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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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military medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec mccarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA mary&Dick Holland Regenerative medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECm).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBms),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBms and outline general strategies for functionalizing and tailoring the BNBms with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBms for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

Allometric relationships between primary size measures and sapwood area for six common tree species in snow-dependent ecosystems in the Southwest United States

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Journal of Forestry Research 2020年第6期31卷 2171-2180页

作者： Bhaskar mitra shirley A.Papuga mRoss Alexander Tyson Lee Swetnam Nate Abramson School of Natural Resources and Environment University of ArizonaTucsonAZ 85721USA Department of Geology Wayne State UniversityDetroitMI 48202USA Laboratory of Tree-Ring Research University of ArizonaTucsonAZ 85721USA BIO5 Institute University of ArizonaTucsonAZ 85721USA Department of Hydrology and Water Resources University of ArizonaTucsonAZ 85721USA

High-elevation,snow-dependent,semiarid ecosystems across southwestern United States are expected to be vulnerable to climate change,including drought and fi re,with implications for various aspects of the water *** that end,much less is known about the dynamics of transpiration,an important component of the water cycle across this *** the individual-tree scale,transpiration is estimated by scaling mean sap fl ux density by the hydroactive sapwood area(SA).SA also remains a key factor in eff ectively scaling individual tree water-use to stand *** across large spatial scales is normally established by relating SA of a few trees to primary size measures,e.g.,diameter at breast height(DBH),tree height(H),or canopy diameter(CD).Considering the importance of SA in scaling transpiration,the primary objective of this study was therefore to establish six species-specifi c(aspen,maple,white fi r,ponderosa pine,Douglas fi r,Englemann spruce)allometric relationships between SA and three primary size measures(DBH,CD,or H)across two high-elevation,snow-dependent,semiarid ecosystems in New mexico and *** on multiple statistical criteria(coeffi cient of determination,index of agreement,Nash–Sutcliff e effi-ciency)and ease of measurement in the forest,we identifi ed DBH as the primary independent variable for estimating SA across all *** on group regression analysis,we found allometric relationships to be signifi cantly(pme species(ponderosa pine,Douglas-fi r)across diff erent ***,our allometric relationships provide a valuable database for estimating transpiration at diff erent spatial scales from sap fl ow data in some of our most vulnerable ecosystems.

关键词： Allometry Diameter at breast height mountain ecosystem Sapwood area Southwestern USA

Physical activity and chronic back conditions:A population-based pooled study of 60,134 adults

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Journal of Sport and Health Science 2019年第4期8卷 386-393页

作者： Hosam Alzahrani Debra shirley Sonia W.m.Cheng martin mackey Emmanuel Stamatakis Discipline of Physiotherapy Faculty of Health SciencesThe University of SydneySydneyNSW 2006Australia Physiotherapy Department College of Applied Medical ScienceTaif UniversityTaif21974Saudi Arabia Charles Perkins Centre Prevention Research CollaborationSchool of Public HealthThe University of SydneySydneyNSW 2006Australia

Background:Little is known about the association between different types of physical activity(PA)and chronic back conditions(CBCs)at the population *** investigated the association between levels of total and type-specific PA participation and ***'.The sample comprised 60,134 adults aged>16 years who participated in the Health Survey for England and Scottish Health Survey from 1994 to *** logistic regression models,adjusted for potential confbunders,were used to examine the association between total and type-specific PA volume(walking,domestic activity,sport/exercise,cycling,football/rugby,running/jogging,manual work,and housework)and the prevalence of ***'.We found an inverse association between total PA volume and prevalence of *** with inactive participants,the fully adjusted odds ratio(OR)for very active participants(≥15 metabolic equivalent h/week)was 0.77(95%confidence interval(CI):0.69—0.85).Participants reporting≥300 min/week of moderate-intensity activity and≥75 min/week of vigorous-intensity activity had 24%(95%CI:6%—39%)and 21%(95%C1:11%—30%)lower odds of CBCs,*** odds of CBCs were observed for participation in high-level manual domestic activity(OR=1.22;95%CI:1.00-1.48).Sport/exercise was associated with CBCs in a less consistent manner(e.g.,OR=1.18(95%CI:1.06—1.32)for low levels and OR=0.82(95%CI:0.72—0.93)for high levels of sport/exercise).Conclusion'.PA volume is inversely associated with the prevalence of CBCs.

