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英语学习 2002年第3期 26-27页

作者： azuma Okwakekekalu 北京语言文化大学

Ag85A DNA疫苗对肠上皮内淋巴细胞FasL mRNA表达的影响

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中国医科大学学报 2006年第3期35卷 225-226页

作者：王庆辉吕昌龙 azuma KALU 吕超方芳李季中国医科大学基础医学院免疫学教研室辽宁沈阳110001 沈阳医学院临床医疗系

目的分析口服Ag85ADNA疫苗对小鼠肠上皮内淋巴细胞(iIEL)FasLmRNA表达的影响。方法减毒伤寒杆菌运载的Ag85ADNA疫苗经口免疫小鼠,检测iIEL和脾淋巴细胞FasLmRNA的表达。结果末次免疫后8d,Ag85ADNA质粒组小鼠iIELFasLmRNA平均表达水平高... 详细信息

目的分析口服Ag85ADNA疫苗对小鼠肠上皮内淋巴细胞(iIEL)FasLmRNA表达的影响。方法减毒伤寒杆菌运载的Ag85ADNA疫苗经口免疫小鼠,检测iIEL和脾淋巴细胞FasLmRNA的表达。结果末次免疫后8d,Ag85ADNA质粒组小鼠iIELFasLmRNA平均表达水平高于正常对照组和空质粒对照组;空质粒对照组和正常对照组的iIELFasLmRNA平均表达水平以及3组脾淋巴细胞FasLmRNA的表达水平均未见显著性差异。结论口服Ag85ADNA疫苗可以上调小鼠iIELFasLmRNA的表达,而对脾淋巴细胞未见有意义的影响。

关键词： Ag85A DNA疫苗肠上皮内淋巴细胞黏膜免疫

Effect of Inhabitation Mouthwash Solution Containing Chlorine Dioxide (Pro Fresh<sup>®</sup>) on Oral Malodor

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Health 2015年第2期7卷 211-219页

作者： Masaki Sawa Senichi Suzuki Masakazu azuma Tomoko Yoshizawa Kaiho Otomi Takuji Yamaguchi Hiroyuki Kobayashi Department of Hospital Administration Juntendo University Graduate School of Medicine Tokyo Japan Sawa Dental Office Aichi Japan Department of Emergency and Disaster Medicine Juntendo University Graduate School of Medicine Tokyo Japan Center for Advanced Kampo Medicine and Clinical Research Juntendo University Graduate School of Medicine Tokyo Japan

Recently, the interest in oral malodor has been grown and the number of people having trouble with oral malodor is increasing year by year. Generally, as the branch of medicine which deals with patients complaining about oral malodor, dentistry is mostly chosen. On the current situation, however, the dental office side typically finds it difficult to deal with several kinds of oral malodor which show no improvement even though cavities or periodontal disease is completely cured. Main components to cause oral malodor are volatile sulfur compounds (methyl mercaptan, dimethyl sulfide, hydrogen sulfide);in the present study, therefore, the effect of mouthwash solution containing chlorine dioxide to relieve oral malodor and increase saliva production was tested. The subjects were 92 patients (Control group: 2 males, 3 females, age;30.8 ± 4 years old, Mouthwash group: 28 males, 59 females, age: 36.9 ± 1.3 years old) who visited the hospital complaining about oral malodor. Intraoral gas, exhaled gas, the saliva production at rest, the ability for salivation and the buffering ability of saliva were examined twice, before the subjects used the mouthwash solution every day for one month. The simple chromatography oral chroma, which was insulated from the influence of temperature and humidity and also was able to measure with a high degree of accuracy, was used to measure odor as the device analysis method. The control group did not change in VSCs, saliva production and the buffering ability of saliva. After using mouthwash solution, the concentration of the 3 major components gas of intraoral gas and exhaled gas, i.e. methyl mercaptan, dimethyl sulfide, hydrogen sulfide, were all decreased. As for hydrogen sulfide, intraoral gas (from 225.8 ± 28.1 ppb to 41.1 ± 8.8 ppb) and exhaled gas (from 212.0 ± 50.4 ppb to 34.6 ± 16.6 ppb) was significantly decreased. Also, saliva production at rest (from 1.3 ± 0.1 ml to 1.7 ± 0.1 ml) and the ability to salivate (from 4.5 ± 0.3 ml to 5.1

关键词： Chlorine Dioxide Oral Malodor Volatile Sulfur Compounds Intraoral Gas Exhaled Gas

Relationship between body surface area and ALT normalization after long-term lamivudine treatment

