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Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner

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World Journal of Cardiology 2017年第8期9卷 673-684页

作者： Danielle R Bruns Alexander R Ghincea Christian V Ghincea Yasu-Taka azuma Peter A Watson Michael V Autieri Lori A Walker Division of Cardiology Department of MedicineUniversity of Colorado-Denver Laboratory of Veterinary Pharmacology Division of Veterinary ScienceOsaka Prefecture University Graduate School of Life and Environmental Science Department of Medicine and Endocrinology University of Colorado-Denver Denver Veterans Affairs Medical Center Independence Blue Cross Cardiovascular Research Center Department of PhysiologyTemple University School of Medicine

AIM To investigate the role of interleukin-19(IL-19) in a murine model of female-dominant heart failure(HF).METHODS Expression of one copy of a phosphorylation-deficient cyclic adenosine monophosphate response-element binding protein(dn CREB) causes HF, with accelerated morbidity and mortality in female mice compared to males. We assessed expression of IL-19, its receptor isoforms IL-20 R α/β, and downstream IL-19 signaling in this model of female-dominant HF. To test the hypothesis that IL-19 is cardioprotective in dn CREB-mediated HF, we generated a novel double transgenic(DTG) mouse of dn CREB and IL-19 knockout and assessed cardiac morbidity by echocardiography and survival of male and female *** IL-19 is expressed in the murine heart with decreased expression in dn CREB female compared to male mice. Further, the relative expression of the two IL-19 receptor isoforms manifests differently in the heart by sex and by disease. Male DTG mice had accelerated mortality and cardiac morbidity compared to dn CREB males, while female DTG mice showed no additional detriment, supporting the hypothesis that IL-19 is cardioprotective in this model. CONCLUSION Together, these data suggest IL-19 is an important cytokine mediating sex-specific cardiac(dys) function. Ongoing investigations will elucidate the mechanism(s) of sex-specific IL-19 mediated cardiac remodeling.

关键词： Cardiac dysfunction Sex differences Heart failure Interleukin-19

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如何化数据库动物为政治动物? 从悖谬逻辑到悖谬-观众《后现代状况》出版四十周年

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新美术 2020年第6期41卷 75-87页

作者： [日]东浩纪张侃侃(译) 不详

一我上次读《后现代状况》是在写《动物化后现代》[Animalizing Postmodernity]的时候,迄今已有近二十年,后现代了这么久。为了做这次演讲,我重温了一下这本书。我可以不费吹灰之力地在书中找到许多"预言"的例证。比如利奥塔写道:后现... 详细信息

一我上次读《后现代状况》是在写《动物化后现代》[Animalizing Postmodernity]的时候,迄今已有近二十年,后现代了这么久。为了做这次演讲,我重温了一下这本书。我可以不费吹灰之力地在书中找到许多"预言"的例证。比如利奥塔写道:后现代知识[savoir]不再涉及自我[self]的文化生成,只是像可供消费的商品或货币一样进入分配,在这个过程中人们不再以传播的透明度为重,且不假思索地认为包括国家边界在内的所有边界都很碍事。这个说法预言了大型组织"谷歌"的影响。

关键词：《后现代状况》利奥塔数据库近二十年悖谬后现代知识动物化

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Esophageal diverticulum exposed during endoscopic submucosal dissection of superficial cancer

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World Journal of Gastroenterology 2015年第10期21卷 3121-3126页

作者： Shinwa Tanaka Takashi Toyonaga Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Tsukasa Ishida Namiko Hoshi Yoshinori Morita Takeshi azuma Department of Endoscopy Kobe University Division of Gastroenterology Department of Internal MedicineGraduate School of MedicineKobe University

Endoscopic submucosal dissection(ESD) is now widely accepted as a strategy to treat superficial esophageal *** rate of adverse events,such as perforation,has been decreasing with the improvement of devices and *** this paper,we report a case of esophageal cancer that had a diverticulum under cancerous *** diverticulum was not detected during preoperative examination,and led to perforation during the ESD *** case shows that,although rare,some diverticula can exist underneath the mucosal surface without obvious *** there is any sign of hidden diverticula during ESD,surgeons should proceed with caution or,depending on the case,the procedure should be discontinued to avoid adverse events.

