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Characteristics of superficial esophageal squamous cell carcinomas undetectable with narrow-band imaging endoscopy

Gastroenterology Report 2021年第5期9卷 402-407,I0001页

作者： shingo ono Akira Dobashi Hiroto Furuhashi Akio Koizumi Hiroaki Matsui Yuko Hara Kazuki Sumiyama Department of Endoscopy The Jikei University School of MedicineTokyoJapan

Background The detection rate of narrow-band imaging(NBI)for superficial esophageal squamous cell carcinoma(SESCC),including high-grade intraepithelial neoplasia,is significantly higher than that of white-light ***,there are SESCCs that are undetectable by NBI but detectable by Lugol chromoendoscopy(LCE)and the characteristics of these SESCCs are still ***,this study aimed to clarify the characteristics of SESCC that are undetectable using *** Patients with current SCC or a history of SCC in the head and neck or in the esophagus were *** inspection of the esophagus was initiated by NBI,followed by *** were taken of all suspected SESCC lesions during NBI observation and Lugol-voiding lesions(LVLs)that were irregularly shaped and>5mmand/or pink in color during LCE *** characteristics of SESCC that were undetectable with NBI were statistically *** Overall,147 lesions in 105 cases were histologically diagnosed as *** in 15 cases were NBI-undetectable lesions,all of which were macroscopic flat type(0-IIb).The median sizes of the NBI-undetectable lesions and NBI-detectable lesions were both 15mm(P=0.47).Multivariate analysis revealed independent factors for NBI-undetectable lesions such as numerous irregularly shaped LVLs(odds ratio[OR]:4.94,95%confidence interval[CI]:1.39–17.5,P<0.05)and anterior wall position(OR:4.99,95%CI:1.58–15.8,P<0.05).Conclusions The detection of SESCCs with NBI is challenging when lesions are morphologically completely flat,in cases with numerous irregularly shaped LVLs,and if located at the anterior wall.

关键词： esophageal squamous cell carcinoma narrow-band imaging Lugol chromoendoscopy Lugol-voiding lesions

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Topological pruning enables ultra-low Rayleigh scattering in pressure-quenched silica glass

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npj Computational Materials 2020年第1期6卷 499-506页

作者： Yongjian Yang Osamu Homma shingo Urata Madoka ono John C.Mauro Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Innovative Technology Research Center AGC Inc.1150 Hazawa-choKanagawa-ku YokohamaKanagawa 221-8755Japan Materials Integration Laboratories AGC Inc.1150 Hazawa-choKanagawa-ku YokohamaKanagawa 221-8755Japan Research Institute for Electronic Science Hokkaido UniversityKita 20 Nishi 10Kita-kuSapporoHokkaido 001-0020Japan

Silica glass is the most indispensable material in optical communication applications due to its superior optical *** transmission loss of silica glass has been reduced over the past 30 years by continuous efforts toward decreasing density fluctuations by lowering of fictive temperature,e.g.,through improvements in processing or doping.A recent study has shown that shrinkage of structural voids by hot compression is a promising way to further decrease the ***,an atomic understanding of the pressure effect is still ***,using molecular simulations,we connect the void shrinkage to topological pruning of silica *** physical models predict that the Rayleigh scattering loss of pressure-quenched silica glass can be reduced by>50%when the glass is quenched at an appropriate pressure(4 GPa in our simulation).Our studies are consistent with available experimental results and demonstrate topologically optimized structure can give desirable properties for optical applications of silica as well as other glasses with similar network structure.

关键词： properties structure glass

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Effect of the backbone structure of bidentate ligands in palladiumand nickel-catalyzed polar monomer copolymerization

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Science China Chemistry 2018年第11期61卷 1349-1350页

作者： shingo Ito Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University

Coordination-insertion copolymerization of non-polar ole- fins and polar monomers by late transition metal catalysts is a powerful method to synthesize functionalized polyolefins [1]. Seminal successes in this copolymerization have been achieved by using group-10 metal catalysts bearing a bidentate ligand such as phosphine-sulfonate and bisphosphine monoxide （BPMO）（Figure 1）.

关键词：金属催化剂梁结构镍氧化物

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Rate-, state-, and pressure-dependent friction model based on the elastoplastic theory

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Friction 2020年第4期8卷 768-783页

作者： shingo OZAKI Takeru MATSUURA Satoru MAEGAWA Division of System Research Yokohama National UniversityTokiwadai 79-5Hodogaya-kuYokohama 240-8501Japan Department of Electrical and Mechanical Engineering Nagoya Institute of TechnologyGokiso-choShowa-kuNagoya 466-8555Japan

Adhesion is one of essences with respect to rubber friction because the magnitude of the friction force is closely related to the magnitude of adhesion on a real contact area. However, the real contact area during sliding depends on the state and history of the contact surface. Therefore, the friction force occasionally exhibits rate-, state-, and pressure dependency. In this study, to rationally describe friction and simulate boundary value problems, a rate-, state-, and pressure-dependent friction model based on the elastoplastic theory was formulated. First, the evolution law for the friction coefficient was prescribed. Next, a nonlinear sliding surface (frictional criterion) was adopted, and several other evolution laws for internal state variables were prescribed. Subsequently, the typical response characteristics of the proposed friction model were demonstrated, and its validity was verified by comparing the obtained results with those of experiments conducted considering the contact surface between a rough rubber hemisphere and smooth acrylic plate.

