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树突状细胞在牙髓或牙周组织中的作用机制

牙体牙髓牙周病学杂志 2006年第12期16卷 707-710页

作者：杨光艳张健東みゆき东京医科齿科大学院医齿学综合研究科

牙髓或牙周的急、慢性炎症是由宿主对病原体发生的免疫反应造成的,明确机体抵御病原微生物的免疫机制对弄清牙髓或牙周病的发病机制十分重要。已经知道在牙髓或牙周系统中存在各种炎性和免疫细胞。在这些细胞中,树突状细胞作为专职的抗... 详细信息

牙髓或牙周的急、慢性炎症是由宿主对病原体发生的免疫反应造成的,明确机体抵御病原微生物的免疫机制对弄清牙髓或牙周病的发病机制十分重要。已经知道在牙髓或牙周系统中存在各种炎性和免疫细胞。在这些细胞中,树突状细胞作为专职的抗原呈递细胞,在诱导免疫反应中扮演着不可缺少的角色。树突状细胞捕捉和搬运来自外界的信息给获得性免疫系统的细胞,所以树突状细胞架起了先天性免疫和获得性免疫之间的桥梁。最近,很多研究集中在树突状细胞怎样调控牙髓或牙周病的免疫应答,从而为疾病的治愈和发展可行的免疫治疗提供依据。

关键词：树突状细胞抗原呈递细胞免疫系统

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基于微粒变化对崇测冰帽浅层冰芯的定年结果

冰川冻土 2005年第6期27卷 846-852页

作者：韩建康中尾正义东久美子张万昌和田朱丰年湖南师范大学资源与环境研究所湖南长沙410081 日本综合地球环境学研究所日本极地研究所南京大学地球系统科学研究所江苏南京210093 日本新泻大学积雪区灾害研究所

冰芯年代学的建立, 对于稳定同位素定年方法失效的钻点尤为困难. 依据粒径在0.66～1.33μm之间的不可溶尘埃微粒的浓度垂向分布, 并结合阳离子Ca2+的浓度剖面变化, 实现了对崇测冰帽冰芯浅层的断代. 该冰芯钻自海拔6 532 m的冰穹顶部, ... 详细信息

冰芯年代学的建立, 对于稳定同位素定年方法失效的钻点尤为困难. 依据粒径在0.66～1.33μm之间的不可溶尘埃微粒的浓度垂向分布, 并结合阳离子Ca2+的浓度剖面变化, 实现了对崇测冰帽冰芯浅层的断代. 该冰芯钻自海拔6 532 m的冰穹顶部, 解析的18.7 m冰芯长度占到钻点冰层深度约2/5, 辅助的定年参数包括钻点表层5 a的实测净积累率和大气核试验的地层标志. 综合各种技巧定年, 崇测冰帽该冰芯覆盖的记录年代为1902-1992年, 最底部累积误差在±2 a(约为2%).

关键词：不可溶微粒冰芯定年崇测冰帽冰芯年代学同位素定年方法

日本人群中白细胞介素-1β-511C/T的多态性与反流性食管炎的关系

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 53-53页

作者： Muramatsu A. azuma T. Okuda T. 程妍 Second Department of Internal Medicine Faculty of Medical Sciences University of Fukui Matsuoka-cho Yoshida-gun Fukui 910-1193 Japan

Background: Interleukin-1β(IL-1β) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylori infection. However, little information is available about the genetic risk factors of reflux esophagitis. In this study we investigated its association with the IL-1β.polymorphisms. Methods: We examined 48 patients with reflux esophagitis and 96 control subjects, 89 with gastric cancer. IL-1β-511C/T genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The frequency of IL-1β-51 1T alleles was significantly higher in reflux esophagitis patients (57.3%) than in controls (41.1%) (P = 0.0215, χ2 = 5.289). The frequency of IL-1β-511T/T genotypes was also significantly higher in reflux esophagitis patients (31.3%) than in controls (15.6%). The odds ratio and the 95%confidence interval were 4.000 and 1.393-11.486, respectively. The frequency of IL-1β-511T/T genotypes was significantly higher in reflux esophagitis patients (31.3%) than in gastric cancer patients (21.4%). The odds ratio and the 95%confidence interval were 2.961 and 1.054-8.316, respectively. Conclusions: IL-1β-511T was associated with reflux esophagitis having hyperacidity. Differences of genetic background regarding gastric acid secretion may exist between Japanese and Caucasians.

