检索结果-南通市图书馆

Psychiatric and substance use disorders co-morbidities and hepatitis C: Diagnostic and treatment implications

World Journal of Hepatology 2015年第15期7卷 1921-1935页

作者： Peter Hauser shira kern VISN 22 Network Office Department of Psychiatry and Human Behavior University of California Irvine Department of Psychiatry University of California San Diego VA Long Beach Healthcare System

Chronic hepatitis C virus(HCV) viral infection is the most common blood-borne viral infection and approximately 2%-3% of the world's population or 170-200 million people are infected. In the United States as many as 3-5 million people may have HCV. Psychiatric and substance use disorders(SUDs) are common co-morbid conditions found in people with HCV and are factors in predisposing people to HCV infection. Also, these co-morbidities are reasons that clinicians exclude people from antiviral therapy in spite of evidence that people with HCV and co-morbid psychiatric and SUD can be safely and effectively treated. Furthermore, the neuropsychiatric side effects of interferon(IFN), until recently the mainstay of antiviral therapy, have necessitated an appreciation and assessment of psychiatric co-morbidities present in people with HCV. The availability of new medications and IFNfree antiviral therapy medication combinations will shorten the duration of treatment and exposure to IFN and thus decrease the risk of neuropsychiatric side effects. This will have the consequence of dramatically altering the clinical landscape of HCV care and will increase the number of eligible treatment candidates as treatment of people with HCV and co-morbid psychiatric and SUDs will become increasingly viable. While economically developed countries will rely on expensive IFN-free antiviral therapy, less developed countries will likely continue to use IFN-based therapies at least until such time as IFNfree antiviral medications become generic. The current manuscript discusses the efficacy and viability of treating HCV in people with psychiatric and SUDs comorbidities, the treatment of the neuropsychiatric side effects of IFN-based therapies and the impact of new medications and new treatment options for HCV that offer the promise of increasing the availability of antiviral therapy in this vulnerable population.

关键词： Hepatitis C Psychiatric disorders Substanceuse disorders Antiviral treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells

引用

World Journal of Stem Cells 2015年第5期7卷 823-838页

作者： shira Yanovsky-Dagan Hagar Mor-Shaked Rachel Eiges Stem Cell Research Laboratory Medical Genetics Institute Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine

Pathogenic mutations involving DNA repeat expansions are responsible for over 20 different neuronal and neuromuscular diseases. All result from expanded tracts of repetitive DNA sequences(mostly microsatellites) that become unstable beyond a critical length whentransmitted across generations. Nearly all are inherited as autosomal dominant conditions and are typically associated with anticipation. Pathologic unstable repeat expansions can be classified according to their length, repeat sequence, gene location and underlying pathologic mechanisms. This review summarizes the current contribution of mutant pluripotent stem cells(diseased human embryonic stem cells and patient-derived induced pluripotent stem cells) to the research of unstable repeat pathologies by focusing on particularly large unstable noncoding expansions. Among this class of disorders are Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome, myotonic dystrophy type 1 and myotonic dystrophy type 2, Friedreich ataxia and C9 related amyotrophic lateral sclerosis and/or frontotemporal dementia, Facioscapulohumeral Muscular Dystrophy and potentially more. Common features that are typical to this subclass of conditions are RNA toxic gain-of-function, epigenetic loss-of-function, toxic repeat-associated non-ATG translation and somatic instability. For each mechanism we summarize the currently available stem cell based models, highlight how they contributed to better understanding of the related mechanism, and discuss how they may be utilized in future investigations.

关键词： Unstable repeat associated disorders Human embryonic stem cells Patient-derived inducedpluripotent stem cells Disease modeling Epigenetics repeat-associated non-ATG translation RNA toxicity Repeat somatic instability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retrospective study of the associations between hepatitis C virus infection and metabolic factors

引用

World Journal of Hepatology 2016年第30期8卷 1269-1278页

作者： shira Yair-Sabag Elchanan Nussinson Ofir Ben-Assuli Fahmi Shibli Azmi Shahbari shira Zelber-Sagi Gastroenterology Institute Emek Medical Center School of Public Health University of Haifa Ono Academic College

