA>4.66)was 1.62(1.29 to 2.03)when compared with the reference(RAnical variables in the propensity score-matching *** trends were observed for the secondary outcomes of hospital and CCU *** operating characteristic curve analysis was performed by combining the RA and sequential organ failure assessment(SOFA)scores,and the C-statistic was higher than that of the SOFA scores(0.733 vs 0.702,P<0.001).CONCLUSION RA is an independent prognostic factor in patients admitted to the *** combined with the SOFA score can improve the predictive ability of the SOFA ***,our results should be verified in future prospective studies.

关键词： Red blood cell distribution width Albumin Prognosis Coronary care unit

Identification of subgroups of self-reported outcomes among breast cancer patients undergoing surgery and chemotherapy:A crosssectional study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2025年第1期12卷 51-58,I0003页

作者： Feixia ni Tingting Cai Tingting Zhou Changrong Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Nursing Fudan UniversityShanghaiChina

Objectives:To identify the subgroups of self-reported outcomes and associated factors among breast cancer patients undergoing surgery and ***:A cross-sectional study was conducted between January and November *** recruited patients from two tertiary hospitals in Shanghai,China,using convenience sampling during their *** were assessed using a questionnaire that included sociodemographic and clinical characteristics,the Patient Reported Outcomes Measurement Information System profile-29(PROMIS-29),and the PROMIS-cognitive function short form *** class analysis was performed to examine possible classes regarding self-reported *** logistic regression analysis was used to determine the associated *** of variance(ANOVA)was conducted for symptoms across the different ***:A total of 640 patients participated in this *** findings revealed three subgroups in terms of self-reported outcomes among breast cancer patients undergoing surgery and chemotherapy:low physical-social-cognitive function,high physical-low cognitive function,and high physical-socialcognitive *** logistic regression analysis showed that age(≥60 years old),menopause,the third chemotherapy cycle,undergoing simple mastectomy and breast reconstruction,duration of disease 3-12 months,stageⅢ/Ⅳcancer,and severe pain were associated factors of the functional decline ***,significant differences in depression and sleep disorders were observed among the three ***:Breast cancer patients receiving surgery and chemotherapy can be divided into three ***,menopause,chemotherapy cycle,surgery type,duration and stage of disease,and severe pain affected the functional decline ***,healthcare professionals should make tailored interventions to address the specific functional rehabilitation and symptom relief needs.

关键词： Breast neoplasms Latent class analysis Function Surgery Chemotherapy

当代青年学子学历焦虑的成因及对策——基于“孔乙己文学”的视角

在线全文

学校读者我要写书评

暂无评论

西部学刊 2025年第1期 75-78页

作者：薛诗雯上海健康医学院上海201318

“孔乙己文学”盛行使年轻人的学历焦虑问题成为社会关注的热点,如何解决大学生的就业问题、缓解大学生由就业引起的学历焦虑成为需要探讨的议题。通过研究认为,学历焦虑形成具有多维成因,经济下行导致企业就业岗位减少,高校扩招带来了... 详细信息

“孔乙己文学”盛行使年轻人的学历焦虑问题成为社会关注的热点,如何解决大学生的就业问题、缓解大学生由就业引起的学历焦虑成为需要探讨的议题。通过研究认为,学历焦虑形成具有多维成因,经济下行导致企业就业岗位减少,高校扩招带来了学历“通货膨胀”,二者叠加使广大青年在求职路上遭遇重重问题,加之个人功利主义的盛行和少数不良媒体大肆渲染“学历无用论”,使一些青年深陷学历焦虑之中。学历焦虑现象具有复杂性,解决问题需要国家、社会和个人共同努力。从国家层面来说,应该扶植中小企业保证就业市场活力,推进职业教育改革缓解就业结构性矛盾。从社会层面来说,企业应该遵循法律法规保障员工权益,媒体应该强化道德规范承担社会责任,社会大众应该对青年多加宽容鼓励。从个人层面来说,青年学子应该提升自己各方面素养,保持良好心态,摒弃功利主义思维,提高明辨是非的能力。

关键词： “孔乙己文学” 青年发展学历焦虑就业困惑

在线全文

学校读者我要写书评

暂无评论

蝶翅花纹的演化发育生物学研究进展

遗传 2025年第2期47卷 258-270页

作者：倪嘉欣张蔚北京大学蛋白质与植物基因研究国家重点实验室生命科学学院生命科学联合中心北京100871

演化发育生物学研究结合演化生物学和发育生物学,关注生物发育过程的演化及性状多样化的机制。自1984年同源异形盒基因被发现,许多模式生物形态建成的遗传机制获得了系统性研究;相对而言,非模式生物具有丰富而复杂的演化创新性状,然而... 详细信息

演化发育生物学研究结合演化生物学和发育生物学,关注生物发育过程的演化及性状多样化的机制。自1984年同源异形盒基因被发现,许多模式生物形态建成的遗传机制获得了系统性研究;相对而言,非模式生物具有丰富而复杂的演化创新性状,然而其背后的演化遗传机制尚未被完全解析,相关的研究亟待加强。在非模式生物类群中,蝶类具有丰富的物种多样性,超过18,700个物种;其翅结构相对简单但呈现出复杂多样的花纹,可能具有防御、求偶等多样的生物学功能,并受到较强的选择压力,因此是演化发育生物学研究的经典体系。聚焦蝶类的演化发育生物学研究历程,早期的比较形态学研究提出了蛱蝶平面图,为蝶翅花纹的演化发育生物学研究提供了理论框架;而之后一系列对蝶类翅盘的干扰实验则证实翅盘发育过程与蝶翅表型的关联;近年来的研究通过整合遗传学、发育生物学、基因组学等研究手段,已在多个蝶类研究体系对其重要的遗传工具包基因/基因座进行了解析,进一步完善了蝶翅花纹演化发育学研究的理论框架。从方法学角度,原位杂交和基因编辑等技术在开展上述研究中发挥了重要作用,而杂交链式反应技术和CRISPR/Cas9技术的发展则进一步提升了蝶类基因功能验证的可行性。在未来的研究中,可通过开发和优化适用于蝶类等鳞翅目昆虫的RNA干扰技术和基因编辑技术,推动更多的基因功能研究,进而比较和解析生物复杂性状,拓展演化发育生物学研究体系;上述研究还可拓展至生态-演化-发育角度,探索遗传和环境因素对以蝶翅花纹为代表的复杂表型的塑造机制,增进理解生物多样性形成和演化这一关键的科学问题。

关键词：蝶翅演化发育生物学遗传工具包原位杂交基因编辑