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Glycerol solutions of highly concentrated biomineral counter-ions towards water-responsive mineralization: Demonstration on bacterial cellulose and its application in hard tissue repair

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Nano Research 2024年第3期17卷 2154-2163页

作者： Yunfei Zhao Xiaohao Liu Zhi Zhou Chaobo Feng Nan Luo Jiajun Yan Shuo Tan Yang Lu Feng Chen Bing-Qiang Lu shisheng he Department of Orthopedic Spinal Pain Research InstituteShanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Preventive Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China

Mineralization has found widespread use in the fabrication of composite biomaterials for hard tissue *** current mineralization processes are mainly carried out in neutral aqueous solutions of biomineral counter-ions(a pair of cation and anion that form the corresponding minerals at certain conditions),which are stable only at very low *** typically results in inefficient mineralization and weak control over biomineral ***,we find that,in the organic solvent glycerol,a variety of biomineral counter-ions(e.g.,Ca/PO_(4),Ca/CO_(3),Ca/SO_(4),Mg/PO_(4),or Fe/OH)corresponding to distinct biominerals at significantly high concentrations(up to hundreds-fold greater than those of simulated body fluid(SBF))are able to form translucent and stable solutions(mineralizing solution of highly concentrated counter-ions(MSCIs)),and mineralization can be triggered upon them with external solvents(e.g.,water or ethanol).Furthermore,with pristine bacterial cellulose(BC)membrane as a model,we demonstrate an effective and controllable mineralization performance of MSCIs on organic *** approach not only forms the homogeneous biominerals on the BC fibers and in the interspaces,but also provides regulations over mineralization rate,mineral content,phase,and *** resulting mineralized BC membranes(MBCs)exhibit high cytocompatibility and favor the proliferation of rat bone marrow mesenchymal stem cells(rBMSC).Following this,we prepare a mineralized bone suture(MBS)from MBC for non-weight bearing bone fixation,which then is tested on a rabbit median sternotomy *** shows firm fixation of the rabbit sternum without causing discernible toxicity or inflammatory *** study,by extending the mineralization to the organic solution system of highly concentrated counter-ions,develops a promising strategy to design and build targeted mineral-based composites.

关键词： biomineralization organic solvent bacterial cellulose(BC) hard tissue repair

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超声在脊柱外科应用的研究进展

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中华骨科杂志 2024年第12期44卷 843-850页

作者：杨凯琪顾广飞贺石生同济大学附属第十人民医院脊柱外科上海200072

超声因具有无辐射、便携、价廉等优势而在普外科、妇产科等领域得到了广泛应用。但超声骨显像受限,因此在脊柱外科的应用并不多见。近年来超声技术与设备的发展拓宽了其在脊柱外科的应用场景。在诊断方面,肌骨超声能够清晰显示肌肉、肌... 详细信息

超声因具有无辐射、便携、价廉等优势而在普外科、妇产科等领域得到了广泛应用。但超声骨显像受限,因此在脊柱外科的应用并不多见。近年来超声技术与设备的发展拓宽了其在脊柱外科的应用场景。在诊断方面,肌骨超声能够清晰显示肌肉、肌腱、关节等组织的解剖结构,对脊柱疾病早期诊断具有重要意义;治疗方面,超声引导下脊柱源性疼痛介入治疗已较为成熟,包括选择性神经根阻滞、关节突关节阻滞等,显示出较高的准确率、安全性及疗效。超声辅助脊柱内镜手术置管应用的增加可减少术者及患者的辐射暴露;基于超声对椎弓根螺钉钉道完整性及钉道内壁与皮质骨距离的评估,研究者对其在脊柱椎弓根螺钉置入手术中的应用进行了进一步探索,开发了新型椎弓根探路器等,但目前对超声设备参数设置仍存在争议。此外,术中超声在脊柱肿瘤手术中可辅助定位肿瘤、评估切除范围以及在减压手术中评估减压效果和脊髓灌注状况。尽管超声在脊柱外科的应用前景广阔,但仍存在一些问题,如图像清晰度不高、分辨精度偏低、骨显像受限等。超声技术在脊柱外科的应用已展现出巨大的发展潜力,随着技术的进步和医生技能的提升,未来将在脊柱外科领域发挥更大的作用。

关键词：超声检查脊椎穿刺外科手术,计算机辅助脊柱疾病

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Research on the controller of an arc welding process based on a PID neural network

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控制理论与应用（英文版） 2008年第3期6卷 327-329页

作者： Kuanfang he shisheng HUANG College of Mechanical Engineering South China University of Technology Guangzhou Guangdong 510640 China

A controller based on a PID neural network （PIDNN） is proposed for an arc welding power source whose output characteristic in responding to a given value is quickly and intelligently controlled in the welding process. The new method syncretizes the PID control strategy and neural network to control the welding process intelligently, so it has the merit of PID control rules and the trait of better information disposal ability of the neural network. The results of simulation show that the controller has the properties of quick response, low overshoot, quick convergence and good stable accuracy, which meet the requirements for control of the welding process.

