检索结果-南通市图书馆

Caspase-8 activation regulates enterovirus D68 infection-induced inflammatory response and cell death

Biosafety and Health 2024年第3期6卷 171-177页

作者： Yuanyuan z.ou Chongtao z.ang Yuhan z.ang Fei Li Jun shen Children’s Hospital of Fudan University National Children's Medical CenterShanghai 201100China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China

Enterovirus D68 (EV-D68) infection causes severe acute respiratory infection and severe neurological complications, such as acute flaccid myelitis (AFM), in children. However, although EV-D68 has pandemic potential, no effective drugs or vaccines are currently clinically available. Furthermore, EV-D68 infection-induced inflammatory response and cell death are not fully understood. In this study, we demonstrated that several inflammatory cytokines were upregulated in a multiplicity of infection (MOI) dependent manner in EV-D68-infected human rhabdomyosarcoma (RD) cells. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) confirmed that tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), C-C motif chemokine ligand-5 (CCL-5), and CXC motif chemokine ligand-5 (CXCL-5) mRNA levels were highly upregulated after EV-D68 infection. IL-1β processing and maturation mediated by caspase-8 was inhibited by the caspase-8 inhibitor z.IETD-FMK. EV-D68 infection activates caspase-8 to mediate IL-1β maturation and secretion. Additionally, EV-D68 activated cell death-related proteins such as caspase-3, poly (ADP-ribose) polymerase 1 (PARP-1), phosphorylation of Mixed Lineage Kinase domain-like protein (pMLKL), and gasdermin E (GSDME). Thus, EV-D68 infection activates caspase-8, which triggers the necroptosis and apoptosis pathways. Overall, our data suggest that caspase-8 activation is associated with the inflammatory response and cell death in EV-D68-infected RD cells. This mechanism represents a novel target for the treatment of EV-D68 infection by inhibiting caspase-8 activation.

关键词： Enterovirus D68(EV-D68) Inflammatory response Cell death Caspase-8

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatology International|基于磁共振的临床-影像组学模型预测药物性肝损伤慢性化

引用

临床肝胆病杂志 2024年第2期40卷 270-270页

作者：沈哲涵李若坤瑞金医院放射科

药物性肝损伤(DILI)严重危害人类健康,约20%的患者会进展至DILI的慢性化,表现为反复持续的肝脏炎症,严重者会持续进展至肝纤维化,损伤患者的生命健康和生活质量,但目前仍缺少有效预测DILI慢性化的工具。越来越多的证据表明,影像组学可... 详细信息

药物性肝损伤(DILI)严重危害人类健康,约20%的患者会进展至DILI的慢性化,表现为反复持续的肝脏炎症,严重者会持续进展至肝纤维化,损伤患者的生命健康和生活质量,但目前仍缺少有效预测DILI慢性化的工具。越来越多的证据表明,影像组学可应用于多种肝脏疾病的诊断分期,包括肝脏肿瘤及弥漫性肝病(如肝纤维化)。但是,目前影像组学尚未应用于DILI的慢性化预测。

关键词：慢性化药物性肝损伤影像组学弥漫性肝病肝脏炎症肝脏肿瘤肝脏疾病肝纤维化

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural transition,electric transport,and electronic structures in the compressed trilayer nickelate La_(4)Ni_(3)O_(10)

引用

Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 9-15页

作者： Jingyuan Li Cui-Qun Chen Chaoxin Huang Yifeng Han Mengwu Huo Xing Huang Peiyue Ma z.engyang Qiu Junfeng Chen Xunwu Hu Lan Chen Tao Xie Bing shen Hualei Sun Dao-Xin Yao Meng Wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China Center for Materials of the Universe School of Molecular SciencesArizona State UniversityTempe 85287USA School of Sciences Sun Yat-sen UniversityShenzhen 518107China

Atomic structure and electronic band structure are fundamental properties for understanding the mechanism of superconductivity. Motivated by the discovery of pressure-induced high-temperature superconductivity at 80 K in the bilayer Ruddlesden-Popper nickelate La_(3)Ni_(2)O_(7), the atomic structure and electronic band structure of the trilayer nickelate La_(4)Ni_(3)O_(10) under pressure up to 44.3 GPa are investigated. A structural transition from the monoclinic P2_(1)/a space group to the tetragonal I4/mmm around 12.6-13.4 GPa is identified, accompanied by a drop of resistance below 7 K. Density functional theory calculations suggest that the bonding state of Ni 3d_(z.(2)) orbital rises and crosses the Fermi level at high pressures, which may give rise to possible superconductivity observed in resistance under pressure in La_(4)Ni_(3)O_(10). The trilayer nickelate La_(4)Ni_(3)O_(10) shows some similarities with the bilayer La_(3)Ni_(2)O_(7) and has unique properties, providing a new platform to investigate the underlying mechanism of superconductivity in nickelates.