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World Journal of Gastroenterology 2005年第44期11卷 6948-6953页

作者： Makoto Nakamuta Shusuke Morizono Yuichi Tanabe Eiji Kajiwara Junya Shimono Akihide Masumoto Toshihiro Maruyama Norihiro Furusyo Hideyuki Nomura Hironori Sakai Kazuhiro Takahashi Koichi azuma Shinji Shimoda Kazuhiro Kotoh Munechika Enjoji Jun Hayashi Kyushu University liver Disease Study Group Department of Medicine and Bioregulatory Science Department of Medicine Department of Internal Medicine Department of Clinical Research Department of Environmental Medicine and Infectious Diseases Department of Gastroenterology Department of Medicine and Clinical Science Department of Medicine and Biosystemic Science

AIM： To further evaluate the relationship between BSA and the effects of lamivudine in a greater number of cases and over a longer period of observation than in our previous evaluation. METHODS： We evaluated 249 patients with chronic hepatitis B. The effects of treatment for one year （n = 249）, two years （n = 147）, and three years （n = 72） were evaluated from the levels of serum ALT and HBVoDNA, as biological and virological effects （undetectable levels by PCR）, respectively. Moreover, several variables that could influence the response to treatment, including ALT, albumin, bilirubin, platelet counts, BSA, HBVoDNA, and HBeAg were analyzed. RESULTS： For 1-year treatment, multivariate analysis revealed that BSA （P = 0.0002） was the only factor for the biological effect, and that ALT （P = 0.0017）, HBV- DNA （P = 0.0004）, and HBeAg （P = 0.0021） were independent factors for the virological effect. For 2-year treatment, multivariate analysis again showed that BSA （P = 0.0147） was the only factor for the biological effect, and that ALT （P = 0.0192） and HBeAg （P = 0.0428） were independent factors for the virological effect. For 3-year treatment, multivariate analysis, however, could not reveal BSA （P = 0.0730） as a factor for the normalization of ALT levels. CONCLUSION： BSA is a significant predictor for the normalizing the effect of lamivudine therapy on ALT for an initial 2-year period, suggesting that lamivudine dosage should be based on the individual BSA.

关键词： Lamivudine Hepatitis B virus Body surface area Dose Long-term treatment

Visceral Fat Accumulation Is Associated with Increased Mortality Rate after Transcatheter Arterial Chemoembolization in Patients with Hepatocellular Carcinoma

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Journal of Cancer Therapy 2015年第13期6卷 1124-1136页

作者： Masaya Saito Yoshihiko Yano Hirotaka Hirano Kenji Momose Yuki Kawano Masaru Yoshida Takeshi azuma Division of Gastroenterology Department of Internal Medicine Graduate School of Medicine Kobe University Kobe Japan Center for Infectious Diseases Graduate School of Medicine Kobe University Kobe Japan Division of Metabolomics Research Department of Internal Medicine Graduate School of Medicine Kobe University Kobe Japan

Aim: Transcatheter arterial chemoembolization (TACE) is thought to be a safe and effective treatment for hepatocellular carcinoma (HCC). However, in some HCC patients, it potentially shortens survival due to liver damage. We aimed to identify independent factors to predict overall survival of HCC after TACE. Methods: We included a total of 96 consecutive HCC patients who underwent TACE at Kobe University Hospital. Areas of skeletal muscle and fat tissue were measured by computed tomography (CT) scan before TACE. We divided the patients into two groups in terms of the presence or absence of 1-year mortality after TACE. Factors associated with 1-year mortality after TACE were assessed by multivariate analyses, and the optimal cut-off values were evaluated using a propensity score. Results: Multivariate analyses showed that visceral fat accumulation on CT was an independent factor associated with 1-year mortality after TACE (p = 0.033). There were no differences in skeletal muscle area and subcutaneous and intermuscular fat area between the two groups. Cut-off values for visceral fat area associated with 1-year mortality after TACE were defined as 33.3 cm2/m2 for males and 24.4 cm2/m2 for females. Conclusions: High visceral fat area was a prognostic factor associated with increased mortality rate in HCC patients undergoing TACE. Using this value, 1-year mortality risk after TACE would be better estimated before the day TACE was performed.

