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Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 545-550页

作者： Tetsuya Muto Shigeki Machida shinichiro Imaizumi Department of Ophthalmology Dokkyo Medical University Saitama Medical CenterKoshigaya 343-8555Japan Imaizumi Eye Hospital Koriyama 963-8877Japan Fukushima Medical University Fukushima 960-1295Japan

●AIM:To evaluate the effect of background diseases and number of previous intravitreal aflibercept injections(IVAIs)on immediate intraocular pressure(IOP)increase and vitreous reflux(VR)rate and to evaluate the correlation of both age and axial length with immediate IOP increase and VR rate.●METHODS:This study included 105 patients with cystoid macular edema secondary to retinal vein occlusion,35 patients with diabetic macular edema,69 patients with neovascular age-related macular degeneration(nAMD),and 12 patients with myopic choroidal neovascularization,which underwent first-time *** correlation of immediate IOP increase and VR rates with the four background diseases was ***,the correlation of age with immediate IOP increase and VR rate as well as correlation of axial length with immediate IOP increase and VR rate were ***,54 patients with nAMD were treated with IVAI>10 times(multiple IVAIs).Moreover,the correlation of immediate IOP increase and VR rates with first-time and multiple IVAIs in nAMD was determined.●RESULTS:The immediate IOP increase(P=0.16)and VR rates(P=0.50)were almost similar among the four background *** immediate postinjection IOP and age,VR rate and age,immediate postinjection IOP and axial length,or VR rate and axial length were not correlated in the four background *** immediate IOP increase(P=0.66)and VR rates(P=0.28)did not significantly differ between first-time and multiple IVAIs in nAMD.●CONCLUSION:Background diseases and number of previous IVAIs have no effect on immediate IOP increase and VR ***,age and axial length have no correlation on immediate IOP increase and VR rate.

关键词： aflibercept intraocular pressure vitreous reflux intravitreal injection

Development of D_α band symmetrical visible optical diagnostic for boundary reconstruction on EAST tokamak

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Plasma Science and Technology 2024年第2期26卷 44-53页

作者：陈明沈飊 shinichiro KADO 郭笔豪陈大龙蔡福瑞肖炳甲 Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031People's Republic of China Science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230026People's Republic of China Institute of Advanced Energy Kyoto UniversityUji 611-0011Japan Graduate School of Energy Science Kyoto UniversityUji 611-0011Japan

To investigate the potential of utilizing visible spectral imaging for controlling the plasma boundary shape during stable operation of plasma in future tokamak, a D_α band symmetric visible light diagnostic system was designed and implemented on the Experimental Advanced Superconducting Tokamak(EAST). This system leverages two symmetric optics for joint plasma imaging. The optical system exhibits a spatial resolution less than 2 mm at the poloidal cross-section, distortion within the field of view below 10%, and relative illumination of 91%.The high-quality images obtained enable clear observation of both the plasma boundary position and the characteristics of components within the vacuum vessel. Following system calibration and coordinate transformation, the image coordinate boundary features are mapped to the tokamak coordinate system. Utilizing this system, the plasma boundary was reconstructed, and the resulting representation showed alignment with the EFIT(Equilibrium Fitting) results. This underscores the system's superior performance in boundary reconstruction applications and provides a diagnostic foundation for boundary shape control based on visible spectral imaging.

关键词： visible optical diagnostic plasma boundary reconstruction EAST

Coated boron layers by boronization and a real-time boron coating using an impurity powder dropper in the LHD

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Plasma Science and Technology 2024年第8期26卷 25-31页

作者： Naoko ASHIKAWA Robert LUNSFORD Federico NESPOLI Erik GILSON Yaowei YU Jiansheng HU shinichiro KADO National Institute for Fusion Science Toki 509-5292Japan Princeton Plasma Physics Laboratory Princeton NJ 08540United States of America Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Institute of Advanced Energy Kyoto UniversityKyoto 611-0011Japan

In the Large Helical Device(LHD),diborane(B2H6)is used as a standard boron source for boronization,which is assisted by helium glow *** 2019,a new Impurity Powder Dropper(IPD)system was installed and is under evaluation as a real-time wall conditioning *** the LHD,which is a large-sized heliotron device,an additional helium(He)glow discharge cleaning(GDC)after boronization was operated for a reduction in hydrogen recycling from the coated boron *** operational time of 3 h was determined by spectroscopic data during glow discharges.A flat hydrogen profile is obtained on the top surface of the coated boron on the specimen exposed to *** results suggest a reduction in hydrogen at the top surface by *** oxygen in coated boron was obtained by boronization,and the coated boron,which has boron-oxide,on the first wall by B-IPD was also *** the difference in coating areas between B2H6 boronization and B-IPD operation,it would be most effective to use the IPD and B2H6 boronization coating together for optimized wall conditioning.

关键词： boron layer oxygen impurity hydrogen recycling impurity powder dropper LHD EAST

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

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东亚的方镇体制与周边诸种族的国家形成

中山大学学报（社会科学版） 2024年第5期64卷 1-12页

作者： [日]渡边信一郎日本京都府立大学文学部(日本京都)

唐宋交替时期政治支配特征是全国化的方镇(节度使)军事支配体制。这种军事支配体制亦被位于中国周边的东亚诸种族所接受。方镇体制既是周边诸种族为了表示从属于中国而有的支配体制,又为周边诸种族从中国独立并建立国家起到支撑作用。... 详细信息