关键词： La_(4)Ni_(3)O_(10) high pressure synchrotron X-ray diffraction structural transition DFT calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface-sensitive electronic structure of kagome superconductor CsV_(3)Sb_(5)

引用

Chinese Physics B 2024年第10期33卷 35-40页

作者： z.isheng z.ao Jianghao Yao Rui Xu Yuz.e Wang Sen Liao z.engtai Liu Dawei shen shengtao Cui z.e Sun Yilin Wang Donglai Feng Juan Jiang School of Emerging Technology and Department of Physics University of Science and Technology of ChinaHefei 230026China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China National Synchrotron Radiation Laboratory School of Nuclear Science and Technology and New Cornerstone Science LaboratoryUniversity of Science and Technology of ChinaHefei 230026China

We systematically study the electronic structure of a kagome superconductor CsV_(3)Sb_(5)at different temperatures coveringboth its charge density wave state and normal state with angle-resolved photoemission *** observe thatthe V-shaped band aroundГshows three different behaviors,referred to as a/a',βandγ,mainly at different *** investigations confirm that these bands are all from the same bulk Sb-p_(z.origin,but they are quite sensitiveto the sample surface conditions mainly modulated by ***,the intriguing temperature dependent electronicbehavior of the band nearГis affected by the sample surface condition,rather than intrinsic electronic behavior originatingfrom the phase *** result systematically reveals the confusing electronic structure behavior of the energy bandsaroundГ,facilitating further exploration of the novel properties in this material.

关键词： kagome ARPES charge density wave surface sensitive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Helicobacter pylori and immunotherapy for gastrointestinal cancer

引用

The Innovation 2024年第2期5卷 51-60页

作者： Keren Jia Yang Chen Yi Xie Xicheng Wang Yajie Hu Yu Sun Yanshuo Cao Liyan z.ang Yakun Wang z.enghang Wang z.ihao Lu Jian Li Xiaotian z.ang Lin shen Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Helicobacter pylori infection is associated with the risk of gastrointestinal(GI)cancers;however,its impact on immunotherapy for GI cancers remains *** this study,we included 10,122 patients who underwent ^(13)C-urea breath *** 636 patients with Epstein-Barr virus–negative microsatellite-stable gastric cancer(GC)who were treated with anti-PD-1/PD-L1 therapy,***–positive patients exhibited significantly longer immune-related progression-free survival(irPFS)compared with ***–negative patients(6.97 months versus 5.03 months,pz.rd ratio[HR]0.76,95%confidence interval[CI]0.62–0.95,p=0.015).Moreover,the ***–positive group demonstrated a trend of 4 months longer median immune-related overall survival(irOS)than the ***–negative ***–positive GC displayed higher densities of PD-L1+cells and nonexhausted CD8+T cells,indicative of a“hot”tumor *** analysis revealed that ***–positive GC shared molecular characteristics similar to those of immunotherapy-sensitive ***,***–positive patients with DNA mismatch repair–deficient(dMMR)/microsatellite instability–high(MSI-H)colorectal adenocarcinoma and esophageal squamous cell carcinoma(ESCC)had shorter irPFS compared with ***–negative patients(16.13 months versus not reached,p=0.042,HR 2.26,95%CI 1.13–4.50,p=0.021 and 5.57 months versus 6.97 months,p=0.029,HR 1.59,95%CI 1.14–2.23,p=0.006,respectively).The difference in irOS between ***–positive and–negative patients had the same trend as that between dMMR/MSI-H colorectal adenocarcinoma and ESCC *** also identified a trend of shorter irPFS and irOS in ***–positive liver cancer and pancreatic cancer *** summary,our findings supported that *** infection is a beneficial factor for GC immunotherapy by shaping hot tumor ***,in dMMR/MSI-H colorectal adenocarcinoma and ESCC patients,*** adversely affects the efficacy of immunothera

关键词： immunotherapy gastrointestinal pylori

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

前言:青藏高原及其周边综合地层、生物群与古地理演化

引用

中国科学：地球科学 2024年第4期54卷 911-914页

作者：沈树忠丁林朱茂炎王向东邓涛南京大学地球科学与工程学院关键地球物质循环前沿科学中心内生金属成矿机制研究国家重点实验室南京210023 中国科学院青藏高原研究所青藏高原地球系统全国重点实验室北京100101 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049 中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科... 详细信息

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科考报告的显著进展.

