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胰腺癌转化手术后辅助治疗的临床价值

中华消化外科杂志 2024年第5期23卷 694-702页

作者：朱凌宇高绥之吴欣乾顾凌云康晓超郭世伟金钢海军军医大学第一附属医院胰腺肝胆外科上海200433

目的探讨胰腺癌转化手术后辅助治疗的临床价值。方法采用回顾性队列研究方法。收集2019年1月至2021年12月海军军医大学第一附属医院收治的173例新辅助和(或)诱导治疗后手术切除胰腺癌患者的临床病理资料;男107例,女66例;年龄为(59±9)... 详细信息

目的探讨胰腺癌转化手术后辅助治疗的临床价值。方法采用回顾性队列研究方法。收集2019年1月至2021年12月海军军医大学第一附属医院收治的173例新辅助和(或)诱导治疗后手术切除胰腺癌患者的临床病理资料;男107例,女66例;年龄为(59±9)岁。观察指标:(1)胰腺癌转化手术后是否行辅助治疗患者的临床病理特征比较。(2)影响胰腺癌转化手术预后的因素分析。(3)随访和生存情况。(4)辅助治疗在各亚组人群中的生存获益。正态分布的计量资料以x±s表示,组间比较采用t检验。偏态分布的计量资料以M(Q1,Q3)表示,组间比较采用Mann⁃Whitney U检验。计数资料以绝对数或百分比表示,组间比较采用χ^(2)检验。等级资料比较采用非参数秩和检验。采用Graphpad prism 8软件绘制生存曲线,Kaplan⁃Meier法计算生存时间和生存率,Log⁃Rank检验进行生存分析。采用COX比例风险回归模型进行单因素和多因素分析。采用交互作用分析确定辅助治疗在各亚组人群中的获益情况。结果(1)胰腺癌转化手术后是否行辅助治疗患者的临床病理特征比较。173例患者胰腺癌转化手术后108例行辅助治疗,65例未行辅助治疗。行辅助治疗和未行辅助治疗患者的年龄、体质量指数分别为(58±9)岁和(61±8)岁、(23.2±2.8)kg/m^(2)和(22.2±2.8)kg/m^(2),两者上述指标比较,差异均有统计学意义(t=-2.036,2.200,P<0.05)。(2)影响胰腺癌转化手术预后的因素分析。多因素分析结果显示:CA19⁃9正常化、病理学N分期、肿瘤分化程度和术后辅助治疗是胰腺癌转化手术患者总生存时间的独立影响因素(风险比=1.598,1.541,2.004,2.571,95%可信区间为1.041~2.453,1.021~2.327,1.288~3.118,1.721~3.843,P<0.05)。(3)随访和生存情况。173例患者均获得随访,随访时间为24.5(5.0,52.0)个月。173例患者术后的中位总生存时间为28.9(5.7,51.9)个月,1、2、3年总生存率分别为90%、59%、40%。2019、2020、2021年胰腺癌转化手术后行辅助治疗患者比例分别为62.8%(27/43)、57.7%(30/52)、65.4%(51/78)。胰腺癌转化手术后行辅助治疗患者中位总生存时间为42.2(8.8,49.7)个月,未行辅助治疗患者中位总生存时间为20.4(5.7,51.9)个月,两者生存情况比较,差异有统计学意义(χ^(2)=29.893,P<0.05)。(4)辅助治疗在各亚组人群中的生存获益。交互作用分析结果显示:在CA19⁃9正常化、病理学N0期、病理学N1和N2期、中高分化肿瘤亚组人群中,胰腺癌转化手术后行辅助治疗患者有更好的生存获益(矫正风险比=0.220,0.300,0.410,0.340,95%可信区间为0.120~0.400,0.170~0.560,0.240~0.690,0.210~0.690)。结论术后辅助治疗是胰腺癌转化手术患者总生存时间的独立影响因素;胰腺癌转化手术后行辅助治疗能够改善患者预后,对新辅助和(或)诱导治疗响应良好的人群生存获益更多。

