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Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?

World Journal of Gastroenterology 2011年第20期17卷 2465-2472页

作者： Akshata Moghe Swati Joshi-barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain shirish barve University of Louisville Alcohol Research Center Department of Pharmacology and Toxicology University of Louisville Department of Internal Medicine Division of GastroenterologyHepatology and NutritionUniversity of Louisville Robley Rex Veterans Affairs Medical Center

Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and *** is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and *** can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease ***,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene *** review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to *** review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD.

关键词： Alcohol Liver disease Nutrients Metabolism Histone Epigenetic modifications S-adenosylmethionine Acetate Zinc NAD

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Elevated Linoleic Acid (A Pro-Inflammatory PUFA) and Liver Injury in a Treatment Naive HIV-HCV Co-Infected Alcohol Dependent Patient

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Journal of Biosciences and Medicines 2016年第7期4卷 23-27页

作者： Vatsalya Vatsalya shirish S. barve Craig J. McClain Vijay A. Ramchandani Division of Gastroenterology Hepatology and Nutrition Department of Medicine University of Louisville School of Medicine Louisville USA Section on Human Psychopharmacology LCTS/DICBR/NIAAA at National Institutes of Health Bethesda USA Department of Pharmacology and Toxicology University of Louisville School of Medicine Louisville USA Robley Rex VA Medical Center Louisville USA

HIV and HCV co-infection is a unique disease condition, and medical management of such condition is difficult due to severity and systemic complications. Added with heavy alcohol drinking, risk of liver injury increases due to several pro-inflammatory responses that subsequently get involved with alcohol metabolism. Elevated levels of fatty acids have been reported both in viral infections as well as alcoholic liver disease though such investigations have not addressed the adverse event with dual viral infection of HIV and HCV along with heavy drinking. This case report of a patient with excessive alcohol drinking and first time diagnosis of HIV and HCV dual infection, elaborating concurrent alteration in Linoleic Acid (LA) levels and pro-inflammatory shift in ω-6/ω-3 ratio along with the elevations in liver injury markers. Elevated LA has been recently studied extensively for its role in alcoholic liver disease;and in the present case, we also found it to be clinically relevant to liver injury.

关键词： Alcohol Fatty Acids HCV HIV Liver Injury

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HIV发病机理中重要的危险因素酒精的作用：临床发现、潜在机制和治疗干预

HIV发病机理中重要的危险因素酒精的作用：临床发现、潜在机制和...

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第十届全国药物依赖性学术会议暨首届中美药物滥用和HIV/HCV共病专题研讨会

作者： shirish barve Department of Medicine and Pharmacology & Toxicology University of LouisvilleLouisvilleKY40292

The well-documented immunosuppressive effects of both alcohol and HIV-1 infection under- score the importance of understanding the potential interactions between these immunosuppressive factors in HIV patients abusing... 详细信息

关键词： alcohol risk factor HIV pathogenesis clinical findings potential mechanisms therapeutic intervention

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