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Neogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1326-1359页

作者： Tao DENG Xiaomin FANG Qiang LI shiqi wang Feixiang WU Sukuan HOU Jiao MA Qigao JIANGZUO Danhui SUN Yan ZHENG Qinqin SHI Boyang SUN Lu LI Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Tibetan Plateau Earth Sciences and Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China

The remarkable uplift of the Tibetan Plateau in the Neogene had great impacts on the climate and environment of East Asia and even the world.Therefore,establishment of the Neogene stratigraphic framework of the Tibetan Plateau is of great significance to research in various fields of geosciences.Based on marine sediments,the international chronostratigraphic system of the Neogene is divided into six stages in the Miocene and two stages in the Pliocene.Since the beginning of the Cenozoic,the share of terrestrial strata on continents has increased rapidly.By the Neogene,it had far exceeded that of marine strata,and almost all deposits on the Tibetan Plateau and its surrounding areas were terrestrial strata.In China,the Miocene includes five stages and the Pliocene includes two stages.Except for the Tunggurian of the Miocene,which has a lower boundary at 15 Ma,the other stages have the same paleomagnetic definitions and time intervals as the corresponding international marine stages.Mammalian fossils play a very important role in the division and correlation of Cenozoic terrestrial strata,and rodent,carnivore,proboscidean,perissodactyl and artiodactyl fossils are especially important in Neogene terrestrial biostratigraphy.There are many basins with well-exposed strata and abundant mammalian fossils in the Tibetan Plateau.The lower boundary stratotype sections of the Neogene Xiejian and Bahean stages are located respectively in the Xining and Linxia basins,and there are precise paleomagnetic dates in coordination with mammalian fossils.The lower boundary stratotypes of other stages can also be effectively determined in the Tibetan Plateau.Many first appearing mammalian genera in East Asia also appeared in the Tibetan Plateau and its surrounding areas,especially in the Linxia Basin on the northeast margin and in the Siwaliks on the southwest margin.Among them,Prodeinotherium first appeared at the bottom of the Miocene in the Siwaliks,and the earliest Hipparion of the Old World first appeared at the bottom of the Bahea

关键词： Tibetan Plateau Neogene Terrestrial stratum Mammalian fossil Paleomagnetism

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Evolution of AVS video coding standards: twenty years of innovation and development

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Science China(Information Sciences) 2022年第9期65卷 50-73页

作者： Siwei MA Li ZHANG shiqi wang Chuanmin JIA Shanshe wang Tiejun HUANG Feng WU Wen GAO Institute of Digital Media School of Computer Science Peking University Bytedance Inc. Department of Computer Science City University of Hong Kong CAS Key Laboratory of Technology in Geo-Spatial Information Processing and Application System University of Science and Technology of China

Ever since the founding of the Audio and Video Coding Standard(AVS) Workgroup of China in 2002, it has been dedicated to advancing and innovating the digital audio-video industry with highly efficient and economical encoding/decoding technologies. Three representative generations of video coding standards have been finalized and published, consistently improving the coding performance in the past two decades.The series of AVS standards establish solid foundations for ubiquitous video applications in the areas including acquisition, coding, production, delivery, integrated system, public service, general screen content, and mixed reality media. Along with the standardization process, an extensive amount of studies have been carried out on efficiency-aware designation, algorithm optimization, and hardware implementation of these innovative video coding techniques. This paper explains how those developed techniques provide a lasting impact on the video coding community, extensively, technologically, and systematically. In particular, we provide a comprehensive survey of the three generations of the standards, and timely and in-depth summarize the efforts of the AVS video coding standards in the twenty years. The rate-distortion performance comparisons,in particular in terms of the 8K ultra-high-definition(UHD) contents, reflect the elegant design of the state-of-the-art AVS3 standards. We have also elaborated on a variety of well-established and promising applications, including commercial level real-time 8K encoder, high-frame-rate decoder chip for cell phone,and live streaming solution for sports. In addition, the China Central Television(CCTV) of China Media Group(CMG), the state television of China, has officially launched the first 8K broadcasting channel(CCTV-8K) since 2021 using AVS3. Given the significant success realized by the AVS standards, it is envisioned that a new era of 8K UHD video is arriving.

