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Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate

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Advances in Bioscience and Biotechnology 2018年第12期9卷 679-690页

作者： shivani N. patel Sandra D. Adams Lee H. Lee Department of Biology Montclair State University Montclair NJ USA

Epigallocatechin gallate (EGCG), a green tea polyphenol possesses antioxidant, antibacterial, anticancer and antiviral properties. EGCG-Stearate (EGCG-S) is of interest for this study because of its stability and lipophilic properties. The chemical modification of EGCG-S increased its lipid solubility. Herpes simplex virus-1 (HSV-1), a member of the family Herpesviridae, and Alphaherpesvirinae subfamily is a leading cause of human viral diseases in the United States. In this study, 25 μM, 50 μM, 75 μM, and 100 μM of EGCG and EGCG-S were used to carry out cytotoxicity, cell viability and cell proliferation assays to determine the maximum non-cytotoxic concentrations on cultured A549 cells. The results suggested that 75 μM of EGCG and EGCG-S is the appropriate concentration to further study the effect on the infection of HSV-1 in A549 cells. Infectivity, antiviral, and inverted microscopy assays were performed to study the effects of EGCG and EGCG-S on HSV-1 infection. An antiviral assay was performed using luminescence and it indicated that EGCG-S treated HSV-1 showed up to 90% inhibition. Confocal microscopy images further supported the inhibitory effects of 75 μM EGCG-S on HSV-1 infection in A549 cells. The long-term goal of this research is to use EGCG-S as a possible novel topical therapeutic treatment to limit the spread of HSV-1 infections.

关键词： HSV-1 EGCG-Stearate EGCG Antiviral A549 Cells

Septic Superficial Femoral Vein Thrombophlebitis Causing Pulmonary Emboli and Respiratory Failure: Case Report and Review of the Literature

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International Journal of Clinical Medicine 2019年第8期10卷 413-420页

作者： Ziad Fayad Paul Guentert Erin Rissler Nuha Zackariya shivani patel Ali Sualeh Mahmoud Al-Fadhl Sufyan Zackariya Grant Wiarda Mallory Martin Joseph Lake Sarah Philbrick Mark Walsh General and Vascular Surgery X-Ray Consultants South Bend IN USA Saint Joseph Regional Medical Center Mishawaka IN USA St. Luc Family Hospital Tabarre Haiti Indiana University School of Medicine South Bend Campus South Bend IN USA

Septic pulmonary emboli rarely cause respiratory failure that requires mechanical ventilation. The most common causes of septic pulmonary emboli are related to intravenous drug abuse, indwelling intravenous catheters, endocarditis and septic pelvic thrombophlebitis. In addition, soft tissue injury-related thrombophlebitis rarely causes septic pulmonary emboli. We describe a unique case of a 43-year-old man who developed septic thrombophlebitis of the femoral vein following soft tissue injury from trauma to the shin with ensuing septic pulmonary emboli which necessitated endotracheal intubation and mechanical ventilation. The patient required mechanical ventilation for eleven days, developed empyema and grew out methicillin-resistant Staphylococcus aureus on blood cultures. A transesophageal echocardiogram was normal, and there was no indication of bacterial endocarditis. In addition to eleven days of mechanical ventilation, the patient was treated with intravenous heparin, cefepime and clindamycin. These medications were then discontinued and the patient was treated with weight-adjusted vancomycin. Following the return of cultures, the patient was treated for six weeks with ceftaroline 600 mg IV twice a day. In addition, the patient received bilateral thoracentesis followed by chest tube drainage until resolution of the pleural effusions. The patient made a complete recovery. We describe this case and the implications for differential diagnosis and treatment of these two uncommon conditions.

关键词： Septic Thrombophlebitis Pulmonary Emboli Respiratory Failure Critical Care

Utilization of Extracorporeal Membrane Oxygenation for Pulmonary Toxicity Caused by Inhaled Synthetic Cannabinoid. A Harbinger of Future Complications Associated with Inhaled Cannabinoid Products

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International Journal of Clinical Medicine 2020年第2期11卷 53-61页

作者： Robert March Paul Guentert Elizabeth Kloska-Kearney David Kwak Cody Yerger Michael McBride J. R. Majewski Ross McCauley Jordan Hatch Jacob Speybroeck Allen Betts Mat Marsee Sufyan Zackariya Faisal Shariff shivani patel Ali Sualeh Anthony Thomas Edward Evans Donald Westerhausen Mark Walsh Saint Joseph Regional Medical Center Mishawaka IN USA Indiana University School of Medicine—South Bend South Bend IN USA Department of Pulmonary and Critical Care Medicine Methodist Hospital Indianapolis IN USA

There has been a dramatic increase in medical complications related to synthetic cannabinoid (SC) use either by water pipe or vaping. The legalization of marijuana in an increasing number of states has also resulted in an increase in a number of complications related not just to marijuana, but in particular, to SC. As a result, there have been recent increased reports of acute pulmonary injury related to inhaled SC products. We describe that rarely endotracheal intubation with mechanical ventilation has been required to treat the acute respiratory distress syndrome (ARDS) and the diffuse alveolar hemorrhage (DAH) associated with the acute toxicity of SC inhalation. We describe the second reported case of successful utilization of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) in order to treat acute pulmonary toxicity caused by SC inhalation by a water pipe. While the exact pathophysiology of these interesting and recent pulmonary complications is unknown, the recent increase in exposure to SC via water pipe systems and vaping suggests that there will be many more cases of patients that will require ECMO as a form of life-saving therapy.