关键词： Welding process Characteristic of output PID neural network Controller

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电子支气管镜治疗儿童重症支原体肺炎对气道粘膜状态、免疫功能和炎症指标的影响

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中外医学研究 2024年第21期22卷 57-61页

作者：杨红和石圣龚卉杨婷丽江市人民医院云南丽江674100 重庆医科大学附属儿童医院

目的:探究电子支气管镜治疗儿童重症支原体肺炎对气道粘膜状态、免疫功能和炎症指标的影响。方法:选取2022年10月—2023年10月丽江市人民医院收治的40例儿童重症支原体肺炎患者作为研究对象,采用猜拳法分为联合组(n=20)和常规组(n=20)... 详细信息

目的:探究电子支气管镜治疗儿童重症支原体肺炎对气道粘膜状态、免疫功能和炎症指标的影响。方法:选取2022年10月—2023年10月丽江市人民医院收治的40例儿童重症支原体肺炎患者作为研究对象,采用猜拳法分为联合组(n=20)和常规组(n=20)。常规组患儿采用抗感染、机械通气等常规治疗,联合组患儿在常规组基础上联合电子支气管镜治疗。比较两组患儿气道粘膜状态、免疫功能、炎症指标和临床疗效情况。结果:治疗后,常规组患儿气道粘膜状态中纵行皱褶和管腔闭塞情况有所改善,差异有统计学意义(P<0.05);联合组患儿气道粘膜状态均有所改善,且改善程度均优于常规组,差异有统计学意义(P<0.05);治疗后,两组患儿CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均升高,且联合组高于常规组,差异有统计学意义(P<0.05);两组患儿CD8^(+)均降低,且联合组低于常规组,差异有统计学意义(P<0.05);治疗后,两组患儿TNF-α、IL-6、IL-8均降低,且联合组低于常规组,差异有统计学意义(P<0.05);联合组临床疗效总有效率(90.00%)高于常规组(60.00%),差异有统计学意义(P<0.05)。结论:对重症支原体肺炎患儿给予电子支气管镜治疗可有效改善气道粘膜状态、增强免疫功能、减轻炎症反应。

关键词：儿童重症支原体肺炎电子支气管镜气道粘膜状态细胞免疫炎症因子

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彩色多普勒成像联合子宫动脉血流参数诊断子宫肌瘤效果

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中国计划生育学杂志 2024年第3期32卷 643-646页

作者：张小敬方群刘赵一贺诗圣安徽省阜阳市妇女儿童医院 236001

目的:探究彩色多普勒成像联合子宫动脉血流参数诊断子宫肌瘤效果。方法:选取2020年1月-2023年3月本院诊治的子宫肌瘤患者38例为观察组,健康体检非子宫肌瘤者65例为对照组。比较两组超声子宫动脉血流参数,观察组以病理学结果为金标准分... 详细信息

目的:探究彩色多普勒成像联合子宫动脉血流参数诊断子宫肌瘤效果。方法:选取2020年1月-2023年3月本院诊治的子宫肌瘤患者38例为观察组,健康体检非子宫肌瘤者65例为对照组。比较两组超声子宫动脉血流参数,观察组以病理学结果为金标准分析彩色多普勒成像联合子宫动脉血流参数诊断子宫肌瘤价值。结果:观察组超声声像子宫肌瘤具有边界清晰、组织低回声、内部结构呈实性特点,观察组子宫动脉阻力指数、子宫动脉搏动指数、子宫动脉收缩期血流速度、子宫动脉舒张期血流速度均高于对照组(均P<0.05)。声像特征联合子宫动脉血流参数诊断子宫肌瘤的曲线下面积为0.932,灵敏度86.8%、特异度93.8%、准确率90.3%等均高于单独指标诊断。结论:彩色多普勒成像联合子宫动脉血流参数诊断子宫肌瘤具有较高的灵敏度和特异度,提高了诊断子宫肌瘤效能。

