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First-line camrelizumab(a PD-1 inhibitor)plus apatinib(an VEGFR-2 inhibitor)and chemotherapy for advanced gastric cancer(SPACE):a phase 1 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1760-1767页

作者： Xiaofeng chen Hao Xu Xiaobing chen Tongpeng Xu Yitong Tian Deqiang Wang Fen Guo Kangxin Wang Guangfu Jin Xiao Li Rong Wang Fengyuan Li Yongbin Ding Jie Tang Yueyu Fang Jing Zhao Liang Liu Ling Ma Lijuan Meng Zhiguo Hou Rongrong Zheng Yang Liu Ni Guan Bei Zhang Shuang Tong shiqing chen Xing Li Yongqian Shu Department of Oncology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Gusu School Nanjing medical UniversitySuzhouChina Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina Department of General surgery The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of Oncology Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer&Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer ZhengzhouChina Department of Oncology Digestive Disease Institute&Cancer Institute of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology Suzhou Hospital of Nanjing Medical UniversitySuzhouChina Department of Oncology Nanjing PuKou People’s HospitalNanjingChina Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingChina Department of Pathology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of general surgery Jurong Branch hospital of Jiangsu Province People HospitalJurongChina Department of Medical Oncology Liyang People’s HospitalLiyangChina Department of radiology Nanjing PuKou People’s HospitalNanjingChina Jiangsu Hengrui Pharmaceuticals ShanghaiChina Department of Medical Affairs 3D Medicines Inc.ShanghaiChina Shanghai OrigiMed Co. Ltd.ShanghaiChina

Patients with advanced gastric cancer typically face a grim *** phase 1a(dose escalation)and phase 1b(dose expansion)study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapyfor advanced gastric or gastroesophageal junction *** primary endpoints included maximum tolerated dose(MTD)in phase 1a and objective response rate(ORR)across phase 1a and *** 1a tested three dose regimens of camrelizumab,apatinib,oxaliplatin,and *** regimen 1:camrelizumab 200 mg on day 1,apatinib 250 mg every other day,oxaliplatin 100 mg/m^(2) on day 1,and S-140 mg twice a day on days *** regimen 2:same as dose regimen 1,but oxaliplatin 130mg/*** regimen3:same as dose regimen 2,but apatinib 250 mg ***-four patients were included(9 in phase 1a,25 in phase 1b).No dose-limiting toxicities occurred so no MTD was *** 3 was set for the recommended phase 2 doses and administered in phase *** confrmed ORR was 76.5%(95%CI 58.8-89.3).The median progression-free survival was 8.4 months(95%CI 5.9-not evaluable[NE]),and the median overall survival(OS)was not mature(11.6-NE).Ten patients underwent surgery after treatment and the multidisciplinary team *** 24 patients without surgery,the median OS was 19.6 months(7.8-NE).Eighteen patients(52.9%)developed grade≥3 treatment-emergent adverse *** plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer(ChiCTR2000034109).

关键词： regimen cancer doses

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间伐保留密度对杉木人工林生长的影响

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东北林业大学学报 2024年第4期52卷 9-16页

作者：卢德浩冯铭淳黄焕强邱展鹏谢惠燕陈世清林娜华南农业大学广州510642

以广东省清远市11年生杉木人工林为研究对象,探究了不同保留密度(1200、1800、2500株·hm^(-2))杉木人工林3 a期间的动态生长规律、环境影响因子间差异、林分生长与环境因子之间的关系。结果表明:随着间伐保留密度的增加,杉木人工林的... 详细信息