关键词：胰腺肿瘤新辅助治疗诱导治疗转化手术辅助治疗预后

Effects of Local Nitrogen Supply on Water Uptake of Bean Plants in a Split Root System

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Journal of Integrative Plant Biology 2007年第4期49卷 472-480页

作者： shiwei guo Qirong Shen Holger Brueckt College of Resource and Environmental Science Nanjing Agricultural University Nanjing 210095 China Institute of Plant Nutrition and Soil Science University of Kiel Kiel D-24118 Germany

To study the effects of local nitrogen supply on water and nutrient absorption, French bean （Phaseolus vulgaris L.） plants were grown in a split root system. Five treatments supplied with different nitrogen forms were compared： homogeneous nitrate （NN） and homogenous ammonium （AA） supply, spatially separated supply of nitrate and ammonium （NA）, half of the root system supplied with N-free nutrient solution, the other half with either nitrate （NO） or ammonium （AO）. The results showed that 10 d after onset of treatments, root dry matter （DM） in the nitratesupplied vessels treated with NA was more than two times higher than that in the ammonium-supplied vessels. Water uptake from the nitrate-supplied vessels treated with NA was 281% higher than under ammonium supply. In treatments NO and AO, the local supply of N resulted in clearly higher root DM, and water uptake from the nitratesupplied vessels was 82% higher than in the -N vessels. However, in AO plants, water uptake from the -N nutrient solution was 129% higher than from the ammonium-supplied vessels. This indicates a compensatory effect, which resulted in almost identical rates of total water uptake of treatments AA and AO, which had comparable shoot DM and leaf area. Ammonium supply reduced potassium and magnesium absorption. Water uptake was positively correlated with N, Mg and K uptake.

关键词： nitrogen form nutrient uptake rates Phaseolus vulgaris split root system water uptake rates.

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基于机理模型的轮毂机加工尺寸链控制研究

新型工业化 2024年第5期14卷 74-84页

作者：张昕炜胡若晨郭世威中信戴卡股份有限公司数智化项目管理部河北秦皇岛065000 中国科学院自动化所北京100000

随着新一代信息技术和制造业的加速融合,制造过程工艺持续智能化升级,成为发展新质生产力的关键。针对轮毂加工过程中复杂尺寸链控制问题,本文在机加工环节设计基于欧氏距离的机理模型,采取该模型算法计算尺寸链最优时的刀具补偿值解集... 详细信息

随着新一代信息技术和制造业的加速融合,制造过程工艺持续智能化升级,成为发展新质生产力的关键。针对轮毂加工过程中复杂尺寸链控制问题,本文在机加工环节设计基于欧氏距离的机理模型,采取该模型算法计算尺寸链最优时的刀具补偿值解集;在控制阶段开发边缘控制程序,将解集下发至机床。经过实践验证,与传统的人工控制尺寸链方式对比,在机加工环节采用该机理模型可以在有效时间内得到确保尺寸链较优的解集,为轮毂机加工制造智能化转型提供参考。

关键词：机理模型尺寸链欧氏距离边缘控制轮毂

Synergistic and antagonistic interactions between potassium and magnesium in higher plants

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The Crop Journal 2021年第2期9卷 249-256页

作者： Kailiu Xie Ismail Cakmak Shiyu Wang Fusuo Zhang shiwei guo Jiangsu Provincial Key Lab of Solid Organic Waste Utilization Jiangsu Collaborative Innovation Center of Solid Organic WastesEducational Ministry Engineering Center of Resource-saving FertilizersNanjing Agricultural UniversityNanjing 210095JiangsuChina School of Land Resources and Environment Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Faculty of Engineering and Natural Sciences Sabanci University34956 IstanbulTurkey International Magnesium Institute College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China

