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Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds

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Asian Journal of Andrology 2009年第5期11卷 583-599,I0003页

作者： Boomi Manivannan[印度] Ruchi Mittal[印度] shipra Goyal[印度] Abdul S. Ansari[印度] Nirmal K. Lohiya[印度] Department of Zoology Centre for Advanced Studies University of Rajasthan Jaipur 302004 India

The contraceptive efficacy of Carica papaya seeds after short-term evaluation has been well established. We have examined the safety and mechanism of contraception in rats after long-term treatment with the methanol subfraction （MSF） of C. papaya seeds. The test substance was administered orally to the male albino rats （n = 40） at 50 mg per kg body weight each day for 360 days. Control animals （n = 40） received olive oil as a vehicle. Recovery was assessed up to 120 days after treatment withdrawal. Sperm parameters, serum testosterone levels, fertility, histology and ultrastructure of the testis, haematology and serum clinical chemistry were evaluated to establish the safety and efficacy of the test substance. Safety of long-term treatment was evidenced by unaltered health status, organ weight, haematology and clinical chemistry, and by an increase in body weight. The mechanism of contraception was shown by reduction in nuclear and cytoplasmic volume, normal nuclear characteristics and vacuolization in the cytoplasmic organelles of the Sertoli cells, as well as nuclear degeneration in spermatocytes and spermatids indicating disturbed spermatogenesis. Leydig cells were normal. Initial effects were observed in Sertoli cells at 60 days of treatment. Spermatocytes and spermatids were affected after 120-240 days of treatment. A significant decline in sperm count and viability, total inhibition of sperm motility, increased numbers of sperm abnormalities, normal serum testosterone levels and 100% sterility were evident after 60 days of treatment. All the altered parameters, including percent fertility, were restored to control level 120 days after treatment withdrawal. It is concluded that the MSF is safe for long-term treatment and the mechanism of contraception is shown by its effect on spermatid differentiation in the testis, possibly mediated by the Sertoli cell factors.

关键词： Carica papaya seeds male contraception spermatozoa testis ultrastructure

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Acoustical Studies of Schiff Bases in 1,4-dioxane and Dimethylformamide at 308.15K

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物理化学学报 2004年第9期20卷 1104-1107页

作者： shipra Baluja Pranav Inamdar Mayur Soni Department of Chemistry Saurashtr a UniversityRajkot-360005(Gujarat )IndiaDepartment of ChemistrySaurashtr a UniversityRajkot-360005(Gujarat )IndiaDepartment of ChemistrySaurashtr a UniversityRajkot-360005(Gujarat )India

Density,viscosity and ultrasonic v elocity of solutions of four Schiff bases in 1,4-dioxane and dimethylfor -mamide(DMF )were measured at *** acoustical properties such as specific impedance(Z),adiabatic compressibility(κ s ),Rao’s molar sound function(R m ),the van der Waals constant (b),molar compressibility(W),intermolecular free length(L f ),relaxation strength(r),solvation number(S n ),were *** results are in terpret-ed in terms of molecular interactions occurring in the solutions.

关键词： 1,4-二氧杂环己环二甲基甲酰胺声学方法 Schiff碱性质

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Prevalence and risks of reproductive tract infections among women of urban slums in North India: A cross-sectional study

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Asian pacific Journal of Reproduction 2022年第6期11卷 253-260页

作者： Mitasha Singh shipra Saini Pooja Goyal Ekta Gupta Shweta Goswami Department of Community Medicine ESIC Medical College and HospitalFaridabadHaryanaIndia ICMR National Institute of Cancer Prevention and Research Sector 39NoidaGautam Budh NagarUttar PradeshIndia

Objective:To identify the prevalence,determinants of reproductive tract infection,and healthcare seeking behavior among ever married women of reproductive age residing in an urban slum of Faridabad,Haryana,North ***:This community based cross-sectional study was conducted among ever married women aged between 15 and 49 years insured under employees state insurance scheme and residing in an urban slum of *** random sampling technique was used to interview 149 eligible women using a predesigned structured *** variables included sociodemographic profile,family planning methods,menstrual absorbent usage,and symptoms of reproductive tract *** logistic regression was used to investigate the determinants of reproductive tract ***:Of the women,46.3%had at least one reproductive tract infection or sexually transmitted infection symptom and 28.9%among them sought treatment for the *** discharge,itching(14.1%)and lower abdominal pain(30.2%)were the major symptoms ***-usage of condoms as contraceptive was significantly associated with a higher rate of symptoms(50.4%vs.20.0%).Abortion had a significantly high odds of having reproductive tract infection symptoms(aOR 3.71,95%CI 1.59-8.62;P<0.01).Less frequent change in absorbent during menstruation was also reported to have a higher rate of *** majority of those who took treatment sought it from government or employees state insurance dispensary.2%also went to faith ***:Nearly half of the study population have reproductive tract infection *** and non-usage of condom increase the risk of reproductive tract *** hygiene and condom usage are the significant interventions,which may reduce the prevalence of these symptoms.