关键词： video coding AVS standards video applications intelligent coding

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Monitoring microenvironment of Hep G2 cell apoptosis using two-photon fluorescence lifetime imaging microscopy

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Journal of Innovative Optical Health Sciences 2022年第3期15卷 36-44页

作者： Kexin wang Shiyao Tang shiqi wang Fangrui Lin Gengjin Zou Junle Qu Liwei Liu Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province&Ministry of Education College of Physics and Optoelectronic Engineering Shenzhen University ShenzhenGuangdong ProvinceP.R.China

Apoptosis is very important for the maintenance of cellular homeostasis and is closely related to the occurrence and treatment of many diseases.Mitochondria in cells play a crucial role in programmed cell death and redox processes.Nicotinamide adenine dinucleotide(NAD(P)H)is the primary producer of energy in mitochondria,changing NAD(P)H can directly reflect the physiological state of mitochondria.Therefore,NAD(P)H can be used to evaluate metabolic response.In this paper,we propose a noninvasive detection method that uses two-photon fluorescence lifetime imaging microscopy(TP-FLIM)to characterize apoptosis by observing the binding kinetics of cellular endogenous NAD(P)H.The result shows that the average fluorescence lifetime of NAD(P)H and the fluorescence lifetime of protein-bound NAD(P)H will be affected by the changing pH,serum content,and oxygen concentration in the cell culture environment,and by the treatment with reagents such as H2O2 and paclitaxel.Taxol(PTX).This noninvasive detection method realized the dynamic detection of cellular endogenous substances and the assessment of apoptosis.

关键词： Apoptosis nicotinamide adenine dinucleotide two-photon fluorescence lifetime imaging microscopy imaging microenvironment Hep G2

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Five-year warming does not change soil organic carbon stock but alters its chemical composition in an alpine peatland

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Pedosphere 2023年第5期33卷 776-787页

作者： Jingcong QIU Minghua SONG Chunmei wang Xiaomin DOU Fangfang LIU Jiaxin wang Chenying ZHU shiqi wang College of Environmental Science and Engineering Beijing Forestry UniversityBeijing 100083China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Climate warming may promote soil organic carbon(SOC)decomposition and alter SOC stocks in terrestrial ecosystems,which would in turn affect climate warming.We manipulated a warming experiment using open-top chambers to investigate the effect of warming on SOC stock and chemical composition in an alpine peatland in Zoigêon the eastern Tibetan Plateau,China.Results showed that 5 years of warming soil temperatures enhanced ecosystem respiration during the growing season,promoted above-and belowground plant biomass,but did not alter the SOC stock.However,labile O-alkyl C and relatively recalcitrant aromatic C contents decreased,and alkyl C content increased.Warming also increased the amount of SOC stored in the silt-clay fraction(0.25 mm,respectively).These changes in labile and recalcitrant C were largely associated with warming-induced increases in soil microbial biomass C,fungal diversity,enzyme activity,and functional gene abundance related to the decomposition of labile and recalcitrant C compounds.The warming-induced accumulation of SOC stored in the silt-clay fraction could increase SOC persistence in alpine peatland ecosystems.Our findings suggest that mechanisms mediated by soil microbes account for the changes in SOC chemical composition and SOC in different aggregate size fractions,which is of great significance when evaluating SOC stability under climate warming conditions.

关键词： functional gene nuclear magnetic resonance simulated global warming soil carbon components soil enzymes soil microbial diversity

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Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

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Bioactive Materials 2023年第5期23卷 471-507页

作者： Jiachen Li shiqi wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos Department of Biomedical Engineering W.J.Kolff Institute for Biomedical Engineering and Materials ScienceUniversity Medical Center GroningenUniversity of GroningenAnt.Deusinglaan 1Groningen9713 AVthe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center GroningenUniversity of GroningenUniversity of GroningenAntonius Deusinglaan 19713 AVGroningenthe Netherlands Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic efficacy.In addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in cancer.In this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer treatment.Then,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles thereof.Finally,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this field.Our review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer.

关键词： Phototherapy Cancer Nanoparticles Therapeutic effect Clinical potential

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Signaling pathways and targeted therapy for myocardial infarction

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1009-1046页

作者： Qing Zhang Lu wang shiqi wang Hongxin Cheng Lin Xu Gaiqin Pei Yang wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei Rehabilitation Medicine Center and Institute of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuanPR China Key Laboratory of Rehabilitation Medicine in Sichuan Province ChengduSichuanPR China National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuanPR China Aging and Geriatric Mechanism Laboratory West China HospitalSichuan UniversityChengduSichuanPR China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuanPR China

Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts.