关键词： Activity Chronic low back pain Chronic musculoskeletal conditions Epidemiology Exercise

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 59-70页

作者： Aoife J mccarthy Runjan Chetty Department of Anatomical Pathology Laboratory Medicine Program University Health Network Department of Laboratory medicine and Pathobiology Faculty of Medicine University of Toronto

AIm To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the *** The English language medical literature on gut-or gastrointestinal-associated lymphoid tissue(GALT) or "dome" carcinoma of the colon was searched and *** GALT/dome-type carcinomas of the colon are thought to arise from the m-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque-or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local *** Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.

关键词： Dome-type carcinoma Gastrointestinal-associated lymphoid tissue carcinoma Gut-associated lymphoid tissue Lymphoglandular complex Colorectal cancer

The CELLULOSE-SYNTHASE LIKE C （CSLC） Family of Barley Includes members that Are Integral membrane Proteins Targeted to the Plasma membrane

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molecular Plant 2009年第5期2卷 1025-1039页

作者： Fenny m. Dwivany Dina Yulia Rachel A, Burton Neil J. shirley Sarah m. Wilson Geoffrey B, Fincher Antony Bacic Ed Newbigin monika S. Doblin Plant Cell Biology Research Centre School of Botany. University of Melbourne Victoria 3010 Australia Australian Centre for Plant Functional Genomics School of Agriculture and Wine University of Adelaide South Australia 5064 Australia Australian Centre for Plant Functional Genomics School of Botany University of Melbourne Victoria 3010 Australia Present address: Department of Biology Institut Teknologi Bandung Bandung Indonesia Present address: Stem Cell and Cancer Institute Jh Jend. Ahmad Yani No.2 Pulo Mas Jakarta 13210 Indonesia

The CELLULOSE SYNTHASE-LIKE C （CSLC） family is an ancient lineage within the CELLULOSE SYNTHASE/CELLULOSE SYNTHASE-LIKE （CESA/CSL） polysaccharide synthase superfamily that is thought to have arisen before the divergence of mosses and vascular plants. As studies in the flowering plant Arabidopsis have suggested synthesis of the （1,4）-β-glucan backbone of xyloglucan （XyG）, a wall polysaccharide that tethers adjacent cellulose microfibrils to each other, as a probable function for the CSLCs, CSLC function was investigated in barley （Hordeum vulgate L.）, a species with low amounts of XyG in its walls. Four barley CSLCgenes were identified （designated HvCSLC1-4）. Phylogenetic analysis reveals three well supported clades of CSLCs in flowering plants, with barley having representatives in two of these clades. The four barley CSLCs were expressed in various tissues, with in situ PCR detecting transcripts in all cell types of the coleoptile and root, including cells with primary and secondary cell walls. Co-expression analysis showed that HvCSLC3 was coordinately expressed with putative XyG xylosyltransferase genes. Both immuno-Em and membrane fractionation showed that HvCSLC2 was located in the plasma membrane of barley suspension-cultured cells and was not in internal membranes such as endoplasmic reticulum or Golgi apparatus. Based on our current knowledge of the sub-cellular locations of polysaccharide synthesis, we conclude that the CSLC family probably contains more than one type of polysaccharide synthase.

关键词： Cellulose synthase-like family C plant cell wall biosynthesis xyloglucan cellulose glycosyltransferase

Sustainable urban development — the public health dimension

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Journal of Environmental Sciences 1999年第3期11卷 279-283页

作者： mark mccarthy Department of Public Health and Epidemiology, University College London, 1 19 Torrington Place, London WC1E 6EA, United Kingdom. E mail: m.mccarthy@ucl.ac.uk Univeristy College London 英国

Public health in England developed during the first half of the nineteenth century with concern for sanitation in urban areas. Since that time environment, behaviour, social relationships, health services and genetic constitution are all recognized to contribute to health and disease in populations. Sustainable development is now of global concern, and its foundations—economy, environment and society—are similar to the determinants of health. However, while improved environment will have an important contribution to health, the broader social objectives are also needed to avoid the downward cycle of inequality and cultural deterioration that has occurred in some western cities. Epidemiological studies at University College London are particularly concerned with these social dimensions, and research opportunities exist for collaboration with environmental sciences in a number of areas, including intersectoral work, societies in social transition, collaboration with business, and research within through the European Union.

