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High-resolution full waveform seismic imaging: Progresses, challenges, and prospects

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Science China Earth Sciences 2025年第2期68卷 315-342页

作者： Dinghui YANG Xingpeng dong Jiandong HUANG Zhilong FANG Xueyuan HUANG Shaolin LIU Mengxue LIU Weijuan MENG Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Institute of Geology China Earthquake AdministrationBeijing 100029China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China School of Mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China

Full waveform inversion(FWI) is a seismic imaging method with a unified mathematical framework based on wave equation constraints. The FWI method can be used to generate a variety of high-resolution seismic parameter models(e.g.,velocity, anisotropy, viscoelasticity, and attenuation), which can facilitate an in-depth understanding of important scientific problems such as the Earth's interior structure and material composition, earthquake preparation and occurrence, and plate motion and dynamic processes. With the development and cross-integration of disciplines such as geophysics, applied mathematics, and computer science, FWI imaging theories and methods not only play a crucial role in revealing the Earth's interior structure, dynamic evolution, and earthquake mechanisms but also show a wide range of application potential in fields such as resource exploration, medical imaging, engineering inspection, carbon dioxide geological sequestration, and earthquake disaster prediction. In this paper, we provide a comprehensive review and analysis of the development of the FWI method,addressing its current challenges, identifying key issues, future directions, and potential research areas in the theory, methodology, and application of high-resolution FWI imaging. We also offer new insights and perspectives to promote advancements of high-resolution FWI research and applications in Earth sciences and other related fields.

关键词： Full waveform inversion High-resolution imaging Interior structure of the Earth Earthquake preparation me-chanism Multidisciplinary integration

Phase-transfer-shuttle generated in situ enables novel SN1-type fluorination of sulfonium ylide with hydrofluoric acid

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Science China Chemistry 2025年第2期68卷 641-648页

作者： Yisa Xiao Rui Wang Zhaoxuan Xu Qunchao Zhao Renyi Pang Tao dong Long Lu Qilong Shen Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryUniversity of Chinese Academy SciencesChinese Academy of SciencesShanghai 200032China

The development of a nucleophilic fluorination protocol using hydrofluoric acid as the fluoride source represents a long-sought goal in the field of organofluorine *** report herein the realization of such a reaction that employed alkyl-substituted sulfonium ylides as the *** key to the success of the protocol was attributed to two factors:First,as a Brϕnsted base,the ylide was able to be protonated by HFaq,thus serving as a phase-transfer shuttle generated in situ to bring F−from aqueous phase to the organic phase promoting desolvation of fluoride ***,after protonation,a sulfonium salt,a good leaving group,was generated and subsequent attacked by the fluoride to afford the alkyl *** investigation indicates that the reaction occurs via an SN1 *** of the nature of the cationic intermediate in the reaction,two attractive rearrangement-fluorination approaches including 1,2-aryl migration fluorination and ring-expansion fluorination were disclosed.

关键词： SN1 fluorination hydrofluoric acid sulfonium ylide cation rearrangement

Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China(Life Sciences) 2025年第1期68卷 158-175页

作者： Wen-Tao Sun Jian-Yong Du Jia Wang Yi-Long Wang Er-Dan dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)Schoolof Health and Life SciencesUniversityof Health and Rehabilitation SciencesQingdao 266071China Department of Cardiology and Instituteof Vascular Medicine Peking University Third HospitalTheInstituteofCardiovascular SciencesPeking UniversityState Key Laboratoryof Vascular Homeostasisand RemodelingPeking UniversityBeijing 100191China

Cardiac rehabilitation,a comprehensive exercise-based lifestyle and medical management,is effective in decreasing morbidity and improving life quality in patients with coronary heart *** function,an irreplaceable indicator in coronary heart disease progression,is measured by various methods in traditional cardiac rehabilitation pathways,including medicinal treatment,aerobic training,and smoking ***,studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are *** article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways,including exercise training,lifestyle modification and psychological intervention in patients with coronary heart disease,and related experimental models,and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial *** exercise training and some lifestyle interventions,the enhanced bioavailability of nitric oxide,increased circulating endothelial progenitor cells(EPCs),and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart ***,the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play *** the one hand,to develop more endothelium-protective rehabilitation methods in coronary heart disease,adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment *** the other hand,additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关键词： cardiac rehabilitation coronary heart disease endothelial function

Fracture behavior of sandstone with partial filling flaw under mixed-mode loading: Three-point bending tests and discrete element method