关键词：期望目标生物群全球构造生物与环境青藏高原周边

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multifunctional mixed analog/digital signal processor based on integrated photonics

引用

Opto-Electronic Science 2024年第8期3卷 1-12页

作者： Yichen Wu Qipeng Yang Bitao shen Yuansheng Tao Xuguang z.ang z.han Tao Luwen Xing z.angfeng Ge Tiantian Li Bowen Bai Haowen Shu Xingjun Wang State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China College of Engineering Peking UniversityBeijing 100871China Peking University Yangtz. Delta Institute of Optoelectronics Nantong 226010China School of Electronic Engineering Xi’an University of Posts&TelecommunicationsXi’an 710121China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China

Photonic signal processing offers a versatile and promising toolkit for contemporary scenarios ranging from digital optical communication to analog microwave *** to its electronic counterpart,it eliminates inherent bandwidth limitations and meanwhile exhibits the potential to provide unparalleled scalability and flexibility,particularly through integrated ***,by far the on-chip solutions for optical signal processing are often tailored to specific tasks,which lacks versatility across diverse ***,we propose a streamlined chip-level signal processing architecture that integrates different active and passive building blocks in silicon-on-insulator(SOI)platform with a compact and efficient *** and in-depth analyses for the architecture are conducted at levels of device,system,and *** by appropriate configuring schemes,the photonic circuitry supports loading and processing both analog and digital signals *** distinct tasks are facilitated with one single chip across several mainstream fields,spanning optical computing,microwave photonics,and optical ***,it has demonstrated competitive performance in functions like image processing,spectrum filtering,and electro-optical bandwidth *** high universality and a compact form factor,the proposed architecture is poised to be instrumental for next-generation functional fusion systems.

关键词： silicon photonics multifunctional signal process microwave photonics optical computing optical communica-tion equaliz.tion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-flammable long chain phosphate ester based electrolyte via competitive solventiz.d structures for high-performance lithium metal batteries

引用

Journal of Energy Chemistry 2024年第10期97卷 156-165,I0004页

作者： Li Liao z.iqiang Han Xuanjie Feng Pan Luo Jialin Song Yin shen Xiaoshuang Luo Xinpeng Li Xuanz.ong Wen Bo Yu Junchen Chen Bingshu Guo Mingshan Wang Yun Huang Hongmei z.ang Mengmeng Yin Jiangtao Liu Yuanhua Lin Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500SichuanChina State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.LtdZunyi 563003GuizhouChina Beijing Advanced Innovation Center for Materials Genome Engineering Center for Green InnovationSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Safety remains a persistent challenge for high-energy-density lithium metal batteries(LMBs).The development of safe and non-flammable electrolytes is especially important in harsh conditions such as high ***,a flame-retardant,low-cost and thermally stable long chain phosphate ester based(tributyl phosphate,TBP)electrolyte is reported,which can effectively enhance the cycling stability of highly loaded high-nickel LMBs with high safety through co-solvation *** interfacial compatibility between TBP and electrode is effectively improved using a short-chain ether(glycol dimethyl ether,DME),and a specially competitive solvation structure is further constructed using lithium borate difluorooxalate(LiDFOB)to form the stable and inorganic-rich electrode *** from the presence of the cathode electrolyte interphase(CEI)and solid electrolyte interphase(SEI)enriched with LiF and Li_(x)PO_(y)F_(z.,the electrolyte demonstrates excellent cycling stability assembled using a 50μm lithium foil anode in combination with a high loading NMC811(15.4 mg cm^(-2))cathode,with 88%capacity retention after 120 ***,the electrolyte exhibits excellent high-temperature characteristics when used in a 1-Ah pouch cell(N/P=0.26),and higher thermal runaway temperature(238℃)in the ARC(accelerating rate calorimeter)demonstrating high *** novel electrolyte adopts long-chain phosphate as the main solvent for the first time,and would provide a new idea for the development of extremely high safety and high-temperature electrolytes.