Magnesium(Mg)affects various critical physiological and biochemical processes in higher plants,and its deficiency impedes plant growth and *** potassium(K)-induced Mg deficiency in agricultural production is widespread,the specific relationship of K with Mg and especially its competitive nature is poorly *** review summarizes current knowledge on the interactions between K and Mg with respect to their root uptake,root-to-shoot translocation and distribution in *** synergistic effects on certain physiological functions are also *** antagonistic effect of K on Mg is stronger than that of Mg on K in root absorption and transport within plants,indicating that the balanced use of K and Mg fertilizers is necessary for sustaining high plant-available Mg and alleviating K-induced Mg deficiency,especially in plant species with high K demand or in highavailable-K *** relationship between Mg and K in plant tissues may be antagonistic or synergistic depending on plant species,cell type,leaf age,source-and sink *** are synergistic effects of K and Mg on photosynthesis,carbohydrate transport and allocation,nitrogen metabolism,and turgor *** of optimal K/Mg ratios for soils and plant tissues is desirable for maintaining proper nutritional status in plants,leading to a physiological state supporting crop *** research should concentrate on identifying the physiological and molecular mechanisms underlying the interactions between K and Mg in a given physiological function.

关键词： Antagonism Functional replacement Magnesium Potassium Synergy

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产红青霉菌对脲醛树脂的降解机制

山西农业大学学报（自然科学版） 2024年第3期44卷 99-107页

作者：郭仕伟向阳仝迎芳刘亚青郭建峰白玉洁高焕秦旭巍王芳中北大学化学与化工学院山西太原030051 纳米功能复合材料山西省重点实验室山西太原030051 山西省高分子复合材料工程技术研究中心山西太原030051

[目的]每年有30多万吨脲醛用做树脂、粘合剂和绝缘材料,由于其降解持久性,此类物质废弃后对环境造成广泛的损害。本研究以产红青霉菌(Penicillium rubens 23229)为对象,研究其对脲醛树脂(UF)的降解过程和降解酶的性质。[方法]用X-射线衍... 详细信息

[目的]每年有30多万吨脲醛用做树脂、粘合剂和绝缘材料,由于其降解持久性,此类物质废弃后对环境造成广泛的损害。本研究以产红青霉菌(Penicillium rubens 23229)为对象,研究其对脲醛树脂(UF)的降解过程和降解酶的性质。[方法]用X-射线衍射(XRD)和失重率评价*** 23229及其酶的降解能力,通过液相-质谱联用(LC-MS)分析降解过程中间代谢产物,应用凝胶色谱柱对降解酶进行纯化。[结果]*** 23229作用于UF,30 d后,材料失重率(降解率)为35%,结晶度由26.21%提升至29.44%,经计算得出,降解的35%包括UF结晶区7%,非结晶区28%;从菌种和脲醛共培养液中得到*** 23229脲醛降解粗酶液,其最适作用温度为50℃,最适pH为4.0,LC-MS结果表明该粗酶液在降解过程中,首先将高分子UF主链降解,形成四甲基五脲、三甲基四脲等短链中间代谢物,然后进一步分解中间代谢产物为二氧化碳以及甲醛等终产物,降解作用位点包括脲醛主链中亚甲基与尿素间的C-N、酰胺键等。进一步对比了*** 23229粗酶液与商业脲酶、蛋白酶对UF的降解能力,发现蛋白酶几乎无降解效果,脲酶有一定降解能力,但显著低于*** 23229粗酶液。粗酶经纯化后降解效率提高28倍,凝胶渗透色谱(GPC)显示出分子量为6.89 kD和220.83 kD的2个峰,对应前面降解过程分析,说明降解过程包含主链降解酶和中间代谢物降解酶至少2种酶的复合体系共同发挥作用。[结论]*** 23229脲醛降解酶由主链降解酶和中间代谢物降解酶共同组成,其中包含脲酶作用类似的酶,但降解主链的酶与已有蛋白酶作用方式不同,其具体的组成与性质有待于进一步研究。本研究对UF的生物降解具有一定的参考价值。

关键词：脲醛树脂 P.rubens 23229 脲醛降解酶生物降解

Elastic energy storage technology using spiral spring devices and its applications:A review