关键词：子宫肌瘤彩色多普勒成像子宫动脉血流参数诊断

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Bioinspired MXene-Based User-Interactive Electronic Skin for Digital and Visual Dual-Channel Sensing

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Nano-Micro Letters 2022年第7期14卷 228-245页

作者： Wentao Cao Zheng Wang Xiaohao Liu Zhi Zhou Yue Zhang shisheng he Daxiang Cui Feng Chen Department of Orthopedic School of MedicineSpinal Pain Research InstituteShanghai Tenth People’s HospitalTongji UniversityShanghai 200072People’s Republic of China National Engineering Research Center for Nanotechnology Shanghai 200241People’s Republic of China Institute of Micro-Nano Science and Technology School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

User-interactive electronic skin(e-skin) that could convert mechanical stimuli into distinguishable outputs displays tremendous potential for wearable devices and health care applications. However, the existing devices have the disadvantages such as complex integration procedure and lack of the intuitive signal display function. here, we present a bioinspired user-interactive e-skin, which is simple in structure and can synchronously achieve digital electrical response and optical visualization upon external mechanical stimulus. The e-skin comprises a conductive layer with a carbon nanotubes/cellulose nanofibers/MXene nanohybrid network featuring remarkable electromechanical behaviors, and a stretchable elastomer layer, which is composed of silicone rubber and thermochromic pigments. Furthermore, the conductive nanohybrid network with outstanding Joule heating performance can generate controllable thermal energy under voltage input and then achieve the dynamic coloration of silicone-based elastomer. Especially, such an innovative fusion strategy of digital data and visual images enables the e-skin to monitor human activities with evermore intuition and accuracy. The simple design philosophy and reliable operation of the demonstrated e-skin are expected to provide an ideal platform for next-generation flexible electronics.

关键词： MXene Electronic skin Electromechanical behavior Joule heating Visualization

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个性化最适角度颈椎牵引治疗

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上海医药 2018年第22期39卷 3-5,11页

作者：贺石生同济大学附属第十人民医院脊柱外科上海200072

颈椎病(cervical spondylosis)是颈椎椎间盘组织退行性改变及病理改变累及其周围组织结构(神经根、脊髓、椎动脉、交感神经等)出现相应临床表现的一种疾病。颈椎病的治疗分手术和非手术两大类,其中牵引治疗是非手术治疗中最常用且最有... 详细信息

颈椎病(cervical spondylosis)是颈椎椎间盘组织退行性改变及病理改变累及其周围组织结构(神经根、脊髓、椎动脉、交感神经等)出现相应临床表现的一种疾病。颈椎病的治疗分手术和非手术两大类,其中牵引治疗是非手术治疗中最常用且最有效的方法。牵引治疗包括牵引体位、牵引时间、牵引重量、牵引角度四要素,个性化最适角度颈椎牵引治疗通过不同个体制定最适牵引参数,促进精准医疗,提高牵引疗效。

关键词：颈椎病牵引治疗个性化

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Machine learning aided investigation on the structure-performance correlation of MOF for membrane-based he/H2 separation

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Green Chemical Engineering 2024年第4期5卷 526-532页

作者： Shitong Zhang Yanjing he Zhengqing Zhang Chongli Zhong State Key Laboratory of Separation Membranes and Membrane Processes Tiangong University School of Chemical Engineering and Technology Tiangong University School of Textile Science and Engineering Tiangong University

The separation of he/H2using membrane technology has gained significant interest in the field of he extraction from natural gas. One of the greatest challenges associated with this process is the extremely close kinetic diameters of the two gas molecules, resulting in low membrane selectivity. In this study, we investigated the structure-performance relationship of metal-organic framework（MOF） membranes for he/H2separation through molecular simulations and machine learning approaches. By conducting molecular simulations, we identified the potential MOF membranes with high separation performance from the Computation-Ready Experimental（Co RE）MOF database, and the diffusion-dominated mechanism was further elucidated. Moreover, random forest（RF）-based machine learning models were established to identify the crucial factors influencing the he/H2separation performance of MOF membranes. The pore limiting diameter（PLD） and void fraction（φ）, are revealed as the most important physical features for determining the membrane selectivity and he permeability, respectively. Additionally, density functional theory（DFT） calculations were carried out to validate the molecular simulation results and suggested that the electronegative atoms on the pore surfaces can enhance the diffusion-based separation of he/H2, which is critical for improving the membrane selectivities of he/H2. This study offers useful insights for designing and developing novel MOF membranes for the separation of he/H2at the molecular level.