以广东省清远市11年生杉木人工林为研究对象,探究了不同保留密度(1200、1800、2500株·hm^(-2))杉木人工林3 a期间的动态生长规律、环境影响因子间差异、林分生长与环境因子之间的关系。结果表明:随着间伐保留密度的增加,杉木人工林的林分平均胸径、树高、冠幅、单株材积的3 a生长量及生长率均有所下降,小、中径材的出材量明显上升,其中,保留密度为1200株·hm^(-2)的林分大径材出材量最高,为22.46 m^(3)·hm^(-2);其次是保留密度为1800株·hm^(-2)的林分,大径材出材量为15.36 m^(3)·hm^(-2);保留密度为2500株·hm^(-2)的林分无大径材产出。保留密度为1800株·hm^(-2)林分的总出材量最大,为131.55 m^(3)·hm^(-2)。随着间伐保留密度的降低,林冠开阔度和光照均有所增加,其中,保留密度为1200株·hm^(-2)的林分光照条件优于其他2种保留密度林分。不同土层间各土壤理化性质变化趋势基本一致,较多的土壤理化性质在保留密度为1200株·hm^(-2)时表现最好。灌木层和草本层物种多样性各指数大多在保留密度为1200株·hm^(-2)时最大。林分的生长主要与林冠开阔度、叶面积指数、林下直射光、散射光、土壤pH、全氮质量分数、土壤密度、草本层Shannon-Wiener指数和Patrick指数显著相关(P<0.05)。将低保留密度(1200株·hm^(-2))作为林分经营密度的效果最佳,最适合大径材的培育;若仅考虑木材产出,则应选择1800株·hm^(-2)为经营密度,该保留密度下总出材量最大。

关键词：杉木人工林间伐保留密度林分生长土壤理化性质林下植被多样性

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基于熵权TOPSIS法的林长制实施成效评估及障碍度研究

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绿色科技 2024年第7期26卷 70-76页

作者：郑梓林陈楚民林娜白昆立何金全陈世清华南农业大学林学与风景园林学院广东广州510642 广东省岭南院勘察设计有限公司广东广州510000

林长制实施成效关系着林业发展质量水平,是社会关注的重大民生问题,因此对其实施成效评估有利于推进林长制工作。通过实地调研,根据中共中央、国务院办公厅印发《关于全面推行林长制的意见》等文件精神,结合专家咨询,构建林长制实施成... 详细信息

林长制实施成效关系着林业发展质量水平,是社会关注的重大民生问题,因此对其实施成效评估有利于推进林长制工作。通过实地调研,根据中共中央、国务院办公厅印发《关于全面推行林长制的意见》等文件精神,结合专家咨询,构建林长制实施成效评估指标,利用熵权TOPSIS法和障碍度模型赋予指标权重后对广东省15个县(市、区)2022年林长制实施成效进行评估与分析,为助力实现“林长治”、提升林草资源保护发展水平提供参考。15个县(市、区)林长制实施成效存在差异,综合接近度介于0.4180~0.8453,平均值为0.5241,整体仍有较大提升空间。林长制建设水平、林长制运行效果、森林灾害防控是制约林长制实施成效的主要障碍因素。据此,从提升林长履职效能、创新管理机制,健全保障体系等方面提出了合理化建议。

关键词：林长制实施成效评估障碍因素责任

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广州市小微湿地分布特征及影响因素分析

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林业与环境科学 2024年第2期40卷 17-26页

作者：黄绮雯张春霞王锋王佳停林娜陈世清华南农业大学广东广州510642 广东省林业调查规划院广东广州510520 广东省德庆林场广东德庆526600

为科学经营和合理利用小微湿地资源,实现小微湿地可持续发展,文章以广州市为研究区,选取2000年、2010年以及2020年遥感影像数据,利用遥感和地理信息系统技术,提取出广州市小微湿地分布信息,采用空间自相关、质心迁移、冷热点分析等方法... 详细信息

为科学经营和合理利用小微湿地资源,实现小微湿地可持续发展,文章以广州市为研究区,选取2000年、2010年以及2020年遥感影像数据,利用遥感和地理信息系统技术,提取出广州市小微湿地分布信息,采用空间自相关、质心迁移、冷热点分析等方法来分析广州市小微湿地的空间分布特征并通过地理探测器探究小微湿地变化的影响因素。结果表明,2000—2020年间,广州市小微湿地的总面积和斑块数量均呈增加趋势。从空间分布上来看,小微湿地分布都呈聚类模式且皆为正向空间自相关性,热点区域逐渐向中部及南部区域扩大。广州市小微湿地的分布受年平均气温和GDP的影响较大。

