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Open Journal of Psychiatry 2011年第3期1卷 132-136页

作者： Mikako Fuji Misaki Iseki Seisho Takeuchi Kyoko Kakeda shinji shimodera Hiromi Seo Shimpei Inoue Department of Neuropsychiatry Kochi Medical School Kochi University Kochi Japan Department of Psychiatry Ichiyou Hospital Kochi Japan Department of Medicine Kochi Medical School Kochi University Kochi Japan

After HAART (highly active antiretroviral therapy), which is a powerful antiviral drug regimen, was introduced into HIV therapy for AIDS patients, AIDS mortality decreased dramatically. The incidence of encephalopathy among AIDS patients was reported to be 10% to 40% in the past, but the introduction of HAART resulted in a decrease in HIV encephalopathy and an increase in mild CNS-related deficits, which affect the quality of life of AIDS patients. We report the case of an AIDS patient who developed schizophrenia-like delusions associated with encephalopathy. Administration of an antipsychotic drug and hypnotics was effective in relieving the symptoms of patients with insomnia, depressed mood, and delusions. Further information on the neuronal mechanism underlying the mental symptoms observed in our patient will be necessary to understand the process of pathogenesis of the encephalopathy and to devise an adequate clinical strategy for treatment.

关键词： HIV Encephalopathy Schizophrenia HAART Antipsychotics

Dopamine receptor D3R and D4R mRNA levels in peripheral lymphocytes in patients with schizophrenia correlate with severity of illness

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Open Journal of Psychiatry 2011年第2期1卷 33-39页

作者： Mitsuhiko Kawano Ken Sawada Emi Tsuru Makoto Nishihara Kunio Kato William G. Honer shinji shimodera Department of Neuropsychiatry Kochi Medical School Kochi Japan

Schizophrenia is a disease that affects many areas of the brain. The dopamine hypothesis is one of the most widely-accepted ideas in the pathophysiology of schizophrenia. Besides alterations in the dopaminergic system in the central nervous system, there have been several reports of changes in dopaminergic systems in the peripheral blood of schizophrenic patients. Several reports have shown that dopamine receptor expression by lymphocytes is altered in patients with schizophrenia, but the results have been conflicting. We therefore re-assessed D3R and D4R mRNA levels in 11 patients with schizophrenia and 12 healthy subjects and correlated levels with severity of symptoms. D3R and D4R expression in lymphocytes and granulocytes was measured by quantitative RT-PCR and the severity of symptoms and cognitive impairment were assessed using the PANSS and BACS-J. There were no significant differences in mean D3R or D4R mRNA levels in lymphocytes from schizophrenic patients and controls and no significant difference in mean D4R mRNA levels in granulocytes (D3R mRNA undetectable). In patients with schizophrenia, D3R expression was inversely correlated with the total PANSS score (r = 0.768, p = 0.009), while D4R expression was positively correlated with working memory scales (r = 0.895, p = 0.001). In conclusion, these results imply that lymphocyte D3R and D4R are involved in the mechanisms of the disorder and could be used as target markers in the treatment of schizophrenia.

关键词： Dopamine receptor D3R Dopamine Receptor D4R Schizophrenia RT-PCR Lymphocyte Cognitive Function

Bipolar I disorder and expressed emotion of families: A cohort study in Japan

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Open Journal of Psychiatry 2012年第4期2卷 258-261页

作者： shinji shimodera Yukiko Yonekura Sosei Yamaguchi Aoi Kawamura Masafumi Mizuno Shimpei Inoue Toshi A. Furukawa Yoshio Mino Department of Cognitive-Behavioral Medicine Kyoto University Graduate School of Medicine/School of Public Health Kyoto Japan Department of Neuropsychiatry Kochi Medical School Kochi University Kochi Japan Department of Neuropsychiatry Toho University School of Medicine Tokyo Japan Department of Psychiatric Rehabilitation National Institute of Mental Health National Center of Neurology and Psychiatry Tokyo Japan Department of Psychiatry Mino Clinic Okayama Japan Department of Social Welfare Kansai University of Social Welfare Hyogo Japan

The relationships between expressed emotion (EE) of the families and the course of bipolar disorder have been examined only in a limited number of cohort studies. No study has yet been reported from Asia. The subjects were 12 patients that had been diagnosed with bipolar I disorder according to DSM-IV and their 12 key family members. The families of the patients were interviewed using the Camberwell Family Interview (CFI) within 2 weeks of the admission of the patients, and their EE were evaluated. The patients were then followed up for 9 months after their discharge from the hospital. The patients were divided into a high-EE group and a low-EE group using the cut-off based on the number of critical comments (CC) and emotional overinvolvement (EOI), and the 9-month relapse risk was compared. When the subjects with 3 or more CC or an EOI score of 3 or more were regarded as the high-EE group, and the others as the low-EE group, the 9-month relapse risk was 100% (3/3) for the high EE group and 0% (0/9) for the low EE group. (Fisher’s exact test p = 0.005) EE based on the CFI appear to be correlated with relapse in bipolar I disorder in Japan.