关键词： Endoscopic submucosal dissection Eso-phageal cance

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Human B7-H3 binds to Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) and enhances T cell responses

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Open Journal of Immunology 2012年第1期2卷 9-16页

作者： Masaaki Hashiguchi Yuka Inamochi Shoya Nagai Noriko Otsuki Jinhua Piao Hiroko Kobori Yumiko Kanno Hidefumi Kojima Tetsuji Kobata Miyuki azuma Department of Immunology Dokkyo Medical University School of Medicine Mibu Tochigi Japan Department of Molecular Immunology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

The B7 family member B7-H3 is broadly expressed in many tissue and tumor types. B7-H3 expression is induced on some immune cells;however, its immunological function remains controversial, because both immunoenhancing and immunoinhibitory effects have been reported in human and mouse systems. We have previously reported the following: 1) murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2), a member of the TREM family of receptors;and 2) the B7-H3:TLT-2 pathway up-regulated T cell responses. However, the expression and function of human TLT-2 has not yet been clarified. A recent study found no evidence to support the existence of an interacttion between human B7-H3 and TLT-2. In this study, we demonstrated that human B7-H3 binds to TLT-2 and augments T cell responses. Human and mouse B7-H3Ig chimeric proteins cross-interacted with both human and mouse species of TLT-2-transduced cells. Human TLT-2 was expressed on freshly isolated, peripheral blood B cells and monocytes, and subpopulations of CD4+ and CD8+ T cells. Human TLT-2 expression on T cells did not correlate with na?ve or memory phenotypes and was diminished after culture, despite the presence of mitogenic stimuli. Constitutive TLT-2 expression on monocytes was also down-regulated after culture. Human B7-H3 transfectants augment IL-2 production from TLT-2-transduced T cell hybridomas, and IFN-γ production from peripheral blood CD4+ and CD8+ T cells. The enhanced responses were inhibited by the addition of anti-TLT-2 mAbs, suggesting TLT-2-mediated costimulatory effect. Our results demonstrate the existence of a functional interaction between human B7-H3 and TLT-2, and the restricted expression of TLT-2 on T cells and monocytes.

关键词： B7-H3 Co-Signal Molecule T Cell TLT-2

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结核分枝杆菌Ag85A DNA的克隆与原核表达

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微生物学杂志 2007年第3期27卷 16-20页

作者：姜燕 azuma Kalu 吕昌龙单风平中国医科大学基础医学院免疫学研究室辽宁沈阳110001

抗原85(Ag85)复合体是BCG合成分泌的可刺激机体产生细胞免疫和体液免疫应答。Ag85A是抗原85复合体组成成分之一,可显著刺激细胞免疫功能增强。研究构建了高效表达的pTrcHisB-Ag85A基因重组质粒,并将其转化至大肠埃希菌TOP10中进行重组... 详细信息

抗原85(Ag85)复合体是BCG合成分泌的可刺激机体产生细胞免疫和体液免疫应答。Ag85A是抗原85复合体组成成分之一,可显著刺激细胞免疫功能增强。研究构建了高效表达的pTrcHisB-Ag85A基因重组质粒,并将其转化至大肠埃希菌TOP10中进行重组蛋白的表达,筛选转化物,SDS-PAGE进行蛋白表达的分子量检测,并通过Western Blotting方法,应用抗Ag85A的单克隆抗体进一步确认重组Ag85A蛋白的表达,建立了Ag85A的原核表达体系,为进一步制备出有效的重组Ag85A疫苗奠定基础。

关键词：重组DNA Ag85A 结核分枝杆菌表达载体

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Mucocele of the appendix due to endometriosis:A rare case report

