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比较内耳内淋巴显像和耳蜗电图及甘油试验在梅尼埃病诊断中的价值

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临床耳鼻咽喉头颈外科杂志 2012年第19期26卷 893-896页

作者： HISAKUNI FUKUOKA YUTAKA TAKUMI KEITA TSUKADA MAIKO MIYAGAWA TOMOHIRO OGUCHI HITOSHI UEDA MASUMI KADOYA shin-ichi usami 张甦琳孔维佳 Department of Otorhinolaryngology Shinshu University School of MedicineMatsumotoJapan Department of Radiology Shinshu University School of MedicineMatsumotoJapan 华中科技大学同济医学院附属协和医院耳鼻咽喉科武汉430022

目的:研究甘油试验、耳蜗电图、3T MRI在梅尼埃病(MD)患者中的关系。方法:评估20例患者,把稀释的钆造影剂通过鼓室注射入患者双侧的鼓室腔,24h后,通过3T MRI评估膜迷路积水的程度,此外为检测耳蜗积水,进行耳蜗电图和甘油试验。结果:经... 详细信息

目的:研究甘油试验、耳蜗电图、3T MRI在梅尼埃病(MD)患者中的关系。方法:评估20例患者,把稀释的钆造影剂通过鼓室注射入患者双侧的鼓室腔,24h后,通过3T MRI评估膜迷路积水的程度,此外为检测耳蜗积水,进行耳蜗电图和甘油试验。结果:经耳蜗电图检测,11例(55%)患者有阳性结果。经甘油试验检测,12例(60%)患者有阳性结果。同时采用甘油试验和耳蜗电图检测同一组患者时,75%的患者有阳性结果。用钆造影剂的3T MRI检查,19例(95%)患者有阳性结果。结论:与耳蜗电图及甘油试验检测相比,鼓室内注射钆造影剂的3T MRI,对内耳膜迷路积水的诊断更有价值。

关键词：膜迷路积水钆耳蜗电图

胸腺素beta4在快速老化鼠耳蜗的过度表达

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中华耳鼻咽喉科杂志 2004年第12期39卷 717-720页

作者：王宇声浅村贤二宇佐美真一吉林大学第一医院耳鼻咽喉头颈外科 130021 日本信州大学医学部耳鼻咽喉科

目的　通过比较年轻与年老的快速老化鼠 (senescence acceleratedmouse ,SAM)耳蜗中基因表达水平 ,筛选并分析可能的与老年聋相关的基因。方法　将分别从 2个月和 12个月的SAM耳蜗中提取的总RNA合成cDNA ,并与载有 110 1鼠基因的基因芯... 详细信息

目的　通过比较年轻与年老的快速老化鼠 (senescence acceleratedmouse ,SAM)耳蜗中基因表达水平 ,筛选并分析可能的与老年聋相关的基因。方法　将分别从 2个月和 12个月的SAM耳蜗中提取的总RNA合成cDNA ,并与载有 110 1鼠基因的基因芯片进行杂交 ,杂交信号通过蓝色素 3荧光显色 ,并使用微机对其图像进行分析。通过实时定量逆转录聚合酶链式反应技术对其结果进行验证。用免疫荧光染色的方法 ,确定候选基因所编码的蛋白在耳蜗中的表达部位。结果　多数基因在老年耳蜗中的表达并没有明显的变化 ,本研究发现有 3个基因的表达较年轻耳蜗中有明显的增加 ,通过定量逆转录聚合酶链式反应技术证实其中的胸腺素beta4mRNA过度表达。免疫荧光染色显示胸腺素beta4主要在耳蜗的盖膜及外毛细胞的支持细胞中表达。结论　通过生物芯片技术 ,显示老年鼠耳蜗中基因表达的情况 ,并发现胸腺素beta4有可能与老年聋相关。这一研究为探讨老年聋的分子生物学机制提供了参考。

关键词：胸腺素 beta4 过度表达老年性耳聋逆转录聚合酶链反应

Gut microbiota and host metabolism in liver cirrhosis

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World Journal of Gastroenterology 2015年第41期21卷 11597-11608页

作者： Makoto usami Makoto Miyoshi Hayato Yamashita Division of Nutrition and Metabolism Department of Biophysics Kobe University Graduate School of Health Sciences Department of Nutrition Kobe University Hospital Kobe University School of Medicine

