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Bioactive Materials 2022年第1期7卷 227-241页

作者： Fiona Louis Yoshihiro Sowa shiro kitano Michiya Matsusaki Osaka University Joint Research Laboratory(TOPPAN)for Advanced Cell Regulatory ChemistryGraduate School of Engineering2-1 YamadaokaSuita Osaka565-0871Japan Osaka University Graduate School of EngineeringDepartment of Applied Chemistry2-1 YamadaokaSuita Osaka565-0871Japan Kyoto Prefectural University of Medicine Department of Plastic and Reconstructive SurgeryGraduate School of Medical SciencesKamigyo-ku Kajii-choKawaramachi-HirokojiKyoto602-8566Japan TOPPAN PRINTING CO. LTD.Technical Research Institute4-2-3 TakanodaiminamiSugito-machiSaitama345-8508Japan

Obesity is a complex and incompletely understood disease,but current drug screening strategies mostly rely on immature in vitro adipose models which cannot recapitulate it *** address this issue,we developed a statistically validated high-throughput screening model by seeding human mature adipocytes from patients,encapsulated in physiological collagen *** drop tissues ensured the maintenance of adipocyte viability and functionality for controlling glucose and fatty acids uptake,as well as glycerol *** such,patients’BMI and insulin sensitivity displayed a strong inverse correlation:the healthy adipocytes were associated with the highest insulin-induced glucose uptake,while insulin resistance was confirmed in the underweight and severely obese *** sensitivity recovery was possible with two type 2 diabetes treatments,rosiglitazone and ***,the addition of blood vasculature to the model seemed to more accurately recapitulate the in vivo physiology,with particular respect to leptin secretion metabolism.

关键词： Mature vascularized adipose tissue reconstruction High-throughput drug-screening model Obesity BMI Diabetes

Bioprinted Vascularized Mature Adipose Tissue with Collagen Microfibers for Soft Tissue Regeneration

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Cyborg and Bionic Systems 2021年第1期2021卷 1-15页

作者： Fiona Louis Marie Piantino Hao Liu Dong-Hee Kang Yoshihiro Sowa shiro kitano Michiya Matsusaki Joint Research Laboratory(TOPPAN)for Advanced Cell Regulatory Chemistry Graduate School of EngineeringOsaka UniversityJapan Department of Applied Chemistry Graduate School of EngineeringOsaka UniversityJapan Department of Plastic and Reconstructive Surgery Graduate School of Medical SciencesKyoto Prefectural University of MedicineJapan Toppan Printing Co. Ltd.TokyoJapan

The development of soft tissue regeneration has recently gained importance due to safety concerns about artificial breast *** autologous fat graft implantations can result in up to 90%of volume loss in long-term outcomes due to their limited *** tissue has a highly vascularized structure which enables its proper homeostasis as well as its endocrine *** adipocytes surrounded by a dense vascular network are the specific features required for efficient regeneration of the adipose tissue to perform host anastomosis after its ***,bioprinting has been introduced as a promising solution to recreate in vitro this architecture in large-scale ***,the in vitro induction of both the angiogenesis and adipogenesis differentiations from stem cells yields limited maturation states for these two *** overcome these issues,we report a novel method for obtaining a fully vascularized adipose tissue reconstruction using supporting bath *** the first time,directly isolated mature adipocytes encapsulated in a bioink containing physiological collagen microfibers(CMF)were bioprinted in a gellan gum supporting *** multilayered bioprinted tissues retained high viability even after 7 days of ***,the functionality was also confirmed by the maintenance of fatty acid uptake from mature ***,this method of constructing fully functional adipose tissue regeneration holds promise for future clinical applications.

关键词： supporting printing fibers

History of Western Philosophy and Quantum Language (Including Quantum Mechanics, Statistics, Fuzzy Logic, etc.)

