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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

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Bioactive Materials 2024年第4期34卷 164-180页

作者： Sungkyu Lee Jounghyun Yoo Gunhyu Bae Ramar Thangam Jeongyun Heo Jung Yeon park Honghwan Choi Chowon Kim Jusung An Jungryun Kim Kwang Rok Mun Seungyong shin Kunyu Zhang Pengchao Zhao Yuri Kim Nayeon Kang Seong-Beom Han Dahee Kim Jiwon Yoon Misun Kang Jihwan Kim Letao Yang Solmaz Karamikamkar Jinjoo Kim Yangzhi Zhu Alireza Hassani Najafabadi Guosheng Song Dong-Hwee Kim Ki-Bum Lee Soong Ju Oh Hyun-Do Jung Hyun-Cheol Song Woo Young Jang Liming Bian Zhiqin Chu Juyoung Yoon Jong Seung Kim Yu Shrike Zhang Yongju Kim Ho Seong Jang Sehoon Kim Heemin Kang Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Chemical and Biological Integrative Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Chemistry Korea UniversitySeoul02841Republic of Korea Materials Architecturing Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442China Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ08854USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Biomedical-Chemical Engineering The Catholic University of KoreaGyeonggi-do14662Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Department of Orthopedic Surgery Korea University Anam HospitalSeoul02841Republic of Korea Department of Electrical and Electronic Engineering and Joint Appointment with School of Biomedical Sciences The University of Hong KongHong Kong518057China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul03760Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA Division of Nano&Information Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea College of Medicine Korea UniversitySeoul02841Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Extracellular matrix(ECM)undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been *** we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo^(+)self-assembly composed of azobenzene derivatives(Azo^(+))stacked via cation-πinteractions and stabilized with RGD ligand-bearing poly(acrylic acid).Near-infrared-upconverted-ultraviolet light induces cis-Azo^(+)-mediated inflation that suppresses cation-πinteractions,thereby inflating liganded *** inflation increases nanospacing of“closely nanospaced”ligands from 1.8 nm to 2.6 nm and the surface area of liganded selfassembly that facilitate stem cell adhesion,mechanosensing,and differentiation both in vitro and in vivo,including the release of loaded molecules by destabilizing water bridges and hydrogen bonds between the Azo^(+)molecules and loaded ***,visible light induces trans-Azo^(+)formation that facilitates cation-πinteractions,thereby deflating self-assembly with“closely nanospaced”ligands that inhibits stem cell adhesion,mechanosensing,and *** stark contrast,when ligand nanospacing increases from 8.7 nm to 12.2 nm via the inflation of self-assembly,the surface area of“distantly nanospaced”ligands increases,thereby suppressing stem cell adhesion,mechanosensing,and ***-term in vivo stability of self-assembly via real-time tracking and upconversion are *** tuning of ligand nanospacing can unravel dynamic ligand-cell interactions for stem cell-regulated tissue regeneration.

关键词： Dynamic self-assembly Ligand nanospacing In vivo tracking Stem cell adhesion Stem cell fate

Analysis of Smoke Distribution in the Subway Station with Various Main Tunnel Ventilations

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Journal of Energy and Power Engineering 2015年第4期9卷 405-410页

作者： Yong-Jun Jang Ji-Min Ryu Sung-Huk park Dong-Hoe Koo Korea Railroad Research Institute Railroad Safety Center Gyeonggi-do 437-757 South Korea

Fire-driven flow analysis in the underground subway station has been performed with various main tunnel ventilations. shin-gum-ho station （depth： 46 m） in Seoul is selected as a simulation model. The ventilation mode is assumed to be emergency state. Various main tunnel ventilations are applied to operate in a proper way for helping of smoke exhaustion in platform. The entire station is covered for simulation. Ventilation diffusers are modeled as 95 square shapes of 0.6 m × 0.6 m in the lobby and as 222 square shapes of 0.6 m × 0.6 m and four rectangular shapes of 1.2 m × 0.8 m in the platform. The total of 7.5 million grids is generated and whole domain is divided to 22 blocks for MPI （massage passing interface） efficiency of calculation. LES （large eddy simulation） is applied to solve the momentum equation. Smagorinsky model （Cs = 0.2） is used as SGS （subgrid scale） model. The distribution of CO （carbon monoxide） is calculated for various capacity of main tunnel ventilation and compared with each other.