关键词： Synthetic Cannabinoid Extracorporeal Membrane Oxygenation Mechanical Ventilation Water Pipe Vaping Pulmonary Toxicity

Artificial Intelligence for Maximizing Agricultural Input Use Efficiency: Exploring Nutrient, Water and Weed Management Strategies

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1569-1598页

作者： Sumit Sow shivani Ranjan Mahmoud F.Seleiman Hiba M.Alkharabsheh Mukesh Kumar Navnit Kumar Smruti Ranjan Padhan Dhirendra Kumar Roy Dibyajyoti Nath Harun Gitari Daniel O.Wasonga Department of Agronomy Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Department of Crop Sciences Faculty of AgricultureMenoufia UniversityShibin El-Kom32514Egypt Department of Water Resources and Environmental Management Faculty of Agricultural TechnologyAl Balqa Applied UniversitySalt19117Jordan Division of Agronomy ICAR-Indian Agricultural Research InstitutePusa CampusNew Delhi110012India Department of Soil Science Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Agricultural Science and Technology School of Agriculture and Environmental SciencesKenyatta UniversityNairobi43844Kenya Department of Crop Sciences University of Illinois Urbana-ChampaignUrbanaIL 61801USA

Agriculture plays a crucial role in the economy,and there is an increasing global emphasis on automating agri-cultural *** the tremendous increase in population,the demand for food and employment has also increased signiﬁ*** methods traditionally used to meet these requirements are no longer ade-quate,requiring solutions to issues such as excessive herbicide use and the use of chemical *** of technologies such as the Internet of Things,wireless communication,machine learning,artiﬁcial intelligence(AI),and deep learning shows promise in addressing these ***,there is a lack of comprehensive documentation on the application and potential of AI in improving agricultural input efﬁ*** address this gap,a desk research approach was used by utilizing peer-reviewed electronic databases like PubMed,Scopus,Goo-gle Scholar,Web of Science,and Science Direct for relevant *** of 327 initially identiﬁed articles,180 were deemed pertinent,focusing primarily on AI’s potential in enhancing yield through better management of nutrients,water,and *** into account researchﬁndings worldwide,we found that AI technologies could assist farmers by providing recommendations on the optimal nutrients to enhance soil quality and deter-mine the best time for irrigation or herbicide *** present status of AI-driven automation in agricul-ture holds signiﬁcant promise for optimizing agricultural input utilization and reducing resource waste,particularly in the context of three pillars of crop management,i.e.,nutrient,irrigation,and weed management.

关键词： Agriculture artiﬁcial intelligence crop management nutrient irrigation weed management resource use efﬁciency

Quadruple Gaussian Laser Beam Profile Dynamics in Collisionless Magnetized Plasma

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Communications in Theoretical Physics 2018年第9期69卷 317-324页

作者： shivani Vij Munish Aggarwal Department of Applied Sciences DAV Institute of Engineering&TechnologyJalandhar 144008India Department of Applied Sciences Lyallpur Khalsa College of EngineeringJalandhar 144001India

This paper presents an investigation of self-focusing of a quadruple Gaussian laser beam in collisionless magnetized *** nonlinearity due to ponderomotive force which arises on account of nonuniform intensity distribution of the laser beam is *** nonlinear partial differential equation governing the evaluation of complex envelope in the slowly varying envelope approximation is solved using a paraxial *** self-focusing mechanism in magnetized plasma,in the presence of self-compression mechanism will be analyzed in contrast to the case in which it is *** can be observed that,in case of ponderomotive nonlinearity,the self-compression mechanism obstructs the pulse self-focusing above a certain intensity *** effect of an external magnetic field is to generate pulses with smaller spot size and shorter compression *** lateral separation parameter and the initial intensity of the laser beam play a crucial role on focusing and compression ***,the three-dimensional analysis of pulse propagation is presented by coupling the self-focusing equation with the self-compression one.

