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Neural substrates of behavioral inhibitory control during the two-choice oddball task:functional neuroimaging evidence

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Psychoradiology 2023年第1期3卷 203-212页

作者： shirui zhao Ruosong Yuan Wei Gao Qiang Liu Jiajin Yuan The Affect Cognition and Regulation Laboratory(ACRLab) Institute of Brain and Psychological SciencesSichuan Normal UniversityChengdu 610066China Faculte des Sciences Psychologiques et de 1'Education Universite Libre de Bruxelles(ULB)Brussels 1050Belgium Faculty of Psychology Southwest University Chongqing 400715China Sichuan Key Laboratory of Psychology and Behavior of Discipline Inspection and Supervision(Sichuan Normal University) Chengdu 610066China

Background:Behavioral inhibitory control(BIC)depicts a cognitive function of inhibiting inappropriate dominant responses to meet the context *** abundant research into neural substrates of BIC during the go/no-go and stop signal tasks,these tasks were consistently shown hard to isolate neural processes of response inhibition,which is of primary interest,from those of response ***,it is necessary to explore neural substrates of BIC using the two-choice oddball(TCO)task,whose design of dual responses is thought to produce an inhibition effect free of the confounds of response ***:The current study aims at depicting neural substrates of performing behavioral inhibitory control in the two-choice oddball task,which designs dual responses to balance response ***,neural substrates of performing BIC during this task are compared with those in the go/no-go task,which designs a motor response in a single ***:The present study integrated go/no-go(GNG)and TCO tasks into a new Three-Choice BIC paradigm,which consists of stan-dard(75%),deviant(12.5%),and no-go(12.5%)conditions ***-eight college students participated in this experiment,which required them to respond to standard(frequent)and deviant stimuli by pressing different keys,while inhibiting motor response to no-go *** analysis and ROI(region of interest)analysis were adopted to identify the unique neural mechanisms that subserve the processes of ***:Both tasks are effective in assessing BIC function,reflected by the significantly lower accuracy of no-go compared to standard condition in GNG,and the significantly lower accuracy and longer reaction time of deviant compared to standard condition in ***,there were no significant differences between deviant and no-go conditions in ***,functional neuroimaging has demonstrated that the anterior cingulate cortex(ACC)activation was observed for

关键词： behavioral inhibitory control two-choice oddball go/no-go fMRI

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双孢蘑菇中一种4R型MYB转录因子的基因克隆和生物信息学分析

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食品研究与开发 2024年第2期45卷 185-194页

作者：刘翔赵紫璇赵月盈赵诗睿贾子怡姜含越袁帅孟德梅天津科技大学食品科学与工程学院天津300457

MYB转录因子广泛存在于真核生物中,在植物的生长发育、逆境胁迫等过程中发挥重要作用。与植物相比,对食用菌中MYB转录因子的研究有限。为探究MYB转录因子在食用菌中的生物学功能,对前期转录组发现的一个编码双孢蘑菇(Agaricus bisporus)... 详细信息

MYB转录因子广泛存在于真核生物中,在植物的生长发育、逆境胁迫等过程中发挥重要作用。与植物相比,对食用菌中MYB转录因子的研究有限。为探究MYB转录因子在食用菌中的生物学功能,对前期转录组发现的一个编码双孢蘑菇(Agaricus bisporus)MYB转录因子的基因进行克隆和生物信息学分析。结果表明,该基因编码区长1209 bp,翻译402个氨基酸;编码的蛋白分子量为45.95 kDa,等电点9.17,是一种不存在跨膜结构、不含信号肽的亲水性蛋白,具有4个高度保守的SANT结构域,属于4R型MYB转录因子,与白环蘑(Leucoagaricus)中的4RMYB转录因子亲缘关系最近;二级结构预测显示以无规则卷曲和α-螺旋结构为主;亚细胞定位分析显示该转录因子位于细胞核中;此外启动子序列分析表明,该基因启动子区域含有多个与生物抗逆应答、激素响应等相关的顺式作用元件。

关键词：双孢蘑菇 MYB转录因子基因克隆生物信息学分析保守结构域

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The pathogenic mechanism of syndactyly type V identified in aHoxd13Q50R knock-in mice

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Bone Research 2024年第2期12卷 349-360页

作者： Han Wang Xiumin Chen Xiaolu Meng Yixuan Cao shirui Han Keqiang Liu Ximeng zhao Xiuli zhao Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13Q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13Q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD13Q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

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Double emulsion-pretreated microwell culture for the in vitro production of multicellular spheroids and their in situ analysis

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Microsystems & Nanoengineering 2021年第3期7卷 73-84页

