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Design of the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS): A Multidisciplinary Observational Epidemiological Study

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Open Journal of Endocrine and Metabolic Diseases 2013年第2期3卷 144-156页

作者： Toshitaka Muneyuki Kaname Suwa Haruki Oshida Tomoya Takaoka Ayano Kutsuma Tsukasa Yoshida Masafumi Saito Yumiko Hori Yoshihiko Kannno Eiichiro Kanda Masafumi Kakei shin-ichi momomura Kei Nakajima Division of Clinical Nutrition Department of Medical Dietetics Faculty of Pharmaceutical Sciences Josai University Sakado Japan

Background: In the past few decades, the incidence of cardiometabolic diseases and disorders of the liver, kidney, pancreas, heart, and lung, have been increasing in Western and Asian countries, including Japan. Numerous factors, including abnormal body weight (obesity, overweight, or underweight), infrequent exercise, and other unfavorable lifestyle factors (e.g., smoking and heavy alcohol drinking) have been proposed as risk factors for the development and the progression of diseases, such as type 2 diabetes, hypertension, and dyslipidemia, which ultimately lead to impaired organ function and possibly death. However, the mechanisms that link these risk factors with diseases are still poorly understood, and the potential treatments, including pharmacotherapy and diet, have not been fully evaluated. Methods: In 2011, we established a new collaborative research program, the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS). This multidisciplinary observational epidemiological research study was designed to cover several high-profile diseases and some traditional fields of internal medicine, as well as apparently unrelated fields and particular lifestyle factors, such as unhealthy eating behaviors. In a series of studies, apparently healthy subjects who underwent a regular medical checkup were retrospectively identified based on the results of their medical checkups. In this way, the incidence, prevalence, causality, and clinical relevance of specific conditions and diseases have been investigated in cross-sectional analyses of 100,000 - 200,000 adults, and in longitudinal studies of several thousand subjects who underwent medical checkups multiple times. Discussion: This article describes the background, rationale, purpose, and methods of the SCDOIS. Using data obtained from annual medical checkups, our goals are to 1) establish criteria or identify clinical features that would enable clinicians to detect the presence of abnormal conditions associat

关键词： Obesity Cardiometabolic Risks Organ Impairments Asians Diabetes Nutrition Saitama Checkup

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阻塞性睡眠呼吸暂停男性的血浆Pentraxin3和动脉硬化的关系

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中华高血压杂志(中英文) 2011年第8期19卷 797-797页

作者： Takatoshi Kasai Kenji Inoue Takiko Kumagai Mitsue Kato Fusae Kawana Mina Sagara Sugao Ishiwata Minoru Ohno Tetsu Yamaguchi shin-ichi momomura Koji Narui 罗冬梅

阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)诱发炎症和血管损伤,增加心血管疾病(cardio-vascular disease,CVD)的风险,然而OSA造成CVD的机制尚不完全清楚。

关键词：阻塞性睡眠呼吸暂停 CAVI OSA Pentraxin3 动脉硬化动脉疾病血浆

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