检索结果-南通市图书馆

STING regulates BCR signaling in normal and malignant B cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第4期18卷 1016-1031页

作者： Chih-Hang Anthony Tang Avery C.Lee shiun chang Qin Xu Andong Shao Yun Lo Walker T.Spalek Javier A.Pinilla-lbarz Juan R.Del Valle Chih-Chi Andrew Hu The Wistar Institute 3601 Spruce StreetPhiladelphiaPA 19104USA Department of Malignant Hematology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Department of Chemistry&Biochemistry University of Notre DameNotre DameIN 46556USA

STING is an endoplasmic reticulum(ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type Ⅰ interferons;however,the role of STING in B cell receptor(BCR)signaling remains *** generated STING V154M knock-in mice and showed that B cells carrying constitutively activated STING specifically degraded membrane-bound IgM,Ig a and Igβ via SEL1L/HRD1-mediated ER-associated degradation(ERAD).B cells with activated STING were thus less capable of responding to BCR activation by phosphorylating Igα and Syk than those without activated *** immunized with T-independent antigens,STING V154M mice produced significantly fewer antigen-specific plasma cells and antibodies than immunized wild-type(WT)*** further generated B cell-specific STING^(KO) mice and showed that STING^(KO) B cells indeed responded to activation by transducing stronger BCR signals than their STING-proficient *** B cell-specific STING^(KO) mice were T-independently immunized,they produced significantly more antigen-specific plasma cells and antibodies than immunized STIN^(WT)*** both human and m ouse IGHV-unmutated malignant chronic lymphocytic leukemia(CLL)cells downregulated the expression of STING,we explored whether STING downregulation could contribute to the well-established robust BCR signaling phenotype in malignant CLL *** generated a STING-deficient CLL mouse model and showed that STING-deficient CLL cells were indeed more responsive to BCR activation than their STING-proficient *** results revealed a novel B cell-intrinsic role of STING in negatively regulating BCR signaling in both normal and malignant B cells.

关键词： STING BCR ER-associated degradation CLL Plasma cells

THE DEVELOPMENT OF TCM AND QUALITY CONTROL OF TCM HERBS AND HERBAL PREPARATIONS IN TAIWAN

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2015年第4期1卷 82-82页

作者： Yuan shiun chang Yu-Ling Ho Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources College of Pharmacy China Medical University Department of Nursing Hung Kuang University

Traditional Chinese Medicine has been very popular in Taiwan in the *** was incorporated in the National Insurance since *** 2012,all new TCM physicians had to be graduated from TCM Department in Medical ***,there are... 详细信息

关键词： TCM THE DEVELOPMENT OF TCM AND QUALITY CONTROL OF TCM HERBS AND HERBAL PREPARATIONS IN TAIWAN GMP

The influence of primary posterior continuous curvilinear capsulorhexis on posterior capsular opacification development in dogs

在线全文

学校读者我要写书评

暂无评论

畜牧与兽医 2012年第S2期44卷 57-58页

作者： Zih-Ling Lai Shu-Hao chang Chu-Yu Tsai shiun-Long Lin Department of Veterinary Medicine College of Veterinary MedicineNational Chung Hsing University Mackay Memorial Hospital

The posterior capsular opacification(PCO)is by far the most common complication following *** continuous curvilinear capsulorhexis(PCCC)is performed to prevent this complication in human *** PCCC,the central part of the posterior capsule is removed during cataract surgery to prevent equatorial lens cell migration onto the posterior capsule from reaching the visual *** to now,there has no any report about PCCC in veterinary *** aim of this study is to evaluate the efficacy of primary PCCC on the severity of posterior capsular opacification in dogs.

关键词： opacification capsular equatorial cataract migration removed capsule severity reaching intraoperative

Optimizing biliary outcomes in living donor liver transplantation:Evolution towards standardization in a high-volume center

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 324-327页

作者： Tsan-shiun Lin Jeffrey Samuel Co Chao-Long Chen Aldwin D.Ong Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao SungKaohsiung 833TaiwanChina

Biliary complications have always been a dreaded cause of morbidity after living donor liver *** intrinsic variations in both graft and recipient biliary anatomy remain a significant factor to the difficulty of biliary reconstruction,our institution has taken advantage of its high volume of cases to critically review and evaluate modifiable operative risk factors,in particular,our surgical *** present herein,the evolution of our reconstructive biliary technique from conventional methods to our current standard of microsurgical biliary reconstruction for both graft and recipient *** this period of transition,our center has created a classification system for biliary reconstruction that decreased the biliary complication rates from 40.0%to 10.2%.

关键词： Living donor liver transplantation Biliary reconstruction Microsurgical biliary reconstruction Biliary classification Biliary complications

Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第1期12卷 123-126页

作者： Yau-Tong You Chung-Rong chang Chien Jeng-Yi Wang Koon-Kwan Ng Jinn-shiun Chen Reiping Tang Jy-Ming Chiang Chien-Yuh Yeh Pao-Shiu Hsieh Division of Colon and Rectal Surgery Chang Gung Memorial HospitalLin-KouTaiwanChina Division of Colon and Rectal Surgery Chang Gung Memorial HospitalJia-YiTaiwanChina Department of Radiology Chang Gung Memorial HospitalKee-LungTaiwanChina

AIM： TO evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS： From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for a period ranging from 20 to 55 mo. Eighty of the four hundred and thirty-four patients showing strong clinical evidence for recurring colorectal cancer during the last followup were enrolled in this study. Each patient underwent contrast-enhanced computed tomographic colonography and colonoscopy on the same day. Any lesions, biopsies, identified during the colonoscopic examination, immediate complications and the duration of the procedure were recorded. The results of contrast-enhanced computed tomographic colonography were evaluated by comparing to those of colonoscopy, surgical finding, and clinical follow-up. RESULTS： Contrast-enhanced computed tomographic colonography had a sensitivity of 100%, a specificity of 83% and an overall accuracy of 94% in detecting local recurrent colorectal cancer. CONCLUSION： Conventional colonoscopy and contrastenhanced tomographic colonography can complement each other in detecting local recurrence of colorectal cancer.

