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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 27-32页

作者： Praveen Sharma Barjesh Chander Sharma shiv kumar Sarin Department of Gastroenterology G.B.Pant Hospital

BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic *** of MHE requires cumbersome *** is effective in the treatment of *** study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after ***:One hundred and ten patients were evaluated by psychometry (number connection tests A,B or figure connection tests A,B),P300 auditory event related potential (P300ERP),venous ammonia,and CFF for *** was diagnosed by abnormal psychometry (>2SD age matched controls) and *** patients were treated with lactulose for one *** was defined by normalization (<2SD of matched controls) of both psychometry and ***:Of the 110 patients [Child Turcott Pugh score A:B:C 39:42:29,(age 41.6±11.6 years,M:F 82:28)],75 (68%) had abnormal results of psychometric tests,and 74 (67%) had prolonged *** (20%) patients with abnormal results of psychometric tests had normal *** sixty (54.5%) patients were diagnosed as having *** treatment for one month,34 (57%) recovered while 26 (43%) continued to have abnormal resents of psychometric or P300ERP *** was <39 Hz in 72 (65.4%) patients before treatment and in 20 (33.3%) after *** sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy for the assessment of recovery of MHE were 65%,91%,85%,77% and 80%,***:CFF is a simple,relatively reliable,and accurate test without any dependence on age or literacy in the diagnosis and assessment of recovery of patients with MHE.

关键词： minimal hepatic encephalopathy critical flicker frequency lactulose

Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms

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Cancer Drug Resistance 2020年第4期3卷 742-761页

作者： shiv Verma kumari Sunita Prajapati Prem Prakash Kushwaha Mohd Shuaib Atul kumar Singh Shashank kumar Sanjay gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA School of Basic and Applied Sciences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOH 44106USA

Androgen deprivation therapy targeting the androgens/androgen receptor(AR)signaling continues to be the mainstay treatment of advanced-stage prostate *** use of second-generation antiandrogens,such as abiraterone acetate and enzalutamide,has improved the survival of prostate cancer patients;however,a majority of these patients progress to castration-resistant prostate cancer(CRPC).The mechanisms of resistance to antiandrogen treatments are complex,including specific mutations,alternative splicing,and amplification of oncogenic proteins resulting in dysregulation of various signaling *** this review,we focus on the major mechanisms of acquired resistance to second generation antiandrogens,including AR-dependent and AR-independent resistance mechanisms as well as other resistance mechanisms leading to CRPC *** knowledge of resistance mechanisms to AR targeted treatments will lead to additional research on designing more effective therapies for advanced-stage prostate cancer.

关键词： Prostate cancer second-generation antiandrogens androgen receptor castration resistance prostate cancer

Pullout of soil nail with circular discs: A three-dimensional finite element analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第5期9卷 967-980页

作者： Saurabh Rawat Ashok kumar gupta Anil kumar Department of Civil Engineering Jaypee University of Information Technology Waknaghat Solan 173234 Himachal Pradesh India

An internal failure mode for a soil-nailed system consists of failure at nail heads,slope facing,nail strength,along groutesoil interface and pullout failure.A better understanding of pullout of soil nail thus becomes important to assess the stability of a soil-nailed *** the present study,an investigation into the pullout behaviour of soil nail with circular discs along the shaft has been carried out by a threedimensional finite element analysis using Abaqus/Explicit routine.A total of 67 simulations have been performed to accurately predict the pullout behaviour of soil *** soil nail under study has circular discs along its shaft varying in numbers from 1 to *** pullout of this soil nail in a pullout test box has been simulated with a constant overburden pressure of 20 kPa acting on the *** pullout load edisplacement characteristics,stresses around soil nail and failure mechanism during pullout are *** of dimensionless factors such as normalised pullout load factor and bearing capacity factor have been obtained with different combinations of parameters in terms of relative disc spacing ratio,anchorage length ratio,embedment ratio,diameter ratio and displacement *** the results of analyses,it is found that nail with more circular discs requires higher pullout *** are critical relative disc spacing ratio and diameter ratio which significantly affect the pullout behaviour of nail.

