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Testing the LCC hypothesis by considering environmental sustainability and economic development:Role of green energy and resource management

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Geoscience Frontiers 2024年第3期15卷 419-430页

作者： Sunil Tiwari Syed Ali Raza shiv kumar gupta Irum Shahzadi Mahendra Babu Kuruva Department of Tourism Studies School of Business StudiesCentral University of KeralaIndia Department of Business Administration IQRA UniversityKarachi 75300Pakistan Centre for Mountain Tourism and Hospitality Studies HNB Garhwal Central UniversitySrinagarUttarakhand 246174India Department of Production Engineering São Paulo State University(UNESP)BauruBrazil Department of Business Administration IQRA University Karachi-75300Pakistan Department of Business Management HNB Garhwal Central UniversitySrinagar GarhwalUttarakhand 246174India

This study aims to demystify the role of green energy and green technology in establishing the nexus between behavioural intentions of tourists,technologies,and digital payments by using Perceived value(PV),Compatibility(CO),Perceived Enjoyment(PE),and Social Influence(SI)as a predictor variables,Trust(TR)and Satisfaction(SA)as a mediating variables and Behavioural Intentions(BI)as an outcome *** the empirical estimation,we employ smart PLS-SEM,TAM(Technology Acceptance Model)and SPSS and Tested the LCC *** findings suggest that green energy and perceived value have the highest positive impact on tourists’trust towards digital payments followed by compatibility,social influence and perceived ***,tourists’satisfaction and green technology is one of the important determinants of choosing any digital mode of payment,is mostly influence by perceived value,perceived enjoyment,compatibility and social ***,if we choose between trust and satisfaction,trust plays a significant role in exploring the behavioural intentions of tourists about green energy and green technology followed by tourists’*** addition,Tourists’trust and satisfaction are highly correlated and influence each *** study offers novel policy implications in terms of use of green technology and green energy in enhancing trust and satisfaction of tourists in order to deeper understanding of different dimensions of digital payments and M-wallets,and allowing them to explore the long-term value inherent of digital payments and M-wallets.

关键词： Digital payment Green technology Green energy Tourism LCC hypothesis

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Comparative H2S Sensing Characteristics of Fe2O3: Thin Film vs. Bulk

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Soft Nanoscience Letters 2013年第4期3卷 6-8页

作者： Vishal Balouria Ajay Singh Niranjan Suryakant Ramgir Anil Krishan Debnath Aman Mahajan Ratish kumar Bedi Dinesh kumar Aswal shiv kumar gupta Material Science Laboratory Department of Physics Guru Nanak Dev University Amritsar India. Technical Physics Division Bhabha Atomic Research Center Mumbai India Technical Physics Division Bhabha Atomic Research Center Mumbai India

Comparative investigations of gas sensing characteristics of Fe2O3 in both thin film as well as bulk forms have been performed. Thin film sensors were realized by first depositing Fe films using electron-beam evaporation followed by thermal oxidation. Bulk sensors in the form of pellets were prepared by cold pressing commercial Fe2O3 powder with subsequent sintering. Both thin film and bulk Fe2O3 sensors exhibited a selective and reversible response characteristics towards H2S with maximum response at an operating temperature of 250°C and 200°C, respectively. A negligible response towards other interfering gases was observed. Thin film sensors exhibited an enhanced response in comparison to that of pellets.

关键词： Fe2O3 Thin Film Pellets H2S Sensor

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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla gupta Arvind kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

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Population structure analysis and determination of neurotoxin content in a set of grass pea (Lathyrus sativus L.) accessions of Bangladesh origin

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The Crop Journal 2018年第4期6卷 435-442页

作者： Priyanka gupta Sripada M. Udupa Debjyoti Sen gupta Jitendra kumar shiv kumar International Center for Agricultural Research in the Dry Areas Rabat Institute Rabat Morocco Department of Plant Sciences North Dakota State University Fargo ND 58105 USA ICAR-Indian Institute of Pulses Research Kanpur Uttar Pradesh 208024 India

Grass pea(Lathyrus sativus L.) is a crop that is considered one of the more resilient to climate change. With protein-rich seeds and leaves, it has strong potential as human food as well as animal feed and fodder. However, genetic improvement in this crop remains stagnant owing to the poor characterization of its genetic resources. In this study, we characterized 118 accessions of grass pea with 18 EST-SSR markers. A total of 118 accessions, 101 of L. sativus(100 cultivated accessions from Bangladesh and one wild accession) and 17 wild accessions of other Lathyrus species, were used. A total of 67 alleles were detected, with an average of 3.72 alleles per locus and average polymorphism information content of 0.52. A dissimilarity matrix was formed and hierarchical cluster analysis performed using the UPGMA method grouped genotypes into four main clusters. Cluster analysis based on the genetic dissimilarity revealed a clear grouping of the 100 cultivated and 18 wild accessions into four main groups. Group I consisted of 20 accessions with high β-N-oxalyl-L-α,β-diaminopropionic acid(β-ODAP) concentration. Of these 20 accessions, 17 were wild accessions. Only one wild accession(L. cicera) was clustered in group II, which contained 35 accessions. Most of the group II accessions contained low β-ODAP. Group III was represented by 34 accessions, many of them with high β-ODAP. Group IV consisted of 29 accessions, a few of which had very high β-ODAP concentrations. Analysis of molecular variance of the microsatellite data showed significantly higher values of molecular variance between(83%) than within(17%) populations. These characterized accessions will be useful in grass pea breeding programs.