关键词：小微湿地空间分布影响因素广州市

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Relaxor antiferroelectric-relaxor ferroelectric crossover in NaNbO_(3)-based lead-free ceramics for high-efficiency large-capacitive energy storage

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Chinese Chemical Letters 2024年第7期35卷 465-469页

作者： Shuangliang Xie Yuyue chen Qing He Liang chen Jikun Yang shiqing Deng Yimei Zhu He Qi School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Department of Condensed Matter Physics and Materials Science Brookhaven National LaboratoryUptonNew York 11973United States

Relaxor ferroic dielectrics have garnered increasing attention in the past decade as promising materials for energy *** them,relaxor antiferroelectrics(AFEs)and relaxor ferroelectrics(FEs)have shown great promise in term of high energy storage density and efficiency,*** this study,a unique phase transition from relaxor AFE to relaxor FE was achieved for the first time by introducing strong-ferroelectricity BaTiO_(3)into NaNbO_(3)-BiFeO_(3)system,leading to an evolution from AFE R hierarchical nanodomains to FE polar nanoregions.A novel medium state,consisting of relaxor AFE and relaxor FE,was identified in the crossover of 0.88NaNbO_(3)–0.07BiFeO_(3)–0.05BaTiO_(3)ceramic,exhibiting a distinctive core-shell grain structure due to the composition *** harnessing the advantages of high energy storage density from relaxor AFE and large efficiency from relaxor FE,the ceramic showcased excellent overall energy storage *** achieved a substantial recoverable energy storage density W_(rec)~13.1 J/cm^(3)and an ultrahigh efficiencyη~88.9%.These remarkable values shattered the trade-off relationship typically observed in most dielectric capacitors between W_(rec)andη.The findings of this study provide valuable insights for the design of ceramic capacitors with enhanced performance,specifically targeting the development of next generation pulse power devices.

关键词： Relaxor ferroelectric Antiferroelectric Core-shell Energy storage High efficiency

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安大简《仲尼曰》简背文字书写者考辨

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安徽大学学报:哲学社会科学版 2023年第5期47卷 71-77页

作者：陈世庆安庆师范大学人文学院安徽安庆246011

安大简《仲尼曰》共有整简13支,记载孔子言论25条。除此之外,简13还有对孔子言论的总体评价“仆快周恒”4字,意为孔子的言论“朴实智慧,无处不达到最高境界”。安大简《仲尼曰》简12背面有“寡人……玉帛”18个字,简8、简7背面有“豫”... 详细信息

安大简《仲尼曰》共有整简13支,记载孔子言论25条。除此之外,简13还有对孔子言论的总体评价“仆快周恒”4字,意为孔子的言论“朴实智慧,无处不达到最高境界”。安大简《仲尼曰》简12背面有“寡人……玉帛”18个字,简8、简7背面有“豫”“人人人人人”6个字,安大简整理者认为这些字是“抄写者练习写的字,与正文内容无关”。实际上这些字可能是战国早期某位熟稔使用楚文字的诸侯王批阅《仲尼曰》所写的文字。该诸侯王对孔子万分景仰,称赞孔子为“善豫之人”,称赞孔子的“教令实在是太伟大了”,要求下属将《仲尼曰》作为诸侯会盟、国使交往时的珍贵礼品,使之发扬光大。这一发现对于研究《论语》成书和流传有着重要意义和价值。

关键词：安大简《仲尼曰》寡人公文批阅书写特征

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Epitaxial quasi-2D/3D hybrid perovskite heterojunctions for photodetector with enhanced detectivity and stability

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Nano Research 2024年第7期17卷 6594-6602页

作者： Yifu chen Lin Zhang Xinxin Peng Weiran Qin shiqing Li Yingwei Wang Zhihui chen Si Xiao Bin Yang Biao Liu Junliang Yang Han Huang Yun Lin Jun He Liming Ding Yongbo Yuan Hunan Key Laboratory of Super Microstructure and Ultrafast Process School of PhysicsCentral South UniversityChangsha 410083China Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangsha 410083China College of Materials Science and Engineering Hunan UniversityChangsha 410082China Department of Photoelectric Information School of PhysicsCentral South UniversityChangsha 410083China Center for Excellence in Nanoscience Key Laboratory of Nanosystem and Hierarchical FabricationNational Center for Nanoscience and TechnologyChinese Academy of ScienceBeijing 100190China