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World Journal of Gastroenterology 2013年第30期19卷 5021-5024页

作者： Motoyuki Tsuda Yukitaka Yamashita Shunjiro azuma Takuji Akamatsu Takeshi Seta Shunji Urai Yoshito Uenoyama Yasunori Deguchi Kazuo Ono Tsutomu Chiba Department of Gastroenterology Japanese Red Cross Wakayama Medical Center Department of Surgery Japanese Red Cross Wakayama Medical Center Department of Pathology Japanese Red Cross Wakayama Medical Center Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine

Mucocele of the appendix due to endometriosis is extremely rare,and there are only 10 previously reported cases in the English *** report a case of mucocele of the appendix due to endometriosis and provide the first review of the literature.A 43-year-old woman was admitted to the hospital because of recurrent right lower abdominal pain during her menstrual *** revealed submucosal tumorlike elevations of the appendiceal *** tomography and magnetic resonance imaging of the abdomen suggested cystic lesions near the ***,mucocele of the appendix was suspected *** open ileocecal resection was *** cystic lesions were observed around the *** cystic lesions contained *** examination was consistent with a mucocele of the appendix due to *** postoperative course was *** present the first review of the literature to clarify the clinical features.

关键词： Mucocele Appendix Endometriosis

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Laparoscopic resection of adult colon duplication causingintussusception

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World Journal of Gastroenterology 2016年第7期22卷 2398-2402页

作者： Kennoki Kyo Masaki azuma Kazuya Okamoto Motohiro Nishiyama Takahiro Shimamura Atsushi Maema Motoaki Shirakawa Toshio Nakamura Kenji Koda Hidetaro Yokoyama Department of Surgery Fujieda Municipal General HospitalFujiedaShizuoka 426-8677Japan Department of Pathology Fujieda Municipal General HospitalFujiedaShizuoka 426-8677Japan

Gastrointestinal duplications are uncommon congenital malformations that can occur anywhere along the gastrointestinal tract. Most cases are recognized before the age of 2 years, and those encountered in adults are rare. We describe here a case of ascending colon duplication in a 20-year-old male that caused intussusception and was treated laparoscopically. Although computed tomography revealed a cystic mass filled with stool-like material, the preoperative diagnosis was a submucosal tumor of the ascending colon. We performed a laparoscopic right colectomy, and the postoperative pathological diagnosis was duplication of the ascending colon, both cystic and tubular components. We conclude that gastrointestinal duplications, although rare, should be considered in the differential diagnosis of all abdominal and submucosal cystic lesions and that laparoscopy is a preferred approach for the surgical treatment of gastrointestinal duplications.

关键词： Gastrointestinal duplication Colonic duplication Laparoscopy Intussusception Congenital abnormalities

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Feasibility and safety of endoscopic submucosal dissection for lower rectal tumors with hemorrhoids

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World Journal of Gastroenterology 2016年第27期22卷 6268-6275页

作者： Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Namiko Hoshi Tsukasa Ishida Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Eiji Umegaki Takeshi azuma Department of Endoscopy Kobe University Hospital Division of Gastroenterology Department of Internal Medicine Graduate School of Medicine Kobe University

AIM: To evaluate the feasibility and safety of endoscopic submucosal dissection(ESD) for lower rectal lesions with ***: The outcome of ESD for 23 lesions with hemorrhoids(hemorrhoid group) was compared with that of 48 lesions without hemorrhoids extending to the dentate line(non-hemorrhoid group) during the same study period. RESULTS: Median operation times(ranges) in the hemorrhoid and non-hemorrhoid groups were 121(51-390) and 130(28-540) min. The en bloc resection rate and the curative resection rate in the hemorrhoid group were 96% and 83%, and they were 100% and 90% in the non-hemorrhoid group, respectively. In terms of adverse events, perforation and postoperative bleeding did not occur in both groups. In terms of the clinical course of hemorrhoids after ESD, the rate of complete recovery of hemorrhoids after ESD in lesions with resection of more than 90% was significantly higher than that in lesions with resection of less than 90%.CONCLUSION: ESD on lower rectal lesions with hemorrhoids could be performed safely, similarly to that on rectal lesions extending to the dentate line without hemorrhoids. In addition, all hemorrhoids after ESD improved to various degrees, depending on the resection range.