唐宋交替时期政治支配特征是全国化的方镇(节度使)军事支配体制。这种军事支配体制亦被位于中国周边的东亚诸种族所接受。方镇体制既是周边诸种族为了表示从属于中国而有的支配体制,又为周边诸种族从中国独立并建立国家起到支撑作用。具体过程分为以下三个类型进行讨论:(1)种族在独立国家的形成及其领域扩大的过程中,领有中原王朝的一部分,并吸收该地域的方镇体制(辽、金);(2)国家形成过程中或国家形成之后,将方镇体制导入到自己支配的地域内部(南诏、高丽);(3)由方镇体制发展为独立国家的形成(西夏、大越=安南)。

关键词：节度使方镇体制化外方镇蕃汉交界周边种族

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EAST等离子体边界可见光成像系统研究

核聚变与等离子体物理 2024年第2期44卷 222-228页

作者：陈明沈飊 shinichiro Kado 陈大龙张恒郭笔豪黄耀蔡福瑞肖炳甲中国科学院合肥物质科学研究院合肥230031 中国科学技术大学合肥230026 京都大学日本京都市左京区227-8568 重庆邮电大学重庆400065

设计了一套针对Hα波段的高精度折叠式光学系统用来观察放电过程中等离子体边界特征,该系统在全视场中实现了4mm的分辨率。基于图像局部特征和相机模型,发展了光学等离子体边界重建算法,在EAST上针对高场侧中平面处的等离子体控制点进... 详细信息

设计了一套针对Hα波段的高精度折叠式光学系统用来观察放电过程中等离子体边界特征,该系统在全视场中实现了4mm的分辨率。基于图像局部特征和相机模型,发展了光学等离子体边界重建算法,在EAST上针对高场侧中平面处的等离子体控制点进行了算法验证,光学重建的控制点随时间的演化与磁平衡重建的结果吻合良好。

关键词： EAST装置等离子体边界光学成像

Improving Ambient Wind Environments of a Cross-flow Wind Turbine near a Structure by using an Inlet Guide Structure and a Flow Deflector

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Journal of Thermal Science 2005年第3期14卷 242-248页

作者： Tadakazu TANINO shinichiro NAKAO Genki UEBAYASHI Nagasaki Institute of Applied Science 536 Aba-machi Nagasaki 851-0193 JapanNagasaki Institute of Applied Science 536 Aba-machi Nagasaki 851-0193 JapanChoryo Engineering Co. Ltd. 5- 717-1 Fukahori-machi Nagasaki 851-0392 Japan

A cross-flow wind turbine near a structure was tested for the performance. The results showed that the performance of a cross-flow wind turbine near a structure was up to 30% higher than the one without a structure. In addition, we tried to get higher performance of a cross-flow wind turbine by using an Inlet Guide Structure and a Flow Deflector. An Inlet Guide Structure was placed on the edge of a structure and a Flow Deflector was set near a cross-flow wind turbine and can improve ambient wind environments of the wind turbine, the maximum power coefficients were about 15 to 40% higher and the tip speed ratio range showing the high power coefficient was wide and the positive gradients were steep apparently.

关键词： vertical axis wind turbine separated flow performance wind power

Effects of Aspect Ratio in a Transonic Shock Tube Airfoil Flow

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Journal of Thermal Science 2012年第5期21卷 435-440页

作者： Masashi KASHITANI Keita MIURA shinichiro NAKAO Yutaka YAMAGUCHI Department of Aerospace Engineering National Defense Academy1-10-20 Hashirimizu Yokosuka 239-8686 JAPAN Department of Mechanical Engineering Nagasaki Institute of Applied Science 536 Aba-MachiNagasaki 851-0193 JAPAN

In the present study, the flow visualizations were performed around the NACA 0012 models which differ in aspect ratios. We discussed the effects of the aspect ratio in the test models. Additionally the unsteady, two-dimensional, compressible Euler equations were solved for the NACA 0012 airfoil. Experiments were performed utilizing the conventional gas driven shock tube as the intermittent transonic wind tunnel. The aspect ratios of the models are about 0.86 and 1.5, respectively. The Mach numbers M 2 are about 0.84. The Reynolds numbers of the present experimental conditions were constant that Re based on chord length is about 4.0×10 5 . The results are as follows: in different aspect ratios, the difference of the shock wave location is confirmed though the Mach number and Reynolds number are same. It indicates the different correction Mach number by the effects of the side wall boundary layer though the nominal Mach number measured the same value. Also, on the difference of shock wave location for the effects of the aspect ratio, the tend of CFD shows the qualitative agreement with the result of an experiment.

关键词： Shock tube Aerodynamics Transonic flows Aspect ratio Wind tunnel correction

Combined disturbance-observer-based control and iterative learning control design for pulsed superconducting radio frequency cavities

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Nuclear Science and Techniques 2021年第6期32卷 11-22页

作者： Feng Qiu shinichiro Michizono Toshihiro Matsumoto Takako Miura High Energy Accelerator Research Organization 1-1 OhoTsukubaIbaraki 305-0801Japan The Graduate University for Advanced Studies HayamaKanagawa 240-0193Japan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

The development of iterative learning control combined with disturbance-observer-based(DOB)control for the digital low-level radio frequency(LLRF)system of the International Linear Collider project is *** objective of this study is to compensate for both repetitive(or predictable)and unpredictable disturbances in a radio frequency system(e.g.,beam loading,Lorentz force detuning,and microphonics).The DOB control approach was verified using the LLRF system at the Superconducting Test Facility(STF)at KEK in the absence of a *** method comprising DOB control combined with an iterative learning control algorithm was then demonstrated in a cavity-simulator-based test bench,where a simulated beam was *** results showed that the performance of the LLRF system was improved,as expected by this combined control *** plan to further generalize this approach to LLRF systems at the STF and the future International Linear Collider project.

关键词： Low-level radio frequency Disturbance observer Iterative learning control