关键词： Reproductive tract infection Sexually transmitted infection Migrants Factory workers Prevalence

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Role of Silver Incorporation on the Specific Heat in Glassy Se<sub>80</sub>Te<sub>20</sub>Alloy

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New Journal of Glass and Ceramics 2014年第4期4卷 66-71页

作者： shipra Saraswat Surendra Dutt Sharma Department of Chemistry IFTM University Moradabad India

Specific heat measurements have been made in glassy Se80-xTe20Agx (0 ≤ x ≤ 15) alloys using differential scanning calorimetry (DSC) technique. An extremely large increase in the specific heat values has been observed at the glass transition temperature. It has also been found that the values of Cp below glass transition temperature and the difference of Cp values before and after glass transition (ΔCp) are highly composition dependent. This indicates that the incorporation of Ag in binary Se80Te20 alloy in the present study influences the structure of the binary alloy. Specific heat of the additive element Ag is found to be important for the observed changes in the specific heat of the ternary alloys as compared to binary alloy.

关键词： Chalcogenide Glasses Differential Scanning Calorimetry Glass Transition Specific Heat

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Sperm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkey, Presbytis entellus entellus

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Asian Journal of Andrology 2008年第2期10卷 298-306页

作者： Nirmal K. Lohiya Boomi Manivannan shipra Goyal Abdul S. Ansari Centre for Advanced Studies Department of Zoology University of Rajasthan Jaipur 302004 India

Aim： To assess the contraceptive efficacy of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkeys. Methods： The test substance was given p.o. to five monkeys at 50 mg/kg body weight/day for 360 days. Control animals （n = 3） received olive oil as vehicle. Sperm parameters as per World Health Organization standards, sperm functional tests, morphology of testis and epididymis, haematology, clinical biochemistry, serum testosterone and libido were evaluated. Following completion of 360 days treatment the animals were withdrawn from the treatment and the recovery pattern was assessed by semen analysis and sperm functional tests. Results： Total inhibition of sperm motility was observed following 60 days of treatment that continued until 360 days study period. Sperm count, percent viability and percent normal spermatozoa showed a drastic decline following 30 days of treatment. Sperm morphology showed predominant mid piece abnormalities. Sperm functional tests scored in sterile range. Histology and ultrastructure of testis revealed vacuolization in the Sertoli cells and germ cells. Loss of cytoplasmic organelles was evident in spermatocytes and round spermatids. Histology and ultrastructure of epididymis of treated animals were comparable to those of control animals. Hematological and serum clinical parameters and testosterone levels fluctuated within the control range throughout the study period. Recovery was evident following 60--120 days of treatment withdrawal. Conclusion- The results suggest that the benzene chro- matographic fraction of the chloroform extract of the seeds of Carica papaya shows contraceptive efficacy without adverse toxicity, mediated through inhibition of sperm motility. （Asian JAndro12008 Mar; 10： 298-306）

关键词： male contraception Carica papaya seeds sperm motility inhibition testis epididymis langur monkeys

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Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to Prostate cancer

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Journal of Acute Disease 2017年第4期6卷 145-153页

作者： Vaibhav Dubey Richard Owusu-Apenten shipra Tripathi Udaya Pratap Singh AlokSemwal Volhart Health Care Pvt.Ltd. Department of Research and DevelopmentSitapur Road YojnaLucknowUPIndia Faculty of Life and Health Sciences School of Biomedical SciencesUniversity of UlsterColeraineBT521SAUnited Kingdom Babu Banarasi Das Northern India Institute of Technology Department of PharmacyFaizabad RoadLucknowUPIndia Sam Higginbottom University of Agriculture Technology and SciencesDepartment of Pharmaceutical SciencesAllahabadNainiUPIndia Department of Pharmacy Himachal Institute of PharmacyPaonta Sahib-173025H.P India

Prostate cancer (PC) is one of the most common and leading cancer amongst the males all around the world. Depending upon it long latency and cost involved in its management and treatment, there is extensive need for more personalized and economical therapeutic approach for its effective therapy. The current review here discusses agents from natural dietary sources and drug class Non-Steroidal Antinflammatory (NSAIDS) that bears chemopreventive potential to regulate PC progression & tumour development and therefore could be devised into effective future treatment strategy against PC along with its metastatic castration-resistant form. Based on the literature search the therapeutic scope of selected agents are delineated, sighting their previous activity and prospects as epigenetic moderators in specific to particular PC causing biomarkers like over expression of AKR1C3, lost intracellular glutathione/glutathione-s-tranferases(GSH/GST) expression, DNA hypermethylation, aberrant cell proliferation and other related factors that are thought to potentiate and aggravate the onset of PC like smoking and use of other narcotics products.