AIMTo evaluate the bidirectional association between metabolic syndrome (MS) components and antiviral treatment response for chronic hepatitis C virus (HCV) infection. METHODSThis retrospective cohort study included 119 HCV + patients treated with pegylated-interferon-α and ribavirin. Metabolic characteristics and laboratory data were collected from medical records. Differences in baseline clinical and demographic risk factors between responders and non-responders were assessed using independent samples t-tests or χ2 tests. The effects of sustained viral response (SVR) to antiviral treatment on de novo impairments in MS components, including impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), were assessed using univariable and multivariable logistic regression analysis, while the effect of MS components on SVR was assessed using univariable logistic regression analysis. RESULTSOf the 119 patients, 80 (67%) developed SVR over the average 54 ± 13 mo follow-up. The cumulative risks for de novo T2DM and IFG were 5.07- (95%CI: 1.261-20.4, P = 0.022) and 3.87-fold higher (95%CI: 1.484-10.15, P = 0.006), respectively for non-responders than responders, when adjusted for the baseline risk factors age, sex, HCV genotype, high viral load, and steatosis. Post-treatment triglyceride levels were significantly lower in non-responders than in responders (OR = 0.27; 95%CI: 0.069-0.962, P = 0.044). Age and HCV genotype 3 were significantly different between responders and non-responders, and MS components were not significantly associated with SVR. Steatosis tended to attenuate SVR (OR = 0.596; 95%CI: 0.331-1.073, P = 0.08). CONCLUSIONSVR was associated with lower de novo T2DM and IFG incidence and higher triglyceride levels. Patients infected with HCV should undergo T2DM screening and antidiabetic treatment.

关键词： Hepatitis C virus Type 2 diabetes mellitus Antiviral therapy Sustained viral response Metabolic syndrome Hepatic steatosis Peg interferon alpha Ribavirin Direct acting antiviral agents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Removing Moisture Effect on Soil Reflectance Properties: A Case Study of Clay Content Prediction

引用

Pedosphere 2019年第4期29卷 421-431页

作者： Yaron OGEN shira FAIGENBAUM-GOLOVIN Amihai GRANOT Yoel SHKOLNISKY Naftaly GOLDSHLEGER Eyal BEN-DOR The Porter School of Environmental Studies Tel Aviv University Tel Aviv 6997801 (Israel) Department of Applied Mathematics Tel Aviv University Tel Aviv 6997801 (Israel) Remote Sensing Laboratory Department of Geography and the Human Environment Tel Aviv University Tel Aviv 6997801 (Israel) Department of Civil Engineering Ariel University Ariel 407000 (Israel)

Visible, near-infrared and shortwave-infrared(VNIR-SWIR) spectroscopy is an efficient approach for predicting soil properties because it reduces the time and cost of analyses. However, its advantages are hampered by the presence of soil moisture, which masks the major spectral absorptions of the soil and distorts the overall spectral shape. Hence, developing a procedure that skips the drying process for soil properties assessment directly from wet soil samples could save invaluable time. The goal of this study was twofold:proposing two approaches, partial least squares(PLS) and nearest neighbor spectral correction(NNSC), for dry spectral prediction and utilizing those spectra to demonstrate the ability to predict soil clay content. For these purposes, we measured 830 samples taken from eight common soil types in Israel that were sampled at 66 different locations. The dry spectrum accuracy was measured using the spectral angle mapper(SAM) and the average sum of deviations squared(ASDS), which resulted in low prediction errors of less than 8% and 14%, respectively. Later, our hypothesis was tested using the predicted dry soil spectra to predict the clay content, which resulted in R^2 of 0.69 and 0.58 in the PLS and NNSC methods, respectively. Finally, our results were compared to those obtained by external parameter orthogonalization(EPO) and direct standardization(DS). This study demonstrates the ability to evaluate the dry spectral fingerprint of a wet soil sample, which can be utilized in various pedological aspects such as soil monitoring, soil classification,and soil properties assessment.

关键词： dry spectral fingerprint nearest neighbor spectral correction partial least squares reflectance spectra soil moisture soil property spectroscopy wet soil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nutritional issues in patients with obesity and cirrhosis

引用

World Journal of Gastroenterology 2018年第30期24卷 3330-3346页

作者： Luigi Schiavo Luca Busetto Manuela Cesaretti shira Zelber-Sagi Liat Deutsch Antonio Iannelli Department of Translational Medical Science University of Campania“Luigi Vanvitelli”Naples 80131Italy Ⅸ Division of General Surgery Vascular Surgery and Applied BiotechnologyNaples University PoliclinicNaples 80131Italy Department of Medicine University of PaduaPadua 35128Italy Center for the Study and the Integrated Management of Obesity University Hospital of PaduaPadua 35128Italy Department of HPB Surgery and Liver Transplantation Hopital BeaujonAP-HPClichy 92110France Department of Nanophysics Italian Institute of TechnologyGenova 16163Italy School of Public Health University of HaifaHaifa 3498838Israel Department of Gastroenterology and Liver disease Tel Aviv Medical Center62431Tel-Aviv 62431Israel The Sackler Faculty of Medicine Tel-Aviv UniversityTel-Aviv 62431Israel Digestive Unit Archet 2 HospitalUniversity Hospital of NiceF-06202NiceFrance Inserm U1065Team 8“Hepatic complications of obesity”Nice F-06204France University of Nice Sophia-Antipolis Nice F-06107France

Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress to *** with obesity also have an increased risk of primary liver malignancies and increased body mass index is a predictor of decompensation of liver *** obesity confers a risk of physical impairment and disability that is significantly higher than the risk induced by each of the two conditions alone as it has been shown to be an independent risk factor for chronicliver disease in patients with obesity and a prognostic negative marker for the evolution of liver cirrhosis and the results of liver *** patients with obesity are at high risk for depletion of various fat-soluble,water-soluble vitamins and trace elements and should be supplemented ***,physical activity and protein intake should be carefully monitored in these fragile patients according to recent *** surgery is sporadically used in patients with morbid obesity and cirrhosis also in the setting of liver *** risk of sarcopenia,micronutrient status,and the recommended supplementation in patients with obesity and cirrhosis are discussed in this ***,the indications and contraindications of bariatric surgery-induced weight loss in the cirrhotic patient with obesity are discussed.

关键词： obesity cirrhosis sarcopenia malnutrition bariatric surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis

引用

World Journal of Gastroenterology 2020年第38期26卷 5849-5862页

作者： Neta Gotlieb Naama Schwartz shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet Department of Gastroenterology and Hepatology Tel-Aviv Sourasky Medical CenterTel Aviv 6423906Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6997801Israel School of Public Health University of HaifaHaifa 3498838Israel Institute for Research and Innovation Maccabi Health ServicesTel Aviv 6812509Israel

BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality *** disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics *** represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk ***,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of *** To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver *** A nested case-control study utilizing a large computerized *** cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:*** participants had multiple laboratory measurements prior to *** calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy *** association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was *** The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of *** leading cirrhosis etiologies were viral,alcoholic and fatty liver *** mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μ*** trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patien

关键词： Cirrhosis Platelets Count Trend Prediction Range

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mediterranean dietary components are inversely associated with advanced colorectal polyps:A case-control study

引用

World Journal of Gastroenterology 2018年第24期24卷 2617-2627页

作者： Naomi Fliss-Isakov Revital Kariv Muriel Webb Dana Ivancovsky Dana Margalit shira Zelber-Sagi Department of Gastroenterology Tel Aviv Medical Center Tel Aviv 6423906Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6423906Israel School of Public Health University of HaifaHaifa 3498838Israel

AIM To evaluate the association between the Mediterranean diet(MD) pattern and its components, and advanced colorectal polyps(adenoma and serrated adenoma).METHODS A case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia(HGD) or villous histology], advanced serrated adenoma(> 10 mm or with dysplasia) or multiple(≥ 3) non-advanced adenomas or serrated adenomas. Cases of non-advanced adenomas were defined as adenomas < 10 mm, without features of HGD or villous histology. Controls were defined as those without polyps at the current colonoscopy and without a history of colorectal polyps. Data collection included: anthropometrics measured according to a standardized protocol, fasting blood tests performed at the same lab, medical history recorded by a structured interview and dietary intake evaluated by a 116-item food frequency questionnaire. Adherence to the MD components was evaluated according to intake above/below the sample median, for potentially beneficial/detrimental components respectively, as accepted. RESULTS We recruited 206 cases with advanced polyps, 192 cases with non-advanced adenoma and 385 controls. The number of adhered MD components was inversely associated with a diagnosis of advanced polyps in a dose-response manner(OR = 0.34, 95%CI: 0.17-0.65; OR = 0.22, 95%CI: 0.11-0.43; and OR = 0.18, 95%CI: 0.07-0.47 for 3-4, 5-7 and 8-10 components, respectively), but not with non-advanced adenomas(OR = 0.54, 95%CI: 0.25-1.13; OR = 0.48, 95%CI: 0.23-0.99; and OR = 0.43, 95%CI: 0.16-1.12 for 3-4, 5-7 and 8-10 components, respectively). Low intake of sugar-sweetened beverages and red meat, as well as high intake of fish, were inversely associated with advanced polyps(OR = 0.56, 95%CI: 0.36-0.87; OR = 0.63, 95%CI: 0.42-0.95; and OR = 0.66

关键词： Fish intake Sugar-sweetened beverages Red meat intake Dietary adherence Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metastatic tumor cells- genotypes and phenotypes

引用

Frontiers in Biology 2018年第4期13卷 277-286页

作者： Dingcheng Gao Vivek Mittal Yi Ban Ana Rita Lourenco shira Yomtoubian Sharrell Lee Department of Cardiothoracic Surgery Department of Cell and Developmental Biology Neuberger Berman Lung Cancer Center WeillCornell Medicine New York NY10065 USA

BACKGROUND： Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research. OBJECTIVE： To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells. METHOD and RESULT： In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell （CSC） and epithelial to mesenchymal transition （EMT） phenotypes are associated with the metastatic cascade. CONCLUSION： In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.

