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Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation

World Journal of Gastroenterology 2012年第20期18卷 2517-2525页

作者： Masahiro Tajika Yasumasa Niwa Vikram Bhatia Hiroki Kawai shinya kondo Akira Sawaki Nobumasa Mizuno Kazuo Hara Susumu Hijioka Kazuya Matsumoto Yuji Kobayashi Akira Saeki Asana Akabane Koji Komori Kenji Yamao Department of Endoscopy Aichi Cancer Center Hospital Nagoya 464-8681Japan Department of Medical Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol(PEG)-electrolyte *** 250 patients undergoing colonoscopy,124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group),and 126 received 2 L PEG plus placebo(placebo group).Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation *** efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's *** primary end point was optimal bowel preparation rates(scores of excellent/good/fair vs poor/inadequate). RESULTS:A total of 249 patients were included in the *** the mosapride group,optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group(78.2%vs 65.6%,P<0.05),but not in the right colon(76.5%vs 66.4%,P=0.08).After excluding patients with severe constipation,there was a significant difference in bowel preparation in both the left and right colon(82.4%vs 66.7%,80.8%vs 67.5%,P<0.05,P<0.01).The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience,a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group(34/72 patients vs 24/74 patients,P<0.05). CONCLUSION:Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation,especially in patients without severe constipation.

关键词： Mosapride citrate Bowel preparation Polyethylene glycol-electrolyte solution Colonoscopy Prokinetics

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Can mosapride citrate reduce the volume of lavage solution for colonoscopy preparation?

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World Journal of Gastroenterology 2013年第5期19卷 727-735页

作者： Masahiro Tajika Yasumasa Niwa Vikram Bhatia shinya kondo Tsutomu Tanaka Nobumasa Mizuno Kazuo Hara Susumu Hijioka Hiroshi Imaoka Koji Komori Kenji Yamao Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Medical Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

AIM:To evaluate the possibility of reducing the volume of polyethylene glycol(PEG)-electrolyte solution using adjunctive mosapride citrate for colonoscopy preparation. METHODS:This was a single-center,prospective, randomized,investigator-blinded,non-inferiority study involving 252 patients of both sexes,aged from 20 to 80 years,scheduled for screening or diagnostic colonoscopy in our department.A total of 126 patients was randomized to receive 1.5 L PEG-electrolyte solution plus 15 mg of mosapride(1.5 L group),and 126 received 2 L PEG-electrolyte solution plus 15 mg of mosapride(2 L group).Patients completed a questionnaire on the acceptability and tolerability of the bowel preparation *** efficacy of bowel preparation was assessed using a 5-point scale based on the Aronchick *** primary end point was adequate bowel preparation rates(score of excellent/good/fair) vs(poor/inadequate).Acceptability and tolerability,as well as disease detection,were secondary end points. RESULTS:A total of 244 patients was included in the *** were no significant differences between the 2 L and 1.5 L groups in age,sex,body mass index, number of previous colonoscopies,and the preparation method used *** adequate bowel preparation rates were 88.5%in the 2 L group and 82.8%in the 1.5 L group[95%lower confidence limit(LCL)for the difference=-14.5%,non-inferiority P=0.019]in the right *** the left colon,the adequate bowel preparation rates were 89.3%in the 2 L group and 81.1%in the 1.5 L group(95%LCL=-17.0%,non-inferiority P=0.066).Compliance,defined as complete (100%)intake of the PEG solution,was significantly higher in the 1.5 L group than in the 2 L group(96.8% vs 85.7%,P=0.002).The proportion of abdominal distension(none/mild/moderate/severe)was significantly lower in the 1.5 L group than in the 2 L group (36/65/22/3 vs 58/48/18/2,P=0.040).Within the subgroup who had undergone colonoscopy previously, a significantly higher number of patients in t

关键词： Mosapride citrate Bowel preparation Polyethylene glycol-electrolyte solution Prokinetics Colonoscopy