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 291-308页

作者： dongdong Ma Yu Wu Xiao Ma Xunjian Hu Wenbao dong Decheng Li Lingyu Li State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China State Key Laboratory of Structural Health and Safety of Bridges Wuhan430034China Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou310058China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress *** filling flaws were intermediate between open fractures and filled fractures,the fracture response may be worth *** this work,the effect of the filling property of sandstone with partial filling flaws on the fracture behavior was systematically investigated based on three-point bending tests and the numerical approach of discrete element method(DEM).In the laboratory,semi-circular three-point bending tests were carried out with partial filling flaws of various filling *** on this,numerical simulations were used to further investigate the effect of the filling ratio and the inclination of the partial filling flaw on the mechanical and fracture responses,and the effect of the partial filling flaw under mixed-mode loading on the fracture mechanism was elucidated coupled with acoustic emission(AE)*** obtained results showed that the increase in filling strength and filling ratio of partial filling flaw led to an increase in peak strength,with a decreasing trend in peak strength with the inclination of partial filling *** terms of crack propagation pattern,the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection,with a tortuosity path,while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction,accompanied with a larger AE event source in ***,the b-value based on the Gutenberg-Richter equation fluctuated between 5 and 4 at low filling ratio and inclination and remained around 5 at high filling ratio and inclination of partial filling *** results may provide an application prospective for reservoir stimulation using the natural fracture system.

关键词： Partial filling flaw Mixed-mode loading Semi-circular three-point bending Acoustic emission(AE) b-value

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China(Life Sciences) 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Beijing 100069China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 *** that p53 activation can also lead to multiple types of cell death,the role of this tumor suppressor in WEE1 inhibitor-based therapies remains *** this study,we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer *** findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake,an action similar to that of ***,inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11,which conferred resistance to ***,AZD1775 prevented the enrichment of H3K9me3,a histone marker of transcriptional repression,on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1,thereby enhancing NRF2-mediated SLC7A11 *** finding was also validated using the H3K9me3 inhibitor ***,we found that the nucleolar stress-inducing agent Actinomycin D(Act.D)inhibited SLC7A11 expression by activating p53,thus augmenting AZD1775-induced ***,the combination of AZD1775 and Act.D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in ***,our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription,and inhibition of SLC7A11 by Act.D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 315-322页

作者： dong-Qing Yuan Wei-Wei Zhang Liu-Wei Gu Qing-Huai Liu Department of Ophthalmology Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Women and Children Health HospitalNanjing 210029Jiangsu ProvinceChina

AIM:To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional ***:Twenty-one children with functional amblyopia,aged 5.7±2.1y(range:4-10y),underwent comprehensive ophthalmic and refractive *** domain-optical coherence tomography(SD-OCT)and multifocal electroretinography(mfERG)were conducted to analyze the macular retinal thickness and the first-order response P1 ring of the mfERG in the amblyopic eye(AE)compared to the fellow good eye(GE).RESULTS:Initially,visual acuity in the AE ranged from 20/800 to 20/40,while the GE exhibited a range of 20/25 to 20/20(P<0.01).After 6mo of treatment,17 patients demonstrated improved visual acuity in the AE to 20/50 or better,while 4 children showed no ***-OCT revealed comparable macular and optic disc structures between the AE and *** to treatment,the mfERG P1 ring amplitude was significantly reduced in the AE compared to GE(P<0.05).The AE/GE ratio of P1 ring amplitude showed significant improvement ***,a smaller AE/GE ratio before treatment was associated with poorer improvement ***:In the management of functional amblyopia,a thorough assessment of amblyopic eye examinations is *** 20%of amblyopic eyes may not achieve significant improvement in visual acuity,despite the absence of detectable organic retinal *** may reveal underlying *** mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.

关键词： functional amblyopia poor response optical coherence tomography multifocal electroretinography retinal defects

Nujiang Canyon ophiolites(eastern Tibetan Plateau): Records of early Jurassic subduction initiation at passive continental margin of the Lhasa block?

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Science China Earth Sciences 2025年第3期68卷 730-749页

作者： Qing QIAN Baolu SUN Feiyu dong State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and Geophysics Chinese Academy of Sciences Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

The formation ages and genesis of the Nujiang Canyon ophiolites in the eastern Tibetan Plateau are still unclear, and it has been debated whether they belong to the Neo-Tethyan or Paleo-Tethyan suture zones. This study exhibits that the Diba and Youba ophiolites in Zogang formed at 190–185 Ma and are of supra-subduction zone(SSZ) type, and belong to the Neo-Tethyan Bangong-Nujiang suture zone. The parental magmas of cumulates in the ophiolites were likely boninitic, and the mantle sources had been metasomatized by subduction fluids and melts derived from subducted sediments with components of ancient continental crust. It is further proposed that subduction initiation in the Bangong-Nujiang oceanic basin developed during the early Jurassic(195–184 Ma) at the northern passive continental margin of the Lhasa block. The inception of subduction beneath the Lhasa block occurred simultaneously along >2000 km length, resulting in synchronous arc granitoids on its northern margin. The early Jurassic ophiolites in the Bangong-Nujiang suture zone represent the fragments of forearc oceanic lithosphere during subduction initiation, which was probably induced by abrupt global plate reorganization during the Pangea breakup.