关键词： Prostate cancer NSAIDS AKR1C GSH/GST DNA hypermethylation

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Use of intravascular lithotripsy in non-coronary artery lesions

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世界心脏病学杂志:英文版(电子版) 2023年第8期15卷 395-405页

作者： Chukwuemeka Anthony Umeh Ashley Stratton Tifani Wagner shipra Saigal Krystal Sood Raghav Dhawan Cory Wagner Jessica Obi Sabina Kumar Tsung Han Scottie Ching Rahul Gupta Internal Medicine Hemet Global Medical CenterHemetCA 92543United States Department of Cardiology Mclaren Macomb-Oakland/Michigan State UniversityMacombMI 48043United States

BACKGROUND Intravascular lithotripsy(IVL)is a novel technique increasingly used for plaque modification and endovascular revascularization in patients with severe calcification and peripheral artery ***,much of the available literature on IVL is focused on its use in coronary arteries,with relatively limited data on non-coronary artery *** To analyze the safety and efficacy of current IVL use in non-coronary artery lesions,as reported in case reports and case *** We searched EMBASE,PubMed,and Reference Citation Analysis databases for case reports and case series on IVL use in peripheral artery *** then extracted variables of interest and calculated the mean and proportions of these *** We included 60 patients from 33 case reports/case ***-eight percent of the cases had IVL usage in only one blood vessel,while four had the IVL used in two vessels(2.0%),resulting in 64 Lesions treated with *** mean age of the patients was 73.7(SD 10.9).IVL was successfully used in severe iliofemoral artery stenosis(51.6%),severe innominate,subclavian,and carotid artery stenosis(26.7%combined),and severe mesenteric vessel stenosis(9.4%).Additionally,IVL was successfully used in severe renal(7.8%)and aortic artery(4.7%)*** were complications in 12%of the cases,with dissection being the *** IVL has successfully used in plaque modification and endovascular revascularization in severely calcified and challenging lesions in the iliofemoral,carotid,subclavian,aorta,renal,and mesenteric *** most severe but transient complications were with IVL use in the aortic arch and neck arteries.

关键词： Intravascular lithotripsy Peripheral artery disease Non-coronary artery

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轨道重构对LaTi1-xMnxO3磁性质的影响（英文）

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低温物理学报 2014年第1期36卷 1-6页

作者：付新闻吴志魏高玉泽 R.shipra 曹桂新 Department of Physics Shanghai University Max-Planck-Institute for Solid State Research Heisenbergstrasse 1 Stuttgart D-70569Germany Materials Science and Technology Division Oak Ridge National Laboratory Oak Ridge Tennessee 37831USA Materials Science and Technology Division Oak Ridge National Laboratory Oak RidgeTennessee 37831USA

详细研究了锰掺杂量为x=0.1,0.3,0.5的LaTiO3样品中轨道重构对磁性质的影响.氧含量过掺杂的母体LaTiO3未出现任何转变,但在锰掺杂的样品中80K附近出现明显的磁性质转变行为.锰掺杂量x=0.1的样品在温度小于45K低场情况下,伴有磁化强度的... 详细信息

详细研究了锰掺杂量为x=0.1,0.3,0.5的LaTiO3样品中轨道重构对磁性质的影响.氧含量过掺杂的母体LaTiO3未出现任何转变,但在锰掺杂的样品中80K附近出现明显的磁性质转变行为.锰掺杂量x=0.1的样品在温度小于45K低场情况下,伴有磁化强度的涨落,表明了在材料中电子相分离的出现.随着锰掺杂量的增加,通过对Ti 3+离子t2 g轨道的有序的影响进而增强了体系的反铁磁成分.

关键词：轨道重构钛酸盐

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DEPOSITIONAL ENVIRONMENT OF BATHONIAN SEDIMENTS OF THE JAISALMER BASIN,RAJASTHAN,WESTERN INDIA

DEPOSITIONAL ENVIRONMENT OF BATHONIAN SEDIMENTS OF THE JAISA...

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侏罗系界限及地质事件国际学术研讨会

作者： D.K.,Pandey F.T.,Fürsich shipra,Choudhary Department of Geology University of RajasthanJaipur 302004India

＜正＞The pericratonic sedimentary basin of Jaisalmer is one of the main structural elements of Rajasthan,situated to the west of the Aravalli ranges on the westerly dipping eastern flank

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在巴塞罗纳第二届世界城市论坛上重新回顾城市规划问题

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人类居住 2005年第2期 6-7页

作者： shipra Narang 宗思语（译）联合国人居署城市治理部门的助理人居官员不详

城市规划一直以来都受到指责，认为它没能充分地应对城市化发展的速度与规模、解决城市化带来的一些问题，例如不断加剧的不平等现象、日益增长的犯罪问题和不断恶化的城市环境问题。许多人都认为“良好治理”如今已经取代了城市规划这... 详细信息

城市规划一直以来都受到指责，认为它没能充分地应对城市化发展的速度与规模、解决城市化带来的一些问题，例如不断加剧的不平等现象、日益增长的犯罪问题和不断恶化的城市环境问题。许多人都认为“良好治理”如今已经取代了城市规划这一概念。

关键词：世界城市规划问题第二届城市化发展回顾论坛城市环境问题城市规划犯罪问题

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