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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1126-1134页

作者： Behrouz Azimian shiva Moshtagh Anamitra Pal Shanshan Ma School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85281USA the School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85281USA Quanta Technology RaleighNC 27607USA

Recently,we demonstrated the success of a time-synchronized state estimator using deep neural networks(DNNs)for real-time unobservable distribution *** this paper,we provide analytical bounds on the performance of the state estimator as a function of perturbations in the input *** has already been shown that evaluating perfor-mance based only on the test dataset might not effectively indi-cate the ability of a trained DNN to handle input *** such,we analytically verify the robustness and trustworthi-ness of DNNs to input perturbations by treating them as mixed-integer linear programming(miLP)*** ability of batch normalization in addressing the scalability limitations of the miLP formulation is also *** framework is val-idated by performing time-synchronized distribution system state estimation for a modified IEEE 34-node system and a real-world large distribution system,both of which are incompletely observed by micro-phasor measurement units.

关键词： Deep neural network(DNN) distribution system state estimation(DSSE) mixed-integer linear programming(miLP) robustness trustworthiness

Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

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Cellular & Molecular Immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie R.Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti michael V.Volin M.Asif Amin Myles J.Lewis Costantino Pitzalis shiva ar.mi Joseph A.Karam Nadera J.Sweiss shiva Shahrara Jesse Brown VA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental Medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated mitofusin-2 and DRP1 *** found that VEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of VEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HIF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

On a Partially Non-Stationary Vector ar Model with Vector GarCH Noises:Estimation and Testing

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Communications in Mathematical Research 2024年第1期40卷 64-101页

作者： Chor-yiu Sin Zichuan mi Shiqing Ling Department of Economics National Tsing Hua UniversityHsinchu 30013TaiwanP.R.China School of Statistics Shanxi University of Finance and EconomicsTaiyuan 030006P.R.China Department of Mathematics The Hong Kong University of Science and TechnologyKowloonHong KongSARP.R.China

This paper studies a partially nonstationary vector autoregressive(Var)model with vector GarCH *** study the full rank and the reduced rank quasi-maximum likelihood estimators(QMLE)of parameters in the *** is shown that both QMLE of long-run parameters asymptotically converge to a functional of two correlated vector Brownian *** these,the likelihood ratio(LR)test statistic for cointegration rank is shown to be a functional of the standard Brownian motion and normal vector,*** far as we know,our test is new in the *** critical values of the LR test are simulated via the Monte Carlo *** performance of this test in finite samples is examined through Monte Carlo *** apply our approach to an empirical example of three interest rates.

关键词： Vector ar model cointegration full rank estimation vector GarCH process partially nonstationary reduced rank estimation

脉冲磁场幅值对制备聚硅氧烷复合材料的电磁屏蔽性能影响规律

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高电压技术 2024年第7期50卷 3249-3257页

作者：米彦刘灿辉朱亚奎陈勇李政民输变电装备技术全国重点实验室(重庆大学电气工程学院) 重庆400044

脉冲磁场已被证实通过诱导纳米粒子在基体中取向排列可以显著提高复合材料的电磁屏蔽性能,然而脉冲磁场幅值对复合材料电磁屏蔽性能的影响规律尚不明确。因此,采用脉宽为10μs、频率为50Hz的脉冲磁场诱导片状羰基铁(flaky carbonyl iron... 详细信息

脉冲磁场已被证实通过诱导纳米粒子在基体中取向排列可以显著提高复合材料的电磁屏蔽性能,然而脉冲磁场幅值对复合材料电磁屏蔽性能的影响规律尚不明确。因此,采用脉宽为10μs、频率为50Hz的脉冲磁场诱导片状羰基铁(flaky carbonyl iron,FCI)在聚二甲基硅氧烷(polydimethylsiloxane,PDMS)中定向排列,研究磁场幅值(0~0.7T)对复合材料电磁屏蔽性能的影响规律。用扫描电子显微镜(scanning electron microscope,SEM)和X射线衍射(X-ray diffraction,XRD)对纳米粒子的取向和排列进行了表征。结果表明,脉冲磁场可以有效控制羰基铁的取向和排列,形成导电网络结构,提高复合材料的导电性,最终显著提高取向复合材料的电磁屏蔽性能。脉冲磁场对复合材料的屏蔽效能增强效果可达27%,达到的最高屏蔽效率为15.36dB。理论分析和实验结果的一致性证实了微秒级脉冲磁场在改善复合材料电磁屏蔽性能方面的有效性。该研究制备的高性能柔性电磁屏蔽复合材料具有应用于先进电子设备的潜力。

关键词：微秒脉冲磁场取向聚硅氧烷羰基铁电磁屏蔽

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数字化技术在建筑设计中的应用

工程建设（维泽科技） 2024年第9期7卷 165-167页

作者：米峰河北建筑设计研究院有限责任公司河北石家庄050000

随着科技的飞速发展,数字化技术已经渗透到了各个行业,建筑设计行业也不例外。建筑设计是建筑行业的重要组成部分,而数字化技术的应用正在改变着建筑设计的方式。通过引入数字化技术,建筑设计不仅可以提高工作效率,还可以提升设计质量... 详细信息

