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Beam Characteristics at Low Dose Monitor Unit Settings for Vero4DRT

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第4期4卷 284-289页

The stability of delivery of low monitor unit (MU) setting is important especially for step-and-shoot intensity-modulated radiotherapy (IMRT), because the nature of the technique is inherent to repeat beam on/off according to the number of the segments. This study evaluates the dose linearity and profile flatness/symmetry under low MU settings for Vero4DRT, a new linear-accelerator based irradiation system that currently implements step-and-shoot IMRT. To evaluate the dose linearity and flatness/symmetry, the point doses and beam profiles were measured as functions of MU and dose rates. The accuracy of dose delivery depended on the dose rate. Under all dose rates, the dose was linear within 1% above 5 MU and within 2% above 3 MU. The beam symmetry was degraded in-line compared with crossline, although both profiles were symmetric within 2% at all dose settings. The profile flatness was also within 2% above 5 MU at any dose rate and showed no significant variation among the low MU settings. To ensure stable beam delivery without increasing the treatment time of Vero4DRT, we recommend a delivery of 5 MU per segment at a dose rate of 500 MU/min.

关键词： Vero4DRT Step-and-Shoot IMRT Low Monitor Unit Beam Characteristic

Unilateral branch retinal artery occlusion in association with COVID-19:a case report

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 777-782页

作者： Kunihiko Hirosawa Takenori Inomata Jaemyoung Sung Yuki Morooka Tianxiang Huang Yasutsugu Akasaki Yuichi Okumura Ken Nagino Kaho Omori shintaro Nakao Department of Ophthalmology Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Digital Medicine Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Telemedicine and Mobile Health Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Hospital Administration Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan AI Incubation Farm Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology Tulane University School of MedicineNew OrleansLA 70112USA

Dear Editor,I am Kunihiko Hirosawa of the Department of Ophthalmology at Juntendo University Hospital.I am writing to present a case of concomitant Coronavirus Disease 2019(COVID-19)with branch retinal artery occlusion(BRAO).BRAO presents as a sudden,painless loss of vision on the afflicted side and is most often focal in nature[1].

关键词： branch COV occlusion

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

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饱和珊瑚砂液化特性动三轴试验研究

地震工程学报 2024年第1期46卷 84-94页

作者：郭舒洋崔杰吴杨单毅中田幸男梶山慎太郎广州大学土木工程学院广东广州510006 山口大学地盘工学日本山口755-8611

为调查饱和珊瑚砂液化相关特性与发展规律,针对饱和Chibishi珊瑚砂,开展一系列不排水循环三轴试验,研究相对密度D r和循环应力比CSR对饱和Chibishi珊瑚砂的超孔隙水压力Δu、轴向应变εa及动强度特性的影响,并分析不同地区珊瑚砂抗液化... 详细信息

为调查饱和珊瑚砂液化相关特性与发展规律,针对饱和Chibishi珊瑚砂,开展一系列不排水循环三轴试验,研究相对密度D r和循环应力比CSR对饱和Chibishi珊瑚砂的超孔隙水压力Δu、轴向应变εa及动强度特性的影响,并分析不同地区珊瑚砂抗液化强度的差异性。结果表明,饱和Chibishi珊瑚砂的Δu发展模式根据不同的CSR水平可以分为前期均匀增长型、前期突增型和后期突增型;此外,采用一种新的孔压模型对前期均匀增长型、前期突增型的孔压比r u进行表征,Chibishi珊瑚砂在相同的D r条件下,双幅应变εDA达到5%的循环次数N随着CSR水平的增加而逐渐减小;各珊瑚砂在同一里氏震级对应的等效循环振动次数下,抗液化强度CRR的增长模式存在显著差异。研究结果可丰富对珊瑚砂液化特征的认知,同时对近岸和沿海工程的抗震设计提供参考依据。

关键词：饱和珊瑚砂孔压发展轴应变发展动强度

The Mechanism for Allocating Limited Working Memory Resources in Multitasking

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Neuroscience Bulletin 2022年第7期38卷 829-833页

作者： Lu Gan Jinglong Wu Ji Dai shintaro Funahashi Research Center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China CAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China University of The Chinese Academy of Sciences Beijing 100049China

Working memory plays an important role in many complex cognitive activities such as thinking,reasoning,decisionmaking,and language *** memory refers to a mechanism involving both the temporary storage and the manipulation of *** an important approach toward understanding the mechanisms of working memory,visual working memory has attracted attention since the 1990s.

关键词： such since has

Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 646-653页

作者： shintaro Akiyama Taku Sakamoto Joshua M Steinberg Yutaka Saito Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaIbaraki 305-8575Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Magnifying endoscopy is a useful technique to differentiate neoplasia from non-neoplastic lesions. Data regarding the clinical utility of magnifying endoscopy for neoplasia in patients with inflammatory bowel disease(IBD) has been *** Kudo’s pit pattern types Ⅲ-Ⅴ are findings suggestive of neoplasia in non-IBD patients, these pit patterns are predictive of IBD-associated neoplasia as ***, active chronic inflammatory processes, particularly regenerative changes, can mimic neoplastic pit patterns and may affect a meticulous evaluation of pit pattern diagnosis in patients with IBD. The clinical evidence regarding the utility of magnifying endoscopy with narrow band imaging or endocytoscopy has also been evolving in regard to the diagnosis of IBD-associated neoplasia. These advanced endoscopic techniques are promising for multiple reasons;not only for making an accurate diagnosis of neoplasia, but also in determining if endoscopic resection is appropriate for such lesions in patients with IBD. In this review, we discuss the diagnostic accuracy and limitations of magnifying endoscopy in assessing IBD-associated neoplasia and examine the feasibility and outcomes of endoscopic resection for these lesions.