关键词：反流性食管炎日本人群白细胞介素多态性遗传危险因素高加索人遗传背景胃酸过多聚合酶链反应

肥厚性心肌病和心肌梗死患者室性早搏后窦性心律周期长度的短期波动

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 56-56页

作者： Kawasaki T. azuma A. Taniguchi T. 刘少伟 Department of Cardiology Matsushita Memorial Hospital Sotojima 5- 55 Moriguchi City Osaka 570- 8540 Japan

Sinus cycle length has been reported to fluctuate after a ventricular premature beat(VPB). The purpose of this study was to assess the short-term fluctuations of sinus cycle length in patients with hypertrophic cardiomyopathy(HCM) and prior myocardial infarction(MI). Methods: The relative deviation of RR intervals from the mean of the last two RR intervals preceding a VPB were calculated during the 20 subsequent beats following the VPB from Holter recordings in 92 patients with non-obstructive HCM, 57 patients with prior MI and 54 healthy controls. Results: In controls, the deviations of the RR intervals were negative for several beats after a VPB and subsequently changed to positive before returning to the baseline. Similar changes in RR intervals following a VPB were exhibited in HCM patients; however, the late positive deviations of RR intervals were more marked than in controls. By contrast, in patients with prior MI, the early negative deviations of RR intervals were smaller compared with controls, and the deviations returned to the baseline without incidence of the positive changes. Conclusions: Short-term fluctuations in sinus cycle length after a VPB differed exclusively among HCM patients, prior MI patients, and healthy controls.

关键词：肥厚性心肌病后窦性心律室性早搏周期长度短期波动心搏非梗阻性正向变化相对偏差正偏差

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北冰洋海冰/气候系统及其对全球气候的影响

极地研究 1999年第4期11卷 301-310页

作者：康建成颜其德孙波温家洪汪大立孙俊英孟广林 Kumiko Goto-azuma 中国极地研究所上海200129 中国科学院兰州冰川冻土研究所兰州730000 国家海洋局海洋环境监测中心大连116023 National Institute of Polar Research

结合前人对北冰洋海冰、气候系统的研究成果和 1 999年 8月在北冰洋对海冰的现场观测 ,本文综述了海冰分布、厚度的变化 ,海冰表面特征、积雪变化及北冰洋天气、气候特征和分区。讨论了北极海冰与南极海冰的差异。文章认为 ,北冰洋与周... 详细信息

结合前人对北冰洋海冰、气候系统的研究成果和 1 999年 8月在北冰洋对海冰的现场观测 ,本文综述了海冰分布、厚度的变化 ,海冰表面特征、积雪变化及北冰洋天气、气候特征和分区。讨论了北极海冰与南极海冰的差异。文章认为 ,北冰洋与周围地区气候变化趋势的不一致 ,主要是由于夏季在北冰洋海冰与开阔水域的相间分布、海冰漂移、融化吸热 ,均衡了周围大气、海洋温度的变化。

关键词：北极北冰洋海冰气候变化全球气候环境分布

Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment

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World Journal of Gastrointestinal Endoscopy 2016年第8期8卷 368-373页

作者： Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine Research and Development Center for New Frontiers Kitasato University School of Medicine Department of Pathology Toho University School of Medicine Department of Surgery Kitasato University School of Medicine

Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required.

关键词： Endoscopic submucosal dissection Early gastric cancer Delayed perforation

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胃癌预防亚太地区共识指南

胃肠病学 2008年第4期13卷 231-240页

作者： Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 Changi General Hospital Singapore Mayo Clinic College of Medicine Rochester USA McMaster University Medical Center Ontario Canada University of Fukui Fukui Jichi Medical University Tochigi Shanghai Institrte of Digestive Disease Shanghai University of Hong Kong Hong Kong University of Malaya Kuala Lumpur Malaysia Kyoto University Kyoto Kure Kyousai General Hospital Kure Japan Chung Ang University College of Medicine Seoul National University College of Medicine Seoul Korea Chulalongkorn University Hospital Bangkok University of New South Wales Sydney New South Wales Australia University of Indonesia Jakarta Indonesia National Taiwan University Hospital Taipei China Thammasat University Hospital Pathumthani Thailand University of Santo Tomas Manila Philippines

背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽... 详细信息

背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(***)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。***感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。***筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行***筛查。***感染的一线治疗应遵循国家治疗指南。结论:高危人群中***筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。

关键词：癌指南幽门螺杆菌预防