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Finite Element Dynamics of Human Ear System Comprising Middle Ear and Cochlea in Inner Ear

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Journal of Biomedical Science and Engineering 2016年第13期9卷 597-610页

作者： Hidayat shingo okamoto Jae Hoon Lee Naohito Hato Hiroyuki Yamada Daiki Takagi Graduate School of Science and Engineering Ehime University Matsuyama Japan Mechanical Engineering Department State Polytechnic of Samarinda Samarinda Indonesia Department of Otorhinolaryngology Head and Neck Surgery Ehime University School of Medicine Matsuyama Japan

A human middle ear consists of an eardrum and three ossicles which are linked by each other, and connect with the eardrum and an inner ear. The inner ear consists of a cochlea and a vestibular system. An abnormality of the human middle ear such as ossicular dislocation may cause conductive hearing loss. The conductive hearing loss is generally treated by surgery using artificial ossicles. The treatments of conductive hearing loss require a better understanding of characteristics and dynamic behaviors of the human middle ear when the sounds transmit from outer inner to inner ear. The purpose of this research is to simulate the dynamic behaviors of a human ear system comprising the middle ear and the cochlea in the inner ear using the finite element method (FEM). Firstly, the eigen-value analysis was performed to obtain the natural frequencies and vibration modes of the total ear system. Secondly, the frequency response analysis was carried out. Thirdly, the time history response analyses were performed using human voices as the external forces. In the time history response analyses, the sounds created as input sound pressures were used. Human voices, for example vowels “I”, “u” and “e” as input sound pressures were created by using the sound pressures downloaded from the opening samples of human voices as wav files in a website. Then it was clarified that the high frequency components of sounds are reduced by the middle ear system.

关键词： Eardrum Middle Ear Dynamics Human Voice Finite Element Method

Molecular Dynamics Analysis on Tensile and Shearing Properties of Nitrogen-Containing Graphene

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通讯和计算机（中英文版） 2013年第1期10卷 19-27页

作者： shingo okamoto Akihiko Ito Graduate School of Science and Engineering Ehime University Matsuyama 790-8577 Japan The Composite Materials Research Laboratories Toray Industries Inc. Masaki-cho790-8577 Japan

The authors investigated the mechanical properties of N (nitrogen)-containing graphene under tensile and shear loading via MD (molecular dynamics) simulations. In the MD simulation, the authors used two types of potential functions for covalent bonds: the second-generation REBO (reactive empirical bond order) potential for covalent C-C bonds, the Tersoff potential for covalent C-N bonds. The effects of N-content and different distributions of N-atoms in graphene on its properties were studied. It was found that both the tensile and shearing strengths decreased greatly when two N-atoms contained in graphene adjoined each other. Then, a N-content of up to 4% had little effect on the tensile properties of graphene except when two N-atoms adjoined each other.

关键词：分子动力学动力学分析石墨抗剪性能抗拉强度含氮 Tersoff势 MD模拟

Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps

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World Journal of Gastroenterology 2009年第17期15卷 2162-2165页

作者： Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa okamoto shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba Department of Gastroenterology Aso Iizuka Hospital Iizuka 820-8505 Japan Department of Pathology Aso Iizuka Hospital Iizuka 820-8505 Japan Fujifilm Corporation Saitama 331-9624 Japan

Endoscopic submucosal dissection （ESD） with a knife is a technically demanding procedure a ssociated with ahigh complication rate. The shortcomings of this meth-od are the inability to fix the knife to the target lesion,and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps （GSF）,which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-ram rectal submucosal *** histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonog-raphy demonstrated a hypoechoic solid tumor limitedto the submucosa without lymph node involvement. Itwas safely and accurately resected without unexpectedincision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excisedwith negative resection margin.

关键词： Endoscopic submucosal dissection New device Rectal carcinoid Grasping type scissors forceps Endoscopic therapy

Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells

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World Journal of Gastroenterology 2014年第47期20卷 17863-17876页

作者： Atsushi Shiozaki Hiroki Shimizu Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma okamoto Daisuke Iitaka shingo Nakashima Yoshito Nako Mingyao Liu Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Latner Thoracic Surgery Research Laboratories University Health Network Toronto General Research InstituteToronto M5G 1L7Canada Department of Surgery Faculty of MedicineUniversity of TorontoToronto M5G 1L7Canada

AIM: To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha (TNF-α)-induced gene expression in human gastric adenocarcinoma cells.

关键词： Tumor necrosis factor alpha Claudin 1 Cell migration Microarray Gene expression change

Surgical treatment of hepatocellular carcinoma with severe intratumoral arterioportal shunt

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World Journal of Gastroenterology 2010年第25期16卷 3211-3214页

作者： Hiromichi Ishii Teruhisa Sonoyama shingo Nakashima Hiroyuki Nagata Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma okamoto Toshiya Ochiai Yukihito Kokuba Chohei Sakakura Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan

We report a case of hepatocellular carcinoma (HCC) that caused a severe arterioportal shunt (APS). A 49-year-old man was admitted to hospital due to esophagogastric variceal hemorrhage and HCC, and underwent endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS). He was then referred to our hospital. Abdominal computed tomography revealed a lowdensity lesion in the posterior segment of the liver and an intratumoral APS, which caused portal hypertension. Although the patient underwent EVL, EIS, Hassab’s operation, and transcatheter arterial embolization for APS, he vomited blood due to rupture of esophagogastric varices. Right hepatectomy was performed for the treatment of HCC and APS, although the indocyanine green retention value at 15 min after intravenous injection was poor (30%). The patient’s postoperative course was uneventful. Eventually, APS disappeared and the esophagogastric varices improved.

关键词： Arterioportal shunt Hepatocellular carcinoma Esophagogastric varices

亚洲人光老化引起的皮肤泛黄与真皮羰基化之间的关系

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亚洲人光老化引起的皮肤泛黄与真皮羰基化之间的关系