Although numerous metal halide perovskite materials have been investigated in the field of optoelectronic,the development of perovskite heterojunctions with exotic structures is still ***,we report the epitaxial growth of quasi-two-dimensional(Q-2D)perovskites on methylammonium lead iodide(MAPbI_(3))single crystals to form perovskite heterojunctions with interfacial *** MAPbI_(3)adjacent to epitaxial Q-2D perovskite shows blue shifted photoluminescence with shortened lifetime,which becomes significant with the reduced layer number of the Q-2D *** findings suggest the presence of an interfacial strain gradient leading to enhanced photocarrier ***,compared to the MAPbI_(3)single crystal detector,the BA_(2)MAPb_(2)I_(7)/MAPbI_(3)(BA:n-butylamine)heterojunction-based photodetector demonstrates a bandpass detecting property and exhibits 5 times enhanced external quantum efficiency and 83 times enhanced specific detectivity(D*=3.26×10^(11)Jones).Remarkably,the unencapsulated BA_(2)MAPb_(2)I_(7)/MAPbI_(3)heterojunction is stable in ambient condition for>300 *** Q-2D/3D heterojunction shows suppressed ion inter-diffusion due to the presence of Q-2D phase.

关键词： epitaxial growth interfacial strain quasi-two-dimensional/three-dimensional(Q-2D/3D)heterojunctions ion inter-diffusion

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A comprehensive review on the potential therapeutic benefits of prospective probiotic Christensenella minuta

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Food Science and Human Wellness 2024年

作者： Yueyao Fan Yuhang Xiao Yingying Zhang shiqing Zhang Weibin Bai Jiali chen Department of Food Science and Engineering Institute of Food Safety and Nutrition Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection Jinan University State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University Centre for Cancer and Inflammation Research School of Chinese Medicine Hong Kong Baptist University

Bacterial family Christensenellaceae performed high heritability and associated with human health status. Numerous studies observed that the abundance of Christensenellaceae could be significantly reduced in patients with intestinal diseases or metabolic disorders， inferred that it may be treated as an effective biomarker. Christensenella minuta (C. minuta) was the first member of Christensenellaceae family isolated from human fecal samples. Accumulating evidences suggested that C. minuta may demonstrate a positive bio-therapeutic effects toward unhealthy status. Hence， this review aimed to systematically summarize the characterization of Christensenellaceae under specific health or diseases， and discover its promising application. Besides， the latest studies on the pharmacological research of C. minuta also summarized. Current important literatures grasped the potential health benefits of C. minuta in managing metabolic disorders， gut ecosystem， and inflammation. Whereas， several critical knowledge gaps about the safe and clinical application remain should be addressed in future verification. C. minuta is worthy to be elevated as the next prospective probiotic star in nutraceutical or medical field and should not be overlooked.

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Analyzing the Form-Finding of a Large-Span Transversely Stiffened Suspended Cable System: A Method Considering Construction Processes

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World Journal of Engineering and Technology 2024年第2期12卷 229-244页

作者： Junyu chen Yanfei Wang Ke chen shiqing Huang Xiaowen Xu MOE Key Lab of Disaster Forecast and Control in Engineering School of Mechanics and Construction Engineering Jinan University Guangzhou China China Construction Second Engineering Bureau Second Company Shenzhen China Department of Civil Engineering Dazhou Technician College Dazhou China Key Laboratory of Product Packaging and Logistics Packaging Engineering Institute College of Packaging Engineering Jinan University Zhuhai China