关键词： adhesion friction model elastoplastic theory contact surface stick-slip

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TC10 as an essential molecule in axon regeneration through membrane supply and microtubule stabilization

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Neural Regeneration Research 2022年第1期17卷 87-88页

作者： Takeshi Nakamura shingo Koinuma Division of Cell Signaling Research Institute for Biomedical SciencesTokyo University of ScienceNodaJapan

Mammalian central nervous system(CNS)neurons lose axon regenerative ability as they *** failure to regenerate shows a clear contrast to a remarkable potential of axon growth during embryonic development and after an injury in the peripheral nervous system(PNS)(Hilton and Bradke,2017).The absence of regeneration in the mature CNS neurons is caused by an inhibitory influence of the environment of the injured axons and the deficit of intrinsic factors that enable regeneration in the PNS(He and Jin,2016).

关键词： stabilization enable axon

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Impacts of invasive Iris pseudacorus L.(yellow flag) establishing in an abandoned urban pond on native semi-wetland vegetation

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Journal of Integrative Agriculture 2018年第8期17卷 1881-1887页

作者： Daisuke Hayasaka shingo Fujiwara Taizo Uchida Graduate School of Agriculture KINDAI University Faculty of Engineering Kyushu Sangyo University

Iris pseudacorus L., intentionally introduced in Japan as an ornamental plant and to improve aquatic environments, has been declared a noxious species in the Invasive Alien Species Act of Japan due to the suspected high ecological risks to the local species and ecosystems. Although prompt responses to I. pseudacorus have been sought to conserve local biodiversity, knowledge about its invasiveness is lacking. Here, we report the relationship between the establishment of I. pseudacorus and floristic changes in semi-wetland vegetation of an abandoned urban pond(Aoike), Nara City, Nara Prepecture, Japan. In total, 64 vascular plants were recorded in the pond, of which 50 were native species, seven were naturalized non-native, and seven were invasive species. On the other hand, most of these vascular plants(42 species) were grassland species and only several aquatic plants(10 species) were found in this study pond. The number of vascular plant species decreased significantly at quadrats with a coverage of I. pseudacorus above 50%. In addition, tendencies of lower number of native species and concomitant higher number of invasive species were found with increasing coverage of I. pseudacorus. From these results, we suggest that it is important to preferentially manage sites where the coverage of I. pseudacorus is above 50%, in order to preserve the local biodiversity. Additionally, as recommended in the literature, it is essential that the cut reproductive organs are kept submerged under deep water for an effective control of I. pseudacorus.

关键词： biodiversity conservation biological invasions ecological impacts exotic species hydrophytes species traits

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Is the crop insurance program effective in China? Evidence from farmers analysis in five provinces

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Journal of Integrative Agriculture 2015年第10期14卷 2109-2120页

作者： WANG Ke ZHANG Qiao shingo Kimura Suraya Akte Agricultural Information Institute Chinese Academy of Agricultural Sciences Key Laboratory of Agri-information Service Technology Ministry of Agriculture Trade and Agricultural Directorate Organization for Economic Cooperation and Development

This paper aims to evaluate the effectiveness of the Chinese crop insurance program in terms of farmers＇ utility and welfare. A simulation model based on the power utility function was first developed to evaluate the effectiveness of crop insurance. Then, the Monte Carlo approach was used to generate the datasets of area, price, yield, cost, and income based on the characteristics of representative farmers, which were clustered and calibrated using the farm-level data of 574 individual farmers from five Chinese provinces. Finally, the effectiveness of Chinese crop insurance was evaluated by comparing the certainty equivalence（CE） of farmers＇ utility/welfare under alternative crop insurance scenarios. Government subsidy is a necessary premise for implementing the crop insurance program. The government should subsidize more than 50% of the crop insurance premium to motivate more farmers to participate in the program. The findings also show that the current crop insurance program in China has increased the farmers＇ welfare but still need to be improved to achieve the Pareto improvement and to make full use of the financial fund of the government. This paper is believed to not only extend academic research but also has significant implications for policymakers, especially in the context of rapid development of Chinese crop insurance with much issues such as rate, subsidy and coverage level needed to be improved.

