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国外医学（泌尿系统分册） 1992年第2期12卷 81-82页

作者： shiro takahara 章咏裳

1990年7月至10月由日本14间大学附属医院或研究所组成肾移植后使用FK506临床研究的协作组,治疗期为3个月,共观察37例病人。在此基础上,他们又开展了第二阶段的研究工作,即更长时间使用FK506的随访观察。 37例病人中,有10例在随访期间将F... 详细信息

1990年7月至10月由日本14间大学附属医院或研究所组成肾移植后使用FK506临床研究的协作组,治疗期为3个月,共观察37例病人。在此基础上,他们又开展了第二阶段的研究工作,即更长时间使用FK506的随访观察。 37例病人中,有10例在随访期间将FK506改为常规药物,1例病人的血型未符合原研究方案ABO必须相同的规定,故未列入内,因此多个研究中心协作随访观察的病人共26例。

关键词：肾移植 FK506 抗生素

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维普期刊数据库

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Safety and Efficacy of Once-Daily Administration of Mycophenolate Mofetil in Kidney Transplant Patients—A New Treatment Option for Non-Adherence

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Journal of Biomedical Science and Engineering 2014年第10期7卷 788-791页

作者： Naotsugu Ichimaru Kazuaki Yamanaka Taigo Kato Yoichi Kakuta Toyofumi Abe Jun-ya Kaimori Ryoichi Imamura Norio Nonomura shiro takahara Department of Advanced Technology for Transplantation Osaka University Graduate School of Medicine Suita Japan Department of Specific Organ Regulation (Urology) Osaka University Graduate School of Medicine Suita Japan

Non-adherence to immunosuppressive therapy is associated with reduced graft survival. Fifteen long-term follow up kidney transplant patients with stable post-transplant clinical courses were enrolled in the study. All patients were prescribed to tacrolimus prolonged release, mycophenolate mofetil (MMF) and corticosteroid at the time of enrolment. Twice-daily administration of MMF was then converted to a single daily dose. As a result, all immunosuppressive agents were administered simultaneously at one time in the morning. The daily total doses of the three immunosuppressants were identical during the study period. No acute rejection or adverse event was observed during the study period. Blood urea nitrogen and estimated glomerular filtration rate did not change significantly after conversion to once-daily administration. The blood tacrolimus trough level and the Mycophenolic acid (MPA) trough level also did not change significantly after conversion to once-daily administration. Interestingly, the meanmedian MPA trough level remained >3 μg/ml even after conversion to once-daily administration. A sufficient plasma MPA level was maintained after conversion to once-daily administration, and no acute rejection was observed during the study period. To our knowledge, this study is the first to report that the plasma MPA concentration can be maintained after once-daily administration of MMF in long-term kidney transplant patients. Once-daily administration of immunosuppressive agents may improve long-term graft survival because of better treatment adherence due to the reduced dosing frequency. The safety or efficacy of conversion to once-daily administration of MMF should be evaluated in a future randomized controlled large-scale clinical study.

关键词： Once-Daily Administration Mycophenolate Mofetil Treatment Adherence

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iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells

iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Re...

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第十二届全国免疫学学术大会

作者： Zhu Ping Cai Songjie Hou Jiangang Fujino Masayuki Zhang Qi Ichimaru Naotsugu takahara shiro Araki Ryoko Lu Lina Chen Ji-Mei Zhuang Jian Li Xiao-Kang Department of Cardiac Surgery Guangdong Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences Division of Transplantation Immunology National Research Institute for Child Health and Development Department of Advanced Technology for Transplantation Osaka University Graduate School of Medicine Huashan Hospital Fudan University AIDS Research Center National Institute of Infectious Diseases Department of Basic Medical Sciences for Radiation Damages National Institute of Radiological Sciences Department of Immunology Lerner Research InstituteCleveland Clinic

Objective:For reducing the use of IS drugs and inducing donor-specific tolerance in transplantation,we hypothesized that donor-type iPS-DCregs expressing donor antigen worked as an immune suppressive vaccine to genera... 详细信息

关键词： TGF-β1 antigen-specific tolerance iPSC murine cardiac allotransplant regulatory T cells

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