随着科技的飞速发展,数字化技术已经渗透到了各个行业,建筑设计行业也不例外。建筑设计是建筑行业的重要组成部分,而数字化技术的应用正在改变着建筑设计的方式。通过引入数字化技术,建筑设计不仅可以提高工作效率,还可以提升设计质量和创新性数字化技术逐渐成为建筑设计的重要工具。文中旨在探讨数字化技术在建筑设计中的应用,包括计算机辅助设计(CAD)、建筑信息模型(BIM)、虚拟现实(VR)和增强现实(ar)等方面,以及这些技术如何提高设计效率、协作能力和创新能力。

关键词：数字化技术建筑设计应用

Mechanochemical spinodal decomposition: a phenomenological theory of phase transformations in multi-component, crystalline solids

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npj Computational Materials 2016年第1期2卷 133-141页

作者： shiva Rudraraju Anton Van der Ven Krishna Garikipati Department of Mechanical Engineering University of MichiganAnn ArborMIUSA Materials Department University of CaliforniaSanta BarbaraCAUSA Department of Mathematics University of MichiganAnn ArborMIUSA

We present a phenomenological treatment of diffusion-driven martensitic phase transformations in multi-component crystalline solids that arise from non-convex free energies in mechanical and chemical *** treatment describes diffusional phase transformations that are accompanied by symmetry-breaking structural changes of the crystal unit cell and reveals the importance of a mechanochemical spinodal,defined as the region in strain–composition space,where the free-energy density function is *** approach is relevant to phase transformations wherein the structural order parameters can be expressed as linear combinations of strains relative to a high-symmetry reference *** governing equations describing mechanochemical spinodal decomposition are variationally derived from a free-energy density function that accounts for interfacial energy via gradients of the rapidly varying strain and composition fields.A robust computational framework for treating the coupled,higher-order diffusion and nonlinear strain gradient elasticity problems is *** the local strains in an inhomogeneous,transforming microstructure can be finite,the elasticity problem must account for geometric *** evaluation of available experimental phase diagrams and first-principles free energies suggests that mechanochemical spinodal decomposition should occur in metal hydrides such as ZrH_(2−2c).The rich physics that ensues is explored in several numerical examples in two and three dimensions,and the relevance of the mechanism is discussed in the context of important electrode materials for Li-ion batteries and high-temperature ceramics.

关键词： microstructure phase chemical

PRISMS-PF:A general framework for phase-field modeling with a matrix-free finite element method

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npj Computational Materials 2020年第1期6卷 1421-1432页

作者： Stephen DeWitt shiva Rudraraju David Montiel W.Beck Andrews Katsuyo Thornton University of michigan Department of Materials Science and Engineering2300 Hayward St.Ann ArborMI 48109USA University of michigan Department of Mechanical Engineering2350 Hayward St.Ann ArborMI 48109USA University of Wisconsin MadisonWI 53706USA

A new phase-field modeling framework with an emphasis on performance,flexibility,and ease of use is *** among the strategies employed to fulfill these objectives are the use of a matrix-free finite element method and a modular,application-centric code *** approach is implemented in the new open-source PRISMS-PF *** performance is enabled by the combination of a matrix-free variant of the finite element method with adaptive mesh refinement,explicit time integration,and multilevel *** testing with a particle growth problem shows PRISMS-PF with adaptive mesh refinement and higher-order elements to be up to 12 times faster than a finite difference code employing a second-order-accurate spatial discretization and first-order-accurate explicit time integration.

关键词： structure finite element

Spatial non-stationary characteristics between temperate grasslands based on a mixed geographically weighted regression model

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Journal of Geographical Sciences 2022年第6期32卷 1076-1102页

作者： SONG Xiaolong mi Nan mi Wenbao LI Longtang College of Agriculture Ningxia UniversityYinchuan 750021China School of Geography and Planning Ningxia UniversityYinchuan 750021China

Spatial models are effective in obtaining local details on grassland biomass,and their accuracy has important practical significance for the stable management of grasses and *** this end,the present study utilized measured quadrat data of grass yield across different regions in the main growing season of temperate grasslands in Ningxia of China(August 2020),combined with hydrometeorology,elevation,net primary productivity(NPP),and other auxiliary data over the same ***,non-stationary characteristics of the spatial scale,and the effects of influencing factors on grass yield were analyzed using a mixed geographically weighted regression(MGWR)*** results showed that the model was suitable for correlation *** spatial scale of ratio resident-area index(PRI)was the largest,followed by the digital elevation model,NPP,distance from gully,distance from river,average July rainfall,and daily temperature range;whereas the spatial scales of night light,distance from roads,and relative humidity(RH)were the most *** influencing factors maintained positive and negative effects on grass yield,save for the strictly negative effect of *** regression results revealed a multiscale differential spatial response regularity of different influencing factors on grass *** parameters revealed that the results of Ordinary least squares(OLS)(Adjusted R^(2)=0.642)and geographically weighted regression(GWR)(Adjusted R^(2)=0.797)models were worse than those of MGWR(Adjusted R^(2)=0.889)*** on the results of the RMSE and radius index,the simulation effect also was MGWR>GWR>OLS ***,the MGWR model held the strongest prediction performance(R^(2)=0.8306).Spatially,the grass yield was high in the south and west,and low in the north and east of the study *** results of this study provide a new technical support for rapid and accurate estimation of grassland yield to dynamically adjust grazing decision in the semi-ar

