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Involvement of Dectin-2 in the Innate Inflammatory Response Triggered by Influenza Virus Hemagglutinin

Advances in Infectious Diseases 2023年第3期13卷 478-497页

作者： Hideki Yamamoto Chikako Tomiyama Sho Yamasaki shinobu saijo Yoichiro Iwakura Kazuyoshi Kawakami Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Department of Molecular Immunology Research Institute for Microbial Diseases Osaka University Osaka Japan Laboratory of Molecular Immunology Immunology Frontier Research Center Osaka University Osaka Japan Project for Cytokine Research Division of Molecular Immunology Medical Mycology Research Center Chiba University Chiba Japan Center for Animal Disease Models Research Institute for Biomedical Sciences Tokyo University of Science Chiba Japan Department of Medical Microbiology Mycology and Immunology Tohoku University Miyagi Japan Department of Internal Medicine Hirose Hospital Miyagi Japan

C-type lectin receptors (CLRs) are representative pattern recognition receptors that recognize microbial polysaccharides expressed on antigen-presenting cells. In the present study, we carried out further detailed analysis on the involvement of Dectin-2, a CLR that senses high mannose polysaccharide, in innate immune responses induced by influenza virus hemagglutinin (HA). Treatment of HA with periodate or PNGase F induced lower interleukin (IL)-12p40 secretion by conventional dendritic cells (DCs) compared with the untreated group. In contrast, treatment with O-glycosidase did not affect cytokine production. Green fluorescent protein expression in canonical Dectin-2-transducing cells was approximately 3% - 12% following HA stimulation, except with the A/H1N1pdm09 subtype HA. This expression was markedly reduced in cells possessing mutated amino acids in the carbohydrate recognition domain of Dectin-2, especially following stimulation with HA derived from the A/H3N2 subtype. Interferon (IFN)-α production from CD11c+Siglec-H+PDCA-1+ plasmacytoid DCs was significantly increased in Dectin-2 knockout mice compared with wild-type mice upon stimulation with HA except for the B/Yamagata lineage HA. These results suggested that Dectin-2 is involved in initiating inflammatory responses via mannose polysaccharide on HA. However, other mechanisms may function in the antiviral response, including the type I IFN axis.

关键词： C-Type Lectin Receptors Influenza Virus Innate Immunity Type I Interferon

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Dectin-2 selectively suppresses liver metastasis by facilitating the uptake of cancer cells by Kupffer cells

Dectin-2 selectively suppresses liver metastasis by facilita...

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第十一届全国免疫学学术大会

作者： Yoshitaka Kimura Hideyuki Yanai Sho Hangai Asuka Inoue Junko Nishio Hideo Negishi shinobu saijo Yoichiro Iwakura Sho Yamasaki Tadatsugu Taniguchi Institute of Industrial Science The University of Tokyo Max Planck-The University of Tokyo Center for Integrative Inflammology Department of Molecular Immunology Medical Mycology Research Center Chiba University Center for Animal Disease Models Research Institute for Biomedical Sciences Tokyo University of Science Division of Molecular Immunology Medical Institute of Bioregulation Kyushu University

Metastasis to distal organ is a fatal cause of cancer death and liver is one of the most common site of metastasis leading to bad *** it has been known that innate immune cells play critical roles in the regulation of liver metastasis,how they control the tumor development is still largely *** using in vivo cancer models,we found that Dectin-2,a C-type lectin receptor(CLR),suppressed liver metastasis although dispensable for the

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Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

Recognition of tumor cells by Dectin-1 orchestrates innate i...

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第九届全国免疫学学术大会

作者： Yoshitaka Kimura Shiho Chiba Hiroaki Ikushima Hiroshi Ueki Hideyuki Yanai Sho Hangai Junko Nishio Hideo Negishi Tomohiko Tamura shinobu saijo Yoichiro Iwakura Tadatsugu Taniguchi Department of Molecular Immunology and Center for International Research on Integrative Biomedical Systems Institute of Industrial ScienceThe University of Tokyo Max Planck-The University of Tokyo Center for Integrative Inflammology Core Research for Evolution Science and Technology Japan Science and Technology Agency Department of Immunology Yokohama City University Graduate School of Medicine Department of Molecular Immunology Medical Mycology Research CenterChiba University Center for Animal Disease Models Research Institute for Biomedical SciencesTokyo University of Science

Innate immune receptors play pivotal roles in the immune response against invading ***,the role of such receptors in anti-tumor immune responses is still *** gain insights into the role of innate immune

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