关键词： inflammation infarction instance

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Dynamic bifunctional THz metasurface via dual-mode decoupling

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Photonics Research 2022年第9期10卷 2008-2014页

作者： XUAN CONG HONGXIN ZENG shiqi wang QIWU SHI SHIXIONG LIANG JIANDONG SUN SEN GONG FENG LAN ZIQIANG YANG YAXIN ZHANG Terahertz Science and Technology Research Center University of Electronic Science and Technology of ChinaChengdu 610000China College of Materials Science and Engineering Sichuan UniversityChengdu 610065China National Key Laboratory of Application Specific Integrated Circuit Hebei Semiconductor Research InstituteShijiazhuang 050051China Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123China Yangtze Delta Region Institute(HuZhou) University of Electronic Science and Technology of ChinaHuzhou 313001China

Metasurfaces have powerful light field manipulation capabilities and have been researched and developed extensively in various fields.With an increasing demand for diverse functionalities,terahertz(THz)metasurfaces are also expanding their domain.In particular,integrating different functionalities into a single device is a compelling domain in metasurfaces.In this work,we demonstrate a functionally decoupled THz metasurface that can incorporate any two functions into one metasurface and switch dynamically through external excitation.This proposed metasurface is formed by the combination of split-ring resonators and phase change material vanadium dioxide(VO_(2)).It operates in the single-ring resonant mode and double-ring resonant mode with varying VO_(2)in insulating and metallic states,respectively.More importantly,the phase modulation is independent in two operating modes,and both cover a 360°cross-polarized phase with efficient polarization conversion.This characteristic makes it obtain arbitrary independent phase information on the metasurface with different modes to switch dual functions dynamically.Here,we experimentally demonstrate the functions of a tunable focal length and large-angle focus deflection of a THz off-axis parabolic mirror to verify the dual-function switching characteristics of the functionally decoupled metasurface.The functionally decoupled metasurface developed in this work broadens the way for the research and application of multifunctional modulation devices in the THz band.

关键词： surface. functional resonant

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纳米氧化铜-镉单一与联合胁迫对油菜营养品质的影响

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环境科学学报 2024年第4期44卷 381-389页

作者：王诗琪孙约兵农业农村部环境保护科研监测所农业农村部产地环境污染防控重点实验室/天津市农业环境与农产品安全重点实验室天津300191 东北农业大学资源与环境学院哈尔滨150030

采用水培实验,探究了纳米氧化铜(CuO NPs)与镉(Cd)联合胁迫对油菜品质的影响.结果表明,单一CuO NPs(10~50 mg·L^(-1))处理对油菜生长和品质有一定抑制作用,油菜鲜重、可溶性糖、抗坏血酸和总酚含量随CuO NPs浓度增加而降低,与未投加相... 详细信息

采用水培实验,探究了纳米氧化铜(CuO NPs)与镉(Cd)联合胁迫对油菜品质的影响.结果表明,单一CuO NPs(10~50 mg·L^(-1))处理对油菜生长和品质有一定抑制作用,油菜鲜重、可溶性糖、抗坏血酸和总酚含量随CuO NPs浓度增加而降低,与未投加相比,分别降低了9.61%~39.26%、6.88%~45.09%、9.20%~29.14%和10.36%~18.47%,硝酸盐含量则显著升高16.44%~72.61%.在1μmol·L^(-1)Cd处理下,施加CuO NPs后油菜鲜重呈先升高后降低趋势.与空白对照相比,油菜叶片Cd含量降低了21.57%~36.14%,可溶性糖、可溶性蛋白和总酚含量最大分别降低了30.9%、39.61%和27.96%,抗坏血酸含量则增加了44.83%~76.21%,硝酸盐含量大幅升高,最大增加了116.18%,黄酮含量增加不明显.CuO NPs促进了油菜叶部Zn、Mg、Al、K和Ca元素的吸收,抑制了Fe元素吸收.研究表明,CuO NPs、Cd单一及联合胁迫整体上对油菜品质产生了负面影响.