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1769-1795页

作者： shiro Ishikawa Department of Mathematics Faculty of Science and Technology Keio University Yokohama Japan

Although there are many different types of philosophy, many philosophers agree that the mainstream of Western philosophy (Socrates, Plato, Aristotle, Descartes, Kant, Wittgenstein) developed toward the perfection of Socrates’ absolutism. But can the absolutism maintain its central position after analytic philosophy? There are pessimistic views on this problem, such as that of R. Rorty, the standard-bearer of neo-pragmatism. Recently, I proposed quantum language (which is including quantum mechanics, statistics, fuzzy sets, etc.). I think that that this theory is not only one of the most fundamental scientific theories, but also the scientific final destination of Western philosophy. If so, Socrates’ dream has come true. The purpose of this paper is to discuss the above and to inform readers that quantum language has the power to create a paradigm shift from the classical mechanical world view to the quantum mechanical worldview.

关键词： Quantum Language Linguistic Copenhagen Interpretation Fuzzy Logic

Population-based X-ray gastric cancer screening in Hiroshima prefecture, Japan

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World Journal of Clinical Oncology 2024年第2期15卷 271-281页

作者： Nhu Thi Hanh Vu Yuji Urabe Duc Trong Quach shiro Oka Toru Hiyama Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan Department of Gastrointestinal Endoscopy and Medicine Hiroshima University HospitalHiroshima 734-8551Japan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551Japan Health Service Center Hiroshima UniversityHigashihiroshima 739-8514Japan

BACKGROUND X-ray gastric cancer(GC)screening has been shown to decrease ***-based X-ray GC screening has been performed in Hiroshima Prefe-cture,Japan,since 1983 but time trends and the efficacy of the method over 39 years have not been *** This was a population-based retrospective *** data were derived from aggregated data of the Hiroshima Regional Health Medical Promotion Organization,including the number and rate of participants and those requiring esophagogastroduodenoscopies(EGDs),the number and rate of participants diagnosed as having GC,and the positive predictive value of the abnormal findings detected by X-ray and confirmed by *** number and rate of esophageal cancers were also ***,the cost of detecting one GC was *** The number of participants has decreased during the last four decades,from 39925 in 1983 to 12923 in *** rate of those requiring EGDs decreased significantly in recent years(P<0.001).The number of participants diagnosed as having GC has also declined,from 76 to 10 ***,the rate of cases diagnosed as GC among the participants remained around 0.1%.The positive predictive value increased significantly in recent years except during *** number and rate of accidentally detected esophageal cancers have risen recently,from 0%in 2008 to 0.02%in 2021,one-fifth of the diagnosis rate of *** GC diagnosis costs approximately 4200000 Japanese Yen(30000 United States Dollars)for the X-ray screenings and *** X-ray GC screening in Hiroshima has been efficient,but one challenge is the *** cancers may also need to be considered because they have gradually increased in recent years.

关键词： Population Retrospective studies X-ray Gastric cancer Screening

High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

Which characteristics are associated with changes in medication status for lower urinary tract symptoms among patients with prostate cancer receiving external beam radiotherapy?

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CURRENT UROLOGY 2024年第2期18卷 122-127页

作者： Kyoda, Yuki Hashimoto, Kohei Takahashi, Atsushi Maehana, Takeshi Tachikawa, Kimihito Muranaka, Takashi Kato, Shuichi Kurisu, Tomoyo Fukuta, Fumimasa Kirisawa, Takahiro Okada, Manabu Kobayashi, Ko Tanaka, Toshiaki Hinotsu, shiro Masumori, Naoya Sapporo Med Univ Sch Med Dept Urol S-1W-16Chuo Ku Sapporo 0608543 Japan Hakodate Goryoukaku Hosp Dept Urol Hakodate Japan Muroran City Gen Hosp Dept Urol Muroran Japan NTT East Sapporo Hosp Dept Urol Sapporo Japan Sunagawa City Med Ctr Dept Urol Sunagawa Japan Oji Gen Hosp Dept Urol Tomakomai Japan Steel Mem Muroran Hosp Dept Urol Muroran Japan Obihiro Kyokai Hosp Dept Urol Obihiro Japan Sapporo Med Univ Sch Med Dept Med Stat Sapporo Japan