关键词： Lathyrus Population structure EST-SSRβ-ODAP Genetic diversity

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Role of prostate cancer stem-like cells in the development of antiandrogen resistance

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Cancer Drug Resistance 2022年第2期5卷 459-471页

作者： Prem Prakash Kushwaha shiv Verma Shashank kumar Sanjay gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA. The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA. Molecular Signaling and Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India. Department of Pathology Case Western Reserve UniversityClevelandOH 44106USA. Department of Pharmacology Case Western Reserve UniversityClevelandOH 44106USA. Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA. Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA.

Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate *** with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate cancer(CRPC).Present research establishes that prostate cancer stem-like cells(CSCs)play a central role in the development of treatment resistance followed by disease *** CSCs are capable of self-renewal,differentiation,and regenerating tumor *** stemness properties in prostate CSCs arise due to various factors such as androgen receptor mutation and variants,epigenetic and genetic modifications leading to alteration in the tumor microenvironment,changes in ATP-binding cassette(ABC)transporters,and adaptations in molecular signaling *** reprograms prostate tumor cellular machinery leading to the expression of various stem cell markers such as Aldehyde Dehydrogenase 1 Family Member A1(ALDH1A1),Prominin 1(PROM1/CD133),Indian blood group(CD44),SRY-Box Transcription Factor 2(Sox2),POU Class 5 Homeobox 1(POU5F1/Oct4),Nanog and ABC *** markers indicate enhanced self-renewal and stemness stimulating CRPC evolution,metastatic colonization,and resistance to *** this review,we discuss the role of ADT in prostate CSCs differentiation and acquisition of CRPC,their isolation,identification and characterization,as well as the factors and pathways contributing to CSCs expansion and therapeutic opportunities.

关键词： Prostate cancer second-generation antiandrogens cancer stem cells castration resistance prostate cancer androgen deprivation therapy

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Spectrum, Manifestations and Outcomes of Dengue Infection in Individuals with and without Liver Disease

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 106-111页

作者： Anand VKulkarni Ashok K.Choudhury Madhumita Premkumar Priyanka Jain Ekta gupta shiv kumar Sarin Department of Hepatology and Transplant Institute of Liver and Biliary SciencesNew DelhiIndia Department of Virology Institute of Liver and Biliary SciencesNew DelhiIndia Department of Statistics Institute of Liver and Biliary SciencesNew DelhiIndia

Background and Aims:Dengue infection is a major health burden,which can result in mild self-limited febrile illness to highly fatal hemorrhagic *** is paucity of literature describing the manifestations of dengue in patients with underlying liver *** studied and compared the manifestations of this tropical infection in patients with and without liver ***:Patients with serologically-confirmed dengue infection were included in this retrospective study,obtained for over a period of 1 *** and laboratory variables were compared for the individuals with no underlying liver disease(Group A,n=71),chronic hepatitis(Group B,n=12),and cirrhosis(Group C,n=12).Results:Males predominated the study population(61%),with a higher mean age in the cirrhotic *** most common clinical manifestation was classical dengue fever,seen in 89 *** presented as dengue hemorrhagic fever(1 each in Group A and Group B),1 presented as acute liver failure,and 3 as acute-on-chronic liver *** was less evident in Group C as compared to Group A and Group B(p<0.001).Patients in Group C had significantly prolonged International Normalized Ratio(INR)and enhanced thrombocytopenia compared to patients in Group A and Group *** in Group C also required prolonged hospital stay(Group A:4.83±2.88,Group B:7.33±2.3,Group C:13±5 days;p<0.001).Three patients expired in Group C compared to the 1 in Group A and none in Group B(p=0.01).On univariate analysis,hemoglobin,albumin,INR,and bilirubin predicted development of liver *** multivariate analysis,INR and bilirubin predicted development of liver ***:Dengue infection can have varied manifestations,ranging from simple fever to acute-on-chronic liver failure and acute liver *** patients lack classical features of dengue and have relatively poor *** should be suspected as a cause of liver failure in endemic areas,where no etiological ca

关键词： Dengue Cirrhosis Acute-on-chronic liver failure Acute liver failure

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Active Learning Query Strategies for Classification,Regression,and Clustering:A Survey

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Journal of Computer Science & Technology 2020年第4期35卷 913-945页