关键词： Nujiang Canyon ophiolites Early Jurassic Subduction initiation Supercontinent breakup Global plate reorganization

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Study on static characteristics of a novel prestress-reinforced railway subgrade

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Railway Engineering Science 2025年第1期33卷 108-126页

作者： Junli dong Fang Xu Qishu Zhang Wuming Leng Yafeng Li Qi Yang School of Civil Engineering Central South UniversityChangsha 410075China MOE Key Laboratory of Engineering Structures of Heavy Haul Railway Central South UniversityChangsha 410075China School of Civil Engineering Central South University of Forestry and TechnologyChangsha 410004China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China

Understanding the reinforcement effect of the newly developed prestressed reinforcement components(PRCs)(a system composed of prestressed steel bars(PSBs),protective sleeves,lateral pressure plates(LPPs),and anchoring elements)is technically significant for the rational design of prestressed subgrade.A three-dimensional finite element model was established and verified based on a novel static model test and utilized to systematically analyze the influence of prestress levels and reinforcement modes on the reinforcement effect of the *** results show that the PRCs provide additional confining pressure to the subgrade through the diffusion effect of the prestress,which can therefore effectively improve the service performance of the *** to the unreinforced conventional subgrades,the settlements of prestressreinforced subgrades are *** settlement attenuation rate(Rs)near the LPPs is larger than that at the subgrade center,and increasing the prestress positively contributes to the stability of the subgrade *** the multi-row reinforcement mode,the reinforcement effect of PRCs can extend from the reinforced area to the unreinforced *** addition,as the horizontal distance from the LPPs increases,the additional confining pressure converted by the PSBs and LPPs gradually diminishes when spreading to the core load bearing area of the subgrade,resulting in a decrease in the *** the singlerow reinforcement mode,PRCs can be strategically arranged according to the local areas where subgrade defects readily occurred or observed,to obtain the desired reinforcement ***,excessive prestress should not be applied near the subgrade shoulder line to avoid the shear failure of the subgrade *** can be flexibly used for preventing and treating various subgrade defects of newly constructed or existing railway lines,achieving targeted and classified prevention,and effectively improving the bearing performance and deformati

关键词： Prestressed subgrade Static characteristic Reinforcement effect Reinforcement mode Settlement Numerical simulation

Influence of the Scandinavian Pattern on Summer Extreme Precipitation over the Eastern Slopes of the Tibetan Plateau

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Advances in Atmospheric Sciences 2025年第3期42卷 438-452页

作者： Quanliang CHEN Ziqi ZHANG Yang LI Yujing LIAO Dandan dong Plateau Atmospheric and Environment Key Laboratory of Sichuan Province School of Atmospheric ScienceChengdu University of Information TechnologyChengdu 610225China Shaoxing Yuecheng Meteorological Bureau Shaoxing 312000China Zhejiang Institute of Meteorological Sciences Hangzhou 310008China

The Scandinavian(SCA)pattern is an important climate signal in regulating the variability of summer extreme precipitation(SEP)over the eastern slopes of the Tibetan Plateau(ESTP).There is a strong negative correlation between the SCA pattern and SEP over the ESTP,with a correlation coefficient *** budget analysis showed that the dynamic component anomalies of both the zonal and vertical moisture advection induced by the SCA pattern play the dominant roles in extreme precipitation variability over the *** anomalies are solely linked to variations in zonal wind and vertical *** anomalies of the SCA pattern propagate downstream through Rossby waves,leading to the formation of cyclonic circulations over northern East Asia and the Iranian *** westerlies on the southern side of these cyclonic circulations play a crucial role in influencing the development of significant anomalous westerlies over the *** anomalous westerlies bring climatologically moist air from the Tibetan Plateau(TP)to the ESTP,resulting in positive zonal moisture advection anomalies over the ***,these anomalous westerlies transport climatologically warm air from the TP to the ESTP,leading to significant warm advection anomalies and vertical upward motion anomalies over the *** upward motion carries lower-tropospheric moisture upward,resulting in positive vertical moisture advection anomalies over the *** combination of these positive zonal and vertical moisture advection anomalies eventually leads to excessive SEP.

关键词： atmospheric circulation extreme precipitation Scandinavian pattern moisture budget