The gut microbiota has the capacity to produce a diverse range of compounds that play a major role in regulatingthe activity of distal organs and the liver is strategically positioned downstream of the gut. Gut microbiota linked compounds such as short chain fatty acids, bile acids, choline metabolites, indole derivatives, vitamins, polyamines, lipids, neurotransmitters and neuroactive compounds, and hypothalamic-pituitary-adrenal axis hormones have many biological functions. This review focuses on the gut microbiota and host metabolism in liver cirrhosis. Dysbiosis in liver cirrhosis causes serious complications, such as bacteremia and hepatic encephalopathy, accompanied by small intestinal bacterial overgrowth and increased intestinal permeability. Gut dysbiosis in cirrhosis and intervention with probiotics and synbiotics in a clinical setting is reviewed and evaluated. Recent studies have revealed the relationship between gut microbiota and host metabolism in chronic metabolic liver disease, especially, non-alcoholic fatty liver disease, alcoholic liver disease, and with the gut microbiota metabolic interactions in dysbiosis related metabolic diseases such as diabetes and obesity. Recently, our understanding of the relationship between the gut and liver and how this regulates systemic metabolic changes in liver cirrhosis has increased. The serum lipid levels of phospholipids, free fatty acids, polyunsaturated fatty acids, especially, eicosapentaenoic acid, arachidonic acid, and docosahexaenoic acid have significant correlations with specific fecal flora in liver cirrhosis. Many clinical and experimental reports support the relationship between fatty acid metabolism and gut-microbiota. Various blood metabolome such as cytokines, amino acids, and vitamins are correlated with gut microbiota in probioticstreated liver cirrhosis patients. The future evaluation of the gut-microbiota-liver metabolic network and the intervention of these relationships using probiotics, s

关键词： Liver cirrhosis Microbiota Metabolism Fatty acids

Running-in friction of hip joint replacements can be significantly reduced:The effect of surface-textured acetabular cup

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Friction 2020年第6期8卷 1137-1152页

作者： David NECAS Hatsuhiko usami Tatsuya NIIMI Yoshinori SAWAE Ivan KRUPKA Martin HARTL Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Faculty of Science and Technology Meijo UniversityNagoya 468-8502Japan Kanefusa Corporation Nagoya 480-0192Japan Faculty of Engineering Kyushu UniversityFukuoka 819-0395Japan

Hip joint replacements represent the most effective way of treatment for patients suffering from joint *** the rapid improvement of implant materials over the last few decades,limited longevity associated with wear-related complications persists as the main ***,improved tribological perfor-mance is required in order to extend the service life of *** effect of surface texturing of ultra-high molecular weight polyethylene(UHMWPE)acetabular cup was investigated in the present *** tilling method was utilized for manufacturing the dimples with controlled diameter and depths on the contact surface of the *** experiments with four commercial femoral components and two model lubricants were *** main attention was paid to a coefficient of friction considering the differences between the original and the dimpled *** showed remarkable lowering of friction,in *** on the simulated human synovial fluid,friction was reduced by 40%(alumina ceramic),38.8%(zirconia toughened ceramic),25.5%(metal),and 9.9%(oxinium).In addition,the dimples helped to keep the friction stable without *** conclude,the paper brings a new insight into frictional behaviour of the hip replacements during running-in phase which is essential for overall implant *** is believed that proper surface texturing may rapidly improve the life quality of millions of patients and may lead to considerable financial savings.

关键词： hip joint replacement friction texturing dimple longevity

Temperature effects of shape memory alloys(SMAs)in damage control design of steel portal frames

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Frontiers of Structural and Civil Engineering 2012年第4期6卷 348-357页

作者： Xiaoqun LUO Hanbin GE Tsutomu usami Department of Building Engineering Tongji UniversityShanghai 200092China Department of Civil Engineering Meijo UniversityNagoya 468-8502Japa

The objective of the present study is to analytically investigate temperature effects of an axial-type seismic damper made of shape memory alloys(SMAs)equipped in steel *** on a modified multilinear one dimensional constitutive model of SMAs,two types of SMAs are employed,which have different stress plateau and different stress growth rate with temperature *** effects of SMA dampers on seismic performance upgrading are discussed in three aspects:different environment temperatures;rapid loading rate induced heat generation and different SMA *** analysis indicates that the effect of environment temperature should be considered for the SMA damper in steel ***,the rapid loading rate induced heat generation has little adverse effect.

