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International Journal of Ophthalmology(English edition) 2024年第4期17卷 777-782页

作者： Kunihiko Hirosawa Takenori Inomata Jaemyoung Sung Yuki Morooka Tianxiang Huang Yasutsugu Akasaki Yuichi Okumura Ken Nagino Kaho Omori shintaro Nakao Department of Ophthalmology Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Digital Medicine Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Telemedicine and Mobile Health Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Hospital Administration Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan AI Incubation Farm Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology Tulane University School of MedicineNew OrleansLA 70112USA

Dear Editor,I am Kunihiko Hirosawa of the Department of Ophthalmology at Juntendo University Hospital.I am writing to present a case of concomitant Coronavirus Disease 2019(COVID-19)with branch retinal artery occlusion(BRAO).BRAO presents as a sudden,painless loss of vision on the afflicted side and is most often focal in nature[1].

关键词： branch COV occlusion

Accuracy and Utility of Vessel Analysis Using Non-Contrast CT for Planning Endovascular Aortic Repair

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Open Journal of Medical Imaging 2024年第3期14卷 96-105页

作者： Midori Komita-Moriya Yukihisa Ogawa Akiyuki Kotoku shintaro Nawata Kenji Kuramochi Yasuyoshi Ogawa Kiyoshi Chiba Hiroshi Nishimaki Hidefumi Mimura Department of Radiology St. Marianna University School of Medicine Kanagawa Japan Department of Radiology Tokai University School of Medicine Hachioji Hospital Tokyo Japan Radiological Technology St. Marianna University School of Medicine Kanagawa Japan Department of Cardiovascular Surgery St. Marianna University School of Medicine Kanagawa Japan

Objectives: This study aimed to determine whether errors in vascular measurements would affect device selection in endovascular aortic repair (EVAR) by comparing measurements obtained using non-contrast computed tomography (NCT) with those obtained using contrast-enhanced CT (CECT). Materials and Methods: This single-center, retrospective study included 25 patients who underwent EVAR for abdominal aortic aneurysm at our institution. A 1-mm horizontal cross-sectional slice of NCT and CECT from each patient was retrospectively reviewed. The area from the abdominal aorta to the common iliac artery was divided into four zones. A centerline was created using the NCT by manually plotting the center points. Subsequently, the centerlines were automatically extracted and manually corrected during the arterial phase of CECT. The diameter and length of each zone were measured for each modality. The mean diameters and lengths of the target vessels were compared between NCT and CECT. Results: The measurements obtained using both methods were reproducible and demonstrated good agreement. The mean differences in vessel length and diameter measurements for each segment between NCT and CECT were not statistically significant, indicating good consistency. Conclusion: NCT may be useful for preoperative EVAR evaluation in patients with renal dysfunction or allergies to contrast agents.

关键词： Non-Contrast CT Vessel Analysis EVAR Contrast-Enhanced CT Abdominal Aortic Aneurysm

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Molecular dynamics simulation of the A-DNA to B-DNA transition in aqueous RbCl solution

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Science China Chemistry 2013年第4期56卷 524-532页

作者： YU YangXin FUJIMOTO shintaro Laboratory of Chemical Engineering Thermodynamics Department of Chemical Engineering Tsinghua University

Unrestrained molecular dynamics （MD） simulations have been carded out to characterize the stability of DNA conformations and the dynamics of A-DNA^B-DNA conformational transitions in aqueous RbC1 solutions. The PARM99 force field in the AMBER8 package was used to investigate the effect of RbC1 concentration on the dynamics of the A^B conformational tran- sition in the DNA duplex d（CGCGAATTCGCG）2. Canonical A- and B-form DNA were assumed for the initial conformation and the final conformation had a length per complete turn that matched the canonical B-DNA. The DNA structure was moni- tored for 3.0 ns and the distances between the C5＇ atoms were obtained from the simulations. It was found that all of the double stranded DNA strands of A-DNA converged to the structure of B-form DNA within 1.0 ns during the unrestrained MD simula- tions. In addition, increasing the RbC1 concentration in aqueous solution hindered the A^B conformational transition and the transition in aqueous RbC1 solution was faster than that in aqueous NaC1 solution for the same electrolyte strength. The effects of the types and concentrations of counterions on the dynamics of the A^B conformational transition can be understood in terms of the variation in water activity and the number of accumulated counterions in the major grooves of A-DNA. The ru- bidium ion distributions around both fixed A-DNA and B-DNA were obtained using the restrained MD simulations to help ex- plain the effect of RbC1 concentration on the dynamics of the A^B conformational transition.

关键词： DNA conformational transition molecular dynamics aqueous RbCI solution

Numerical simulation of dam break flow impact on vertical cylinder by cumulant lattice Boltzmann method

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Journal of Hydrodynamics 2021年第2期33卷 185-194页

作者： Seiya Watanabe shintaro Fujisaki Changhong Hu Research Institute for Applied Mechanics Kyushu UniversityFukuokaJapan School of Engineering Sciences Kyushu UniversityFukuokaJapan

The purpose of this study is to apply the cumulant lattice Boltzmann method(LBM)to simulate high Reynolds number free surface *** single-phase cumulant LBM is extended to solve the free surface flows by using the phase-field method as the interface capturing *** simulations are performed on an experimental problem of dam break flow impact on a vertical *** numerical aspects such as collision model,grid resolution,time step and interface mobility parameter are *** is found that the severe impact pressure oscillation in the simulation by the conventional SRT model,can be significantly suppressed by the cumulant *** agreement between the cumulant LBM numerical simulation and the experiment has been obtained on both the free surface profiles and the impact *** numerical results obtained by the present study demonstrate that the cumulant LBM can be a powerful numerical tool for simulations of violent free surface flow problems.

