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Treatment-Plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. Yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary Brandon Gunn Amol J. Ghia Jay P. Reddy Shaan M. Raza Franco De Monte Mark S. Chambers Paul D. Brown shirley su Jack Phan Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Oncologic Dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMPT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMPT, and compared the quality of the three sets of plans. Methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMPT were generated with multi-field optimization. The optimized VMAT and IMPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated Proton Therapy Spot Scanning Proton Therapy

基于里德伯原子Stark效应射频电场测量灵敏度研究

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物理学报 2024年第9期73卷 88-94页

作者：韩小萱孙光祖郝丽萍白素英焦月春太原师范学院物理系晋中030619 太原学院材料与化学工程系太原030032 山西师范大学物理与信息工程学院太原030031 山西大学激光光谱研究所量子光学与光量子器件国家重点实验室太原030006

里德伯原子极化率大,在外加电场作用下原子能级发生Stark分裂和频移,可实现里德伯原子高灵敏电场传感器的研究.采用shirley的简化不含时Floquet哈密顿量模型,计算了Cs里德伯原子的AC Stark能谱,修正后与实验上测得的弱场中Cs里德伯原子... 详细信息

里德伯原子极化率大,在外加电场作用下原子能级发生Stark分裂和频移,可实现里德伯原子高灵敏电场传感器的研究.采用shirley的简化不含时Floquet哈密顿量模型,计算了Cs里德伯原子的AC Stark能谱,修正后与实验上测得的弱场中Cs里德伯原子的DC Stark离子能谱拟合,在获得60D_(5/2)和70D_(5/2)里德伯原子态极化率αDC的同时实现低频弱场灵敏度的计算.并计算了Cs里德伯原子60D_(5/2)态频率在0—500 GHz范围内振荡电场中的AC Stark能级频移量,对里德伯原子传感器在其宽光谱范围内的灵敏度进行定量分析,实现任意场频率最佳灵敏度的计算,为里德伯原子传感器的研究提供理论基础.

关键词： AC Stark效应里德伯传感器 Floquet模型

Carbon Nanotubes Inhibit the Hemolytic Activity of the Pore-Forming Toxin Pyolysin

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Nano Research 2009年第7期2卷 517-525页

作者： Apraku David Donkor Zhengding su Himadri S.Mandal Xu Jin Xiaowu(shirley)Tang Department of Chemistry University of WaterlooWaterlooON N2L 3G1Canada

Functionalized carbon nanotubes have already demonstrated great biocompatibility and potential for drug *** have synthesized acid oxidized and non-covalently PEGlyated single-walled carbon nanotubes(SWNTs),which were previously prepared for drug delivery purposes,and explored their potential for detoxification in the *** investigations of the binding of SWNTs to a pore-forming toxin pyolysin show that SWNTs prevented toxin-induced pore formation in the cell membrane of human red blood *** hemolysis assay and scanning electron microscopy were used to evaluate the inhibition of hemolytic activity of *** to Raman spectroscopy data,human red blood cells,unlike HeLa cells,did not internalize oxidized *** modeling and circular dichroism measurements were used to predict the 3-D structure of pyolysin(domain 4)and its interaction with *** tryptophan-rich hydrophobic motif in the membrane-binding domain of pyolysin,a common construct in a large family of cholesterol-dependent cytolysins,shows high affinity for SWNTs.

关键词： Single-walled carbon nanotubes(SWNT) pore-forming toxin pyolysin hemolytic activity red blood cell protein-nanotube interaction detoxification

Genome-Wide Analysis of Histone Modifications： H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica

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Molecular Plant 2013年第5期6卷 1463-1472页

作者： Zhou Du Hui Li Qiang Wei Xin Zhao Chunchao Wang Qilin Zhu Xin Yi Wenying Xua X. shirley Liu Weiwei Jin Zhen su State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China National Maize Improvement Center of China Key Laboratory of Biology and Genetic Improvement of Maize Ministry of Agriculture China Agricultura University Beijing 100193 China Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard School of Public Health 450 Brookline Ave Boston MA 02215 USA These authors contributed equally to the article. Present address: Department of Bioinformatics School of Life Sciences andTechnology Tongji University 1239 Siping Road Shanghai 200092 China

While previous studies have shown that histone modifications could influence plant growth and devel- opment by regulating gene transcription, knowledge about the relationships between these modifications and gene expression is still limited. This study used chromatin immunoprecipitation followed by high-throughput sequencing （ChlP-Seq）, to investigate the genome-wide distribution of four histone modifications： di and trimethylation of H3K4 （H3K4me2 and H3K4me3） and acylation of H3K9 and H3K27 （H3K9ac and H3K27ac） in Oryza sativa L. japonica. By analyz- ing published DNase-Seq data, this study explored DNase-Hypersensitive （DH） sites along the rice genome. The histone marks appeared mainly in generic regions and were enriched around the transcription start sites （TSSs） of genes. This analysis demonstrated that the four histone modifications and the DH sites were all associated with active transcription. Furthermore, the four histone modifications were highly concurrent with transcript regions-a promising feature that was used to predict missing genes in the rice gene annotation. The predictions were further validated by experimentally confirming the transcription of two predicted missing genes. Moreover, a sequence motif analysis was constructed in order to identify the DH sites and many putative transcription factor binding sites.

关键词： bioinformatics chromatin structure and remodeling epigenetics gene regulation genomics rice.

The Principal Component Analysis of Element Contents in Chinese Herbs of the Caine Kidney Mixture

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Engineering（科研） 2012年第10期4卷 39-42页

作者： Shurong su Xiaoxi Yang Yi Xie Weiqun Tian shirley Z Shen Biology Base Class2 College of Life Sciences at Wuhan University Luo-jia-shan Wuhan 430072 P. R. China Department of Biomedical Engineering Wuhan University School of Basic Medical Sciences 185 Donghu Rd.Wuhan 430071 P. R. China Division of Materials Science and Engineering CSIRO 37 Graham Rd. Highett VIC 3190 Australia Wuhan University School of Mathematics and Statistics Luo-jia-shan Wuhan 430072 P. R. China

Objective: This research compares the nature of 11 kinds of Chinese herbs in the caine kidney mixture, and provides a theoretical way to concentrated prescriptions. Methods: Based on the principal component analysis of element contents in Chinese herbs, the effects of 25 chemical elements in the 11 kinds of Chinese herbs in the caine kidney mixture have been analyzed. Results: The traditional Chinese medicines of rehmannia, astragalus, mulberry, salvia miltiorrhiza, rhubarb in the caine kidney mixture play a major role in the treatment of chronic renal failure. Conclusion: The principal component analysis is very practical in the compatibility of medicines and concentrated prescriptions.

关键词： Chemical Element Principal Com- ponent Analysis the Caine Kidney Mixture Concentrated Prescriptions

CistromeMap:A knowledgebase and web server for ChlP-Seq and DNase-Seq studies in mouse and human

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CistromeMap:A knowledgebase and web server for ChlP-Seq and ...