关键词： Pullout behaviour Finite element analysis Soil nail Circular discs Dimensionless factors

Identification and characterization of genotype A and D recombinant hepatitis B virus from Indian chronic HBV isolates

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World Journal of Gastroenterology 2008年第40期14卷 6228-6236页

作者： Ranjit Chauhan Syed Naqui Kazim Manoj kumar Jayashree Bhattacharjee Narayanasamy Krishnamoorthy shiv kumar Sarin Department of Gastroenterology and Advanced Center for Liver Diseases G.B.Pant Hospital Department of Biochemistry Lady Hardinge Medical College Centre for Interdisciplinary Research in Basic Sciences The Centre for Genomic Application

AIM： To confirm the presence of recombination, fulllength hepatitis B virus （HBV） from chronic patients was sequenced and analyzed. METHODS： Full-length HBV genomes from 12 patients were amplified and sequenced in an automated sequencer. Phylogenetic analysis was carried out on full-length, Core and preS2/Surface regions using MEGA software. SimPIot Boot Scanning and amino acid sequence analysis were performed for confirmation of recombination. RESULTS： Eight patients were infected with genotype D strain; one patient with genotype A and three patients had genotype A and D recombination; two of them had cirrhosis and one had hepatocellular carcinoma. Phylogenetic analysis of core and preS2/surface regions separately showed evidence of genotype A and D recombination. The breakpoints of recombination were found to be at the start of preS2 and at the endof surface coding regions. CONCLUSION： We identified and characterized recombinant A and D genotype HBV in hepatitis B surface antigen （HBsAg）-positive patients.

关键词： Hepatitis B virus Genotype Variation Evolution Recombination

Prediction of COVID-19 Confirmed, Death, and Cured Cases in India Using Random Forest Model

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Big Data Mining and Analytics 2021年第2期4卷 116-123页

作者： Vishan kumar gupta Avdhesh gupta Dinesh kumar Anjali Sardana Department of Computer Science and Engineering(CSE) Graphic Era Deemed to be UniversityDehradun 248002India Department of CSE IMS Engineering CollegeGhaziabad 201009India Department of CSE KIET Group of InstitutionsGhaziabad 201206India

A novel coronavirus(SARS-CoV-2) is an unusual viral pneumonia in patients, first found in late December 2019, latter it declared a pandemic by World Health Organizations because of its fatal effects on public health. In this present, cases of COVID-19 pandemic are exponentially increasing day by day in the whole world. Here, we are detecting the COVID-19 cases, i.e., confirmed, death, and cured cases in India only. We are performing this analysis based on the cases occurring in different states of India in chronological dates. Our dataset contains multiple classes so we are performing multi-class classification. On this dataset, first, we performed data cleansing and feature selection, then performed forecasting of all classes using random forest, linear model, support vector machine,decision tree, and neural network, where random forest model outperformed the others, therefore, the random forest is used for prediction and analysis of all the results. The K-fold cross-validation is performed to measure the consistency of the model.

关键词： coronavirus COVID-19 respiratory tract multi-class classification random forest

Development of a panel of unigene-derived polymorphic EST–SSR markers in lentil using public database information

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The Crop Journal 2016年第5期4卷 425-433页

作者： Debjyoti Sen gupta Peng Cheng Gaurav Sablok Dil Thavarajah Pushparajah Thavarajah Clarice J.Coyne shiv kumar Michael Baum Rebecca J.McGee Department of Plant Sciences North Dakota State University ICAR-ARS Indian Institute of Pulses Research Division of Plant Sciences University of Missouri Department of Biodiversity and Molecular Ecology Research and Innovation Centre Fondazione Edmund Mach Agricultural and Environmental Sciences Clemson University International College Beijing China Agricultural University USDA-ARS Western Regional Plant Introduction Station Washington State University BIGM Program International Center for Agricultural Research in the Dry Areas (ICARDA) USDA-ARS Grain Legume Genetics and Physiology Research Unit Washington State University

Lentil(Lens culinaris Medik.), a diploid(2n = 14) with a genome size greater than 4000 Mbp, is an important cool season food legume grown worldwide. The availability of genomic resources is limited in this crop species. The objective of this study was to develop polymorphic markers in lentil using publicly available curated expressed sequence tag information(ESTs). In this study, 9513 ESTs were downloaded from the National Center for Biotechnology Information(NCBI) database to develop unigene-based simple sequence repeat(SSR) markers. The ESTs were assembled into 4053 unigenes and then analyzed to identify 374 SSRs using the MISA microsatellite identification tool. Among the 374 SSRs, 26 compound SSRs were *** pairs for these SSRs were designed using Primer3 version 1.14. To classify the functional annotation of ESTs and EST–SSRs, BLASTx searches(using E-value 1 × 10-5) against the public UniP rot(http://***/) and NCBI(http://***/) databases were performed. Further functional annotation was performed using PLAZA(version3.0) comparative genomics and GO annotation was summarized using the Plant GO slim category. Among the synthesized 312 primers, 219 successfully amplified Lens DNA. A diverse panel of 24 Lens genotypes was used to identify polymorphic markers. A polymorphic set of 57 markers successfully discriminated the test genotypes. This set of polymorphic markers with functional annotation data could be used as molecular tools in lentil breeding.