作者： Punit kumar Atul gupta Indian Institute of Information Technology Design and ManufacturingJabalpurMadhya Pradesh 482005India

Generally,data is available abundantly in unlabeled form,and its annotation requires some *** labeling,as well as learning cost,can be minimized by learning with the minimum labeled data *** learning(AL),learns from a few labeled data instances with the additional facility of querying the labels of instances from an expert annotator or *** active learner uses an instance selection strategy for selecting those critical query instances,which reduce the generalization error as fast as *** process results in a refined training dataset,which helps in minimizing the overall *** key to the success of AL is query strategies that select the candidate query instances and help the learner in learning a valid *** survey reviews AL query strategies for classification,regression,and clustering under the pool-based AL *** query strategies under classification are further divided into:informative-based,representative-based,informative-and representative-based,and ***,more advanced query strategies based on reinforcement learning and deep learning,along with query strategies under the realistic environment setting,are *** a rigorous mathematical analysis of AL strategies,this work presents a comparative analysis of these ***,implementation guide,applications,and challenges of AL are discussed.

关键词： active learning active learning query strategy active classification active regression active clustering deep active learning

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Linear and nonlinear propagation characteristics of multi-Gaussian laser beams

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Chinese Physics B 2020年第11期29卷 370-379页

作者： Naveen gupta Sandeep kumar Lovely Professional University PhagwaraIndia

Theoretical investigation on the propagation characteristics of a new class of laser beams known as multi Gaussian(M.G)laser beams has been *** investigate the linear characteristics,propagation of the laser beam in vacuum has been ***,the nonlinear characteristics have been investigated in *** nonlinearity of the plasma has been modeled by relativistic mass nonlinearity of the plasma electrons in the field of laser *** is based on finding the semi analytical solution of the wave equation for the slowly varying envelope of the laser ***,the dynamical evolutions of the beam width and longitudinal phase of the laser beam have been investigated in detail.

关键词： self-focusing multi Gaussian self phase modulation self-channeling

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The non-coding RNA SVALKA locus produces a cis-natural antisense transcript that negatively regulates the expression of CBF1 and biomass production at normal temperatures

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Plant Communications 2023年第4期4卷 77-87页

作者： Vasiliki Zacharaki shiv kumar Meena Peter Kindgren UmeåPlant Science Centre Department of Forest Genetics and Plant PhysiologySwedish University of Agricultural Sciences90187 Umea°Sweden

Non-coding transcription is present in all eukaryotic genomes,but we lack fundamental knowledge about its importance for an organism’s ability to develop *** plants,emerging evidence highlights the essential biological role of non-coding transcription in the regulation of coding ***,we have few molecular insights into this ***,we show that a long isoform of the long noncoding RNA SVALKA-L(SVK-L)forms a natural antisense transcript to the host gene CBF1 and negatively regulates CBF1 mRNA levels at normal temperatures in the model plant Arabidopsis ***,we show detailed evidence for the specific mode of action of *** pathway includes the formation of double-stranded RNA that is recognized by the DICER proteins and subsequent downregulation of CBF1 mRNA ***,the CBF1-SVK regulatory circuit is not only important for its previously known role in cold temperature acclimation but also for biomass production at normal *** study characterizes the developmental role of SVK-L and offers mechanistic insight into how biologically important overlapping natural antisense transcripts can act on and fine-tune the steady-state levels of their host gene’s mRNA.

关键词： SVALKA cis-natural antisense transcript non-coding transcription CBF1 Arabidopsis

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New treatment options for alcoholic hepatitis

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World Journal of Gastroenterology 2016年第15期22卷 3892-3906页

作者： Saggere Muralikrishna Shasthry shiv kumar Sarin Depart-ment of Hepatology Institute of Liver and Biliary Sciences

The burden of alcoholic liver disease has rapidly grown in the past two decades and is expected to increase further in the coming years. Alcoholic hepatitis, the most florid presentation of alcoholic liver disease, continues to have high morbidity and mortality, with significant financial and healthcare burden with limited treatment options. Steroids remain the current standard of care in severe alcoholic hepatitis in carefully selected patients. No specific treatments are available for those patients who are steroid ineligible, intolerant or unresponsive. Liver transplant has shown good short-term outcome; however, feasibility, ethical and economic concerns remain. Modification of gut microbiota composition and their products, such as lipopolysaccharide, nutritional interventions, immune modulation, increasing steroid sensitivity, genetic polymorphism and epigenetic modification of alcohol induced liver damage, augmenting hepatic regeneration using GCSF are potential therapeutic avenues in steroid non-responsive/ineligible patients. With better understanding of the pathophysiology, using “Omics” platforms, newer options for patients with alcoholic hepatitis are expected soon.

关键词： Alcoholic liver disease Alcoholic steatosis Alcoholic hepatitis Gut microbiota Lipopolysaccharide Steroid non-response

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