关键词： metastasis epithelial to mesenchymal transition (EMT) cancer stem cell circulating tumor cells cellular plasticity phenotype dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Breast Cancer Lifestyle Intervention Pilot Study

引用

Journal of Cancer Therapy 2014年第12期5卷 1031-1038页

作者： Elizabeth kern Jennifer Chun shira Schwartz Jessica Billig Erica Friedman Martha Eddy Deirdre Kiely Amber Guth Deborah Axelrod Freya Schnabel Department of Surgery New York University Langone Medical Center New York USA School of Medicine New York University Langone Medical Center New York USA Moving for Life New York USA

Purpose: Weight loss after breast cancer diagnosis has been associated with a decrease in risk of breast cancer recurrence and mortality. The purpose of this study is to examine the barriers, acceptance, and sustainability of an exercise intervention program offered at our institution to overweight women with newly diagnosed breast cancer. Methods: The Breast Cancer Database was queried for women newly diagnosed with breast cancer and a body mass index (BMI) ≥ 25 kg/m2. Eligible patients participated in the Moving for Life (MFL) exercise program for 16 sessions. Questionnaires were administered. Statistical analyses included descriptives and paired t-tests to summarize patient characteristics and assess changes over time. Results: Of 40 patients, 22 declined, 18 consented and 13 (72%) completed the study. The mean age was 61 years (range: 38 - 76). The mean BMI was 31 kg/m2. After the intervention, there was a decrease in weight and BMI (p?= 0.04). The average weight loss was 10 lbs. Participants reported greater enjoyment of exercise (p?= 0.02) and decreased pain related to treatment (p?= 0.05). These initial positive results were not maintained after 6 months and 1 year. Conclusions: The MFL intervention had a high rate of acceptance among overweight women newly diagnosed with breast cancer. These results demonstrated significant benefits of exercise immediately after cancer diagnosis and highlight the importance of developing sustainable lifestyle interventions. Interventions targeted at modifiable lifestyle factors in women with early stage disease may provide benefit that is comparable to certain adjuvant systemic therapies. Therefore, adjuvant lifestyle interventions supported by clinicians may improve breast cancer survival outcomes.

关键词： Breast Cancer Lifestyle Intervention Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer

引用

World Journal of Gastroenterology 2018年第39期24卷 4472-4481页

作者： Nir Bar Naama Schwartz Michal Nissim Naomi Fliss-Isacov shira Zelber-Sagi Revital Kariv Department of Gastroenterology Tel Aviv Medical CenterTel Aviv 6423906Israel Faculty of Medicine Tel Aviv UniversityTel Aviv 6423906Israel School for Public Health University of HaifaHaifa 31905Israel

AIM To study factors associated with esophageal and nonesophageal cancer morbidity among Barrett's esophagus(BE) patients. METHODS A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Cancer morbidity was obtained from the national cancer registry. Main outcomes were BE related(defined as esophagus and cardia) and non-BE related cancers(all other cancers). Cancer incidence and all-causemortality were compared between patients with highgrade dysplasia(HGD) and with low-grade or no dysplasia(non-HGD) using Kaplan-Meier curves and cox regression *** Of the 386 patients, 12 had HGD, 7 had a BE related cancer. There were 75(19.4%) patients with 86 cases of lifetime cancers, 76 of these cases were non-BE cancers. Seven(1.8%) and 18(4.7%) patients had BE and non-BE incident cancers, respectively. Twelve(3.1%) patients had HGD as worst histologic result. Two(16.7%) and 16(4.4%) incident non-BE cancers occurred in the HGD and non-HGD group, respectively. Ten-year any cancer and non-BE cancer free survival was 63% and 82% in the HGD group compared to 93% and 95% at the non-HGD group, respectively. Log-rank test for patients with more than one endoscopy, assuring longer follow up, showed a significant difference(P < 0.001 and P = 0.017 respectively). All-cause mortality was not significantly associated with BE *** Patients with BE and HGD, may have a higher risk for all-cause cancer morbidity. The implications on cancer prevention recommendations should be further studied.

关键词： Barrett’s esophagus High grade dysplasia Esophageal cancer Upper endoscopy Cancer morbidity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：