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Energy and Built Environment

Energy and Built Environment 2023年第6期4卷 669-679页

作者： shiwei guo Li Yang Yanping Yuan Zutao Zhang Xiaoling Cao School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China

Harvesting and storing energy is a key problem in some *** energy storage technology has the advantages of wide-sources,simple structural principle,renewability,high effectiveness and *** paper elaborates the operational principles and technical properties and summarizes the appli-cability of elastic energy storage technology with spiral *** energy storage using spiral spring can realize the balance between energy supply and demand in some *** input-spontaneous out-put working style can provide simple energy sources for short-time energy supply,and provide strong moment impact and rapid start,or realize the energy conservation for reciprocating *** output working style can realize energy output with uniform speed for timekeeping and *** input working style can harvest and store random mechanical energy or convert small torque into a large moment to drive external ***,this paper proposes new researches and developments of elastic energy storage technology on new materials and structures,mechanical properties and structural dynamics analyses,design and control for new functions.

关键词： Mechanical energy storage Elastic energy storage Spiral spring system Energy input/output characteristics Implementation mechanism

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东佛里生羊杂交改良湖羊泌乳性能分析

黑龙江畜牧兽医 2024年第16期 42-47,116页

作者：张玉庭郝志云杨舒童王龙斌刘圆郭世伟王继卿甘肃农业大学动物科学技术学院/甘肃省草食动物生物技术重点实验室/甘肃省牛羊基因改良工程实验室兰州730070

为了探讨东佛里生羊作为父本对湖羊的杂交改良效果,试验以东佛里生羊(31只)、东佛里生(♂)×湖羊(♀)杂交一代(F1代,204只)、东佛里生(♂)×湖羊(♀)级进杂交二代(F2代,156只)、湖羊(45只)4个试验群体为研究对象,测定了东佛里生羊、F1代... 详细信息

为了探讨东佛里生羊作为父本对湖羊的杂交改良效果,试验以东佛里生羊(31只)、东佛里生(♂)×湖羊(♀)杂交一代(F1代,204只)、东佛里生(♂)×湖羊(♀)级进杂交二代(F2代,156只)、湖羊(45只)4个试验群体为研究对象,测定了东佛里生羊、F1代和F2代8个月的泌乳量和湖羊3个月的泌乳量,计算4个试验群体的月泌乳量、周泌乳量、总泌乳量和日均泌乳量;分析品种、产羔数、胎次和年龄对母羊泌乳量的影响,比较Wood模型、Wilmink模型和逆多项式模型对4个试验群体泌乳曲线的拟合度(R2),筛选拟合度最高的模型拟合4个试验群体的泌乳曲线。结果表明:东佛里生羊总泌乳量和日均泌乳量分别为(243.19±1.64)kg和(1.01±0.05)kg,显著高于F1代[(227.54±0.61) kg和(0.95±0.02)kg]、F2代[(230.09±0.65)kg和(0.96±0.02)kg]和湖羊[(71.36±1.32) kg和(0.79±0.05)kg,P0.05),但产多羔母羊的泌乳量总体高于产单羔母羊。经产母羊的泌乳量总体高于初产母羊;5胎次母羊的日均泌乳量最大[(1.03±0.10)kg],显著高于其他胎次(P<0.05);1胎次母羊的泌乳量最小,为(0.93±0.02)kg。随着年龄的增长,母羊总泌乳量呈现增加趋势;1~4岁母羊的总泌乳量分别为(223.33±0.87)kg、(226.51±0.60)kg、(236.60±0.87)kg和(237.59±1.66)kg,日均泌乳量分别为(0.93±0.03)kg、(0.94±0.02)kg、(0.99±0.03)kg和(0.99±0.06)kg, 3,4岁母羊的总泌乳量、日均泌乳量均显著高于1,2岁母羊(P<0.05);4岁母羊第1,3,4,6个月泌乳量均最大,而3岁母羊第2,5个月泌乳量最大。4个试验群体的Wood模型的R2均最大,由Wood模型可知东佛里生羊泌乳潜力最大,湖羊泌乳潜力最小;湖羊在第4周达到泌乳高峰,而东佛里生羊、F1代和F2代在第8周达到泌乳高峰。说明通过与东佛里生羊杂交可以明显改善湖羊的泌乳性能;产羔数对母羊泌乳量影响不明显,胎次和年龄对母羊泌乳量有明显影响,其中Wood模型对4个试验群体泌乳曲线的拟合效果最好。