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Interventional endoscopic ultrasonography for pancreatic cancer

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World Journal of Clinical Oncology 2011年第2期2卷 108-114页

作者： Kazuo Hara Kenji Yamao Nobumasa Mizuno Susumu Hijioka Akira Sawaki Masahiro Tajika Hiroki Kawai shinya kondo Yasuhiro Shimizu Yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastrointestinal Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

Endoscopic ultrasonography(EUS)represents the combination of endoscopy and intraluminal *** allows use of a high-frequency transducer(5-20 MHz)that,due to the short distance to the target lesion,provides ultrasonographic images of higher resolution than those obtained from other imaging modalities,including multiple-detector-row-computed tomography,magnetic resonance imaging,and positron emission *** is now a widely accepted modality for diagnosing pancreatic ***,the most important limitation of EUS has been the lack of specificity in differentiating between benign and malignant *** 1992,EUS-guided fine needle aspiration(FNA)of lesions in the pancreas head was introduced into clinical practice,using a curved linear-array *** then,EUS has evolved from EUS imaging to EUSFNA and wider *** EUS for pancreatic cancer includes EUS-FNA,EUS-guided fine needle injection,EUS-guided biliary drainage and anastomosis,EUS-guided celiac neurolysis,radiofrequency ablation,brachytherapy,and delivery of a growing number of anti-tumor *** review focuses on interventional EUS,including EUS-FNA and therapeutic EUS for pancreatic cancer.

关键词： Endoscopic ultrasonography-biliary drainage Endoscopic ultrasonography-choledochoduodenostomy Endoscopic ultrasonography-fine needle aspiration Endoscopic ultrasonography-guided biliary drainage Interventional endoscopic ultrasonography

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Identifying bereaved grievers with greatest medical or social service needs in Japan

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Family Medicine and Community Health 2022年第1期10卷 1-9页

作者： Carl Becker Yozo Taniyama Megumi kondo-Arita Noriko Sasaki shinya Yamada Kayoko Yamamoto Policy Science Unit School of MedicineKyoto UniversityKyotoJapan Department of Religious Studies Tohoku UniversitySendaiJapan Nakayama International Center Osaka Medical CollegeTakatsukiJapan Department of Healthcare Economics and Quality Management Graduate School of MedicineKyoto UniversityKyotoJapan Department of Ethnology National Museum of Japanese HistorySakuraJapan Department of Nursing Tenri Health Care UniversityTenriJapan

Objective Severe grief adversely affects the health of bereaved families,potentially burdening medical and community health *** for effective community health maintenance must identify the people likely to face severe effects of *** present study identified characteristics of mourners who experience severe grief within a year of bereavement to confirm whether this grief increased their reliance on Japanese medical and social *** We conducted a nationwide postal survey of Japanese bereaved within the previous year,to compare those reporting daily or overwhelming‘heavy’grief to those with less heavy grief,in terms of demographic and socioeconomic details,daily work and non-work activity,frequency of medical and social service ***/participants In 2019,with the support of the Ministry of Education and the All Japan Funeral Co-Operation,we distributed approximately 5500 questionnaires to Japanese who had presided at funerals within the past year for anonymous *** January of 2020,we received 1078 complete voluntary responses from bereaved *** Half of the‘heavy grief’group(n=143)reported adverse effects on health and daily life,including needs for pharmacological,medical or welfare *** of husbands or children were particularly connected to severe grief;‘unexpected’death from cancer caused the greatest ***(even part-time)buffered against severe grief;grief was greater for the unemployed and substantially worse for those who lost significant income at the same time as they lost loved *** These findings suggest that prior counselling should reduce the shock of bereavement and economic loss,which increases subsequent medical *** professionals and community health workers can use the above factors to target in advance the family members in greatest danger of heavy grief,to intervene lest grief adversely affect their physical and psychological health after ber

关键词： service sided return

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