作者： Fuyang Qu shirui zhao Guangyao Cheng Habibur Rahman Qinru Xiao Renee Wan Yi Chan Yi-Ping Ho Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina CUHK-UMCU Joint Research Laboratory of Respiratory Virus and Immunobiology The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Laboratory for Paediatric Respiratory Research Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Hong Kong Hub of Paediatric Excellenee The Chinese University of Hong KongHong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina The Ministry of Education Key Laboratory of Regeneration Medicine ShatinNew TerritoriesHong Kong SARChina Centre for Novel Biomaterials The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

Multicellular spheroids have served as a promising preclinical model for drug efficacy testing and disease *** microfluidic tech no logies,in eluding those based on water-oil-water double emulsions,have been introduced for the production of ***,sustained culture and the in situ characterization of the gen erated spheroids are currently unavailable for the double emulsion-based spheroid *** study presents a streamlined workflow,termed the double emulsion-pretreated microwell culture(DEPMiC),incorporating the features of(1)effective initiation of uniform-sized multicellular spheroids by the pretreatment of double emulsions produced by microfluidics without the requirement of biomaterial scaffolds;(2)sustained maintenance and culture of the produced spheroids with facile removal of the oil confinement;and(3)in situ characterization of individual spheroids localized in microwells by a built-in analytical *** by microscopic observations and Raman spectroscopy,the DEPMiC cultivated spheroids accumulated elevated lipid ordering on the apical membran巳similar to that observed in their Matrigel *** possible by the proposed tech no logical advancement,this study subsequently examined the drug responses of these in vitro-generated multicellular *** developed DEPMiC platform is expected to gen erate health benefits in personalized cancer treatment by offering a pre-animal tool to dissect heterogeneity from individual tumor spheroids.

关键词： emulsion sized culture

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Demarcating the membrane damage for the extraction of functional mitochondria

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Microsystems & Nanoengineering 2018年第1期4卷 1-12页

作者： Md Habibur Rahman Qinru Xiao shirui zhao Fuyang Qu Chen Chang An-Chi Wei Yi-Ping Ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Shun Hing Institute of Advanced Engineering The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University

Defective mitochondria have been linked to several critical human diseases such as neurodegenerative disorders,cancers and cardiovascular ***,the detailed characterization of mitochondria has remained relatively unexplored,largely due to the lack of effective extraction methods that may sufficiently retain the functionality of mitochondria,particularly when limited amount of sample is *** this study,we explore the possibility of modulating hydrodynamic stress through a cross-junction geometry at microscale to selectively disrupt the cellular membrane while mitochondrial membrane is *** operational conditions are empirically optimized to effectively shred the cell membranes while keeping mitochondria intact for the model mammalian cell lines,namely human embryonic kidney cells,mouse muscle cells and neuroblastoma ***,the disruption of cell membranes with higher elastic moduli(neuroblastoma)requires elevated *** study also presents a comparative analysis of total protein yield and concentrations of extracted functional mitochondria with two commercially available mitochondria extraction approaches,the Dounce Homogenizer and the Qproteome®Mitochondria Isolation Kit,in a range of cell *** findings show that the proposed“microscale cell shredder”yields at least 40%more functional mitochondria than the two other approaches and is able to preserve the morphological integrity of extracted mitochondria,particularly at low cell concentrations(5–20×10^(4) cells/mL).Characterized by its capability of rapidly processing a limited quantity of samples(200μL),demarcating the membrane damage through the proposed microscale cell shredder represents a novel strategy to extract subcellular organelles from clinical samples.

关键词： damage elevated preserve

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多巴胺及运动干预对胃癌大鼠肿瘤发生发展的影响

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中国医科大学学报 2020年第5期49卷 400-404页

作者：韩娟娟赵师锐张新安沈阳体育学院运动人体科学学院运动生理生化教研室沈阳110102

目的探讨多巴胺(DA)及游泳运动对胃癌大鼠肿瘤发生发展的影响。方法将N-甲基-N’-硝基-N-亚硝基胍诱导的胃癌Wistar大鼠随机分为A组和B组,每组再分为对照(Ca)组、游泳(Sw)组、DA组、DA+多潘立酮(DA+DP)组、游泳+DA(Sw+DA)组。分别给予D... 详细信息