关键词： Glucose Metabolism Liver Cirrhosis Obesity Overall Survival Sarcopenia

北极楚科奇海海冰特征研究——以1999年夏季为例

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冰川冻土 2002年第2期24卷 173-180页

作者：康建成孙波孙俊英孟广琳 GOTO-azuma Kumiko 张小伟中国极地研究所上海200129 中国科学院寒区旱区环境与工程研究所甘肃兰州730000 国家海洋环境监测中心辽宁大连116023 National Institute of Polar Research

对北冰洋楚科奇海海冰分布、厚度、气 /冰 /海界面温度场观测 ,钻取海冰冰芯 ,观测冰结构的变化 ,发现 3种海冰组合结构 :1)表面融化型 ;2 )表面和底部融化型 ;3)整体融化型 .海冰结构形成的热力学过程为 :在气 /冰界面上 ,海冰上表面... 详细信息

对北冰洋楚科奇海海冰分布、厚度、气 /冰 /海界面温度场观测 ,钻取海冰冰芯 ,观测冰结构的变化 ,发现 3种海冰组合结构 :1)表面融化型 ;2 )表面和底部融化型 ;3)整体融化型 .海冰结构形成的热力学过程为 :在气 /冰界面上 ,海冰上表面吸收辐射能使冰体升温 ,出现表面融化 ;在冰 /海水界面上 ,海冰盘与开阔水域的相间分布、相对运动 ,将周围温度较高的水体输送到海冰的底部 ,加热、融化海冰底部 ;冰体升温 ,冰晶间盐水膜首先融化 ,分离冰晶 ,破坏海冰整体结构 .冰的相变吸热 ,使其温度维持在融点。

关键词：楚科奇海 1999年夏季北极海冰气候厚度分布

Primers for the Amplification of the Circular Chloroplast DNA from the A-genome Group of Cultivated Cotton

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棉花学报 2008年第S1期20卷 28-页

作者： IBRAHIM Rashid Ismael Hag azuma Jun-Ichi SAKAMOTO Masahiro University of KwaZulu-Natal Faculty of Science and Agriculture Research Center of Plant Growth and Development Pietermaritzburg South Africa Graduate School of Agriculture Kyoto 606-8502 Kitashirakawa Oiwake-cho Japan

The availability of the plastid genome sequences is one of the bases for comparative,functional,and structural genomic studies of plastid-containing living organisms,in addition to the application

关键词： Primers for the Amplification of the Circular Chloroplast DNA from the A-genome Group of Cultivated Cotton DNA

细胞因子诱导剂硬脂酰胞壁酰三肽的实验研究和临床应用

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国外医学（药学分册） 1993年第2期20卷 94-96页

作者： azuma I 宋涛

硬脂酰胞壁酰三肽是第一个合成的胞壁酰二肽的衍生物,在实验模型中它能有效地刺激非特异性宿主对抗细菌和病毒的感染,诱导细胞因子和刺激造血。在临床双盲实验中,硬脂酰胞壁酰三肽能有效地逆转白细胞减少症,帮助化疗和/或放疗的癌症患... 详细信息

硬脂酰胞壁酰三肽是第一个合成的胞壁酰二肽的衍生物,在实验模型中它能有效地刺激非特异性宿主对抗细菌和病毒的感染,诱导细胞因子和刺激造血。在临床双盲实验中,硬脂酰胞壁酰三肽能有效地逆转白细胞减少症,帮助化疗和/或放疗的癌症患者的中性粒细胞、单核细胞和血小板的数目回升。

关键词：细胞因子免疫调节剂

Improved postischaemic heart function in sucrose - fed diabetic oletf rats

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Improved postischaemic heart function in sucrose - fed diabe...

Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy

中国药理学会第八次全国代表大会

作者：陈红 Hideaki Higashino Makiko azuma Zdravko A.Kamenov Wen - Xiong Lee Department of Pharmacology Second Military Medical University Shanghai 200433 China Department of Pharmacology Kinki University School of Medicine Osaka 589 - 8511 Japan Clinic of Endocrinology Alexandrov Hospital High Medical School Sofia 1431 Bulgaria Department of Anatomy Second Military Medical University Shanghai 200433 China

Cardiovascular disease is one of the most important causes of morbidity and mortality in diabetes mellitus (DM), but there has been controversy over functional impairment of diabetic hearts and their response to ischaemia. This study was aimed to examine basic and postischaemic heart function in type 2 diabetic rats with different degrees of hyperglycemia and its possible relationship with cardiac norepinephrine (NE) release during ischaemia and reperfusion. Method: Otsuka Long-Evans

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World Journal of Gastroenterology 2017年第11期23卷 2060-2067页

作者： Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi azuma Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of Medicine Department of Pharmacy Kobe University Hospital

AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical *** The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were *** The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P rosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P rosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P roximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms.

关键词： Gastroesophageal reflux disease CYP2C19 FSSG Residual symptoms Proton pump inhibitor