关键词： he/H 2 Membrane separation Molecular simulation Machine learning DFT calculation

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聚(ε-己内酯)-多肽共聚物胶束增强抗生素的抗菌活性

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物理化学学报 2021年第10期37卷 78-86页

作者：陈灵珊洪苑秀贺石生范震杜建忠同济大学附属上海市第十人民医院骨科上海200072 同济大学材料科学与工程学院高分子材料系上海201804 同济大学高等研究院上海200092 同济大学先进土木工程材料教育部重点实验室上海201804

细菌感染对人类健康构成了严重威胁,而传统抗生素治疗可能导致如胃病、细菌耐药等一系列副作用。因此,亟需发展提高抗生素抗菌效率的新方法。在本文中,我们通过氨基酸环内酸酐和ε-己内酯开环聚合合成了多肽基的聚合物[PCL_(34)-b-PGA_(... 详细信息

细菌感染对人类健康构成了严重威胁,而传统抗生素治疗可能导致如胃病、细菌耐药等一系列副作用。因此,亟需发展提高抗生素抗菌效率的新方法。在本文中,我们通过氨基酸环内酸酐和ε-己内酯开环聚合合成了多肽基的聚合物[PCL_(34)-b-PGA_(30)-b-P(Lys_(16)-stat-Phe_(12))]。在碱性环境中,此聚合物能够自组装成带负电荷的胶束(其zeta电位值为−26.7 mV)。通过透射电子显微镜和动态光散射可以证实组装体的胶束结构。此胶束具有药物缓释的特性,并且胶束上含有的抗菌多肽链段能够有效杀死细菌,因此该胶束能够很大程度上提高抗生素的抗菌效率。实验证实该载药胶束对革兰氏阴性菌(大肠杆菌)和革兰氏阳性菌(金黄色葡萄球菌)均具有较好的抗菌活性,最小抑菌浓度值分别为7.8和18.2μg·mL^(−1)。这种胶束包载妥布霉素的载药率和载药量分别为24.3%和5.2%。因此,胶束中实际含有的抗生素量为0.4和0.9μg·mL^(−1),小于妥布霉素的最小抑菌浓度值。总的来说,该胶束有望大幅降低抗生素的使用量,并减少临床上抗生素过量使用造成的副作用。

关键词：抗生素自组装多肽聚合物胶束抗菌性缓释

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In-situ TEM study of the effect of hydrogen-helium ratio on defect characteristics in Fe9Cr1.5W0.4Si F/M steel during H_(2)^(+)&he^(+)simultaneous irradiation

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Journal of Materials Science & Technology 2024年第6期173卷 192-201页

作者： Dewang Cui Ziqi Cao Kun he Yuanming Li Xi Qiu Guang Ran College of Energy Xiamen UniversityXiamen 361102China Fujian Provincial Nuclear Energy Engineering Technology Research Center Xiamen 361102China Science and Technology on Reactor Fuel and Materials Laboratory Chengdu 610041China Nuclear Power Institute of China Chengdu 610041China Science and Technology on Reactor System Design Technology Laboratory Chengdu 610041China

The effect of hydrogen and helium interaction,especially H-he ratio,on the irradiation behavior of nuclear materials has not yet been ***,this is an important basis for evaluating the irradiation properties of nuclear materials and developing high irradiation resistant ***,30 keV H_(2)^(+)and he^(+)dual beams with four H-he ratios of 0:10,3:10,15:10,and 30:10 were used to irradiate the newly developed Fe9Cr1.5W0.4Si F/M steel in TEM to in-situ study the interaction and ratio effect of hydrogen and *** addition of H atoms significantly promoted the nucleation of dislocation loops and *** the early stage of irradiation,the average size and density of dislocation loops increased with the increase of H-he ***,the larger the H-he ratio,the easier it was to form a complex dislocation ***,the final saturation size of bubbles increased with the increase of H-he *** was first found that the swelling was affected by H concentrations,with high H concentrations slowing down the increase in *** a certain irradiation dose,a specific H-he ratio would lead to a swelling peak of Fe9Cr1.5W0.4Si F/M *** super-sized bubbles at grain boundaries(GBs)were found after H addition,resulting in a bigger swelling of GBs than the *** the swelling of the GBs and the matrix show a dependence on the H-he *** current work is of great significance for understanding the interaction between hydrogen and helium in nuclear materials.

关键词： Dose ratio effect Ferritic-martensitic steel Hydrogen&helium synergetic irradiation In-situ TEM

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