关键词： environment health policy sustainable development urban.

Food waste and associated carbon footprint:evidence from Chinese universities

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Ecosystem Health and Sustainability 2022年第1期8卷 228-241页

作者： Long Qian Qingling Rao Hongbo Liu Breda mccarthy Li Xian Liu Lingen Wang Institute of Food and Strategic Reserves Nanjing University of Finance&EconomicsNanjingChina Institute of Finance and Economics Shanghai University of Finance&EconomicsShanghaiChina Academy of Strategies of Innovation and Development Anhui UniversityHefeiChina College of Business Law and Governance James Cook UniversityTownsvilleQLDAustralia Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijingChina

In recent years,there has been widespread concern regarding the carbon footprint(CF)of food waste due to the key impact of CF on climate change,particularly as China’s food waste is rising with its economic *** has the largest scale of higher education in the world,and the amount of food waste in university canteens is considerable and cannot be *** study attempts to assess the carbon footprint(CF)of food waste at Chinese universities for the first time based on a national *** is estimated that 1.55 million tons of food were wasted in Chinese university canteens in 2018,based on 9,192 samples covering 29 provinces in *** associated CF was 2.51 mt *** top two food categories contributing to the total CF were meat and grains,accounting for 46.28%and 36.52%,***,the location of the university was significantly associated with the CF of plate *** also indicated that household income,meal satisfaction,sex,education,meal days,and food-saving campaigns were important factors influencing the CF of food *** study highlights areas that can help reduce the environmental impact of plate *** also provides targeted measures to reduce the associated CF of food waste in Chinese universities.

关键词： Food waste plate waste carbon footprint university canteens China

Nurses' views of fundamental relational skills used in clinical practice: a cross-sectional pilot study

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Frontiers of Nursing 2021年第3期8卷 223-232页

作者： Fiona Timmins Jan m.A.de Vries Yvonne muldowney Catherine mc Cabe Jacqueline Whelan Sinead Buckley Sandra mccarthy The School of Nursing and midwifery Trinity CollegeDublin 2Ireland Portlaoise General Hospital BallyroanPortlaoiseCo.LaoisIreland

Objective:Effective communication skills are one of the core competencies of nursing curricula *** are generally regarded as *** our complete trust in the profession,deficiencies and gaps ***,it is not clear to which extent nurses use key communication skills in practice,and whether or not confident in using these skills compounds environmental issues that *** study explored nurse’s confidence and application of relational skills competencies in nursing ***:A 13-item online survey was used to collect ***:Being self-aware on key areas where there was more *** also lacked confidence in exploring the impact of their personal feelings and values on their *** were also less confident on responding appropriately to instances of unsafe or unprofessional practice and using information and communication systems and ***:Given the potential impact of poor relational skills on quality client care,an increased emphasis on caring and compassion,and the ever-expanding use of communication technologies,there is a need to explore the need for reflective practice to enhance continuous professional development for nurses to enhance their relational skills.

关键词： communication relational nurse caring nursing competencies technology listening

Applications of circulating tumor cells for prostate cancer

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Asian Journal of Urology 2016年第4期3卷 254-259页

作者： shirley Cheng Jie-Fu Chen Yi-Tsung Lu Leland W.K.Chung Hsian-Rong Tseng Edwin m.Posadas Urologic Oncology Program Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Division of Hematology/Oncology Department of MedicineCedars-Sinai Medical CenterLos AngelesCAUSA Department of Internal medicine John H Stroger HospitalChicagoILUSA Cancer Biology Program Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA California Nanosystems Institute University of CaliforniaLos AngelesCAUSA Department of molecular Pharmacology University of CaliforniaLos AngelesCAUSA Translational Oncology Program Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA

One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease *** cancer is among these diseases and greatly affects the health of men *** tumor cells(CTCs)are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral *** until recently,clinical applications of CTCs have been limited to using enumeration as a prognostic tool in ***,advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate *** is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes,biochemical analyses,and genomic *** advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic *** recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men.

关键词： Prostate cancer Circulating tumor cell Biomarker Liquid biopsy molecular oncology