关键词： Lens culinaris EST-SSRs Functional annotation Unigene sequences EST database Genetic resources

Design of a 2-DOF-PID controller using an improved sine-cosine algorithm for load frequency control of a three-area system with nonlinearities

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Protection and Control of Modern Power Systems 2022年第1期7卷 490-507页

作者： Neelesh kumar gupta Manoj kumar Kar Arun kumar Singh Department of Electrical Engineering NIT JamshedpurJamshedpurJharkhand 831014India

This paper proposes an improved sine-cosine algorithm(ISCA)based 2-DOF-PID controller for load frequency control.A three-area test system is built for study,while some physical constraints(nonlinearities)are considered for the investigation of a realistic power *** proposed method is used as the parameter optimizer of the LFC control-ler in different *** 2-DOF-PID controllers are used because of their capability of fast disturbance rejection without significant increase of overshoot in set-point *** 2-DOF-PID controllers’efficacy is observed by examining the responses with the outcomes obtained with PID and FOPID *** simulation results with the suggested scheme are correlated with some of the existing algorithms,such as SCA,SSA,ALO,and PSO in three dif-ferent scenarios,i.e.,a disturbance in two areas,in three areas,and in the presence of physical *** addition,the study is extended to a four-area power *** analysis is performed using the Wilcoxon Sign Rank Test(WSRT)on 20 independent *** confirms the supremacy of the proposed method.

关键词： 2-DOF-PID FOPID Load frequency control WSRT Statistical analysis Improved sine-cosine algorithm

Numerical modelling of pullout of helical soil nail

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第4期9卷 648-658页

作者： Saurabh Rawat Ashok kumar gupta Department of Civil Engineering Jaypee University of Information Technology Waknaghat Solan 173234 India

An investigation into the pullout response of helical soil nail using finite element subroutine Plaxis 2D is *** numerical modelling of actual pullout response is achieved by axisymmetric and horizontal loading *** effect of varying number of helical plates,helical plate spacing and helical plate diameter is studied to understand the pullout capacity *** failure surfaces for various helical soil nail configurations and their pullout mechanisms are also analysed and *** pullout capacity is found to increase with increase in number of helical *** helical plate spacing ratio（s/D;） and diameter ratio（D;/D;） are found to increase the pullout only up to a critical *** response of helical soil nail using axisymmetric finite element simulation is found similar to the uplift behaviour of helical piles and helical soil *** the absence of literature regarding numerical modelling of helical soil nail,simulation results are validated with uplift responses of helical piles and soil anchors.A good agreement in their comparative study for pullout response is also observed.

关键词： Finite element Helical soil nail Pullout response Plate spacing Plate diameter Failure mechanism

Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra kumar Pandey shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

Prediction and optimization of machining forces using oxley’s predictive theory and RSM approach during machining of WHAs

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Defence Technology（防务技术） 2019年第6期15卷 923-935页

作者： Chithajalu Kiran Sagar Tarun kumar Amrita Priyadarshini Amit kumar gupta Mechanical Engineering Department BITS-PilaniHyderabad Campus

Tungsten heavy alloys have come up as one of the best alternatives for high density fragmenting devices and armor piercing *** is mandatory for obtaining the final shapes of such kind of ***,due to high density and elastic stiffness of WHAs,cutting forces will be higher than for most of the metals and alloys;thus,making the machining operation *** machining variable,namely,cutting force components are significantly influenced by the cutting *** paper makes use of Oxley’s predictive analytical model in conjunction with Johnson-Cook constitutive equation to predict forces under different speed and feed combinations during machining of 95 W tungsten heavy *** cutting forces,so predicted by Ml,are considered as input data for the optimization of cutting parameters(cutting speed and feed)using Response Surface Method(RSM).

关键词： Tungsten heavy alloy Machinability Response surface method Oxley’s method