关键词： damage control design shape memory alloy temperature effect

Parametric study on damage control design of SMA dampers in frame-typed steel piers

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Frontiers of Structural and Civil Engineering 2009年第4期3卷 384-394页

作者： Xiaoqun LUO Hanbin GE Tsutomu usami Advanced Research Center for Seismic Experiments and Computations Meijo UniversityNagoya 468-8502Japan Department of Building Engineering Tongji UniversityShanghai 200092China Department of Civil Engineering Meijo UniversityNagoya 468-8502Japan

This paper focuses on damage control design of SMA dampers in steel frame piers.A parametric study based on time history analyses is carried out on frametyped bridge piers with axial-type SMA damping *** parameters examined are design parameters of strength ratioαF and stiffness ratioα*** performance indexes on displacement and strain are investigated under three JRA recommended Level 2 Ground TypeПstrong earthquake *** recommendations are suggested following the results of the parametric study.

关键词： damage control design shape memory alloy parameter study displacement-based verification strainbased verification time history analysis

Simulation of Plasma Flow Injectionwith Multi-Hierarchy Model Aiming Magnetic Reconnection Studies

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Communications in Computational Physics 2012年第3期11卷 1006-1021页

作者： S.usami H.Ohtani R.Horiuchi M.Den Department of Helical Plasma Research National Institute for Fusion ScienceToki509-5292Japan The Graduate University for Advanced Studies(Soken-dai) Toki509-5292Japan National Institute of Information and Communications Technology Koganei 184-8795Japan

A multi-hierarchy simulation model aiming magnetic reconnection studies is developed and improved in which macroscopic and microscopic physics are computed consistently and *** physics is solved by magnetohydrodynamics(MHD)algorithm,while microscopic dynamics is expressed by particle-in-cell(PIC)*** multi-hierarchy model relies on the domain decomposition method,and macro-and micro-hierarchies are interlocked smoothly by hand-shake *** examination,plasma flow injection is simulated in the multihierarchy *** is observed that plasmas flow from a macro-hierarchy to a microhierarchy across the magnetic field smoothly and continuously.

关键词： Multi-hierarchy simulation magnetic reconnection MHD PIC

Simulation of Fast-Recovery Cross-Modulation Characteristics in Semiconductor Optical Amplifier with Assist Light

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光学学报 2003年第S1期23卷 453-454页

作者： Atsushi Matusmoto Kosuke Nishimura Katsuyuki Utaka Masashi usami School of Science and Engineering Waseda University 3-4-1 Ohkubo Shinjuku Tokyo 169-8555 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka Saitama 356-8502 JapanSchool of Science and Engineering Waseda University 3-4-1 Ohkubo Shinjuku Tokyo 169-8555 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka Saitama 356-8502 Japan

We analyzed the characteristics of cross-modulations (XM) and their recovery times in a semiconductor optical amplifier by a newly-developed TMM. The calculated results suggest faster recovery of the XMs by introducin... 详细信息

关键词： Simulation of Fast-Recovery Cross-Modulation Characteristics in Semiconductor Optical Amplifier with Assist Light as for of XPM SOA in with

Intergenerational Justice： Rights versus Fairness

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Journal of Philosophy Study 2011年第4期1卷 237-246页

作者： Makoto usami Tokyo Institute of Technology

Among various views on intergenerational justice, the most widely accepted theory invokes the rights of future generations. However, the rights theory seems to suffer from the non-identity problem addressed by Derek Parfit. Some rights theorists attempt to circumvent the problem by examining causal links between actions taken by preceding generations and their effects on succeeding ones, Others try to do so by replacing future individual rights with such collective rights. This paper argues that both individualist and collectivist versions of the rights theory fail to supply grounds for intergenerational concern. The paper then offers an alternative theory that refines the idea of duty of fair play developed by John Rawls and applies it to the context of intergenerational relationships. To begin with, I identify several characteristics of posterity and explicate the adverse implications these characteristics have for other major theories of intertemporal concern than the rights theory. Next, different versions of the rights theory are closely examined from the perspective of the non-identity problem. Then, I offer an alternative argument for caring about future people, which is founded on the idea of intergenerational fair play. This paper concludes by noting that the fairness theory, unlike its rivals, does not face the non-identity problem or any other problems stemming from the features of posterity previously identified.

关键词： duty of fair play non-identity problem resourcism rights of future generations sufficientarianism