关键词： Subway station main tunnel ventilation fire-driven flow LES.

Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions

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Nano-Micro Letters 2021年第12期13卷 452-467页

作者： Guillermo U.Ruiz-Esparza Xichi Wang Xingcai Zhang Sofia Jimenez-Vazquez Liliana Diaz-Gomez Anne-Marie Lavoie Samson Afewerki Andres AFuentes-Baldemar Roberto Parra-Saldivar Nan Jiang Nasim Annabi Bahram Saleh Ali K.Yetisen Amir Sheikhi Thomas H.Jozefiak Su Ryon shin Nianguo Dong Ali Khademhosseini Biomaterials Innovation Research Center Division of Engineering in MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Division of Health Sciences and Technology Harvard University-Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering and Science Tecnologico de MonterreyCampus MonterreyMonterreyNuevo Leon 64849Mexico School of Medicine and Health Science Campus GuadalajaraZapopanJalisco 45201Mexico West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Chemical Engineering Imperial College LondonLondon SW72AZUK Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Terasaki Institute for Biomedical Innovation 11570 W Olympic BlvdLos AngelesCA 90024USA

More than 90%of surgical patients develop postoper-ative adhesions,and the incidence of hospital re-admissions can be as high as 20%.Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive *** solve thisclinical limitation,we developed an injectable and sprayable shear-thinning hydrogel barrier(STHB)composed of silicate nanoplatelets and poly(ethylene oxide).We optimized this technology to recover mechanical integrity after stress,enabling its delivery though inject-able and sprayable *** also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in *** STHB was then tested in a rodent model of peritoneal injury to determine its e cacy preventing the formation of postoperative *** two weeks,the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions,and STHB formulations presented superior e cacy compared to a commercially available adhesion *** and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB *** technology demonstrated increased e cacy,ease of use in complex anatomies,and compatibility with di erent delivery methods,providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions.

关键词： Postoperative adhesions Shear-thinning hydrogel Silicate nanoplatelets Nanotechnology Nanomedicine

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旋转浓缩-蓄热氧化法处理涂装废气的中试研究

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现代化工 2009年第12期29卷 75-78页

作者：崔龙哲蔡俊雄申哲昊朴泰善容誉凌海波中南民族大学化学与材料科学学院湖北武汉430074 湖北省环境科学研究院湖北武汉430072 Seohae Enviromment Science Institute Korea 565854 H - Plus ENG Ltd. Jeonllanam - do Korea 555260

用旋转浓缩-蓄热氧化(RC-RTO)系统对某车轮厂涂装废气进行了中试处理研究,以废气处理前后总挥发性有机物(T-VOCs)浓度及苯、甲苯、乙苯、对二甲苯、邻二甲苯浓度的变化为指标,考察了RC转速对吸附性能、RTO氧化效果的影响。结果表明,RC... 详细信息

用旋转浓缩-蓄热氧化(RC-RTO)系统对某车轮厂涂装废气进行了中试处理研究,以废气处理前后总挥发性有机物(T-VOCs)浓度及苯、甲苯、乙苯、对二甲苯、邻二甲苯浓度的变化为指标,考察了RC转速对吸附性能、RTO氧化效果的影响。结果表明,RC转速对吸附效果及进入RTO单元浓缩气体中VOCs浓度有较大的影响,RC转速过高或过低均不利于系统稳定高效的运行。系统在RC转速为3r/h的条件下连续运行1个月,期间系统不需外加能源即可维持热量平衡,且RC单元及RTO单元排气中5种VOC物质浓度均远低于国家规定的排放标准(GB16297—1996)。

关键词：蓄热氧化系统涂装废气吸附挥发性有机物(VOCs)

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三阴性乳腺癌治疗前MR影像表现:与新型辅助化疗疗效和无复发生存率的关系

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国际医学放射学杂志 2017年第1期 81-82页

作者： M.S.Bae S.U.shin H.S.Ryu W.Han S.A.Im I.A.park 赵玉娇 Department of Radiology Seoul National University College of edicine and Seoul National University Hospital