The precise control of the shape of transversely stiffened suspended cable systems is crucial. However, existing form-finding methods primarily rely on iterative calculations that treat loads as fixed known conditions. These methods are inefficient and fail to accurately control shape results. In this study, we propose a form-finding method that analyzes the load response of models under different sag and stress levels, taking into account the construction process. To analyze the system, a structural finite element model was established in ANSYS, and geometric nonlinear analysis was conducted using the Newton-Raphson method. The form-finding analysis results demonstrate that the proposed method achieves precise control of shape, with a maximum shape error ranging from 0.33% to 0.98%. Furthermore, the relationships between loads and tension forces are influenced by the deformed shape of the structures, exhibiting significant geometric nonlinear characteristics. Meanwhile, the load response analysis reveals that the stress level of the self-equilibrium state in the transversely stiffened suspended cable system is primarily governed by strength criteria, while shape is predominantly controlled by stiffness criteria. Importantly, by simulating the initial tensioning process as an initial condition, this method solves for a counterweight that satisfies the requirements and achieves a self-equilibrium state with the desired shape. The shape of the self-equilibrium state is precisely controlled by simulating the construction process. Overall, this work presents a new method for analyzing the form-finding process of large-span transversely stiffened suspended cable system, considering the construction process which was often overlooked in previous studies.

关键词： Cable Structure Long-Span Structure Form-Finding Analysis Finite Element Simulation Transverse Cable Stiffening System

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程序性死亡受体1抑制剂相关1型糖尿病的临床特点分析

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中华糖尿病杂志 2023年第10期15卷 972-978页

作者：陈世清魏倩雯王菁菁北京市顺义区医院内分泌科北京101300

目的分析程序性死亡受体1(PD-1)抑制剂相关1型糖尿病(T1DM)患者的临床特点。方法对2020年5月至2022年12月在北京市顺义区医院内分泌科住院的5例PD-1抑制剂引起T1DM患者的临床资料进行分析。收集患者的一般临床资料、实验室检查结果,追踪... 详细信息

目的分析程序性死亡受体1(PD-1)抑制剂相关1型糖尿病(T1DM)患者的临床特点。方法对2020年5月至2022年12月在北京市顺义区医院内分泌科住院的5例PD-1抑制剂引起T1DM患者的临床资料进行分析。收集患者的一般临床资料、实验室检查结果,追踪4例新发糖尿病患者接受PD-1抑制剂治疗期间、T1DM发生前的血糖监测结果。记录患者住院期间的诊治方案、观察转归及出院后进行随访的血糖及C肽等结果。结果 5例患者中男4例、女1例,中位年龄63(53~71)岁,其中暴发性T1DM患者4例。4例以糖尿病酮症酸中毒(DKA)症状首次就诊。接受PD-1抑制剂第1次治疗到发生T1DM的中位时间为232 d(82~288 d),中位周期为10(2~14)个周期,其中3例分别在PD-1抑制剂治疗中断后44、40、65 d发生了DKA,期间未监测血糖。5例患者在诊断T1DM时的中位血糖为28.83(25.16~43.24)mmol/L,糖化血红蛋白为8.5%(6.8%~9.7%),空腹C肽为<0.02(<0.02~0.37)ng/ml,2 h C肽为0.06(<0.02~0.68)ng/ml,尿酮体阳性++~+++。胰岛自身抗体和甲状腺相关抗体阳性各2例。4例新发糖尿病患者,共完成了26个治疗周期,其中21个治疗周期前检测了空腹血糖,中位血糖为5.72(5.09~6.97)mmol/L。9个治疗周期后7 d内复查了空腹血糖,中位血糖为7.22(5.88~8.95)mmol/L。5例T1DM患者均救治成功,住院10~19 d。出院后1例采用胰岛素泵、4例采用基础+餐时胰岛素治疗,胰岛素用量为每日0.53~0.77 U/kg。4例患者出院后36~49 d复查C肽均低至检测水平下限。5例患者均遵循出院降糖方案控制血糖,血糖波动在6~13 mmol/L。结论 PD-1抑制剂可导致T1DM,多表现为暴发性T1DM,常以DKA起病,即使停止PD-1抑制剂治疗后仍可发生,胰岛β细胞破坏不可逆转,需要采用胰岛素进行治疗。为了早期识别,及时救治,需要在PD-1抑制剂治疗过程中以及停止治疗后持续血糖监测。

关键词：糖尿病,1型程序性死亡受体1抑制剂免疫检查点抑制剂糖尿病酮症酸中毒

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