关键词： Expressed Emotion Family Bipolar Disorder

Simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： shinji Bono Ryotaro Nakai Satoshi Konishi Research Organization of Science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system

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Neural Regeneration Research 2024年第4期19卷 855-862页

作者： Mingyue Jin Shengming Wang Xiaodie Gao Zhenyou Zou shinji Hirotsune Liyuan Sun Guangxi Key Laboratory of Brain and Cognitive Neuroscience Guilin Medical University Department of Genetic Disease Research Osaka Metropolitan University Graduate School of Medicine Department of Scientific Research Brain Hospital of Guangxi Zhuang Autonomous Region

α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,*** works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s *** intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent ***,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical ***,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in *** the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent *** findings indicate strong cross-talk between the two proteins in physiology and *** this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.

关键词： alpha-synuclein microtubule-associated protein neurodegenerative disease tau

Hydrogen Permeation Characteristics of Pd-CuMembrane in Plasma Membrane Reactor

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Energy Engineering 2024年第2期121卷 259-272页

作者： Muhd Hadi Iskandar Abd Razak Motoki Tsuda YukioHayakawa shinji Kambara Graduate School of Engineering Gifu UniversityGifu501-1193Japan

Hydrogen is an alternative energy source that has the potential to replace fossil *** of the hydrogen applications is as a material for Polymer Electrolyte Membrane Fuel Cells(PEMFC)in fuel cell ***-purity hydrogen can be obtained using a hydrogen separation membrane to prevent unwanted contaminants from potentially harming the PEMFC *** this study,we fabricated a plasma membrane reactor and investigated the permeation performance of a hydrogen separation membrane in a plasma membrane reactor utilizing atmospheric pressure *** result showed the hydrogen permeation rate increasing with time as reactor temperature is increased through joule *** decreasing the gap length of the reactor from 2 to 1 mm,the hydrogen permeation rate increases by up to 40%.The hydrogen permeation rate increases by 30%when pressure is applied to the plasma membrane reactor by up to 100 kPa.

关键词： Hydrogen energy hydrogen separation membrane atmospheric pressure plasma

Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku Asano shinji Kudo Taisuke Maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro Hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto shinji Oe Koichiro Miyagawa Yuichi Honma Masaru Harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

Bipolar I disorder and expressed emotion of families: A cohort study in Japan

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Towards an ultrafast 3D imaging scanning LiDAR system:a review

Open Journal of Psychiatry（精神病学期刊） 2012年第4期

作者： shinji shimodera Yukiko Yonekura Sosei Yamaguchi Aoi Kawamura Masafumi Mizuno Shimpei Inoue Toshi A. Furukawa Yoshio Mino

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Photonics Research 2024年第8期12卷 1709-1729页

作者： ZHI LI YAQI HAN LICAN WU ZIHAN ZANG MAOLIN DAI SZE YUN SET shinji YAMASHITA QIAN LI H.Y.FU Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-8656Japan Research Center for Advanced Science and Technology The University of TokyoTokyo 153-8904Japan School of Electronic and Computer Engineering Peking UniversityShenzhen 518055China

Light detection and ranging(LiDAR),as a hot imaging technology in both industry and academia,has undergone rapid innovation and *** current mainstream direction is towards system miniaturization and *** are many metrics that can be used to evaluate the performance of a LiDAR system,such as lateral resolution,ranging accuracy,stability,size,and *** recently,with the continuous enrichment of LiDAR application scenarios,the pursuit of imaging speed has attracted tremendous research ***,for autonomous vehicles running on motorways or industrial automation applications,the imaging speed of LiDAR systems is a critical *** this review,we will focus on discussing the upper speed limit of the LiDAR *** on the working mechanism,the limitation of optical parts on the maximum imaging speed is *** beam scanner has the greatest impact on imaging *** provide the working principle of current popular beam scanners used in LiDAR systems and summarize the main constraints on the scanning ***,we highlight the spectral scanning LiDAR as a new paradigm of ultrafast ***,to further improve the imaging speed,we then review the parallel detection methods,which include multiple-detector schemes and multiplexing ***,we summarize the LiDAR systems with the fastest point acquisition rate reported *** the outlook,we address the current technical challenges for ultrafast LiDAR systems from different aspects and give a brief analysis of the feasibility of different approaches.

关键词： LiDAR scanner system