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Chromosome 11 aneusomy in esophageal cancers and precancerous lesions-an early event in neoplastic transformation:An interphase fluorescence in situ hybridization study from south India

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World Journal of Gastroenterology 2007年第4期13卷 503-508页

作者： Vasavi Mohan shivani ponnala Hemakumar M Reddy Radha Sistla Rachel A Jesudasan Yog Raj Ahuja Qurratulain Hasan Department of Genetics & Molecular Medicine Kamineni Hospitals LB Nagar Hyderabad AP India Department of Molecular Biology Center for Cellular and Molecular Biology Uppal Road Hyderabad AP India Department of Genetics & Molecular Medicine Kamineni Hospitals LB Nagar Hyderabad AP IndiaDepartment of Pathology Kamineni Hospitals Hyderabad AP India Department of Genetics Vasavi Hospital and Research Center Lakdi-ka-pul Hyderabad AP India Department of Genetics & Molecular Medicine Kamineni Hospitals LB Nagar Hyderabad AP IndiaDepartment of Genetics Bhagwan Mahavir Medical Research Center AC Guards Hyderabad AP India

AIM: To detect aneusomic changes with respect to chromosome 11 copy number in esophageal precancers and cancers wherein the generation of cancer-specific phenotypes is believed to be associated with specific chromosomal aneuploidies. METHODS: We performed fluorescence in situ hybridization (FISH) on esophageal tissue paraffin sections to analyze changes in chromosome 11 copy number using apotome-generated images by optical sectioning microscopy. Sections were prepared from esophageal tumor tissue, tissues showing preneoplastic changes and histologically normal tissues (control) obtained from patients referred to the clinic for endoscopic evaluation. RESULTS: Our results demonstrated that aneusomy was seen in all the cancers and preneoplastic tissues, while none of the controls showed aneusomic cells. There was no increase in aneusomy from precancers to cancers. CONCLUSION: Our results suggest that evaluation of chromosome 11 aneusomy in esophageal tissue using FISH with an appropriate signal capture-analysis system, can be used as an ancillary molecular marker predictive of early neoplastic changes. Future studies can be directed towards the genes on chromosome 11,which may play a role in the neoplastic transformation of esophageal precancerous lesions to cancers.

关键词： Esophageal cancer Aneusomy Chromosome11 Fluorescence in situ hybridization Early detection

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