BackgroundWe clarified the predictive factors for changes in the status of medications for lower urinary tract symptoms (LUTS) 2 years after local radiotherapy for nonmetastatic prostate cancer. Materials and methodsWe retrospectively included patients who underwent local external radiotherapy for nonmetastatic prostate cancer in 8 institutions between April 2001 and March 2016. Patients were divided into the medication and no-medication group based on the use of drugs for LUTS before radiotherapy. We defined improvement of LUTS as when the patient did not require medication for LUTS at 24 months after radiotherapy in the medication group and as deterioration when medication was required in the no-medication group. Logistic regression analysis was used to evaluate predictive factors for changes in medication status. ResultsAltogether, 505 patients were divided into a no-medication group (n = 352) and a medication group (n = 153). The number of patients with deterioration and improvement in LUTS was 49 (14%) and 36 (23%), respectively. In the multivariate analysis, the predictive variables for deterioration were the International Prostate Symptom Score (>= 8; odds ratio [OR], 2.21; p = 0.014) and the biopsy Gleason score (= 50%; OR, 2.530; p = 0.027) in the medication group. ConclusionsThese predictive factors for changes in the status of medications for LUTS at 2 years after external radiotherapy may help determine the definitive therapy for nonmetastatic prostate cancer.

关键词： Prostate cancer Radiotherapy Lower urinary tract symptoms Medications ANDROGEN DEPRIVATION THERAPY QUALITY-OF-LIFE RADIATION VOLUME MEN TOXICITY RELIEF

Cellulose decomposition behavior in hot-compressed aprotic solvents

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Science China Chemistry 2008年第5期51卷 479-486页

作者： shiro SAKA Department of Socio-Environmental Energy Science Graduate School of Energy ScienceKyoto University

Microcrystalline cellulose (avicel) is treated in hot-compressed aprotic solvents, sulfolane and 1,4-dioxane, using a batch-type reaction system with a molten tin bath in a range from 290 to 390°C. The corresponding densities of the solvent are 0.25–1.26 g/cm3 and 0.21–1.03 g/cm3 for sulfolane and 1,4-dioxane, respectively. As a result, in both solvents, more than 90% of cellulose is found to be decomposed to the solvent-soluble portion in which levoglucosan is the main component with the highest yield of about 35% on original cellulose basis. The decomposition rate to levoglucosan is, however, faster in sulfolane than in 1,4-dioxane, while levoglucosan is more stable in 1,4-dioxane. In addition, its yield is found to be solvent-density dependent to be highest around 0.4–0.5 g/cm3 for both solvents. To elucidate these decomposition behaviors, the results obtained in this study with aprotic solvents are compared with protic solvents such as water and methanol in previous works.

关键词： cellulose aprotic solvent solvent density decomposition behavior

Pyogenic liver abscess after choledochoduodenostomy for biliary obstruction caused by autoimmune pancreatitis

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World Journal of Gastroenterology 2006年第39期12卷 6397-6400页

作者： Nobuyuki Toshikuni Kyohei Kai Shizo Sato Motoko kitano Masayoshi Fujisawa Hiroaki Okushin Kazuhiko Morii Shinjiro Takagi Masahiro Takatani Hirofumi Morishita Koichi Uesaka shiro Yuasa Department of Internal Medicine Himeji Red Cross Hospital Himeji Japan Department of Surgery Himeji Red Cross Hospital Himeji Japan Department of Pathology Himeji Red Cross Hospital Himeji Japan

A 68-year-old man underwent cholecystectomy and choledochoduodenostomy for biliary obstruction and nephrectomy for a renal tumor. Based on clinical and histopathologic findings, autoimmune pancreatitis (AIP) was diagnosed. The renal tumor was diagnosed as a renal cell cancer. Steroid therapy was started and thereafter pancreatic inflammation improved. Five years after surgery, the patient was readmitted because of pyrexia in a preshock state. A Klebsiella pneumoniae liver abscess complicated by sepsis was diagnosed. The patient recovered with percutaneous abscess drainage and administration of intravenous antibiotics. Liver abscess recurred 1 mo later but was successfully treated with antibiotics. There has been little information on long-term outcomes of patients with AIP treated with surgery. To our knowledge, this is the second case of liver abscess after surgical treatment of AIP.