目的探讨多巴胺(DA)及游泳运动对胃癌大鼠肿瘤发生发展的影响。方法将N-甲基-N’-硝基-N-亚硝基胍诱导的胃癌Wistar大鼠随机分为A组和B组,每组再分为对照(Ca)组、游泳(Sw)组、DA组、DA+多潘立酮(DA+DP)组、游泳+DA(Sw+DA)组。分别给予DA或游泳干预,A组观察大鼠生存率,B组干预6周后测定血清及肿瘤组织DA、血管内皮生长因子(VEGF)水平及肿瘤大小,分析指标变化情况。结果Sw+DA组生存率高于对照组(P<0.05)。Sw+DA组肿瘤体积小于对照组(P<0.05)。Sw+DA组血清及组织DA水平高于其他组(P<0.05)。Sw+DA组血清VEGF水平亦明显低于其他组(P<0.05)。结论DA及游泳运动可抑制胃癌大鼠肿瘤发生发展,提高大鼠生存率,且DA与运动干预共同作用效果更佳。

关键词：胃癌游泳多巴胺多潘立酮血管内皮生长因子

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对乌素图召庆缘寺大殿壁画研究的再认识

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民族艺林 2019年第3期 114-121页

作者：王小维赵世睿西藏大学艺术学院西藏拉萨850012 布达拉宫管理处西藏拉萨850012

乌素图召庆缘寺是藏传佛教再次传入内蒙古地区的早期寺庙之一,该大殿壁画独特的艺术风格迥异于内蒙古其他召庙壁画,多位学者对该壁画题材、造型特征、绘画风格、绘制技法以及色彩特征均有过论述。文章基于以往研究的基础,通过对大殿壁... 详细信息

乌素图召庆缘寺是藏传佛教再次传入内蒙古地区的早期寺庙之一,该大殿壁画独特的艺术风格迥异于内蒙古其他召庙壁画,多位学者对该壁画题材、造型特征、绘画风格、绘制技法以及色彩特征均有过论述。文章基于以往研究的基础,通过对大殿壁画图像内容的再辨识、护法神形貌和色彩特征的分析,结合相关文献,对庆缘寺在大殿护法神壁画绘制时期的宗派传承,护法神壁画局部色彩空置现象及其原因做进一步探讨。

关键词：庆缘寺壁画图像辨识宗派传承色彩

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原子层沉积技术及其创新运用

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纳米技术与精密工程 2014年第5期12卷 328-333页

作者：施云波于明岩饶志鹏赵士瑞哈尔滨理工大学测控技术与通信工程学院测控技术与仪器黑龙江省高校重点实验室哈尔滨150080 中国科学院微电子研究所中国科学院微电子器件与集成技术重点实验室北京100029

本文分析并总结了涉及原子层沉积(atomic layer deposition,ALD)技术基本原理的若干问题.介绍了等离子增强原子层沉积(plasma enhanced atomic layer deposition,PEALD)技术的优势及常见运用.相对于传统ALD系统,PEALD最大的特点在于其... 详细信息

本文分析并总结了涉及原子层沉积(atomic layer deposition,ALD)技术基本原理的若干问题.介绍了等离子增强原子层沉积(plasma enhanced atomic layer deposition,PEALD)技术的优势及常见运用.相对于传统ALD系统,PEALD最大的特点在于其能够通过等离子体放电来活化前驱体源,提高对前驱体源,尤其是气态源的利用.利用PEALD这一特点可以增加传统ALD技术中可用氮源的种类.同时PEALD原位掺杂作为一种掺杂方法能够用于对光催化材料的掺杂改性,提高其光催化性能.此外,PEALD技术还适用于温度敏感材料和柔性材料上的薄膜沉积,可以获得更低的电阻率和更高的薄膜密度等.本文重点介绍了本课题组提出的PEALD原位掺杂技术及其对TiO2光催化剂的掺杂改性运用.最后对原位掺杂技术的研究方向和发展进行了展望.

关键词：原子层沉积等离子体增强型原子层沉积原位掺杂 TiO2-xNx

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A comprehensive diagnostic system of ultra-thin liquid sheet targets

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High Power Laser Science and Engineering 2024年第3期 46-55页

作者： Ziyang Peng Zhengxuan Cao Xuan Liu Yinren Shou Jiarui zhao Shiyou Chen Ying Gao Pengjie Wang Zhusong Mei Zhuo Pan Defeng Kong shirui Xu Zhipeng Liu Yulan Liang Tianqi Xu Tan Song Xun Chen Qingfan Wu Yujia Zhang Zihao Zhang Xueqin Yan Wenjun Ma State Key Laboratory of Nuclear Physics and Technology School of Physics Peking University National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid Physics China Academy of Engineering Physics Center for Relativistic Laser Science Institute for Basic Science Gwangju Republic of Korea Institute of Radiation Physics Helmholtz-Zentrum Dresden Rossendorf Dresden Germany Beijing Laser Acceleration Innovation Center Institute of Guangdong Laser Plasma Technology

To meet the demands of laser-ion acceleration at a high repetition rate, we have developed a comprehensive diagnostic system for real-time and in situ monitoring of liquid sheet targets (LSTs). The spatially resolved rapid characterizations of an LST’s thickness, flatness, tilt angle and position are fulfilled by different subsystems with high accuracy. With the help of the diagnostic system, we reveal the dependence of thickness distribution on collision parameters and report the238-nm liquid sheet generated by the collision of two liquid jets. Control methods for the flatness and tilt angle of LSTs have also been provided, which are essential for applications of laser-driven ion acceleration and others.