关键词： Endoscopic submucosal dissection Rectum Hemorrhoid Outcome Bleeding

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Accessibility for All, Becak Drivers in Jakarta Since 1988

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Cultural and Religious Studies 2019年第7期7卷 360-379页

作者： Yoshifumi azuma Ritsumeikan University KyotoJapan

The Becak (a manpowered tricycle taxi) was exported to major Indonesian cities via China from Yokohama in the 1930s. During the mid-20th century they spread throughout the major cities of Asia, and came to be used as a vehicle for daily use. However, since the 1970s, growing traffic congestion caused by an increase in the number of motorcycles and cars, has pushed the becak into the back streets of cities. In the case of Indonesia, government came to strictly prohibit them through the perception that they were a symbol of backwardness and they have gradually disappeared from the city. This culture of viewing becak as a symbol of backwardness has remained ingrained over the decades. In Jakarta, they were banned from use in lanes and back-alleys to finally disappear from public view through a brutal clearance method known as ‘becak hunting’(crackdowns) in 1992. However, they re-emerged on Jakarta’s streets during the chaos after Suharto’s resignation in 1998. Governor Sutiyoso at the time banned them anew, yet democratic transformation through the rise of civil society did not tolerate subsequent crackdowns As of 2016, hundreds of becak vehicles now plow the streets of Jakarta, mainly concentrated in back-alley neighbourhoods. Based on primary data sources gathered over a 30-year period (1989, 1998, and 2011-2015), this paper examines socio-economic transformation and continuity and investigates the extent in which the changing political economy of Jakarta affects drivers’ accessibility. Furthermore, the paper forecasts the survival strategies of becak drivers under ungoing policy changes and the positions of previous and present Governors.

关键词： accessibility beca or becak Jakarta urban poor migration

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Risk Factors for Postoperative Acute Exacerbation of Idiopathic Interstitial Pneumonia Following Surgery for Primary Lung Cancer

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Open Journal of Respiratory Diseases 2014年第2期4卷 48-54页

作者： Toru Tanaka Shinji Abe Hiroki Hayashi Koichiro Kamio Yoshinobu Saito Jiro Usuki Arata azuma Iwao Mikami Shuji Haraguchi Kiyoshi Koizumi Jitsuo Usuda Akihiko Gemma Department of Pulmonary Medicine and Oncology Nippon Medical School Tokyo Japan Department of Thoracic Surgery Graduate School of Medicine Nippon Medical School Tokyo Japan

Objective: Postoperative acute exacerbation of idiopathic interstitial pneumonia (IIP) is a serious complication in patients with lung cancer. This study was aimed to investigate risk factors for postoperative acute exacerbation of IIP in surgery for primary lung cancer. Method: We evaluated retrospectively 37 IIP patients combined with primary lung cancer who underwent lung resection for lung cancer from January 2006 and March 2010. Preoperative and perioperative clinical data were collected and analyzed. Results: Ten of 37 patients (27.0%) developed acute exacerbation of IIP after surgery for primary lung cancer and five patients (13.5%) died of progressive respiratory failure. There was no significant difference in preoperative clinical factors between acute exacerbation (AE) group and non-acute exacerbation (non-AE) group. In perioperative factors, the duration of anesthesia is significantly longer in AE group than in non-AE group. Conclusion: These data suggest that it is unable to predict postoperative acute exacerbation of IIP from preoperative clinical data. Perioperative and postoperative management might be important to prevent acute exacerbation of IIP combined lung cancer.

关键词： Postoperative Acute Exacerbation Idiopathic Interstitial Pneumonia Lung Cancer

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