关键词： Magnifying endoscopy Neoplasia Ulcerative colitis Inflammatory bowel disease Endoscopic resection

Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases

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World Journal of Gastroenterology 2022年第25期28卷 2843-2853页

作者： shintaro Akiyama Soma Fukuda Joshua M Steinberg Hideo Suzuki Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaTsukuba 305-8575IbarakiJapan Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Patients with inflammatory bowel disease(IBD)are more likely to have concurrent immune-mediated inflammatory diseases(IMIDs)than those without *** have been observed to alter the phenotype and outcomes of IBD in recent *** studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes,and are considered to be at increased risk of requiring biologics and IBD-related surgeries,suggesting that having multiple IMIDs is a poor prognostic factor for ***,IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes,suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory *** this review,we discuss the pathogenesis,disease phenotypes,and clinical outcomes in IBD patients with concomitant IMIDs.

关键词： Inflammatory bowel disease Phenotypes Outcomes Concurrent immunemediated inflammatory diseases

Pregnancy and medications for inflammatory bowel disease:An updated narrative review

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World Journal of Clinical Cases 2023年第8期11卷 1730-1740页

作者： shintaro Akiyama Joshua M Steinberg Mariko Kobayashi Hideo Suzuki Kiichiro Tsuchiya Department of Gastroenterology Faculty of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80027United States

Inflammatory bowel disease(IBD)is often diagnosed during the peak reprodu-ctive years of young *** with active IBD around conception are at a significantly increased risk of disease relapse during pregnancy,which is associated with poor pregnancy and neonatal *** these substantial risks,it is prudent that disease remission should ideally be achieved before ***,some patients may experience a disease flare-up even if they are in a state of remission before *** must continue their IBD medications to reduce the risk of disease flare and subsequent poor outcomes during the gestational and postpartum *** treating IBD flare-ups during pregnancy,the management is quite similar to the therapeutic approach for non-pregnant patients with IBD,including 5-aminosalicylate,steroids,calcineurin inhibitors(CNIs),and biologic *** the data regarding the safety of CNIs in pregnant women with IBD is limited,the findings in our recent meta-analysis suggest that CNIs may be safer to use in those with IBD than in solid organ transplant *** are several types of biologics and small-molecule therapies currently approved for IBD,and physicians should thoroughly understand their clinical benefits and safety profiles when utilizing these treatments in the context of *** review highlights recent studies,including our systematic review and meta-analysis,and discusses the clinical advantages and safety considerations of biologics and small molecules for pregnant women with IBD.

关键词： Inflammatory bowel disease Pregnancy Safety Biologics Small molecules

Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1329-1339页

作者： Ryo Yamamoto Sayuri Suzuki Koichiro Homma shintaro Yamaguchi Tomohisa Sujino Junichi Sasaki Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 1608582Japan Division of Endocrinology Metabolism and NephrologyDepartment of Internal MedicineKeio University School of MedicineTokyo 1608582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 1608582Japan

BACKGROUND Patients with mesenteric ischemia frequently suffer from bowel necrosis even after *** gas has showed promising effects for ischemiareperfusion injury by reducing reactive oxygen species in various animal and clinical *** examined intestinal tissue injury by ischemia and reperfusion under continuous initiation of 3%hydrogen *** To clarify the treatment effects and target cells of hydrogen gas for mesenteric *** Three rat groups underwent 60-min mesenteric artery occlusion(ischemia),60-min reperfusion following 60-min occlusion(reperfusion),or ischemiareperfusion with the same duration under continuous 3%hydrogen gas inhalation(hydrogen).The distal ileum was *** staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5(LGR5),a specific marker of intestinal stem cell,was conducted to evaluate the injury location and cell types protected by *** expressions of LGR5,olfactomedin 4(OLFM4),hairy and enhancer of split 1,Jagged 2,and Neurogenic locus notch homolog protein 1 were measured by quantitative polymerase chain *** oxidative stress was analyzed with immunostaining for 8-hydroxy-2'-deoxyguanosine(8-OHdG).Systemic oxidative stress was evaluated by plasma *** Ischemia damaged the epithelial layer at the tip of the villi,whereas reperfusion induced extensive apoptosis of the cells at the crypt base,which were identified as intestinal stem cells with double immunofluorescence *** mitigated such apoptosis at the crypt base,and the LGR5 expression of the tissues was higher in the hydrogen group than in the reperfusion ***4 was also relatively higher in the hydrogen group,whereas other measured RNAs were comparable between the groups.8-OHdG concentration was high in the reperfusion group,which was reduced by hydrogen,particularly at the crypt *** 8-OHdG concentrations were relatively higher in both reperfusion and

关键词： Hydrogen molecule Intestinal ischemia Ischemia-reperfusion injury Tissue protection Nonoperative management Leucine-rich repeat-containing G-protein-coupled 5