关键词： self-focusing quadruple Gaussian beam magnetoplasma spatiotemporal ponderomotive force

An intuitive general rank-based correlation coefficient

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Frontiers of Information Technology & Electronic Engineering 2018年第6期19卷 699-711页

作者： Divya PANDOVE shivani GOEL Rinkle RANI Research Lab Computer Science and Engineering Department Thapar University Department of Computer Science Engineering School of Engineering and Applied SciencesBennett University Computer Science and Engineering Department Thapar University

Correlation analysis is an effective mechanism for studying patterns in data and making *** interesting discoveries have been made by formulating correlations in seemingly unrelated data. We propose an algorithm to quantify the theory of correlations and to give an intuitive, more accurate correlation *** propose a predictive metric to calculate correlations between paired values, known as the general rank-based correlation coefficient. It fulfills the five basic criteria of a predictive metric： independence from sample size,value between-1 and 1, measuring the degree of monotonicity, insensitivity to outliers, and intuitive ***, the metric has been validated by performing experiments using a real-time dataset and random number simulations. Mathematical derivations of the proposed equations have also been provided. We have compared it to Spearman＇s rank correlation coefficient. The comparison results show that the proposed metric fares better than the existing metric on all the predictive metric criteria.

关键词： General rank-based correlation coefficient Multivariate analysis Predictive metric Spearman's rankcorrelation coefficient

Formation of E-cyanomethamine in a nitrile rich environment

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Research in Astronomy and Astrophysics 2017年第1期17卷 1-10页

作者： shivani Alka Misra Poonam Tandon Department of Mathematics & Astronomy University of Lucknow Lucknow India Department of Physics University of Lucknow Lucknow 226007 India

Recently a new molecule, cyanomethamine, has been detected towards Sagittarius B2（N）（Sgr B2（N））. Studying the formation mechanisms of complex interstellar molecules is difficult. Hence, a theoretical quantum chemical approach for analyzing the reaction mechanism describing the forma- tion of interstellar cyanomethamine through detected interstellar molecules and radicals （NCCN＋H） is discussed in the present work. Calculations are performed by using quantum chemical techniques, such as Density Functional Theory （DFT） and Mφ11er-Plesset perturbation （MP2） theory with a 6-311G（d,p） basis set, both in the gas phase and in icy grains. The proposed reaction path （NCCN＋H＋H） has exother- micity with no barrier which indicates the possibility of cyanomethamine formation in the interstellar medium.

关键词： interstellar medium: abundances general - general: extraterrestrial intelligence - mete-orites - individual: Sgr B2(N) region

Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 117-129页

作者： shivani Verma Puneet Utreja Department of Pharmaceutics Rayat-Bahra College of Pharmacy I. K. Gujral Punjab Technical University Faculty of Pharmaceutical Sciences Department of Pharmaceutics PCTE Group of Institutes

Occurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immunocompromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Although, a large number of antifungal agents are available for treatment of skin fungal infections, but, their toxic profile and physicochemical characteristics reduce therapeutic outcome. When these antifungal agents are delivered topically using conventional formulations like creams and gels, they may cause various side effects like redness, burning, and swelling at the site of application. Therefore, various vesicular formulations(phospholipid based or non phospholipid based) have been explored by pharmaceutical scientists to treat skin fungal infections topically. Vesicular formulation explored for the purpose are liposomes, ethosomes, transfersomes, transethosomes, niosomes, spanlastics, oleic acid vesicles, and *** formulations show various advantages like bioavailability enhancement of bioactives,high skin permeation power, no side effects at application site, dosing frequency reduction,and sustained drug release. Therefore, in the present article, we have discussed about the utility of various vesicular nanocarrier systems to treat skin fungal infections.

关键词： Conventional Nanoparticle Spanlastics Transfersomes Vesicular

Self-Focusing of Quadruple Gaussian Laser Beam in an Inhomogenous Magnetized Plasma with Ponderomotive Non-Linearity:Effect of Linear Absorption

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Communications in Theoretical Physics 2015年第11期64卷 565-570页

作者： Munish Aggarwal shivani Vij Niti Kant Department of Physics Lyallpur Khalsa College of Engineering Department of Applied Sciences DAV Institute of Engineering & Technology Department of Physics Lovely Professional University

The propagation of quadruple Gaussian laser beam in a plasma characterized by axial inhomogeneity and nonlinearity due to ponderomotive force in the paraxial ray approximation is *** appropriate expression for the nonlinear dielectric constant has been developed in the presence of external magnetic field,with linear absorption and due to saturation effects for arbitrary large *** effects of different types of plasma axial inhomogeneities on self-focusing of laser beam have been studied with the typical laser and plasma ***-focusing of quadruple Gaussian laser beam in the presence of externally applied magnetic field and saturating parameter is found significantly improved in the case of extraordinary *** results reveal that initially converging beam shows oscillatory convergence whereas initially diverging beam shows oscillatory *** beam is more focussed at lower intensity in both cases *** and ordinary mode.

关键词： self-focusing quadruple inhomogeneous magnetized p