关键词： crop insurance effectiveness evaluation expected utility model China

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Flow and geochemical modeling of drainage from Tomitaka mine,Miyazaki,Japan

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Journal of Environmental Sciences 2015年第10期27卷 130-143页

作者： Kohei Yamaguchi shingo Tomiyama Hideya Metugi Hiroyuki Ii Akira Ueda Mitsubishi Materials Corporation 1-297 KitabukuroOmiyaSaitama 330-0835Japan Mitsubishi Materials Techno Corporation 1-14-16 KudankitaChiyoda-kuTokyo 102-8205Japan Faculty of Systems Engineering Wakayama University Japan Oil Gas and Metals National Corporation Graduate School Division of Science and Engineering University of Toyama

The chemistry and flow of water in the abandoned Tomitaka mine of Miyazaki, western Japan were investigated. This mine is located in a non-ferrous metal deposit and acid mine drainage issues from it. The study was undertaken to estimate the quantities of mine drainage that needs to be treated in order to avoid acidification of local rivers, taking into account seasonal variations in rainfall. Numerical models aimed to reproduce observed water levels and fluxes and chemical variations of groundwater and mine drainage. Rock–water interactions that may explain the observed variations in water chemistry are proposed. The results show that：（1） rain water infiltrates into the deeper bedrock through a highly permeable zone formed largely by stopes that are partially filled with spoil from excavations（ore minerals and host rocks）;（2） the water becomes acidic（p H from 3 to 4） as dissolved oxygen oxidizes pyrite;（3） along the flow path through the rocks, the redox potential of the water becomes reducing, such that pyrite becomes stable and p H of the mine drainage becomes neutral; and（4） upon leaving the mine, the drainage becomes acidic again due to oxidation of pyrite in the rocks. The present numerical model with considering of the geochemical characteristics can simulate the main variations in groundwater flow and water levels in and around the Tomitaka mine, and apply to the future treatment of the mine drainage.

关键词： Mine drainage Hydrogen isotope Oxygen isotope Rock–water interaction Water movement

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Application of the Solvothermal Process in the Synthesis of High-performance Ag/γ-Al_2O_3 Catalysts

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过程工程学报 2006年第4期6卷 633-638页

作者：唐清李锐星殷澍 shingo Goto Daisuke Nagai Tsugio Sato Institute of Process Engineering Chinese Academy of Sciences Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan

Ag/γ-Al2O3 is a kind of promising catalyst with the relatively lower cost compared with those using noble metals,good resistance against catalytic poisoning and excellent behaviour for NOx *** the present study,Ag/γ-Al2O3 catalysts were synthesized by the solvothermal process and characterized by XRD,TG?DTA,TEM,UV?Vis and FT?*** was found that high-performance Ag/γ-Al2O3 catalysts could be synthesized by properly selecting starting materials,controlling the composition of solvent and other reaction *** microstructure evolution of the catalysts was also discussed.

关键词： Ag/γ-Al2O3 solvothermal process catalyst microstructure

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Phototropin-and photosynthesis-dependent mitochondrial positioning in Arabidopsis thaliana mesophyll cells^FA

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Journal of Integrative Plant Biology 2020年第9期62卷 1352-1371页

作者： Md Sayeedul Islam Toan Van Nguyen Wataru Sakamoto shingo Takagi Department of Biological Sciences Graduate School of ScienceOsaka UniversityMachikaneyama-cho 1-1ToyonakaOsaka 560-0043Japan Agricultural Genetics Institute National Key Laboratory for Plant Cell BiotechnologyPham Van Dong roadBac Tu Liem districtHa NoiVietnam Institute of Plant Science and Resources Okayama UniversityKurashikiOkayama 710-0046Japan

Mitochondria are frequently observed in the vicinity of chloroplasts in photosynthesizing cells, and this association is considered necessary for their metabolic in-teractions. We previously reported that, in leaf palisade cel s of Arabidopsis thaliana, mitochondria exhibit blue-light-dependent redistribution together with chloroplasts, which conduct accumulation and avoidance responses under the control of blue-light receptor phototropins. In this study, precise motility analyses by fluorescent micro-scopy revealed that the individual mitochondria in palisade cel s, labeled with green fluorescent protein, exhibit typical stop-and-go movement. When exposed to blue light, the velocity of moving mitochondria increased in 30 min, whereas after 4 h, the frequency of stoppage of mi-tochondrial movement markedly increased. Using different mutant plants, we concluded that the presence of both phototropin1 and phototropin2 is necessary for the early acceleration of mitochondrial movement. On the contrary, the late enhancement of stoppage of mitochondrial movement occurs only in the presence of phototropin2 and only when intact photosynthesis takes place. A plasma-membrane ghost assay suggested that the stopped mi-tochondria are firmly adhered to chloroplasts. These re-sults indicate that the physical interaction between mi-tochondria and chloroplasts is cooperatively mediated by phototropin2- and photosynthesis-dependent signals. The present study might add novel regulatory mechanism for light-dependent plant organel e interactions.

关键词： tropin Arabidopsis movement

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