关键词： Lattice Boltzmann method(LBM) free surface flow wave impact pressure dam break flow cumulant model

Simulation study on dynamics of A- to B-form transition in aqueous DNA solution:Effect of alkali metal counterions

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Science China Chemistry 2013年第12期56卷 1735-1742页

作者： YU YangXin FUJIMOTO shintaro Laboratory of Chemical Engineering Thermodynamics Department of Chemical EngineeringTsinghua University

DNA and its conformational transition can be used to design nanometer-scale structures, nano-tweezers and nanomechanical devices. Experiments and molecular simulations have been used to study the concentration effect on the A-DNA→B-DNA conformational transition, but a systematical investigation on counterion effect on the dynamics of this transition has not been reported up to now. In present work, restrained and unrestrained molecular dynamics （MD） simulations have been performed to characterize the stability of DNA conformations and the dynamics of A-DNA→B-DNA transitions in aqueous solutions with different alkali metal counterions. The DNA duplex d（CGCGAATTCGCG）2, coion Cl- and counterions Li＋, Na＋, K＋, Rb＋ and Cs~ as well as water molecule were considered using the PARM99 force field in the AMBER8 package. It was found that B-form DNA is more stable than A-form DNA in aqueous electrolyte solutions with different alkali metal counterions. In- creasing KCI concentration in solution hinders the A-DNA^B-DNA transition and the transition times for different alkali metal counterions conform to neither the simple sequence related to naked ion size nor to hydrated diameter, but an apparently abnormal sequence of K＋〈 Rb＋〈 Cs＋〈 Na＋〈 Li＋. This abnormal sequence can be well understood in terms of an electrostatic model based on the effective cation diameters and the modified mean-spherical approximation （MMSA）. The present results provide valuable information for the design of DNA-based nanomaterials and nanodevices.

关键词： A-DNA B-DNA conformational transition alkali metal ion molecular dynamics

A two-stage process with temperature-shift for enhanced anthocyanin production in strawberry cell suspension cultures

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Science China Chemistry 1999年第4期42卷 345-350页

作者：张卫 shintaro Furusaki Chris Franco Department of Chemistry and Biotechnology Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113 Japan Biotechnology School of Medicine Flinders University of South Australia Bedford Park SA 5042 Australia

A two-stage process with temperature-shift has been developed to enhance the anthocyanin yield in suspension cultures of strawbeny cells. The effect of the temperature-shift interval and the shift-time point was investigated for the optimization of this strategy. In this process, strawbeny cells were grown at 30°C (the optimum temperature for cell gowth) for a certain period as the first stage, with the temperature shifted to a lower temperature for the second stage. In response to the temperature shift-down, anthocyanin synthesis was stimulated and a higher content could be achieved than that at both boundary temperatures but cell growth was suppressed. When the lower boundary temperature. was decreased, cell growth was lowered and a delayed, sustained maximum anthocyanin content was achieved. Anthocyanin synthesis was strongly influenced by the shift-time point but cell growth was not. Consequently, the maximum anthocyanin content of 2.7 mg.g-fresh cell-1 was obtained on day 9 by a temperature-shift from 309°C, after 3-d culture, to 15°C. The highest anthocyanin yield of 318 mg. L-1 on day 12 was achieved when the temperature was shifted from 30°C, after 5-d culture, to 20°C. For a global optimization of both the yield and productivity, the optimum anthocyanin yield and productivity of 272 mg.L-1 1 and 30.2 mg.L-1d1 on day 9 were achieved by a two-stage culture with a temperature-shift from 30°C after 3 d to 20°C.

关键词： strawberry cell suspension cultures anthocyanin temperature two-stage culture temperature-shift.

Small-for-size syndrome in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 570-576页

作者： shintaro Yagi Shinji Uemoto Department of Hepatobiliary Pancreas and Transplant Surgery Kyoto University Graduate School of Medicine 54 Kawara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan

When the graft volume is too small to satisfy the recipient’s metabolic demand, the recipient may thus experience small-for-size syndrome (SFSS). Because the occurrence of SFSS is determined by not only the liver graft volume but also a combination of multiple negative factors, the definitions of small-for-size graft (SFSG) and SFSS are different in each institute and at each time. In the clinical setting, surgical inflow modulation and maximizing the graft outflow are keys to overcoming SFSS. Accordingly, relatively smaller-sized grafts can be used with surgical modification and pharmacological manipulation targeting portal circulation and liver graft quality. Therefore, the focus of the SFSG issue is now shifting from how to obtain a larger graft from the living donor to how to manage the use of a smaller graft to save the recipient, considering donor safety to be a priority.

关键词： living donor liver transplantation small-for-size syndrome

Large deformation simulations of geomaterials using moving particle semi-implicit method

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1122-1132页

作者： shintaro Nohara Hiroshi Suenaga Kunihiko Nakamura Central Research Institute of Electric Power Industry ChibaJapan

Numerical simulation tools are required to describe large deformations of geomaterials for evaluating the risk of geo-disasters. This study focused on moving particle semi-implicit(MPS) method, which is a Lagrangian gridless particle method, and investigated its performance and stability to simulate large deformation of geomaterials. A calculation method was developed using geomaterials modeled as Bingham fluids to improve the original MPS method and enhance its stability. Two numerical tests showed that results from the improved MPS method was in good agreement with the theoretical ***, numerical simulations were calibrated by laboratory experiments. It showed that the simulation results matched well with the experimentally observed free-surface configurations for flowing sand. In addition, the model could generally predict the time-history of the impact force. The MPS method could be a useful tool to evaluate large deformation of geomaterials.

关键词： Particle method Moving particle semi-implicit(MPS) method Large deformation analysis Geomaterials Bingham model