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遗忘型轻度认知障碍和阿尔茨海默病患者精神行为症状的性别差异

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中华健康管理学杂志 2024年第09期18卷 655-661页

作者：蒋施瑞姜季委赵敏李汶逸徐俊首都医科大学附属北京天坛医院神经病学中心认知障碍性疾病科国家神经系统疾病临床医学研究中心北京

目的分析遗忘型轻度认知障碍(aMCI)和阿尔茨海默病(AD)患者精神行为症状(BPSD)的性别差异。方法本研究为横断面研究, 连续收集2021年6月1日至2023年2月1日首都医科大学附属北京天坛医院阿尔茨海默病生物标志物与生活方式研究(CIBL)队列... 详细信息

目的分析遗忘型轻度认知障碍(aMCI)和阿尔茨海默病(AD)患者精神行为症状(BPSD)的性别差异。方法本研究为横断面研究, 连续收集2021年6月1日至2023年2月1日首都医科大学附属北京天坛医院阿尔茨海默病生物标志物与生活方式研究(CIBL)队列中的201例aMCI及146例AD患者为研究对象, 比较不同性别患者BPSD亚型的差异。将存在性别差异的BPSD亚型分为抑郁组(126例)和无抑郁组(221例)、焦虑组(140例)和无焦虑组(207例)、淡漠组(131例)和无淡漠组(216例), 采用假设检验比较各组入组年龄、性别、受教育年限、婚姻状况、高血压、糖尿病、卒中、心脏疾病、高脂血症、吸烟史、饮酒史、是否携带载脂蛋白E(APOE)ε4基因以及简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、神经精神问卷(NPI)和日常生活活动能力评定量表(ADL)评分的差异;采用多因素logistic回归分析aMCI和AD患者BPSD的性别差异。结果女性抑郁、焦虑比例均显著高于男性(44.93%比23.57%、44.93%比33.57%), 淡漠比例显著低于男性(32.37%比45.71%)(均P<0.05)。抑郁组女性比例、ADL评分均显著高于无抑郁组[73.81%比51.58%、22.00(20.00, 30.00)比20.00(20.00, 26.00)分], 吸烟史及饮酒史比例、MoCA评分均显著低于无抑郁组[13.49%比25.79%、19.84%比35.75%、16.00(10.00, 22.00)比19.00(13.00, 24.00)分](均P<0.05);焦虑组女性比例、ADL评分均显著高于无焦虑组[66.43%比55.07%、23.00(20.00, 30.75)比20.00(20.00, 25.00)分], MMSE评分、MoCA评分均显著低于无焦虑组[23.00(16.00, 27.00)比24.00(19.00, 28.00)分、16.00(10.00, 21.00)比20.00(13.00, 24.00)分](均P<0.05);淡漠组女性比例、MMSE评分、MoCA评分均显著低于无淡漠组[51.15%比64.81%、19.00(11.00, 25.00)比26.00(22.00, 28.00)分、14.00(7.00, 19.00)比21.00(15.25, 24.00)分], 入组年龄、携带APOE ε4比例、ADL评分均显著高于无淡漠组[67.0(61.0, 76.0)比66.0(60.0, 71.0)岁、42.74%比31.31%、27.00(22.00, 38.00)比20.00(20.00, 22.00)分](均P<0.05)。女性(OR=2.384, 95%CI:1.274～4.459)、MoCA评分降低(OR=0.955, 95%CI:0.914～0.998)均与抑郁发生呈正相关, 女性(OR=1.704, 95%CI:1.077～2.695)与焦虑发生呈正相关, 男性(OR=0.558, 95%CI:0.333～0.936)、MoCA评分降低(OR=0.937, 95%CI:0.894～0.983)、ADL评分升高(OR=1.070, 95%CI:1.027～1.116)均与淡漠发生呈正相关(均P<0.05)。结论 aMCI和AD患者BPSD存在明显的性别差异, 女性与抑郁、焦虑发生呈正相关, 男性与淡漠发生呈正相关, 临床应注意不同性别BPSD患者的分层管理。

关键词：认知认知障碍阿尔茨海默病精神行为症状性别影响因素

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