关键词： Computed tomographic colonography Recurrent colorectal cancer

A GA-Based Global Decision Support System for Garment Production

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A GA-Based Global Decision Support System for Garment Produc...

Role of body mass index in colon cancer patients in Taiwan

2005 International Conference on Neural Networks and Brain(ICNN&B’05)

作者： Rong-chang Chen Shiue-shiun Li Chih-chang Lin Chen-chang Feng Department of Logistics Engineering and Management Graduate Institute of Business Administration Graduate Institute of Computer Science and Information Technology National Taichung Institute of Technology Director of Information Center Eclat Textile Company Limited No.28 Wu-Chuan Rd.Wu-Ku Industrial ParkTaipei

＜正＞It is hard to make decisions with a human’s brain alone,especially in global *** improving technology, each industry has to face the problem "How can I get the lower cost in the global markets?" and solve the *** this study,we try to develop a decision support system for garment industry because the garment industry operates on low profits and can’t bear too much cost. The system includes three major parts,i.e.,an input database,an analytical tool,and presentation *** information in the data is real data provided by a garment corporation and is collected from the Enterprise Resource Planning（ERP） *** tool for analyzing in this study is genetic algorithm（GA）.Finally,visualized charts and reports are used to show the scheduling result to decision *** system is designed to be easy to use and suitable to the garment industry.

关键词： Decision support systems Production systems Clothing industry Costs Enterprise resource planning Globalization Visual databases Data analysis Algorithm design and analysis Genetic algorithms

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第31期18卷 4191-4198页

作者： Chih-Chien Chin Yi-Hung Kuo Chien-Yuh Yeh Jinn-shiun Chen Reiping Tang Chung-Rong changchien Jeng-Yi Wang Wen-Shih Huang Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalLinko 333Taiwan

AIM： To determine the effect of body mass index （BMI） on the characteristics and overall outcome of colon cancer in Taiwan. METHODS： From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in this study. BMI categories （in kg/m2） were established according to the classification of the Department of Health of Tai- wan. Postoperative morbidities and mortality, and survival analysis including overall survival （OS）, disease- free survival （DFS）, and cancer-specific survival （CSS） were compared across the BMI categories.27 kg/m2） patients. Being female, apparently anemic, hypoalbuminemic, and having body weight loss was more likely among underweight patients than among the other patients （P 〈 0.001）. Underweight patients had higher mortality rate （P = 0.00.7） and lower OS （P 〈 0.001） and DFS （P = 0.002） than the other pa- tients. OS and DFS did not differ significantly between normal-weight, overweight, and obese patients, while CSS did not differ significantly with the BMI category. CONCLUSION： In Taiwan, BMI does not significantly affect colon-CSS. Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients. Obesity does not predict a worse survival.

关键词： Body mass index Colon cancer Survival IVlorbidity Outcome

Passive Heat Dissipation Devices for High Power LEDs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Passive Heat Dissipation Devices for High Power LEDs

The Eighth Chinese Optoelectronics Symposium

作者： Yeeu-chang Lee Jyh-Chen Chen Farn-shiun Hwu Gwo-Jiun Sheu Wen-Dong Chen Jenq-Yang chang Optical Science Center National Central University Jung-Li City Department of Mechanical Engineering National Central University Jung-Li City Department of Mechanical Engineering National Central University Jung-Li City Department of Mechanical EngineeringNanya Institute of TechnologyJune-Li City Institute of Optical Science National Central University Jung-Li City

Introduction High power LEDs are currently in high demand for a variety of applications including flat panel displays, printers, optical interconnects in computers, and general lighting. However, due to the production of large amounts of heat in a small area, LEDs suffer severe cooling problems. Non-optimal heat dissipation will cause the junction temperature of device rising rapidly, and it will not only decrease the light efficiency, induce the peak wavelength shift and also significantly reduce the lifetime of LEDs. Therefore, the heat generation becomes the major barrier for the development high power LEDs. A proper thermal management to keep a good reliability and performance of LEDs is necessary. In this paper, we proposed three passive solutions to take away the waste heat of LEDs.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

简易桥墩基础之地震反应分析

岩土工程学报 2006年第4期28卷 442-450页

作者：张德文郑世豪林伯勋淡江大学土木工程学系

建议以间接分析法将完整之土壤和桥墩基础拆解成个别之子结构系统,并依叠加概念分别诠释不同子结构行为模式,最后加总各系统行为以仿真整体结构反应。研究首先利用集中质块分析法建立自由场受震之位移,并以此为前置解代入桩基础波动方... 详细信息

建议以间接分析法将完整之土壤和桥墩基础拆解成个别之子结构系统,并依叠加概念分别诠释不同子结构行为模式,最后加总各系统行为以仿真整体结构反应。研究首先利用集中质块分析法建立自由场受震之位移,并以此为前置解代入桩基础波动方程分析,求解基桩受震反应。上部桥梁结构则简化为双自由度质块系统纳入分析,以上部结构和地下桩基础间之传递力为收敛依据,逐次修正系统变形量,并仿真隔震设施功效。该项分析经与有限元素法结果比较证明可行,且可节省大量分析时间。

关键词：桥墩基础叠加集中质块分析波动方程分析隔震设施