摘要目的在三阴性乳腺癌应用新辅助化疗(NAC)的病人中,探讨治疗前MR影像特征是否与病理完全缓解和无复发生存相关。材料与方法收集2004—2010年三阴性乳腺

关键词：三阴性乳腺癌病人病理完全缓解影像表现 MR

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矩阵建筑

建筑实践 2010年第9期 52-57页

作者：王丹 Kyungsub shin Yong-Kwan Kim Mass Studies Wan Soon park

S-Trenue大厦坐落在韩国首尔的汝矣岛上,它是一栋商业、办公、居住的综合体建筑。它的确立反映了建筑师面对全球化和城市化问题的思考和应对策略,同时也是MASS事务所矩阵系列建筑中的一个代表性作品。

关键词：建筑体量韩国矩阵数学分析大厦建筑师美术家

The biodiversity of Paecilomyces cicadae

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The biodiversity of Paecilomyces cicadae

中国植物病理学会2007年学术年会

作者： Liu Ai Ying~(**) Zou Xiao Hu Hai Yan Luo Li Liang zong Qi(Institute of Fungus Resource Guizhou University,Guiyang 550025) Chul Soo shin Kim Yong Ook park Hae Wong(Department of Biotechnology,College of Engineering,Yonsei University,Seoul,Republic Korea)

＜正＞The purpose of this paper is to study the feasible evaluation of Paecilomyces cicadae abroad *** the classical methods,some physiological and biochemical indexes were tested. combining with the reference information,we could get follow results:1,In virtue of its high content of cordycep polysaccharide,Paecilomyces cicadae has been successfully developed as modem traditional chinese pharmacy.2,It could be developed to biocontrol fungus because of its drought-resistance, UV-Resistant,high activities of chitinase,proteinase,and lysozyme,and heterokaryon or diploid strain with high pathogenicity.3,It could be developed as health-care foods and cosmetic products basing on its bioactive substances,such as hyaluronic acid,polysaturated fatty acids,SOD,POD,lysozyme, protein,amino acids,nucleoside,mannitol,ergosterol,***,Paecilomyces cicadae which came from different ecological conditions had physiological,biochemical,and genetic ***, we could screen and cultivate high functional strains according to our development purpose.

关键词： Paecilomyces cicadae polysaccharide pathogenicity heterokaryon bioactivè substances

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实现实时动力总成硬件系统的安全引导

汽车与新动力 2019年第3期2卷 36-40页

作者： D.Kim[韩] E.shin[韩] J.S.park[韩] K.S.Lee[韩] K.C.Gui[韩] K.Scheibert[韩] 武涛(译) 不详

汽车安全意味着保护车辆,避免潜在的威胁、意外故障和篡改参数行为,直接关系到驾驶者和行人的生命安全,这是汽车系统的重要问题之一。汽车系统需要加强安全策略,以防止黑客的攻击。然而,在某些系统实现安全功能时,首先要考虑的是性能。... 详细信息

汽车安全意味着保护车辆,避免潜在的威胁、意外故障和篡改参数行为,直接关系到驾驶者和行人的生命安全,这是汽车系统的重要问题之一。汽车系统需要加强安全策略,以防止黑客的攻击。然而,在某些系统实现安全功能时,首先要考虑的是性能。特别是发动机管理系统(EMS),在启动发动机时,保证发动机实现快速同步被视为第一要务。介绍针对EMS的一种安全引导设计。介绍安全引导的概念,并根据前台和后台的安全引导模式,介绍几种不同的应用案例;阐述EMS在发动机起动过程中的作用,以及发动机同步后的燃油喷射和点火过程;讨论在发动机运行过程中,EMS复位在发动机重起过程中出现的一些严重问题。为了确保在任何情况,即使在重起的情况下,发动机依然能稳定运行,提出一种有效的安全引导应用策略,可以确保发动机重起和再同步的稳定性。这些策略包括操作系统中的任务分配,基于多核的任务分解和存储区分配。

关键词：汽车安全安全引导发动机管理系统发动机

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Primary Study on the Fungus *** and Its Sectors

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