关键词：东佛里生羊湖羊杂交泌乳量胎次年龄泌乳曲线

Identification and functional analysis of heterogeneous FOXP3^+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma

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Science Bulletin 2018年第15期63卷 972-981页

作者： Gang Yi shiwei guo Wenyu Liu Huan Wang Rendong Liu Andy Tsun Gang Jin Bin Li Shanghai Key Laboratory of Bio-energy Crops School of Life Science Shanghai University Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine CAS Center for Excellence in Molecular Cell Science Unit of Molecular Immunology Institute Pasteur of Shanghai Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Medical School Chinese Academy of Sciences Department of General Surgery Changhai Hospital Second Military Medical University

CD4^＋ CD25^＋ regulatory T （Treg） cells express the transcription factor FOXP3 and play an essential role in preventing autoimmunity. Abundant Treg cell accumulation in tumors and tumor draining lymph nodes （TDLNs） has been reported to correlate with both poor and favorable prognosis in various cancers, which suggests that Tregs may have multiple effects on antitumor immunity. However, the heterogeneity of tumor- and TDLN-infiltrating Treg cells remains unclear. Here we provide heterogeneity analysis of tumor infiltrating human CD4^＋ Treg cells and their matched adjacent tissues and TDLNs. We defined three different subpopulations of tumor- and TDLN-infiltrating Treg cells by Helios and CCR8 expression in pancreatic ductal adenocarcinoma （PDAC） and confirmed their functional heterogeneity. Helios^＋ CCR8^＋ Treg cells with potent suppressor function and limited IL-2 and IFN-7 secretion were identified in tumors and TDLNs. On the contrary, Helios^- CCR8^- Treg cells have impaired suppressive activity, and elevated expression of pro-inflammatory cytokines. More advanced grades of PDAC have predominantly Helios^＋ CCR8^＋ Treg cells and few Helios^- CCR8^- Treg cells both in tumors and TDLNs that suggests poor prognosis. These data could help further define the role of Treg cells and their functional role in tumors and TDLNs.

关键词： Pancreatic ductal adenocarcinoma Regulatory T cells Heterogeneity Tumor draining lymph nodes

Observer-based robust high-order fully actuated attitude autopilot design for spinning glide-guided projectiles

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Defence Technology（防务技术） 2024年第4期34卷 282-294页

作者： Wei Wang Yuchen Wang shiwei Chen Yongcang guo Zhongjiao Shi School of Aerospace Engineering Beijing Institute of TechnologyBeijing 10081China Northwest Industries Group CO. Ltd.Xi'an 710043China

This paper investigates the design of an attitude autopilot for a dual-channel controlled spinning glideguided projectile(SGGP),addressing model uncertainties and external *** on fixed-time stable theory,a disturbance observer with integral sliding mode and adaptive techniques is proposed to mitigate total disturbance effects,irrespective of initial *** introducing an error integral signal,the dynamics of the SGGP are transformed into two separate second-order fully actuated ***,employing the high-order fully actuated approach and a parametric approach,the nonlinear dynamics of the SGGP are recast into a constant linear closed-loop system,ensuring that the projectile's attitude asymptotically tracks the given goal with the desired *** the proposed composite control framework,the ultimately uniformly bounded stability of the closed-loop system is rigorously demonstrated via the Lyapunov *** of the effectiveness of the proposed attitude autopilot design is provided through extensive numerical simulations.

关键词： Spinning glide-guided projectile Attitude control Sliding mode disturbance observer Fixed-time stable theory High-order fully actuated approach