关键词： grass yield spatial non-stationary mixed geographically weighted regression model temperate grassland Ningxia

IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion

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Cellular & Molecular Immunology 2021年第9期18卷 2199-2210页

作者： Sadiq Umar Karol Palasiewicz Katrien Van Raemdonck michael V.Volin Bianca Romay MAsif Amin Ryan K.Zomorrodi shiva ar.mi Mark Gonzalez Vikram Rao Brian Zanotti David A.Fox Nadera Sweiss shiva Shahrara Jesse Brown VA Medical Center ChicagoIL60612USA Department of Medicine Division of RheumatologyUniversity of Illinois at ChicagoChicagoIL60612USA Department of microbiology and Immunology Midwestern UniversityDowners GroveIL60515USA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMI481096USA Department of Orthopedic Surgery University of Illinois at ChicagoChicagoIL60612USA Pfizer Research CambridgeMA02139USA

Flares of joint inflammation and resistance to currently available biologic therapeutics in rheumatoid arthritis(RA)patients could reflect activation of innate immune ***,we show that a TLR7 GU-rich endogenous ligand,miR-Let7b,potentiates synovitis by amplifying RA monocyte and fibroblast(FLS)***-Let7b ligation to TLR7 in macrophages(MΦs)and FLSs expanded the synovial inflammatory ***,secretion of M1 monokines triggered by miR-Let7b enhanced Th1/Th17 cell *** showed that IRAK4 inhibitor(i)therapy attenuated RA disease activity by blocking TLR7-induced M1 MΦor FLS activation,as well as monokine-modulated Th1/Th17 cell ***4i therapy also disrupted RA osteoclastogenesis,which was amplified by miR-Let7b ligation to joint myeloid ***,the effectiveness of IRAK4i was compared with that of a TNF inhibitor(i)or anti-IL-6R treatment in collagen-induced arthritis(CIA)and miR-Let7b-mediated *** found that TNF or IL-6R blocking therapies mitigated CIA by reducing the infiltration of joint F480+iNOS+MΦs,the expression of certain monokines,and Th1 cell ***,these biologic therapies were unable to alleviate miR-Let7b-induced *** superior efficacy of IRAK4i over anti-TNF or anti-IL-6R therapy in miR-Let7b-induced arthritis or CIA was due to the ability of IRAK4i therapy to restrain the migration of joint F480+iNOS+MΦs,vimentin+fibroblasts,and CD3+T cells,in addition to negating the expression of a wide range of monokines,including IL-12,miP2,and IRF5 and Th1/Th17 *** conclusion,IRAK4i therapy may provide a promising strategy for RA therapy by disconnecting critical links between inflammatory joint cells.

关键词： TLR7 MΦs RA FLSs osteoclasts T cells IRAK4

The effect of diet-induced insulin resistance on DNA methylation of the androgen receptor promoter in the penile cavernosal smooth muscle of mice

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Asian Journal of Andrology 2013年第4期15卷 487-491,I0007页

作者： Jin-Wook Kim mi-mi Oh Cheol-Yong Yoon Jae-Hyun Bae Je-Jong Kim Du-Geon Moon Department of Urology Korea University Medical Center Guro Hospital Seou1152-703 Korea and Department of Urology Korea University College of Medicine Seou1152 703 Korea

Population studies have suggested an association between diabetes and the symptoms of testosterone deficiency. Recently, the expression of the androgen receptor （ar） has been shown to be decreased in diabetic patients. Furthermore, diabetes has been shown to induce global methylation. In this study, we used an animal model to investigate whether diabetes results in increased methylation of the ar promoter and whether these changes are associated with the decreased expression of ar in penile cavernosal smooth muscle tissue. Twenty C57BL/6J mice were divided into two groups, receiving either high- （mature diabetic） or low- （mature control） caloric meals for 14 weeks. Another 10 mice were killed at 1 week （young control）. Animals in the mature diabetic group showed decreased testosterone levels, although this was not statistically significant. In both control groups, no significant methylation was observed in the ar promoter region CpG island （-85 to ＋339）. In the mature diabetic group, significant methylation was observed at ＋ 185 and ＋200 of the ar promoter. These changes were associated with increased homeostatic model assessment for insulin resistance （HOMA-IR） and decreased corpus cavernosal tissue mass and expression of ar mRNA and protein. We conclude that in these animals, insulin resistance increased the methylation of the GC-rich regions of the ar promoter, leading to decreased ar expression.

关键词： androgen receptor (ar) diabetes DNA methylation