关键词：纳米氧化铜镉胁迫油菜营养品质

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新生代特提斯海峡关闭过程及其圈层耦合效应

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科学通报 2024年第2期69卷 184-199页

作者：孙继敏沙金庚王世骐中国科学院地质与地球物理研究所北京100029 中国科学院大学地球与行星科学学院北京100049 中国科学院南京地质与古生物研究所南京210008 中国科学院古脊椎动物与古人类研究所北京100044

新生代是地球历史上岩石圈、水圈、大气圈、生物圈发生宏观巨变的重要地质时期,包括了冈瓦纳大陆的快速裂解、海峡的开启与闭合、海洋与大气环流的重组、温室到冰室的气候转型以及动植物的快速演替,因而是开展圈层耦合研究的关键地质时... 详细信息

新生代是地球历史上岩石圈、水圈、大气圈、生物圈发生宏观巨变的重要地质时期,包括了冈瓦纳大陆的快速裂解、海峡的开启与闭合、海洋与大气环流的重组、温室到冰室的气候转型以及动植物的快速演替,因而是开展圈层耦合研究的关键地质时期.本文以特提斯海峡为例,从地球系统科学角度,阐述特提斯海峡的闭合过程、时间及其对生物圈、海洋环流、大气圈的链式影响和反馈.核心思想如下:特提斯海峡自渐新世至中-中新世晚期(34∼12.8 Ma)历经了阶段性的演化过程,渐新世时期的特提斯海峡很好地连通了低纬度的印度洋-古地中海-大西洋;早中新世时(21∼19 Ma),伴随着非洲-阿拉伯板块与欧亚大陆的汇聚,海峡的连通能力下降了90%;中-中新世气候适宜期(17∼15 Ma)以海岸潟湖相为主、夹浅海相环境;15∼12.8 Ma期间演化为陆相环境为主、夹短暂的周期性海侵,且具有10万年的准周期;12.8 Ma之后,海峡永久关闭.特提斯海峡的闭合过程对生物圈产生了显著影响,伴随海峡的逐渐闭合,海洋无脊椎动物的腹足类、棘皮类,逐渐从特提斯海向印度洋、西太平洋迁移.对哺乳动物而言,尽管早中新世已经有零星的哺乳动物在非洲-阿拉伯与欧亚大陆之间迁徙,但真正大规模的哺乳动物双向迁徙主要发生在18∼17 Ma之后.此时,以海岸潟湖相为主的海峡已不足以构成善于利用迁徙路径的哺乳动物的地理屏障,表现为非洲的灵长类、长鼻类、蹄兔类等向欧亚大陆迁徙.而欧亚大陆的食肉类、犀类、猪类、反刍类、啮齿类等向非洲-阿拉伯迁徙.特提斯海峡的关闭对海洋环流也有重要影响,主要表现为特提斯海峡的关闭减少了来自低纬的温暖、高盐海水向大西洋及印度洋南部的注入,由此降低了低纬的热量向南半球高纬的径向输送,在一定程度上加强了东南极冰盖的扩张及南极的变冷.特提斯海的退缩以及特提斯海峡在13 Ma左右的永久关闭,也深刻影响到南亚季风环流,表现为索马里急流和南亚季风的加强.

关键词：阿拉伯与欧亚大陆汇聚特提斯海峡闭合海陆分布地球圈层相互作用环境效应

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基于扩散模型和爬坡趋势分类的风电功率自适应区间预测

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电网技术 2024年第6期48卷 2448-2457,I0051-I0054页

作者：韩丽程颖洁王施琪陈硕中国矿业大学电气工程学院江苏省徐州市221116

扩散模型基于马尔可夫链的概率性质,能够定量描述风电的随机性和不确定性。然而,传统基于扩散模型的时序预测方法以当前输入前一段样本的均值作为基准进行特征缩放,导致预测区间在高峰时段过大、低谷时段过小。因此,提出一种基于扩散模... 详细信息

扩散模型基于马尔可夫链的概率性质,能够定量描述风电的随机性和不确定性。然而,传统基于扩散模型的时序预测方法以当前输入前一段样本的均值作为基准进行特征缩放,导致预测区间在高峰时段过大、低谷时段过小。因此,提出一种基于扩散模型和爬坡趋势分类的风电功率自适应区间预测方法。首先,利用基于扩散模型的区间预测框架获取初始预测区间。然后,将风电波动过程划分为6种模式,对不同模式下的预测区间采取自适应规整策略,进而获得初始改进区间。接着,针对高出力模式中非爬坡时段的区间带宽不匹配问题,建立爬坡趋势分类评估模型,并结合所属出力模式进行区间修正,获得最终的区间预测结果。最后,实验结果表明所提方法的区间预测效果更优。

关键词：扩散模型自适应规整波动特征爬坡趋势分类区间预测

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