关键词： Autoimmune pancreatitis Biliary reconstruction Liver abscess

Role of Salix reinii patches in spatio-temporal patterns of cohabitants on a Japanese volcano

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Journal of Plant Ecology 2022年第1期15卷 71-84页

作者： Miyuki Matsuda shiro Tsuyuzaki Division of Integrated Environmental Science Graduate School of Environmental Earth ScienceHokkaido UniversitySapporo 060-0810Japan IDEA Consultants Inc. 3-15-1 KomazawaSetagaya WardTokyo 154-8585Japan

Shrub patches often support the colonizers particularly under stressful and/or disturbed *** intensities of stresses and disturbances on mountains are often related to an elevation gradient and are decreased by shrub patches(canopy and litter).We aim to clarify these relationships by using shrub patches at different elevations on a *** monitored all shoots in plots established inside and outside of patches of Salix reinii(Salicaceae)and their related environments,such as temperature,light,moisture and chemistry,at three elevations on Mount Koma(1131 m a.s.l.),northern Japan,from early spring in 2005 to summer in *** patch structures were evaluated by area,branch density and litter *** structures of shrub patches did not differ among the *** patches increased the diversity of rare species,by an overall increase in plant species *** moisture,nitrogen and phosphate contents in the patches were higher than outside of *** effects of shrub patches on the cohabitants were overall positive,although the effects were negative on seedling abundance,shoot survival and *** results suggest that the growth patterns of shrub patches determine the plant community structures and facilitate plant diversity.

关键词： elevational difference interspecific interaction litter accumulation microenvironment shrub patch

Changes in microbial community composition in the leaf litter of successional communities after volcanic eruptions of Mount Usu, northern Japan

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Journal of Mountain Science 2016年第9期13卷 1652-1662页

作者： Michiru OTAKI Fumiko TAKEUCHI shiro TSUYUZAKI Graduate School of Environmental Science Hokkaido University

Changes in the fungal and bacterial biomass and community structure in litter after the volcanic eruptions of Mount Usu, northern Japan were investigated using a chronosequence approach, which is widely used for analyzing vegetation succession. The vegetation changed from bare ground （10 years after the eruptions） with little plant cover and poor soil to monotonic grassland dominated by Polygonum sachalinense with undeveloped soil （33 years） and then to deciduous broad-leaved forest dominated by Populus maximowiczii with diverse species composition and well-developed soil （100 years）. At three chronosequential sites, we evaluated the compositions of phospholipid fatty acids （PLFAs）, carbon （C） and nitrogen （N） contents and the isotope ratios of C （δ13C） and N （δ15N） in the litter of two dominant species, Polygonum sachalinense and Populus maximowiezii. The C/N ratio, δ13C and δ15N in the litter of these two species were higher in the forest than that in the bare ground and grassland. The PLFAs gradually increased from the bare ground to the forest, showing that microbial biomass increased with the development of the soil and/or vegetation. The fungi-to-bacteria ratio of PLFA was constant at 5.3 ± 1.4 in all three sites, suggesting that fungi were predominant. A canonical correspondence analysis suggested that the PLFA comoosition was related to the successional ages and the developing soil properties （P 〈 0.05, ANOSIM）. The chrono- sequential analysis effectively detected the successional changes in both microbial and plant communities.

关键词： Volcanic succession Fungi-to-bacteriaratio Litter decomposition Microbial community Phospholipid fatty acids (PLFAs) Primary succession