关键词： Non-flammable electrolyte Long chain phosphate ester Solvation structure Lithium metal batteries Battery safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国北方兴隆遗址早期农业人群对木材的利用和管理

引用

中国科学：地球科学 2024年第6期54卷 1937-1949页

作者：沈慧邱振威赵克良周新郢李小强中国科学院古脊椎动物与古人类研究所脊椎动物演化与人类起源重点实验室北京100044 中国国家博物馆北京100006 中国科学院大学地球与行星科学学院北京100049

农业起源、发展及其与植被环境间关系是环境考古学研究的热点科学问题.本文选择我国北方新石器时代兴隆遗址,针对木炭遗存进行种属鉴定和年轮曲率统计等系统分析,重建了兴隆遗址局地林地植被环境,揭示了早期黍粟农业人群对林地的利用、... 详细信息

农业起源、发展及其与植被环境间关系是环境考古学研究的热点科学问题.本文选择我国北方新石器时代兴隆遗址,针对木炭遗存进行种属鉴定和年轮曲率统计等系统分析,重建了兴隆遗址局地林地植被环境,揭示了早期黍粟农业人群对林地的利用、改造和适应.研究结果显示,兴隆遗址周围曾经分布有丰富的林地植被,包括山杏(Prunus sibirica)灌丛,榆属(Ulmus)、槭属(Acer)疏林,杨属(Populus)林地等.距今8000~7000年时期,中国北方地区温暖湿润的气候环境可能促使了槭属、鼠李属(Rhamnus)、圆柏属(Juniperus)等木本植物的广泛分布以及早期黍粟旱作农业的快速发展.其中,大量可食用李属植物的发现,可能指示了丰富的果树林地的存在,成为早期黍粟农业聚落的重要植被组成.结合不同植物生境分布信息,兴隆先民对聚落周边木材资源有着充分利用,杨属和榆属植物是最主要的薪材来源.木炭年轮曲率统计结果显示,兴隆先民主要利用榆属、杨属、槭属和圆柏属的枝干或者较粗的枝条部位作为薪材,在8000~7000a BP时期可能已经开始通过植株修剪、砍伐非果树类植物等方式对山杏灌丛进行有意识的保护和管理,以获取更多的果类食物资源,显示了早期黍粟农业人群适应和影响植被生态的方式和策略.

关键词：兴隆遗址木炭木材利用林地管理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A z.E isomeric cation designed organic-inorganic cadmium chloride ferroelectric with broadband white-light emission

引用

Science China Chemistry 2024年

作者： Jun-Chao Qi Yan Qin Hang Peng Hui-Peng Lv Yong-Ju Bai Xin shen z.ang-Tian Xia Wei-Qiang Liao Ordered Matter Science Research Center Nanchang University

Hybrid organic-inorganic metal halides（HOMHs） have attracted tremendous interest in the past decades due to their diverse functional properties, such as ferroelectricity and luminescence. However, although a large number of ferroelectric HOMHs and luminescent HOMHs have been reported, the HOMH ferroelectrics with white-light emission remain very sparse. Here, for the first time, by using the z.E isomeric organic cation, we designed a cadmium-based HOMH ferroelectric [EE-PMU]CdCl4（EEPMU = pyridin-2-ylmethanamide muconate） with broadband white-light emission. In contrast to the [z.-PMU]CdCl4with centrosymmetric crystal structure at room temperature, [EE-PMU]CdCl4adopts the polar crystal symmetry, which shows piez.electricity with a piez.electric coefficient of d33up to 19 pC/N and ferroelectricity with the saturated polariz.tion of 1.52μC/cm2. Moreover, [EE-PMU]CdCl4exhibits a broadband white-light emission with an ultra-high color rendering index of 91 under UV excitation, which is related to the severely distorted [CdCl4]2-tetrahedron in the structure. To our knowledge, [EEPMU]CdCl4is the first example of z.E isomeric cation-designed HOMH ferroelectric and the first cadmium halide white-light emissive ferroelectric. This finding paves a new way for the design of organic-inorganic molecular ferroelectrics with white-light emission.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：